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Deadlock quartet
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==Evidence== There is no peer-reviewed evidence in support of either a four-way deadlock in methylation or in the use of the deadlock quartet to treat it. The deadlock quartet was developed by [[Phoenix Rising]] forum member Freddd, based on work by ME/CFS patient [[Rich Van Konynenburg]].<ref name="Methylcyclehypothesis">{{Cite web | title = Status of methylation cycle model and treatment | date = Sep 19, 2009|last =Van Konynenburg|first = Rich | authorlink = Rich Van Konynenburg| website = Phoenix Rising| url =https://forums.phoenixrising.me/threads/status-of-methylation-cycle-model-and-treatment.406/|access-date=2022-05-19}}</ref> The concept of a block or deadlock affecting [[energy metabolism]] is also part of the [[metabolic trap]] hypothesis, which was developed independently using the [[ME/CFS Severely Ill, Big Data Study]], and which has different proposed treatments.{{citation needed | date = 2022}}
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