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Fibromyalgia
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=== Fibromyalgia is not the same as depression === * Oct 24, 2003, [https://www.webmd.com/depression/news/20031024/fibromyalgia-isnt-depression#1 Fibromyalgia Isn't Depression]<ref name="webmd-notdepress" /> <blockquote>[[Depression]] doesn't cause the pain of fibromyalgia, a new study shows.<ref name="webmd-notdepress" /></blockquote> <blockquote>"People still doubt fibromyalgia is a disease," Giesecke tells WebMD. "Previously, we found that fibromyalgia patients really do have increased central pain processing. Now we can show this is not affected by depression. Something is wrong here, and it is not at all connected with depression."<ref name="webmd-notdepress" /></blockquote> <blockquote>"Giesecke's group looked at [[brain]] responses to painful stimuli, and then checked to see if there was any difference between depressed and nondepressed fibromyalgia patients. They showed the activation of areas of the brain related to pain were not different in patients with and without depression." But there is a difference between people with and without fibromyalgia, he says.<ref name="webmd-notdepress" /> </blockquote><blockquote>The researchers use an imaging device called [[functional magnetic resonance imaging]], or fMRI, to look at how the brain responds to pain. Study participants get a mildly painful pressure on their thumb, which makes the brain's pain centers "light up" on the image. Thumb pressure -- at a level healthy people hardly feel -- sets off a firestorm in the pain centers of fibromyalgia patients' brains.<ref name="webmd-notdepress" /></blockquote> * 2013, Small fibre pathology in patients with fibromyalgia syndrome<ref name="brain-1857" /> :A study involving skin biopsies funds that fibromyalgia is neuropathic - and not a form of [[depression]] or a [[Psychosomatic illness|Psychosomatic Disorder]] <blockquote>The study authors stated, "This strengthens the notion that fibromyalgia syndrome is not a variant of depression, but rather represents an independent entity that may be associated with depressive symptoms". The findings also point "towards a neuropathic nature of pain in fibromyalgia syndrome... with regard to the persistent somatoform pain disorder that is sometimes assumed to be underlying in patients with fibromyalgia syndrome, our study shows a clear distinction to fibromyalgia syndrome: persistent somatoform pain disorder (ICD-10 F45.40) may be present in patients with fibromyalgia syndrome, however, in the majority of cases the definition of pain starting in connection with an emotional conflict situation or psycho-social stress strong enough to be taken as a crucial aetiological influence and pain in the course of a primary depressive disorder or schizophrenia in addition to chronic widespread pain lasting longer than 6 months is not fulfilled."<ref name="brain-1857">{{Cite journal | last = Üçeyler | first = Nurcan | last2 = Zeller | first2 = Daniel | last3 = Kahn | first3 = Ann-Kathrin | last4 = Kewenig | first4 = Susanne | last5 = Kittel-Schneider | first5 = Sarah | last6 = Schmid | first6 = Annina | last7 = Casanova-Molla | first7 = Jordi | last8 = Reiners | first8 = Karlheinz | last9 = Sommer | first9 = Claudia | date = 2013-03-09 | title = Small fibre pathology in patients with fibromyalgia syndrome | url =https://doi.org/10.1093/brain/awt053|journal=Brain|volume=136|issue=6 | pages = 1857–1867|doi=10.1093/brain/awt053|issn=1460-2156}}</ref></blockquote>
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