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Dysautonomia
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== Ehlers-Danlos Syndrome == A study of 39 female Hypermobile EDS patients showed increased sympathetic activity at rest and reduced sympathetic reactivity to stimuli. It also showed an increased rate of [[orthostatic intolerance]] (74% in hEDS v. 34% in controls).<ref name="DeWandele2014">{{Cite journal | last = De Wandele | first = Inge | last2 = Rombaut | first2 = Lies | last3 = Leybaert | first3 = Luc | last4 = Van de Borne | first4 = Philippe | last5 = De Backer | first5 = Tine | last6 = Malfait | first6 = Fransiska | last7 = De Paepe | first7 = Anne | last8 = Calders | first8 = Patrick | date = 2014-08-01 | title = Dysautonomia and its underlying mechanisms in the hypermobility type of Ehlers–Danlos syndrome | url =http://www.sciencedirect.com/science/article/pii/S0049017213002928|journal=Seminars in Arthritis and Rheumatism|volume=44|issue=1 | pages = 93–100|doi=10.1016/j.semarthrit.2013.12.006|issn=0049-0172}}</ref> A study of hEDS patients found that 74.4% had Orthostatic Intolerance.<ref name="Malfait2016">{{Cite journal | last = Malfait | first = Fransiska | last2 = Calders | first2 = Patrick | last3 = De Paepe | first3 = Anne | last4 = De Mits | first4 = Sophie | last5 = Da Silva | first5 = Hellen | last6 = Peersman | first6 = Wim | last7 = De Backer | first7 = Tine | last8 = Rombaut | first8 = Lies | last9 = De Wandele | first9 = Inge | date = 2016-08-01 | title = Orthostatic intolerance and fatigue in the hypermobility type of Ehlers-Danlos Syndrome | url =https://academic.oup.com/rheumatology/article/55/8/1412/2566504|journal=Rheumatology|language=en|volume=55|issue=8 | pages = 1412–1420|doi=10.1093/rheumatology/kew032|issn=1462-0324}}</ref> A study of 48 patients meeting the 1998 [[Brighton criteria]] found that 78% had orthostatic intolerance versus 10% of controls.<ref name="Gazit2003">{{Cite journal | last = Gazit | first = Yael | last2 = Nahir | first2 = A. Menahem | last3 = Grahame | first3 = Rodney | last4 = Jacob | first4 = Giris | date = 2003-07-01 | title = Dysautonomia in the joint hypermobility syndrome | url =http://www.sciencedirect.com/science/article/pii/S0002934303002353|journal=The American Journal of Medicine|volume=115|issue=1 | pages = 33–40|doi=10.1016/S0002-9343(03)00235-3|issn=0002-9343}}</ref>
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