FINE trial

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The FINE trial which stands for Fatigue Intervention by Nurses Evaluation[1] was a study to examine two treatments, self-help treatment and pragmatic rehabilitation, for patients meeting the 1991 Oxford criteria for CFS.[1] About 10% of the trial participants were non-ambulatory and about 30% met the 1994 London criteria for ME, but separate results for these groups were not published.[2] It is considered to be the 'sister' trial to the PACE trial.

The FINE trial authors concluded after a 70-week follow-up that the 18-week program was not an effective treatment for CFS/ME because the small improvement in fatigue, sleep and depression that were initially observed were not maintained in a long-term follow-up: "Pragmatic rehabilitation delivered at home by trained general nurses over a period of 18 weeks improved fatigue, sleep, and depression among patients with CFS/ME, but these effects were not maintained in the long term once treatment was completed. Supportive listening delivered by trained general nurses was not an effective treatment for CFS/ME in primary care. More studies are needed to determine the optimal conditions under which pragmatic rehabilitation can be delivered to patients in the community with CFS/ME and whether the limited benefits seen in this trial can be sustained."[2]

Study[edit | edit source]

Funding[edit | edit source]

The FINE trial was funded by the UK's Medical Research Council.[6]

Results[edit | edit source]

Sam Carter applied the criteria from a PACE trial study to the data from the FINE trial and questioned whether the recovery rates in the PACE study had been inflated by as much as six-fold as a result.[7]

Criticism[edit | edit source]

Consent Form[edit | edit source]

Investigators[edit | edit source]

  • Alison J. Wearden - FINE Trial Principal Investigator, Reader (University Lecturer) in psychology, School of Psychological Sciences, University of Manchester, Manchester, UK
  • Lisa Riste - FINE Trial Manager, School of Psychological Sciences, University of Manchester, Manchester, UK
  • Christopher Dowrick, Professor of primary medical care, School of Population, Community and Behavioural Sciences, University of Liverpool, Liverpool, UK
  • Carolyn Chew-Graham, Professor of primary care, School of Community Based Medicine, University of Manchester, Manchester, UK
  • Richard P. Bentall, Professor of clinical psychology, School of Psychology, University of Bangor, Adeilad Brigantia, Bangor, Gwynedd, UK
  • Richard K. Morriss, Professor of psychiatry and community mental health, School of Community Health Sciences, Institute of Mental Health, University of Nottingham, Nottingham, UK
  • Sarah Peters, Senior lecturer in psychology, School of Psychological Sciences, University of Manchester, Manchester, UK
  • Graham Dunn - FINE trial statistician, Professor of biomedical statistics, School of Community Based Medicine, University of Manchester, Manchester, UK
  • Gerry Richardson, Senior research fellow in health economics, Centre for Health Economics, University of York, York and Hull York Medical School, University of York, Heslington, York, UK
  • Karina Lovell, Professor of mental health, School of Nursing, Midwifery and Social Work, University of Manchester, Manchester, UK
  • Pauline Powell, Infectious Diseases Unit, Royal Liverpool University Hospital, UK

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 Wearden, A.; Riste, L.; Dowrick, C.; Chew-Graham, C.; Bentall, R.; Morriss, R.; Peters, S.; Dunn, G.; Richardson, G.; Lovell, K.; Powell, P. (2006). "Fatigue Intervention by Nurses Evaluation – The FINE Trial. A randomised controlled trial of nurse led self-help treatment for patients in primary care with chronic fatigue syndrome: study protocol. [ISRCTN74156610]". BMC Medicine. 4 (9). doi:10.1186/1741-7015-4-9. PMID 16603058.
  2. 2.0 2.1 Wearden, A.; Dowrick, C.; Chew-Graham, C.; Bentall, R.; Morriss, R.; Peters, S.; Riste, L.; Richardson, G.; Lovell, K.; Dunn, G. (2010). "Nurse led, home based self help treatment for patients in primary care with chronic fatigue syndrome: randomised controlled trial". The BMJ. 2010 (340). doi:10.1136/bmj.c1777.
  3. Wearden, A. J.; Riste, L.; Dowrick, C.; Chew-Graham, C.; Bentall, R. P.; Morriss, R. K.; Peters, S.; Dunn, G.; Richardson, G. (April 7, 2006). "Fatigue Intervention by Nurses Evaluation--the FINE Trial. A randomised controlled trial of nurse led self-help treatment for patients in primary care with chronic fatigue syndrome: study protocol. [ISRCTN74156610]". BMC medicine. 4: 9. doi:10.1186/1741-7015-4-9. ISSN 1741-7015. PMC 1456982. PMID 16603058.
  4. Wearden, Alison J.; Dowrick, Christopher; Chew-Graham, Carolyn; Bentall, Richard P.; Morriss, Richard K.; Peters, Sarah; Riste, Lisa; Richardson, Gerry; Lovell, Karina (April 23, 2010). "Nurse led, home based self help treatment for patients in primary care with chronic fatigue syndrome: randomised controlled trial". BMJ. 340: c1777. doi:10.1136/bmj.c1777. ISSN 0959-8138. PMID 20418251.
  5. Wearden, Alison J.; Dowrick, Christopher; Chew-Graham, Carolyn; Bentall, Richard P.; Morriss, Richard K.; Peters, Sarah; Riste, Lisa; Richardson, Gerry; Lovell, Karina (April 23, 2010). "COMMENTS | Nurse led, home based self help treatment for patients in primary care with chronic fatigue syndrome: randomised controlled trial". BMJ (Clinical research ed.). 340: c1777. ISSN 1756-1833. PMC 2859122. PMID 20418251.
  6. Invest in ME Research. "FINE Trials". www.investinme.org. Retrieved January 28, 2019. Cite has empty unknown parameter: |dead-url= (help)
  7. 7.0 7.1 Carter, Sam (February 15, 2016). "Exploring changes to PACE trial outcome measures using anonymised data from the FINE trial". PubMed Commons. Archived from the original on February 15, 2016. Unknown parameter |dead-url= ignored (|url-status= suggested) (help)
  8. Carter, Sam (June 9, 2010). "FINE Trial for CFS: Both significant and small?". BMJ. 340: c2988. doi:10.1136/bmj.c2988. ISSN 0959-8138. PMID 20534659.
  9. Carter, Sam (May 5, 2012). "A valedictory dispatch from the Psychosocial School? | Rapid Responses to articles". BMJ. Retrieved January 29, 2019. Cite has empty unknown parameter: |(empty string)= (help)