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Fecal matter transplant
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=== Multi-drug resistant organisms === The FDA reported two cases in immunocompromised adults of bacterial infections with multi-drug resistant organisms (MDROs) that occurred due to use of investigational FMT.<ref name="FDA-sar2019" /> In both cases, the FMT was prepared from stool obtained from the same donor, and the recipients became infected with extended-spectrum beta-lactamase (ESBL)-producing [[Escherichia coli]] (E.coli), which was later found to be present in donor stool.<ref name="FDA-sar2019" /> One of the recipients died.<ref name="FDA-sar2019" /> As a result of these cases, the FDA has determined that donor screening must include questions that address risk factors for MDROs and donor stools must be tested for MDROs.<ref name="FDA-sar2019" />
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