Diamine oxidase

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Diamine oxidase (DAO), also known as histaminase, is an enzyme that breaks down histamine. The highest concentrations of DAO are found in the digestive tract and the placenta.[1] Two studies have investigated serum levels of DAO as a potential diagnostic test for histamine intolerance (HIT), but this is not a widely accepted diagnostic test.[2]:40-41

Supplementation[edit | edit source]

DAO food supplements are taken for histamine intolerance in patients with low DAO, for example the supplement DAOsin.[3][4]

DAO food supplements form are sometimes taken by individuals with mast cell activation disorder.[citation needed]

In rats, Magnesium is an important cofactor in the production of DAO and magnesium deficiency may result in decreased DAO activity and excess histamine levels.[5]

Copper, Vitamin B6[6] and Vitamin C are other important DAO cofactors.

Heparin increases the activity of DAO in the blood.[7]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ Agúndez, JA; Ayuso, P; Cornejo-García, JA; Blanca, M; Torres, MJ; Doña, I; Salas, M; Blanca-López, N; Canto, G; Rondon, C; Campo, P; Laguna, JJ; Fernández, J; Martínez, C; García-Martín, E (2012), "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs", PLOS ONE, 7 (11): e47571, doi:10.1371/journal.pone.0047571, PMID 23152756
  2. ↑ https://books.google.co.uk/books?id=niFHDwAAQBAJ&lpg=PA43&dq=histamine%20intolerance%20test&pg=PA40#v=onepage&q=histamine%20intolerance%20test&f=true
  3. ↑ https://pubmed.ncbi.nlm.nih.gov/31807350/
  4. ↑ https://clinicaltrials.gov/ct2/show/NCT03298568
  5. ↑ Nishio, A.; Ishiguro, S.; Miyao, N. (1987), "Specific change of histamine metabolism in acute magnesium-deficient young rats", Drug-Nutrient Interactions, 5 (2): 89–96, ISSN 0272-3530, PMID 3111814
  6. ↑ Martner-Hewes, P. M.; Hunt, I. F.; Murphy, N. J.; Swendseid, M. E.; Settlage, R. H. (December 1, 1986), "Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers.", The American Journal of Clinical Nutrition, 44 (6): 907–913, ISSN 0002-9165, PMID 3098085, retrieved November 9, 2016
  7. ↑ Klocker, Josef; Perkmann, Reinhold; Klein-Weigel, Peter; Mörsdorf, Gabriele; Drasche, Astrid; Klingler, Anton; Fraedrich, Gustav; Schwelberger, Hubert G. (January 2004), "Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase", Vascular Pharmacology, 40 (6): 293–300, doi:10.1016/j.vph.2004.02.002, ISSN 1537-1891, PMID 15063833

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

cofactor A substance that acts with another substance to bring about certain effects. In biochemistry, a cofactor is a molecule that is necessary for a given biochemical reaction, but is not an enzyme or substrate of the reaction.

cofactor A substance that acts with another substance to bring about certain effects. In biochemistry, a cofactor is a molecule that is necessary for a given biochemical reaction, but is not an enzyme or substrate of the reaction.

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