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[[File:Donald Staines.png|thumb|Source: investinme.org]] | [[File:Donald Staines.png|thumb|Source: investinme.org]] | ||
Professor '''Donald R. Staines''', MBBS, MPH, FAFPHM, FAFOEM, is a Clinical Professor at Menzies Health Institute Queensland and the co-director (alongside [[Sonya Marshall-Gradisnik]]) of the [[National Centre for Neuroimmunology and Emerging Diseases]] (NCNED) at Griffith University in Queensland in north-eastern Australia.<ref>https://www.griffith.edu.au/health/ | Professor '''Donald R. Staines''', MBBS, MPH, FAFPHM, FAFOEM, is a Clinical Professor at Menzies Health Institute Queensland and the co-director (alongside [[Sonya Marshall-Gradisnik]]) of the [[National Centre for Neuroimmunology and Emerging Diseases]] (NCNED) at Griffith University in Queensland in north-eastern Australia.<ref>{{Cite web | url = https://www.griffith.edu.au/menzies-health-institute-queensland/about-menzieshiq/Infectious-Diseases-and-Immunology/neuroimmunology-and-emerging-diseases | title = National Centre for Neuroimmunology and Emerging Diseases | website = griffith.edu.au|language=en|access-date=2019-11-14}}</ref> His research team is working towards discovery of diagnostic tools and treatments for [[chronic fatigue syndrome]].<ref>{{Cite web | url = https://www.goldcoastbulletin.com.au/lifestyle/gold-coast-team-getting-closer-to-discovering-test-for-chronic-fatigue-syndrom/news-story/1627b3fcc41c53efac927200a53cc756 | title = Coast team zeroing in on CFS test | date = 2016-12-01 | website = goldcoastbulletin.com.au|language=en|access-date=2019-04-26}}</ref> | ||
==International Consensus Criteria== | ==International Consensus Criteria== | ||
Staines is one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal|last=Carruthers|first=Bruce M.| | Staines is one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | author-link6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | author-link9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | author-link10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | author-link11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | author-link12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria | url = https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> | ||
==Diagnostic test== | ==Diagnostic test== | ||
In February 2016 the research team led by Donald Staines and Sonya Marshall-Gradisnik announced it had created a diagnostic test for the disease using [[CD8]] T cells.<ref name="BioABC">[http://www.abc.net.au/pm/content/2016/s4415928.htm Australian scientists make breakthrough in Chronic Fatigue Syndrome testing], ''ABC News (Australia)'', 29 February 2016</ref> They have been awarded a $4-million grant to be administered during the next five years that will enable them to continue research into developing a diagnostic test for [[ME/CFS]].<ref>{{Cite web|url=https://www.goldcoastbulletin.com.au/lifestyle/gold-coast-team-getting-closer-to-discovering-test-for-chronic-fatigue-syndrom/news-story/1627b3fcc41c53efac927200a53cc756|title=Coast team zeroing in on CFS test|date=2016-12-01|website= | In February 2016 the research team led by Donald Staines and Sonya Marshall-Gradisnik announced it had created a diagnostic test for the disease using [[CD8]] T cells.<ref name="BioABC">[http://www.abc.net.au/pm/content/2016/s4415928.htm Australian scientists make breakthrough in Chronic Fatigue Syndrome testing], ''ABC News (Australia)'', 29 February 2016</ref> They have been awarded a $4-million grant to be administered during the next five years that will enable them to continue research into developing a diagnostic test for [[ME/CFS]].<ref>{{Cite web | url = https://www.goldcoastbulletin.com.au/lifestyle/gold-coast-team-getting-closer-to-discovering-test-for-chronic-fatigue-syndrom/news-story/1627b3fcc41c53efac927200a53cc756 | title = Coast team zeroing in on CFS test | date = 2016-12-01 | website = goldcoastbulletin.com.au|language=en|access-date=2019-04-26}}</ref> | ||
==Open Letters to ''The Lancet''== | ==Open Letters to ''The Lancet''== | ||
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==Notable studies== | ==Notable studies== | ||
*2011, Immunological abnormalities as potential [[biomarker]]s in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{ | *2011, Immunological abnormalities as potential [[biomarker]]s in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{Cite journal | last1 = Brenu | first1 = EW | author-link1 = Ekua Brenu | last2 = van Driel | first2 = ML | authorlink2 = | last3 = Staines | first3 = DR | authorlink3 = Donald Staines | last4 = Ashton | first4 = KJ | authorlink4 = | last5 = Ramos | first5 = SB | authorlink5 = Sandra Ramos | last6 = Keane | first6 = J | author-link6 = | last7 = Klimas | first7 = NG | author-link8 = Nancy Klimas | last8 =Marshall-Gradisnik | first8 = SM | author-link8 = Sonya Marshall-Gradisnik | title = Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|journal = Journal of Translational Medicine|volume =9|issue = 81| page =| date = 2011| doi= 10.1186/1479-5876-9-81}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120691/ (Full Text)] | ||
| last1 | *2012, The Effects of [[Influenza vaccine|Influenza Vaccination]] on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{cite journal | last = Brenu | first1 = Ekua W | author-link1 = Ekua Brenu | last2 = van Driel | first2 = Mieke L | authorlink2 = | last3 = Staines | first3 = Donald R | authorlink3 = Donald Staines | last4 = Kreijkamp-Kaspers | first4 = Sanne | authorlink4 = | last5 = Hardcastle | first5 = Sharni L | authorlink5 = Sharni Hardcastle | last6 = Marshall-Gradisnik | first6 = Sonya M | author-link6 = Sonya Marshall-Gradisnik | title = The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | journal = International Journal of Clinical Medicine|volume=3|issue=6 | page = 544-551| date = 2012 | doi = 10.4236/ijcm.2012.36098 | url = https://file.scirp.org/pdf/IJCM20120600017_29918208.pdf}}</ref> - [https://file.scirp.org/pdf/IJCM20120600017_29918208.pdf (Full Text)] | ||
| last2 | *2014, Characterization of [[Natural killer cell|Natural Killer Cell]] Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="Huth, 2014">{{Cite journal | last = Huth | first1 = Teilah K. | author-link1 = Teilah Huth | last2 = Brenu | first2 = Ekua | authorlink2 = Ekua Brenu | last3 =Nguyen | first3 = Thao | authorlink3 = | last4 = Hardcastle | first4 = Sharni L. | authorlink4 = Sharni Hardcastle | last5 = Johnston | first5 = Samantha| authorlink5 = Samantha Johnston | last6 = Ramos | first6 = Sandra | author-link6 = Sandra Ramos | last7 =Staines | first7 = Donald R. | author-link8 = Donald Staines | last8 =Marshall-Gradisnik | first8 = Sonya M. | author-link8 = Sonya Marshall-Gradisnik | title = Characterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis| journal = Journal of Clinical & Cellular Immunology | volume = 5 | issue = 3 | pages = | date = 2014 | pmid = | doi = 10.4172/2155-9899.1000223}}</ref> - [https://www.omicsonline.org/open-access/characterization-of-natural-killer-cell-phenotypes-in-chronic-fatigue-syndrome-2155-9899.1000223.pdf (Full Text)] | ||
| last3 | *2014, The Role of Adaptive and Innate Immune Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="BrenuEW2014">{{cite journal | last1 = Brenu | first1 = EW | author-link1 = Ekua Brenu | last2 = Huth | first2 = TK | authorlink2 = Teilah Huth | last3 =Hardcastle | first3 = SL | authorlink3 = Sharni Hardcastle | last4 = Fuller | first4 = K | authorlink4 = | last5 = Kaur | first5 = M | authorlink5 = | last6 = Johnston | first6 = S | author-link6 = Samantha Johnston | last7 =Ramos | first7 = S | author-link8 = Sandra Ramos | last8 =Staines | first8 = D | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = S | author-link9 = Sonya Marshall-Gradisnik | title = The Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis | journal = International Immunology | year = 2014 | volume = 26 | issue = 4 | pages = 233-42 | pmid = 24343819 | doi = 10.1093/intimm/dxt068}}</ref> - [https://www.researchgate.net/publication/259350347_The_Role_of_Adaptive_and_Innate_Immune_Cells_in_Chronic_Fatigue_Syndrome_Myalgic_Encephalomyelitis (Full Text)] | ||
| last4 | *2014, The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings<ref>{{Cite journal | last = Johnston | first = S.C. | authorlink = Samantha Johnston | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Staines | first3 =D.R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = S.M. | authorlink4 = Sonya Marshall-Gradisnik | date = 2014-01-02 | title = The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings |url =http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.860779|journal = Fatigue: Biomedicine, Health & Behavior |language=en|volume=2|issue=1 | pages = 28–39|doi=10.1080/21641846.2013.860779|issn=2164-1846|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://www.tandfonline.com/doi/full/10.1080/21641846.2013.860779 (Abstract)] | ||
| last5 | *2014, Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis ([[CFS/ME]])<ref <ref name="Hardcastle, 2014">{{Cite journal | last1 = Hardcastle | first1 = Sharni L. | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = Ekua W. | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = Samantha | authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = Thao | authorlink4 = | last5 = Huth | first5 = Teilah K. | authorlink5 = Teilah Huth | last6 = Kaur | first6 = Manprit| author-link6 = | last7 =Ramos | first7 = Sandra | author-link8 = Sandra Ramos | last8 =Salajegheh | first8 = Ali | author-link8 = | last9 =Staines | first9 = Donald R. | author-link9 = Donald Staines | last10 = Marshall-Gradisnik | first10 = Sonya | author-link10 = Sonya Marshall-Gradisnik | title = Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) | journal = Journal of Clinical & Cellular Immunology | volume = 5 | issue = 190 | pages = | date = 2014 | pmid = | doi = 10.4172/2155-9899.1000190}}</ref> - [https://www.omicsonline.org/open-access/analysis-relationship-immune-dysfunction-symptom-severity-patients-chronic-fatigue-2155-9899.1000190.php?aid=22894 (Full Text)] | ||
| last6 | *2015, A Comparison of [[Cytokine]] Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and [[Multiple Sclerosis]] Patients<ref name="Wong, 2015">{{Cite journal | last = Wong | first1 = Naomi | author-link1 = | last2 = Nguyen | first2 = Thao | authorlink2 = | last3 =Brenu | first3 = Ekua Weba | authorlink3 = Ekua Brenu | last4 = Broadley | first4 = Simon | authorlink4 = | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | title = A Comparison of Cytokine Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis Patients| journal = International Journal of Clinical Medicine | volume = 6 | issue = 10 | pages = 769-783 | date = 2015 | pmid = | doi = 10.4236/ijcm.2015.610103 }}</ref> | ||
| last7 | *2015, [[Metabolic]] profiling reveals anomalous [[Portal:Energy metabolism|energy metabolism]] and [[Neuroinflammation|oxidative stress]] pathways in chronic fatigue syndrome patients<ref>{{Cite journal | last1 = Armstrong | first1 = Christopher W. | authorlink = Christopher Armstrong | last2 = McGregor | first2 = Neil R. | authorlink2 = Neil McGregor | last3 = Lewis | first3 = Donald P. | authorlink3 = Donald Lewis | last4 = Butt | first4 = Henry L. | authorlink4 = Henry Butt | last5 = Gooley | first5 = Paul R. | authorlink5 = Paul Gooley | title = Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients|journal=Metabolomics|volume=11|issue=6 | page = 1626–1639 | date = 2015 | doi=10.1007/s11306-015-0816-5}}</ref> - [https://link.springer.com/article/10.1007%2Fs11306-015-0816-5 (Abstract)] | ||
| last8 | *2015, Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients<ref name="Hardcastle, 09052015">{{Cite journal | last1 = Hardcastle | first1 = SL | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = EW | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = S | authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = T | authorlink4 = | last5 = Huth | first5 = T | authorlink5 = Teilah Huth | last6 = Wong | first6 = N | author-link6 = | last7 =Ramos | first7 = S | author-link8 = Sandra Ramos | last8 =Staines | first8 = DR | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = SM | author-link9 = Sonya Marshall-Gradisnik | title = Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients | journal = International Journal of Medical Sciences | volume = 12 | issue = 10 | pages = 764-772 | date = 2015 | doi = 10.7150/ijms.12399}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615236/ (Full Text)] | ||
| title | *2015, Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients<ref name="Marshall-Gradisnik, 2015">{{Cite journal | last1 = Marshall-Gradisnik | first1 = Sonya M. | author-link1 = Sonya Marshall-Gradisnik | last2 = Smith | first2 = Peter | authorlink2 = | last3 =Brenu | first3 = Ekua W. | authorlink3 = Ekua Brenu | last4 = Nilius | first4 = Bernd | authorlink4 = | last5 = Ramos | first5 = Sandra B. | authorlink5 = | last6 = Staines | first6 = Donald R. | author-link6 = Donald Staines | title = Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients | journal = Immunology and Immunogenetics Insights | volume = 2015 | issue = 7 | pages = 1-6 | date = 2015 | pmid = | doi = 10.4137/III.S25147| url = http://insights.sagepub.com/examination-of-single-nucleotide-polymorphisms-snps-in-transient-recep-article-a4824}}</ref> - [http://journals.sagepub.com/doi/full/10.4137/III.S25147 (Full Text)] | ||
*2012, The Effects of [[Influenza vaccine|Influenza Vaccination]] on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{ | *2015, Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)<ref name="Hardcastle, 2015">{{Cite journal | last1 = Hardcastle | first1 = SL | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = EW | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = S | authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = T | authorlink4 = | last5 = Huth | first5 = T | authorlink5 = Teilah Huth | last6 = Wong | first6 = N | author-link6 = | last7 =Ramos | first7 = S | author-link8 = Sandra Ramos | last8 =Staines | first8 = DR | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = SM | author-link9 = Sonya Marshall-Gradisnik | title = Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)| journal = BMC Immunology | volume = 16 | issue = 35 | pages = | date = 2015 | doi = 10.1186/s12865-015-0101-4}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450981/ (Full Text)] | ||
| | *2015, Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Hardcastle, 092015">{{Cite journal | last1 = Hardcastle | first1 = Sharni Lee | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = Ekua Weba | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = Samantha| authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = Thao | authorlink4 = | last5 = Huth | first5 = Teilah | authorlink5 = Teilah Huth | last6 = Ramos | first6 = Sandra | author-link6 = Sandra Ramos | last7 =Staines | first7 = Donald | author-link8 = Donald Staines | last8 =Marshall-Gradisnik | first8 = Sonya | author-link8 = Sonya Marshall-Gradisnik | title = Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients| journal = Journal of Translational Medicine | volume = 13 | issue = 299 | pages = | date = 2015 | doi = 10.1186/s12967-015-0653-3}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568602/ (Full Text)] | ||
| last2 | *2015, Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="Peterson, 2015">{{Cite journal | last1 = Peterson | first1 = D | author-link1 = Daniel Peterson | last2 = Brenu | first2 = EW | authorlink2 = Ekua Brenu | last3 = Gottschalk | first3 = G | authorlink3 = Gunnar Gottschalk | last4 = Ramos | first4 = Sandra B | authorlink4 = Sandra Ramos | last5 = Nguyen | first5 = T | authorlink5 = | last6 = Staines | first6 = D | author-link6 = Donald Staines | last7 =Marshall-Gradisnik | first7 = S | author-link8 = Sonya Marshall-Gradisnik | title = Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis| journal = Mediators of Inflammation | volume = 2015 | issue = | pages = | date = 2015 | doi = 10.1155/2015/929720}}</ref> | ||
| last3 | *2016, Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients<ref name="Huth,TK, 2016">{{Cite journal | last1 = Huth | first1 = T.K. | author-link1 = Teilah Huth | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Staines | first3 =D.R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = S.M. | authorlink4 = Sonya Marshall-Gradisnik | title = Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients | journal = Gene Regulation and Systems Biology | volume = 10 | issue = | pages = 43–49| date = 2016 | pmid = | doi = 10.4137/GRSB.S39861}}</ref> - [http://www.la-press.com/redirect_fi...enotype-and-Haplotype-Invest.pdf&fileType=pdf (Full Text)] | ||
| last4 | *2016, A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="Collatz, 2016">{{Cite journal | last1 = Collatz | first1 = Ansel | author-link1 = | last2 = Johnston | first2 = Samantha C. | authorlink2 =Samantha Johnston | last3 = Staines | first3 = Donald R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya M. | authorlink4 = Sonya Marshall-Gradisnik | title = A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | ||
| last5 | |journal = Clinical Therapeutics | volume =38 | issue = 6 | pages = 1263-1271.e9 | date = 2016 | pmid = 27229907 | ||
| last6 | | doi = 10.1016/j.clinthera.2016.04.038}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/27229907 (Abstract)] | ||
| title | *2016, Progressive [[brain]] changes in patients with chronic fatigue syndrome: A longitudinal MRI study<ref name="Shan, 2016">{{Cite journal | last1 = Shan | first1 = Zack Y. | author-link1 =Zack Shan | last2 = Kwiatek | first2 = Richard | authorlink2 = Richard Kwiatek | last3 =Burnet | first3 = Richard | authorlink3 =Richard Burnet | last4 = Del Fante | first4 = Peter | authorlink4 =Peter Del Fante | last5 = Staines | first5 = Donald R. | authorlink5 = Donald Staines | last6 = Marshall‐Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | last7 =Barnden | first7 = Leighton R. | author-link8 =Leighton Barnden | title = Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study | journal = Journal of Magnetic Resonance Imaging | volume = 44 | issue = | pages = 1301–1311 | date = 2016 | pmid = | doi = 10.1002/jmri.25283}}</ref> - [https://www.scienceopen.com/document/read?vid=ac2948b6-48d1-4ebd-8f96-3a3c5a57f770 (Full Text)] | ||
| journal = International Journal of Clinical Medicine|volume=3|issue=6|page=544-551|date=2012|doi=10.4236/ijcm.2012.36098|url=https://file.scirp.org/pdf/IJCM20120600017_29918208.pdf}}</ref> - [https://file.scirp.org/pdf/IJCM20120600017_29918208.pdf (Full Text)] | *2016, [[Regulatory T cell|Regulatory T]], [[Natural killer T cell|natural killer T]] and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison<ref name="Ramos, 2016">{{Cite journal | last = Ramos | first1 = S | author-link1 = Sandra Ramos | last2 = Brenu | first2 = E | authorlink2 = Ekua Brenu | last3 =Broadley | first3 = S | authorlink3 = | last4 = Kwiatek | first4 = R | authorlink4 = Richard Kwiatek | last5 = Ng | first5 = J | authorlink5 = | last6 = Nguyen | first6 = T | author-link6 = | last7 =Freeman | first7 = S | author-link7 = | last8 =Staines | first8 = D | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = S | author-link9 = Sonya Marshall-Gradisnik | title = Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison | journal = Asian Pac J Allergy Immunol | volume = | issue = | pages = | date = March 20, 2016 | doi = 10.12932/AP0733}}</ref> - [http://apjai-journal.org/wp-content/uploads/2016/12/8RegulatoryTnaturalkillerAPJAIVol34No4December2016P300.pdf (Full Text)] | ||
*2014, Characterization of [[Natural killer cell|Natural Killer Cell]] Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="Huth, 2014" | *2016, ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Huth, 2016">{{Cite journal | last = Huth | first1 = Teilah K. | author-link1 = Teilah Huth | last2 = Staines | first2 = Donald | authorlink2 = Donald Staines | last3 =Marshall-Gradisnik | first3 = Sonya | authorlink3 = Sonya Marshall-Gradisnik| title = ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients| journal = Journal of Translational Medicine | volume = 14 | issue = 97 | pages = | date = 2016 | pmid = | doi = 10.1186/s12967-016-0859-z}}</ref> - [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0859-z (Full Text)] | ||
*2016, [[Natural killer cell]]s and single nucleotide polymorphisms of specific [[Ion transportation|ion channels]] and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome<ref name="Marshall-Gradisnik,SM 2016">{{Cite journal | last1 = Marshall-Gradisnik | first1 = Sonya M. | author-link1 =Sonya Marshall-Gradisnik | last2 = Huth | first2 = Teilah | authorlink2 = Teilah Huth | last3 =Chacko | first3 = Anu | authorlink3 = Ekua Brenu | last4 = Johnston | first4 = Samantha | authorlink4 = Samantha Johnston | last5 = Smith | first5 = Peter | authorlink5 = | last6 = Staines | first6 = Donald R. | author-link6 = Donald Staines | title = Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome| journal = The Application of Clinical Genetics | volume = 9 | issue = | pages = 39—47 | date = 2016 | pmid = | doi = 10.2147/TACG.S99405}}</ref> - [https://www.dovepress.com/natural-killer-cells-and-single-nucleotide-polymorphisms-of-specific-i-peer-reviewed-fulltext-article-TACG (Full Text)] | |||
*2017, Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review<ref>{{Cite journal | last = Campagnolo | first = N. | last2 = Johnston | first2 = S. | authorlink2 = Samantha Johnston | last3 = Collatz | first3 = A. | last4 = Staines | first4 =D. | authorlink4 = Donald Staines | last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 22 Jan 2017 | title = Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review | url =http://doi.wiley.com/10.1111/jhn.12435|journal=Journal of Human Nutrition and Dietetics|language=en|volume=30|issue=3 | pages = 247–259|doi=10.1111/jhn.12435|issn=0952-3871|pmc=|pmid=28111818|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434800/ (Full Text)] | |||
*2017, Impaired [[calcium]] mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels<ref name="Nguyen, 2017">{{Cite journal | last1 = Nguyen | first1 = T. | author-link1 = | last2 = Hardcastle | first2 = S. | authorlink2 = Sharni Hardcastle | last3 =Clarke | first3 = L. | authorlink3 = | last4 = Smith | first4 = P. | authorlink4 = | last5 = Staines | first5 =D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | author-link6 = Sonya Marshall-Gradisnik | title = Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels | journal = Clinical and Experimental Immunology | volume = 187 | issue = 2 | pages = 284–293 | date = 2017| doi = 10.1111/cei.12882}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217865/ (Full Text)] | |||
* | *2017, Novel characterisation of [[mast cell]] phenotypes from [[Peripheral blood mononuclear cell|peripheral blood mononuclear cells]] in chronic fatigue syndrome/myalgic encephalomyelitis patients<ref name="Nguyen, et al, 2017">{{Cite journal | last1 = Nguyen | first1 = T. | authorlink = | last2 = Johnston | first2 = S. | authorlink2 = Samantha Johnston | last3 = Chacko | first3 = A. | authorlink3 = | last4 = Gibson | first4 =D. | authorlink4 = | last5 = Cepon | first5 = J. | authorlink5 = | last6 = Smith | first6 =D. | author-link6 = | last7 = Staines | first7 =D. | author-link8 = Donald Staines | last8 = Marshall-Gradisnik | first8 = S. | author-link8 = Sonya Marshall-Gradisnik | title = Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients|journal=Asian Pac J Allergy Immunol|volume=35|issue=2 | page = 75-81 | date = 2017 | doi=10.12932/AP0771}}</ref> - [http://apjai-journal.org/wp-content/uploads/2017/07/75-81-AP0771.pdf (Full Text)] | ||
*2018, Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{Cite journal | last = Marshall-Gradisnik | first = Sonya | authorlink = Sonya Marshall-Gradisnik | last2 = Fretel | first2 = Marshall | last3 = Eaton | first3 = Natalie | authorlink3 = Natalie Eaton-Fitch | last4 = Cabanas | first4 = Helene | authorlink4 = Hélène Cabanas | last5 = Balinas | first5 = Cassandra | last6 = Gopalan | first6 = Vinod | last7 = Petersen | first7 = Daniel | author-link8 = Daniel Peterson | last8 = Passmore | first8 = Rachel | last9 = Tang | first9 = Kevin | last10 = Haque | first10 = Mazhar | author-link10 = | last11 = Lam | first11 = Alfred | author-link11 = | last12 = Staines | first12 = Donald | author-link12 = Donald Staines | date = 2018-05-31 | title = Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis |url =http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85005&#abstract|journal=International Journal of Clinical Medicine|language=en|volume=09|issue=05 | pages = 467|doi=10.4236/ijcm.2018.95040|via=}}</ref> - [http://file.scirp.org/Html/11-2101759_85005.htm (Full text)] | |||
* | *2018, Brain function characteristics of chronic fatigue syndrome: A task [[Functional magnetic resonance imaging|fMRI]] study<ref name="Shan, 2018">{{Cite journal | last1 = Shan | first1 = Zack Y. | author-link1 = | last2 = Finegan | first2 = Kevin | authorlink2 = | last3 =Bhuta | first3 = Sandeep | authorlink3 = | last4 = Ireland | first4 = Timothy | authorlink4 = | last5 = Staines | first5 = Donald R. | authorlink5 = Donald Staines | last6 = Marshall‐Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | last7 =Barnden | first7 = Leighton R. | author-link8 = | title = Brain function characteristics of [[chronic fatigue syndrome]]: A task fMRI study | journal = NeuroImage: Clinical | volume = 19 | issue = | pages = 279-286 | date = 2018 | pmid = | doi = 10.1016/j.nicl.2018.04.025}}</ref> - [https://www.sciencedirect.com/science/article/pii/S2213158218301347 (Full Text)] | ||
*2018, A Systematic Review of [[Probiotic]] Interventions for Gastrointestinal Symptoms and [[Irritable bowel syndrome|Irritable Bowel Syndrome]] in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)<ref name="Corbitt, 2018">{{Cite journal | last1 = Corbitt | first1 = M | author-link1 = | last2 = Campagnolo | first2 = N | authorlink2 = | last3 = Staines | first3 = D | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = S | authorlink4 = Sonya Marshall-Gradisnik | title = A Systematic Review of Probiotic Interventions for Gastrointestinal Symptoms and Irritable Bowel Syndrome in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)| journal = Probiotics Antimicrob Proteins | volume = | issue = | pages = | date = 2018 | pmid = | doi = 10.1007/s12602-018-9397-8}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/29464501 (Abstract)] | |||
*2018, A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis<ref>{{Cite journal | last = Du Preez | first = S. | authorlink = | last2 = Corbitt | first2 = M. | authorlink2 = | last3 = Cabanas | first3 = H. | authorlink3 = Hélène Cabanas | last4 = Eaton | first4 = N. | authorlink4 = Natalie Eaton-Fitch | last5 = Staines | first5 =D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | author-link6 = Sonya Marshall-Gradisnik | date = 2018-12-20 | title = A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis |url =https://doi.org/10.1186/s13643-018-0909-0|journal=Systematic Reviews|volume=7|issue=1 | pages = 241|doi=10.1186/s13643-018-0909-0|issn=2046-4053|pmc=|pmid=30572962|quote=|via=}}</ref> - [https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-018-0909-0 (Full text)] | |||
*2015, | *2018, [[Rituximab]] impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation<ref name="Eaton, 2018">{{cite journal | last1 = Eaton | first1 = Natalie | author-link1 = Natalie Eaton-Fitch | last2 = Cabanas | first2 = Hélène | authorlink2 = Hélène Cabanas | last3 = Balinas | first3 = Cassandra | authorlink3 = | last4 = Klein | first4 = Anne | authorlink4 = | last5 = Staines | first5 = Donald R. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik| title = Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation| journal = BMC Pharmacology & Toxicology | year = 2018 | volume = 19 | issue = 12 | pages = | pmid = 29587879 | doi = 10.1186/s40360-018-0203-8}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870391/ (Full Text)] | ||
*2018, Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation<ref name="Nguyen, 2018">{{Cite journal | last1 = Nguyen | first1 = T. | authorlink = | last2 = Staines | first2 =D. | authorlink2 = Donald Staines | last3 = Johnston | first3 = S. | authorlink3 = Samantha Johnston | last4 = Marshall-Gradisnik | first4 = S. | authorlink4 = Sonya Marshall-Gradisnik| title =Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation| journal=Asian Pac J Allergy Immunol|volume=|issue=| page = | date = Jul 2018|doi=10.12932/AP-011117-0188}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/29981562 (Abstract)] | |||
*2018, Hyperintense sensorimotor T1 spin echo [[MRI]] is associated with [[brainstem]] abnormality in chronic fatigue syndrome<ref>{{Cite journal | last = Barnden | first = Leighton R. | last2 = Shan | first2 = Zack Y. | last3 = Staines | first3 = Donald R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | last5 = Finegan | first5 = Kevin | last6 = Ireland | first6 = Timothy | last7 = Bhuta | first7 = Sandeep | date = 2018 | title = Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome | url =https://www.sciencedirect.com/science/article/pii/S2213158218302237|journal=NeuroImage: Clinical|volume=20 | pages = 102-109|doi=10.1016/j.nicl.2018.07.011|via=}}</ref> - [https://www.sciencedirect.com/science/article/pii/S2213158218302237 (Full Text)] | |||
* | *2018, Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = Hélène | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | last3 = Eaton | first3 = Natalie | last4 = Balinas | first4 = Cassandra | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | date = 2018-08-14 | title = Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients |url =https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1|journal=Molecular Medicine|language=en|volume=24|issue=1 | pages = |doi=10.1186/s10020-018-0046-1|issn=1076-1551|via=}}</ref> - [https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1 (Full Text)] | ||
*2019, Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study<ref>{{Cite journal | last = Słomko | first = Joanna | authorlink = | last2 = Newton | first2 = Julia L | authorlink2 = Julia Newton | last3 = Kujawski | first3 = Sławomir | authorlink3 = | last4 = Tafil-Klawe | first4 = Małgorzata | authorlink4 = | last5 = Klawe | first5 = Jacek | authorlink5 = | last6 = Staines | first6 = Donald | author-link6 = Donald Staines | last7 = Marshall-Gradisnik | first7 = Sonya | author-link8 = Sonya Marshall-Gradisnik | last8 = Zalewski | first8 = Pawel | date = Mar 2019 | title = Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study | url = http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-023955|journal=BMJ Open|language=en|volume=9|issue=3| pages = e023955|doi=10.1136/bmjopen-2018-023955|issn=2044-6055|pmc=|pmid=30850404|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429942/ (Full text)] | |||
*2019, Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = H. | authorlink = Hélène Cabanas | last2 = Muraki | first2 = K. | authorlink2 = | last3 = Balinas | first3 = C. | authorlink3 = | last4 = Eaton-Fitch | first4 = N. | authorlink4 = Natalie Eaton-Fitch | last5 = Staines | first5 =D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | author-link6 = Sonya Marshall-Gradisnik | date = Dec 2019 | title = Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients |url =https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0083-4|journal=Molecular Medicine|language=en|volume=25|issue=1 | pages = |doi=10.1186/s10020-019-0083-4|issn=1076-1551|quote=|via=}}</ref> - [https://link.springer.com/article/10.1186/s10020-019-0083-4 (Full text)] | |||
* | *2019, A systematic review of [[cytokines]] in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)<ref>{{Cite journal | last = Corbitt | first = Matthew | authorlink = | last2 = Eaton-Fitch | first2 = Natalie | authorlink2 = Natalie Eaton-Fitch | last3 = Staines | first3 = Donald | authorlink3 = Donald Staines | last4 = Cabanas | first4 = Hélène | authorlink4 = Hélène Cabanas | last5 = Marshall-Gradisnik | first5 = Sonya | authorlink5 = Sonya Marshall-Gradisnik | date = Dec 2019 | title = A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID) | url = https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1433-0|journal=BMC Neurology|language=en|volume=19|issue=1 | pages = |doi=10.1186/s12883-019-1433-0|issn=1471-2377|pmc=|pmid=31445522|access-date=|quote=|via=}}</ref> - [https://link.springer.com/article/10.1186/s12883-019-1433-0#citeas (Full text)] | ||
* 2019, [[Low dose naltrexone|Naltrexone]] restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients<ref>{{Cite journal | last = Cabanas | first = Helene | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | authorlink2 = | last3 = Staines | first3 = Donald | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | date = 14 Oct 2019 | title = Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients |url =https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract|journal=Frontiers in Immunology|volume=|issue= | pages = |doi=10.3389/fimmu.2019.02545|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract (Abstract)] | |||
* | * 2019, Intra [[brainstem]] connectivity is impaired in chronic fatigue syndrome<ref>{{Cite journal | last = Barnden | first = Leighton R | authorlink = Leighton Barnden | last2 = Shan | first2 = Zack Y | authorlink2 = Zack Shan | last3 = Staines | first3 = Donald R | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | last5 = Finegan | first5 = Kevin | authorlink5 = | last6 = Ireland | first6 = Timothy | author-link6 = | last7 = Bhuta | first7 = Sandeep | date = 2019 | title=Intra brainstem connectivity is impaired in chronic fatigue syndrome | url =https://linkinghub.elsevier.com/retrieve/pii/S2213158219303924|journal=NeuroImage: Clinical|language=en|volume=24|issue= | pages = 102045|doi=10.1016/j.nicl.2019.102045|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/pii/S2213158219303924 (Full text)] | ||
* | * 2019, [[Transient receptor potential melastatin 2]] channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients<ref name="Balinas2019">{{Cite journal | last = Balinas | first = Cassandra | authorlink = Cassandra Balinas | last2 = Cabanas | first2 = Hélène | authorlink2 = Hélène Cabanas | last3 = Staines | first3 = Donald | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | date = 2019-12-03 | title = Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients |url =https://doi.org/10.1186/s12967-019-02155-4|journal=Journal of Translational Medicine|volume=17|issue=1 | pages = 401|doi=10.1186/s12967-019-02155-4|issn=1479-5876|pmc = 6891975|pmid=31796045|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-02155-4 (Full text)] | ||
* 2020, Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study<ref>{{Cite journal | last = Eaton-Fitch | first = N. | authorlink = Natalie Eaton-Fitch | last2 = Johnston | first2 = S. C. | authorlink2 = Samantha Johnston | last3 = Zalewski | first3 = P. | authorlink3 = | last4 = Staines | first4 =D. | authorlink4 = Donald Staines | last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 2020-01-22 | title = Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study | url = http://link.springer.com/10.1007/s11136-019-02411-6|journal=Quality of Life Research|language=en|volume=|issue= | pages = |doi=10.1007/s11136-019-02411-6|issn=0962-9343|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://link.springer.com/article/10.1007%2Fs11136-019-02411-6 (Full text)] | |||
* 2020, Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans<ref>{{Cite journal | last = Thapaliya | first = Kiran | authorlink = | last2 = Marshall-Gradisnik | first2 = Sonya | authorlink2 = Sonya Marshall-Gradisnik | last3 = Staines | first3 = Don | authorlink3 = Donald Staines | last4 = Barnden | first4 = Leighton | authorlink4 = Leighton Barnden | date = 2020 | title=Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans |url =https://linkinghub.elsevier.com/retrieve/pii/S2213158220302035|journal=NeuroImage: Clinical|language=en|volume=28|issue= | pages = 102366|doi=10.1016/j.nicl.2020.102366|pmc = 7417892|pmid=32777701|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417892/ (Full text)] | |||
*2021, Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Maksoud2021">{{Cite journal | last = Maksoud | first = Rebekah | authorlink = | last2 = Eaton-Fitch | first2 = Natalie | authorlink2 = Natalie Eaton-Fitch | last3 = Matula | first3 = Michael | authorlink3 = | last4 = Cabanas | first4 = Hélène | authorlink4 = Hélène Cabanas | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | date = May 2021 | title = Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | url =https://www.mdpi.com/2227-9032/9/5/568|journal=Healthcare|language=en|volume=9|issue=5 | pages = 568|doi=10.3390/healthcare9050568|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.mdpi.com/2227-9032/9/5/568/htm (Full text)] | |||
* | *2021, Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment<ref name="Cabanas2021">{{Cite journal | title = Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment | date = 2021 | url = https://www.frontiersin.org/articles/10.3389/fimmu.2021.687806|journal=Frontiers in Immunology|volume=12|issue= | pages = 687806 | last = Cabanas | first = Helene | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | authorlink2 = | last3 = Eaton-Fitch | first3 = Natalie | authorlink3 = Natalie Eaton-Fitch | last4 = Staines | first4 = Donald Ross | authorlink4 = Donald Staines | last5 = Marshall-Gradisnik | first5 = Sonya | authorlink5 = Sonya Marshall-Gradisnik|doi=10.3389/fimmu.2021.687806|pmc=PMC8313851|pmid=34326841|access-date=|issn=1664-3224|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2021.687806/full (Full text)] | ||
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==Talks and interviews== | ==Talks and interviews== | ||
*2015, [http://blogs.abc.net.au/queensland/2015/08/who-are-you-professor-don-staines-mecfs-research-griffith-university-gold-coast.html Who Are You? Professor Don Staines, ME/CFS research, Griffith University Gold Coast] (31 | *2015, [http://blogs.abc.net.au/queensland/2015/08/who-are-you-professor-don-staines-mecfs-research-griffith-university-gold-coast.html Who Are You? Professor Don Staines, ME/CFS research, Griffith University Gold Coast] (August 31, 2015) | ||
*2016, Speaker at the 11th Invest in ME International ME Conference on "Update from NCNED: Receptor identification and intracellular signalling"<ref | *2016, Speaker at the 11th [[Invest in ME International ME Conference]] on "Update from NCNED: Receptor identification and intracellular signalling"<ref name="IiMER-2019" />[http://www.investinme.org/IIMEC11.shtml#dvd DVD available] | ||
*2017, Speaker at the 12th [[Invest in ME International ME Conference]] | *2017, Speaker at the 12th [[Invest in ME International ME Conference]]; Speech title: ''Dysregulation of Transient Receptor Potential (TRP) ion channels and calcium in natural killer cells in CFS/ME patients''<ref name="IiMER-2019">{{Cite web | url = http://investinme.org/cindex.shtml | title = UK Charity for Myalgic Encephalomyelitis Centre of Excellence for ME Blog|website=investinme.org|access-date=2019-04-26}}</ref> - [https://www.youtube.com/watch?v=BFYLytMFFNE (Video)] | ||
*2018, [https://meaustralia.net/2019/01/24/meet-the-scientists-prof-don-staines/ Meet the Scientists: Prof Don Staines] on ME Australia | *2018, [https://meaustralia.net/2019/01/24/meet-the-scientists-prof-don-staines/ Meet the Scientists: Prof Don Staines] on [[ME Australia]] | ||
*13 | *Mar 13, 2019, ''[https://mecfsconference.org.au/videos/sonyamarshall-gradisnik/ Immunological & Calcium Signalling Define ME/CFS]'' given at the International Research Symposium, Geelong, Australia, sponsored by [[Emerge Australia]] (presentation with [[Sonya Marshall-Gradisnik]]) | ||
*May 31, 2019, Speaker at the 14th [[Invest in ME International ME Conference|Invest in ME Conference]] 2019; Speech title: ''Transient receptor potential ion channels in the aetiology and pathomechanism of CFS/ME''<ref name="IiMER-14th">{{Cite web | url = http://www.investinme.org/IIMEC14.shtml | title = IIMEC14 14th Invest in ME Reseaerch International ME Conference 2019 | website = [[Invest in ME Research]]|access-date=2020-02-26}}</ref> ''-'' [https://www.youtube.com/watch?v=S6saqOqed3c (Video)] | |||
==Learn more== | ==Learn more== | ||
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==References== | ==References== | ||
{{reflist}} | |||
}} | |||
[[Category:Researchers]] | [[Category:Researchers]] |
Latest revision as of 20:00, July 29, 2023
Professor Donald R. Staines, MBBS, MPH, FAFPHM, FAFOEM, is a Clinical Professor at Menzies Health Institute Queensland and the co-director (alongside Sonya Marshall-Gradisnik) of the National Centre for Neuroimmunology and Emerging Diseases (NCNED) at Griffith University in Queensland in north-eastern Australia.[1] His research team is working towards discovery of diagnostic tools and treatments for chronic fatigue syndrome.[2]
International Consensus Criteria[edit | edit source]
Staines is one of the authors of the 2011 case definition, International Consensus Criteria.[3]
Diagnostic test[edit | edit source]
In February 2016 the research team led by Donald Staines and Sonya Marshall-Gradisnik announced it had created a diagnostic test for the disease using CD8 T cells.[4] They have been awarded a $4-million grant to be administered during the next five years that will enable them to continue research into developing a diagnostic test for ME/CFS.[5]
Open Letters to The Lancet[edit | edit source]
Three open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Staines, along with 41 colleagues in the ME/CFS field, signed the second letter. In June 2018, Dr. Staines signed the third letter, this time along with approximately 100 colleagues.
- 10 February 2016, An open letter to The Lancet, again - Virology blog
- 19 June 2018, Trial By Error: An Open Letter to The Lancet, Two Years On - Virology blog
Notable studies[edit | edit source]
- 2011, Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[6] - (Full Text)
- 2012, The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[7] - (Full Text)
- 2014, Characterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[8] - (Full Text)
- 2014, The Role of Adaptive and Innate Immune Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[9] - (Full Text)
- 2014, The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings[10] - (Abstract)
- 2014, Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)[11] - (Full Text)
- 2015, A Comparison of Cytokine Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis Patients[12]
- 2015, Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients[13] - (Abstract)
- 2015, Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients[14] - (Full Text)
- 2015, Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients[15] - (Full Text)
- 2015, Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)[16] - (Full Text)
- 2015, Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients[17] - (Full Text)
- 2015, Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[18]
- 2016, Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients[19] - (Full Text)
- 2016, A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[20] - (Abstract)
- 2016, Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study[21] - (Full Text)
- 2016, Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison[22] - (Full Text)
- 2016, ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients[23] - (Full Text)
- 2016, Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome[24] - (Full Text)
- 2017, Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review[25] - (Full Text)
- 2017, Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels[26] - (Full Text)
- 2017, Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients[27] - (Full Text)
- 2018, Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[28] - (Full text)
- 2018, Brain function characteristics of chronic fatigue syndrome: A task fMRI study[29] - (Full Text)
- 2018, A Systematic Review of Probiotic Interventions for Gastrointestinal Symptoms and Irritable Bowel Syndrome in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)[30] - (Abstract)
- 2018, A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis[31] - (Full text)
- 2018, Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation[32] - (Full Text)
- 2018, Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation[33] - (Abstract)
- 2018, Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome[34] - (Full Text)
- 2018, Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients[35] - (Full Text)
- 2019, Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study[36] - (Full text)
- 2019, Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients[37] - (Full text)
- 2019, A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)[38] - (Full text)
- 2019, Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients[39] - (Abstract)
- 2019, Intra brainstem connectivity is impaired in chronic fatigue syndrome[40] - (Full text)
- 2019, Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients[41] - (Full text)
- 2020, Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study[42] - (Full text)
- 2020, Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans[43] - (Full text)
- 2021, Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[44] - (Full text)
- 2021, Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment[45] - (Full text)
Talks and interviews[edit | edit source]
- 2015, Who Are You? Professor Don Staines, ME/CFS research, Griffith University Gold Coast (August 31, 2015)
- 2016, Speaker at the 11th Invest in ME International ME Conference on "Update from NCNED: Receptor identification and intracellular signalling"[46]DVD available
- 2017, Speaker at the 12th Invest in ME International ME Conference; Speech title: Dysregulation of Transient Receptor Potential (TRP) ion channels and calcium in natural killer cells in CFS/ME patients[46] - (Video)
- 2018, Meet the Scientists: Prof Don Staines on ME Australia
- Mar 13, 2019, Immunological & Calcium Signalling Define ME/CFS given at the International Research Symposium, Geelong, Australia, sponsored by Emerge Australia (presentation with Sonya Marshall-Gradisnik)
- May 31, 2019, Speaker at the 14th Invest in ME Conference 2019; Speech title: Transient receptor potential ion channels in the aetiology and pathomechanism of CFS/ME[47] - (Video)
Learn more[edit | edit source]
- Donald Staines Griffith University - Donald Staines
- 2014, Gold Coast’s Griffith University to lead way in the battle against chronic fatigue (Gold Coast Bulletin, July 30 2014)
- 2016, Australian scientists make breakthrough in Chronic Fatigue Syndrome testing
- 2018, Profile in Meet the Scientists: Prof Don Staines
Online presence[edit | edit source]
See also[edit | edit source]
- Sonya Marshall-Gradisnik
- Invest in ME International ME Conference
- National Centre for Neuroimmunology and Emerging Diseases
References[edit | edit source]
- ↑ "National Centre for Neuroimmunology and Emerging Diseases". griffith.edu.au. Retrieved November 14, 2019.
- ↑ "Coast team zeroing in on CFS test". goldcoastbulletin.com.au. December 1, 2016. Retrieved April 26, 2019.
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A.C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ Australian scientists make breakthrough in Chronic Fatigue Syndrome testing, ABC News (Australia), 29 February 2016
- ↑ "Coast team zeroing in on CFS test". goldcoastbulletin.com.au. December 1, 2016. Retrieved April 26, 2019.
- ↑ Brenu, EW; van Driel, ML; Staines, DR; Ashton, KJ; Ramos, SB; Keane, J; Klimas, NG; Marshall-Gradisnik, SM (2011). "Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". Journal of Translational Medicine. 9 (81). doi:10.1186/1479-5876-9-81.
- ↑ Brenu, Ekua W; van Driel, Mieke L; Staines, Donald R; Kreijkamp-Kaspers, Sanne; Hardcastle, Sharni L; Marshall-Gradisnik, Sonya M (2012). "The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis" (PDF). International Journal of Clinical Medicine. 3 (6): 544-551. doi:10.4236/ijcm.2012.36098.
- ↑ Huth, Teilah K.; Brenu, Ekua; Nguyen, Thao; Hardcastle, Sharni L.; Johnston, Samantha; Ramos, Sandra; Staines, Donald R.; Marshall-Gradisnik, Sonya M. (2014). "Characterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". Journal of Clinical & Cellular Immunology. 5 (3). doi:10.4172/2155-9899.1000223.
- ↑ Brenu, EW; Huth, TK; Hardcastle, SL; Fuller, K; Kaur, M; Johnston, S; Ramos, S; Staines, D; Marshall-Gradisnik, S (2014). "The Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis". International Immunology. 26 (4): 233–42. doi:10.1093/intimm/dxt068. PMID 24343819.
- ↑ Johnston, S.C.; Brenu, E.W.; Staines, D.R.; Marshall-Gradisnik, S.M. (January 2, 2014). "The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings". Fatigue: Biomedicine, Health & Behavior. 2 (1): 28–39. doi:10.1080/21641846.2013.860779. ISSN 2164-1846.
- ↑ Hardcastle, Sharni L.; Brenu, Ekua W.; Johnston, Samantha; Nguyen, Thao; Huth, Teilah K.; Kaur, Manprit; Ramos, Sandra; Salajegheh, Ali; Staines, Donald R.; Marshall-Gradisnik, Sonya (2014). "Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)". Journal of Clinical & Cellular Immunology. 5 (190). doi:10.4172/2155-9899.1000190.
- ↑ Wong, Naomi; Nguyen, Thao; Brenu, Ekua Weba; Broadley, Simon; Staines, Donald; Marshall-Gradisnik, Sonya (2015). "A Comparison of Cytokine Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis Patients". International Journal of Clinical Medicine. 6 (10): 769–783. doi:10.4236/ijcm.2015.610103.
- ↑ Armstrong, Christopher W.; McGregor, Neil R.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2015). "Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients". Metabolomics. 11 (6): 1626–1639. doi:10.1007/s11306-015-0816-5.
- ↑ Hardcastle, SL; Brenu, EW; Johnston, S; Nguyen, T; Huth, T; Wong, N; Ramos, S; Staines, DR; Marshall-Gradisnik, SM (2015). "Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients". International Journal of Medical Sciences. 12 (10): 764–772. doi:10.7150/ijms.12399.
- ↑ Marshall-Gradisnik, Sonya M.; Smith, Peter; Brenu, Ekua W.; Nilius, Bernd; Ramos, Sandra B.; Staines, Donald R. (2015). "Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients". Immunology and Immunogenetics Insights. 2015 (7): 1–6. doi:10.4137/III.S25147.
- ↑ Hardcastle, SL; Brenu, EW; Johnston, S; Nguyen, T; Huth, T; Wong, N; Ramos, S; Staines, DR; Marshall-Gradisnik, SM (2015). "Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)". BMC Immunology. 16 (35). doi:10.1186/s12865-015-0101-4.
- ↑ Hardcastle, Sharni Lee; Brenu, Ekua Weba; Johnston, Samantha; Nguyen, Thao; Huth, Teilah; Ramos, Sandra; Staines, Donald; Marshall-Gradisnik, Sonya (2015). "Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients". Journal of Translational Medicine. 13 (299). doi:10.1186/s12967-015-0653-3.
- ↑ Peterson, D; Brenu, EW; Gottschalk, G; Ramos, Sandra B; Nguyen, T; Staines, D; Marshall-Gradisnik, S (2015). "Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". Mediators of Inflammation. 2015. doi:10.1155/2015/929720.
- ↑ Huth, T.K.; Brenu, E.W.; Staines, D.R.; Marshall-Gradisnik, S.M. (2016). "Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients". Gene Regulation and Systems Biology. 10: 43–49. doi:10.4137/GRSB.S39861.
- ↑ Collatz, Ansel; Johnston, Samantha C.; Staines, Donald R.; Marshall-Gradisnik, Sonya M. (2016). "A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". Clinical Therapeutics. 38 (6): 1263-1271.e9. doi:10.1016/j.clinthera.2016.04.038. PMID 27229907.
- ↑ Shan, Zack Y.; Kwiatek, Richard; Burnet, Richard; Del Fante, Peter; Staines, Donald R.; Marshall‐Gradisnik, Sonya; Barnden, Leighton R. (2016). "Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study". Journal of Magnetic Resonance Imaging. 44: 1301–1311. doi:10.1002/jmri.25283.
- ↑ Ramos, S; Brenu, E; Broadley, S; Kwiatek, R; Ng, J; Nguyen, T; Freeman, S; Staines, D; Marshall-Gradisnik, S (March 20, 2016). "Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison". Asian Pac J Allergy Immunol. doi:10.12932/AP0733.
- ↑ Huth, Teilah K.; Staines, Donald; Marshall-Gradisnik, Sonya (2016). "ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients". Journal of Translational Medicine. 14 (97). doi:10.1186/s12967-016-0859-z.
- ↑ Marshall-Gradisnik, Sonya M.; Huth, Teilah; Chacko, Anu; Johnston, Samantha; Smith, Peter; Staines, Donald R. (2016). "Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome". The Application of Clinical Genetics. 9: 39–47. doi:10.2147/TACG.S99405.
- ↑ Campagnolo, N.; Johnston, S.; Collatz, A.; Staines, D.; Marshall-Gradisnik, S. (January 22, 2017). "Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review". Journal of Human Nutrition and Dietetics. 30 (3): 247–259. doi:10.1111/jhn.12435. ISSN 0952-3871. PMID 28111818.
- ↑ Nguyen, T.; Hardcastle, S.; Clarke, L.; Smith, P.; Staines, D.; Marshall-Gradisnik, S. (2017). "Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels". Clinical and Experimental Immunology. 187 (2): 284–293. doi:10.1111/cei.12882.
- ↑ Nguyen, T.; Johnston, S.; Chacko, A.; Gibson, D.; Cepon, J.; Smith, D.; Staines, D.; Marshall-Gradisnik, S. (2017). "Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients". Asian Pac J Allergy Immunol. 35 (2): 75-81. doi:10.12932/AP0771.
- ↑ Marshall-Gradisnik, Sonya; Fretel, Marshall; Eaton, Natalie; Cabanas, Helene; Balinas, Cassandra; Gopalan, Vinod; Petersen, Daniel; Passmore, Rachel; Tang, Kevin; Haque, Mazhar; Lam, Alfred; Staines, Donald (May 31, 2018). "Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". International Journal of Clinical Medicine. 09 (05): 467. doi:10.4236/ijcm.2018.95040.
- ↑ Shan, Zack Y.; Finegan, Kevin; Bhuta, Sandeep; Ireland, Timothy; Staines, Donald R.; Marshall‐Gradisnik, Sonya; Barnden, Leighton R. (2018). "Brain function characteristics of chronic fatigue syndrome: A task fMRI study". NeuroImage: Clinical. 19: 279–286. doi:10.1016/j.nicl.2018.04.025.
- ↑ Corbitt, M; Campagnolo, N; Staines, D; Marshall-Gradisnik, S (2018). "A Systematic Review of Probiotic Interventions for Gastrointestinal Symptoms and Irritable Bowel Syndrome in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)". Probiotics Antimicrob Proteins. doi:10.1007/s12602-018-9397-8.
- ↑ Du Preez, S.; Corbitt, M.; Cabanas, H.; Eaton, N.; Staines, D.; Marshall-Gradisnik, S. (December 20, 2018). "A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis". Systematic Reviews. 7 (1): 241. doi:10.1186/s13643-018-0909-0. ISSN 2046-4053. PMID 30572962.
- ↑ Eaton, Natalie; Cabanas, Hélène; Balinas, Cassandra; Klein, Anne; Staines, Donald R.; Marshall-Gradisnik, Sonya (2018). "Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation". BMC Pharmacology & Toxicology. 19 (12). doi:10.1186/s40360-018-0203-8. PMID 29587879.
- ↑ Nguyen, T.; Staines, D.; Johnston, S.; Marshall-Gradisnik, S. (July 2018). "Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation". Asian Pac J Allergy Immunol. doi:10.12932/AP-011117-0188.
- ↑ Barnden, Leighton R.; Shan, Zack Y.; Staines, Donald R.; Marshall-Gradisnik, Sonya; Finegan, Kevin; Ireland, Timothy; Bhuta, Sandeep (2018). "Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome". NeuroImage: Clinical. 20: 102–109. doi:10.1016/j.nicl.2018.07.011.
- ↑ Cabanas, Hélène; Muraki, Katsuhiko; Eaton, Natalie; Balinas, Cassandra; Staines, Donald; Marshall-Gradisnik, Sonya (August 14, 2018). "Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients". Molecular Medicine. 24 (1). doi:10.1186/s10020-018-0046-1. ISSN 1076-1551.
- ↑ Słomko, Joanna; Newton, Julia L; Kujawski, Sławomir; Tafil-Klawe, Małgorzata; Klawe, Jacek; Staines, Donald; Marshall-Gradisnik, Sonya; Zalewski, Pawel (March 2019). "Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study". BMJ Open. 9 (3): e023955. doi:10.1136/bmjopen-2018-023955. ISSN 2044-6055. PMID 30850404.
- ↑ Cabanas, H.; Muraki, K.; Balinas, C.; Eaton-Fitch, N.; Staines, D.; Marshall-Gradisnik, S. (December 2019). "Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients". Molecular Medicine. 25 (1). doi:10.1186/s10020-019-0083-4. ISSN 1076-1551.
- ↑ Corbitt, Matthew; Eaton-Fitch, Natalie; Staines, Donald; Cabanas, Hélène; Marshall-Gradisnik, Sonya (December 2019). "A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)". BMC Neurology. 19 (1). doi:10.1186/s12883-019-1433-0. ISSN 1471-2377. PMID 31445522.
- ↑ Cabanas, Helene; Muraki, Katsuhiko; Staines, Donald; Marshall-Gradisnik, Sonya (October 14, 2019). "Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients". Frontiers in Immunology. doi:10.3389/fimmu.2019.02545.
- ↑ Barnden, Leighton R; Shan, Zack Y; Staines, Donald R; Marshall-Gradisnik, Sonya; Finegan, Kevin; Ireland, Timothy; Bhuta, Sandeep (2019). "Intra brainstem connectivity is impaired in chronic fatigue syndrome". NeuroImage: Clinical. 24: 102045. doi:10.1016/j.nicl.2019.102045.
- ↑ Balinas, Cassandra; Cabanas, Hélène; Staines, Donald; Marshall-Gradisnik, Sonya (December 3, 2019). "Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients". Journal of Translational Medicine. 17 (1): 401. doi:10.1186/s12967-019-02155-4. ISSN 1479-5876. PMC 6891975. PMID 31796045.
- ↑ Eaton-Fitch, N.; Johnston, S. C.; Zalewski, P.; Staines, D.; Marshall-Gradisnik, S. (January 22, 2020). "Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study". Quality of Life Research. doi:10.1007/s11136-019-02411-6. ISSN 0962-9343.
- ↑ Thapaliya, Kiran; Marshall-Gradisnik, Sonya; Staines, Don; Barnden, Leighton (2020). "Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans". NeuroImage: Clinical. 28: 102366. doi:10.1016/j.nicl.2020.102366. PMC 7417892. PMID 32777701.
- ↑ Maksoud, Rebekah; Eaton-Fitch, Natalie; Matula, Michael; Cabanas, Hélène; Staines, Donald; Marshall-Gradisnik, Sonya (May 2021). "Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Healthcare. 9 (5): 568. doi:10.3390/healthcare9050568.
- ↑ Cabanas, Helene; Muraki, Katsuhiko; Eaton-Fitch, Natalie; Staines, Donald Ross; Marshall-Gradisnik, Sonya (2021). "Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment". Frontiers in Immunology. 12: 687806. doi:10.3389/fimmu.2021.687806. ISSN 1664-3224. PMC 8313851. PMID 34326841.
- ↑ 46.0 46.1 "UK Charity for Myalgic Encephalomyelitis Centre of Excellence for ME Blog". investinme.org. Retrieved April 26, 2019.
- ↑ "IIMEC14 14th Invest in ME Reseaerch International ME Conference 2019". Invest in ME Research. Retrieved February 26, 2020.