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Diphenhydramine
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==Evidence== Clinical trials of the effects of diphenhydramine on ME/CFS patients have not been conducted. ===Long COVID === Two female patients have been reported to have experienced rapid and significant improvements in their [[Long COVID]] symptoms after taking diphenhydramine, in particular in [[exercise intolerance|exercise tolerance]] and [[post-exertional malaise]]. The patients used doses of 50mg and 25mg of diphenhydramine respectively, with one of these patients also responding to 50mg [[hydroxyzine pamoate]].<ref name="Pinto2022" /> These effects did not occur using [[fexofenadine]].<ref name="Pinto2022" /> Pinto et al. (2022) stated that some COVID-19 patients had improved after [[:Category:Antihistamines|antihistamine]] treatment, and according to [[Natalie Lambert]], long covid patients in a [[Survivor Corps]] social media group has frequently posted about antihistamines. Glynne et al. (2022) also commented on anecdoteal reports of long COVID patients improving with antihistamines, and the role of [[histamine]] in COVID-19.<ref name="Glynne2022" /> Glynne et al. conducted a small observational study using a combination of H1 ([[loratadine]] or [[fexofenadine]]) and H2 ([[famotidine]] or [[nizatidine]] histamine receptor antagonists (HRAs) for a minimum of 4 weeks, finding clinically significant improvement in the majority of patients.<ref name="Glynne2022" />
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