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Diagnostic biomarker
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===Ratio of active:inactive PKR=== In 2018, [[Eiren Sweetman]] discovered, during work for her doctorate thesis, that a changed ratio of active:inactive [[Protein Kinase R]] (PKR) in people with ME/CFS vs age-gender matched controls could potentially be used as a diagnostic biomarker. Protein Kinase R (PKR) is an innate antiviral immune response protein. Upon measuring an antibody against a non-phosphorylated PKR fragment and an antibody against a [[Thr-446]] phosphorylated PKR peptide, an increased ratio of phosphorylated PKR to non-phosphorylated inactive PKR was detected ME/CFS patients.<ref name="Sweetman2018">Sweetman, E. C. (2018). Comprehensive molecular analysis of different classes of molecules in a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome pilot study group, and investigation of RNA-activated Protein Kinase R (PKR) as a diagnostic biomarker (Thesis, Doctor of Philosophy). University of Otago. Retrieved from http://hdl.handle.net/10523/7834</ref> Obstacles in use: Further testing needed for confirmation; test would need to be adapted from a research setting to a clinical setting for wide availability.
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