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Diagnostic biomarker
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=== Hand grip strength === A 2018 [[UK ME/CFS biobank]] study led by [[Luis Nacul]] assessed over 200 patients with [[ME/CFS]] found that hand grip strength was both a possible biomarker for ME/CFS, and an indicator of disease severity. Hand grip strength results were compared with healthy controls and patients with [[Multiple sclerosis|Multiple Sclerosis]].<ref name="handgrip2018">{{Cite journal | last = Nacul|first = Luis Carlos | authorlink = Luis Nacul | last2 = Mudie | first2 = Kathleen | authorlink2 = Kathleen Mudie | last3 = Kingdon | first3 = Caroline | authorlink3 = Caroline Kingdon | last4 = Clark | first4 = Taane G. | authorlink4 = Taane Clark | last5 = Lacerda | first5 = Eliana Mattos | author-link5 = Eliana Lacerda | date = 2018 | title = Hand grip strength as a clinical biomarker for ME/CFS and disease severity | url = https://www.frontiersin.org/articles/10.3389/fneur.2018.00992/abstract|journal=Frontiers in Neurology|language=English|volume=9|issue=| pages=|doi=10.3389/fneur.2018.00992|issn=1664-2295|quote=|via=}}</ref> Jäkel et al. (2021) investigated repeat maximum handgrip strength (HGS) as a measure of [[muscle fatigability]] in 105 ME/CFS patients meeting the [[Canadian Consensus Criteria|Canadian consensus criteria]], compared to 18 with [[cancer-related fatigue]] (CRF) and healthy controls.<ref name="Jäkel2021">{{Cite journal | title = Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS | date = 2021-04-19 | url = https://doi.org/10.1186/s12967-021-02774-w|journal=Journal of Translational Medicine|volume=19|issue=1 | pages = 159 | last = Jäkel|first = Bianka | authorlink = Bianka Jäkel | last2 = Kedor | first2 = Claudia | authorlink2 = | last3 = Grabowski | first3 = Patricia | authorlink3 = Patricia Grabowski | last4 = Wittke | first4 = Kirsten | authorlink4 = Kirsten Wittke | last5 = Thiel | first5 = Silvia | author-link5 = Silvia Thiel | last6 = Scherbakov | first6 = Nadja | author-link6 = | last7 = Doehner | first7 = Wolfram | last8 = Scheibenbogen | first8 = Carmen | author-link8 = Carmen Scheibenbogen | last9 = Freitag | first9 = Helma | author-link9 = Helma Freitag|doi=10.1186/s12967-021-02774-w|pmc=PMC8056497|pmid=33874961|access-date=|issn=1479-5876|quote=|via=}}</ref>
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