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Deadlock quartet
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The '''deadlock quartet''' is a combination of four nutrients used to overcome a proposed "deadlock" in the [[methylation cycle]].<ref name="PR-symptoms2013">{{Cite web | access-date=2022-05-19 | title = Symptoms By Deadlock Quartet and other nutrients | last = Freddd|website=[[Phoenix Rising]] | date = 2013-02-07 | url = https://forums.phoenixrising.me/threads/symptoms-by-deadlock-quartet-and-other-nutrients.27482/}}</ref><ref name="Methylcyclehypothesis" /> The deadlock quartet consists of: *cyanocobalamin - a form of [[vitamin B12]] *Hydroxocobalamin - a form of vitamin B12 *[[Folic acid]] *[[Folinic acid]] ==Theory== A hypotheical four-way "deadlock" in the methylation process is believed to cause energy limitations due to impaired metabolism. ==Evidence== There is no peer-reviewed evidence in support of either a four-way deadlock in methylation or in the use of the deadlock quartet to treat it. The deadlock quartet was developed by [[Phoenix Rising]] forum member Freddd, based on work by ME/CFS patient [[Rich Van Konynenburg]].<ref name="Methylcyclehypothesis">{{Cite web | title = Status of methylation cycle model and treatment | date = Sep 19, 2009|last =Van Konynenburg|first = Rich | authorlink = Rich Van Konynenburg| website = Phoenix Rising| url =https://forums.phoenixrising.me/threads/status-of-methylation-cycle-model-and-treatment.406/|access-date=2022-05-19}}</ref> The concept of a block or deadlock affecting [[energy metabolism]] is also part of the [[metabolic trap]] hypothesis, which was developed independently using the [[ME/CFS Severely Ill, Big Data Study]], and which has different proposed treatments.{{citation needed | date = 2022}} ==Clinicians== ==Risks and safety== Largely unknown since clinicial trials have not taken place. Cyanocobalamin has significant safety risks, including the loading of [[potassium]] levels.<ref name="PMC5312744">{{Cite journal | title = Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms | date = Feb 2017 | url = https://pubmed.ncbi.nlm.nih.gov/28223907/|journal=Integrative Medicine (Encinitas, Calif.)|volume=16|issue=1 | pages = 42–49 | last = Paul|first = Cristiana | authorlink = | last2 = Brady | first2 = David M. | authorlink2 = | last3 = | first3 = | authorlink3 = | last4 = | first4 = | author-link4 = | last5 = | first5 = | author-link5 = |doi=|pmc=5312744|pmid=28223907|access-date=|issn=1546-993X|quote=|via=}}</ref> Both cyanocobalamin and hydroxocobalamin are available as supplements and in other forms, including injections of higher doses as a perscription drug.<ref name="cyano">{{Cite web | url = https://www.drugs.com/pro/cyanocobalamin.html | title = Cyanocobalamin - FDA prescribing information, side effects and uses|website=Drugs.com|language=en|access-date=2022-05-19}}</ref><ref name="hydrox">{{Cite web | url = https://www.drugs.com/mtm/hydroxocobalamin-injection.html | title = Hydroxocobalamin injection Uses, Side Effects & Warnings|website=Drugs.com|language=en|access-date=2022-05-19}}</ref> Allergies and anaphylatic shock also occur in some people given cyanocobalamin or other B12 forms.<ref name="PMC5312744" /> ==Costs and availability== ==See also== *[[Methylation cycle hypothesis]] (Freddd's protocol) *[[Rich Van Konynenburg]] ==Learn more== *[https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/ Vitamin B12] - Office of Dietary Supplements *[https://www.drugs.com/pro/cyanocobalamin.html Cyanocobalamin - FDA prescribing information, side effects] - drugs.com *[https://www.drugs.com/mtm/hydroxocobalamin-injection.html Hydroxocobalamin (injection): Uses, Side Effects & Warnings] - drugs.com ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Supplements]] [[Category:Nutrients]] [[Category:Medical hypotheses]]
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