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Excessive irritability
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==Presentation== ==Prevalence== *Katrina Berne reports a prevalence of 70-90% for mood swings, excessive irritability, and overreaction in people with [[chronic fatigue syndrome]].<ref>{{cite book | last = Berne | first = Katrina | date = Dec 1, 1995 | author-link = Katrina Berne | title = Running on Empty: The Complete Guide to Chronic Fatigue Syndrome (CFIDS)|edition=2nd | url = https://www.amazon.co.uk/Running-Empty-Complete-Chronic-Syndrome/dp/0897931912/ | publisher = Hunter House | page = 60 |isbn= 978-0897931915}}</ref> ==Symptom recognition== *In the [[Holmes criteria]], '''excessive irritability''' is an optional criteria for diagnosis, under the section ''Minor Symptom Criteria - Neuropsychologic Complaints''.<ref>[http://www.cfids-me.org/holmes1988.html The 1988 Holmes Definition for CFS]</ref> ==Notable studies== ==Possible causes== ==Potential treatments== Severe irritability is a common symptom in autism, and the main treatment for this is atypical [[:Category:antipsychotics|anti-psychotic]] drugs such as [[amisulpride]] (Solian), [[risperidone]] (Risperdal) or [[aripiprazole]] (Abilify).<ref>{{Cite journal | last = Posey | first = David J. | last2 = Stigler | first2 = Kimberly A. | last3 = Erickson | first3 = Craig A. | last4 = McDougle | first4 = Christopher J. | date = 2008-01-02 | title = Antipsychotics in the treatment of autism| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171144/|journal=The Journal of Clinical Investigation|volume=118|issue=1 | pages = 6–14|doi=10.1172/JCI32483|issn=0021-9738|pmc=2171144|pmid=18172517}}</ref> Very low dose amisulpride has also been shown to reduce the [[fatigue]] and bodily symptoms of ME/CFS<ref>{{Cite journal | last = Pardini | first = Matteo | last2 = Guida | first2 = Silvia | last3 = Primavera | first3 = Alberto | last4 = Krueger | first4 = Frank | last5 = Cocito | first5 = Leonardo | last6 = Gialloreti | first6 = Leonardo Emberti | date = Mar 2011 | title = Amisulpride vs. fluoxetine treatment of chronic fatigue syndrome: a pilot study| url = https://www.ncbi.nlm.nih.gov/pubmed/21112746|journal=European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology|volume=21|issue=3 | pages = 282–286|doi=10.1016/j.euroneuro.2010.10.008|issn=1873-7862|pmid=21112746}}</ref>. [[N-acetyl-cysteine]] can help the irritability in autism, but the research showed this is not quite as effective as atypical anti-psychotics.<ref>{{Cite journal | last = Hardan | first = Antonio Y. | last2 = Fung | first2 = Lawrence K. | last3 = Libove | first3 = Robin A. | last4 = Obukhanych | first4 = Tetyana V. | last5 = Nair | first5 = Surekha | last6 = Herzenberg | first6 = Leonore A. | last7 = Frazier | first7 = Thomas W. | last8 = Tirouvanziam | first8 = Rabindra | date = Jun 2012 | title = A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism| url = http://linkinghub.elsevier.com/retrieve/pii/S0006322312000534|journal=Biological Psychiatry|volume=71|issue=11 | pages = 956–961|doi=10.1016/j.biopsych.2012.01.014|issn=0006-3223|pmc=4914359|pmid=22342106}}</ref> ==Learn more== *[https://forums.phoenixrising.me/index.php?threads/amisulpride-—-a-multipurpose-drug-for-me-cfs.20964/ Amisulpride — A Multipurpose Drug for ME/CFS] ==See also== ==References== {{Reflist}} [[Category:Signs and symptoms]] [[Category:Psychological signs and symptoms]]
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