Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Diagnostic biomarker
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
=== Phenylalanine measured via Raman microspectroscopy === A research team (Xu, et al, 2018) in the [[United Kingdom|UK]] used [[single-cell Raman microspectroscopy]] (SCRM) on rho zero cells (Ο<sup>0</sup> cells) that lack [[mitochondrial DNA]] (mtDNA) compared to [[peripheral blood mononuclear cell]]s (PBMCs) from CFS patients and healthy controls. They found that Raman [[phenylalanine]] bands associated with CFS patient PBMCs were significantly higher and were increased in intensities compared to controls. The results suggest that the increase in cellular phenylalanine may relate to [[mitochondrion|mitochondrial]]/energetic dysfunction in CFS and that phenylalanine can be used as a potential biomarker for diagnosis of CFS by SCRM. They achieved an accuracy rate of 98% correctly determining between CFS patients and healthy controls.<ref>{{Cite journal | last = Xu|first = Jiabao | last2 = Potter | first2 = Michelle | last3 = Tomas | first3 = Cara | authorlink3 = Cara Tomas | last4 = Elson | first4 = Jo | last5 = Morten | first5 = Karl | author-link5 = Karl Morten | last6 = Poulton | first6 = Joanna | last7 = Wang | first7 = Ning | last8 = Jin | first8 = Hanqing | last9 = Hou | first9 = Zhaoxu | date = 2018 | title = A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy | url = https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/unauth#!divRelatedContent&articles|journal=The Analyst|language=en|volume=| pages=|doi=10.1039/C8AN01437J|issn=0003-2654|via=}}</ref> Obstacles in use: Further testing needed for confirmation.
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs