Cytomegalovirus: Difference between revisions
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'''Cytomegalovirus''' (CMV) is a common [[herpesvirus]] found in humans. Like other herpesviruses, it is a life-long infection that remains in a latent state inside the human body, until it is 'reactivated' by appropriate conditions. | '''Cytomegalovirus''' (CMV) is a common [[herpesvirus]] found in humans. Like other herpesviruses, it is a life-long infection that remains in a latent state inside the human body, until it is 'reactivated' by appropriate conditions. | ||
==Prevalence == | ==Prevalence == | ||
CMV infects between 60% to 70% of adults in industrialized countries and close to 100% in emerging countries.{{citation needed|date=2022}} | CMV infects between 60% to 70% of adults in industrialized countries and close to 100% in emerging countries.{{citation needed | date = 2022}} | ||
Much is unknown about CMV, although it has been found in salivary glands and myeloid blood cells such as [[monocyte]]s. It has also been linked to the development of certain cancers. Congenital CMV is a leading infectious cause of deafness, learning disabilities, and intellectual disability. A common treatment for CMV is [[valganciclovir]], commonly known as Valcyte.<ref name="Gupta2019">{{Cite book|last=Gupta|first=Mohit|last2=Shorman|first2=Mahmoud|date=2019|title=Cytomegalovirus|url=http://www.ncbi.nlm.nih.gov/books/NBK459185/|location=Treasure Island (FL)|publisher=StatPearls Publishing|pmid=29083720}}</ref> | Much is unknown about CMV, although it has been found in salivary glands and myeloid blood cells such as [[monocyte]]s. It has also been linked to the development of certain cancers. Congenital CMV is a leading infectious cause of deafness, learning disabilities, and intellectual disability. A common treatment for CMV is [[valganciclovir]], commonly known as Valcyte.<ref name="Gupta2019">{{Cite book | last = Gupta | first = Mohit | last2 = Shorman | first2 = Mahmoud | date = 2019 | title=Cytomegalovirus |url =http://www.ncbi.nlm.nih.gov/books/NBK459185/|location=Treasure Island (FL)| publisher = StatPearls Publishing|pmid=29083720}}</ref> | ||
Several herpesviruses including cytomegalovirus may cause false positives on [[Lyme disease]] tests.<ref name="Goossens1999a">{{Cite journal|title=Epstein-barr virus and cytomegalovirus infections cause false-positive results in IgM two-test protocol for early lyme borreliosis|date=1999-05-01|url=https://doi.org/10.1007/BF02561539|journal=Infection|volume=27|issue=3|pages=231–231|last=Goossens|first=H. A. T.|last2=van den Bogaard|first2=A. E. J. M.|last3=Nohlmans|first3=M. K. E.|last4=van den Bogaard|first4=A. E. J. M.|language=en|doi=10.1007/BF02561539|issn=1439-0973}}</ref><ref name="Goossens1999b">{{Cite journal|title=Evaluation of Fifteen Commercially Available Serological Tests for Diagnosis of Lyme Borreliosis|date=1999-09-01|url=https://doi.org/10.1007/s100960050347|journal=European Journal of Clinical Microbiology and Infectious Diseases|volume=18|issue=8|pages=551–560|last=Goossens|first=H. A. T.|last2=van den Bogaard|first2=A. E.|last3=Nohlmans|first3=M. K. E.|language=en|doi=10.1007/s100960050347|issn=1435-4373}}</ref><ref name="Dessau2018">{{Cite journal|title=To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borreliosis|date=2018-02-01|url=https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(17)30488-3/abstract|journal=Clinical Microbiology and Infection|volume=24|issue=2|pages=118–124|last=Dessau|first=R. B.|last2=Dam|first2=A. P. van|last3=Fingerle|first3=V.|last4=Gray|first4=J.|last5=Hovius|first5=J. W.|last6=Hunfeld|first6=K. | Several herpesviruses including cytomegalovirus may cause false positives on [[Lyme disease]] tests.<ref name="Goossens1999a">{{Cite journal | title = Epstein-barr virus and cytomegalovirus infections cause false-positive results in IgM two-test protocol for early lyme borreliosis | date = 1999-05-01 | url = https://doi.org/10.1007/BF02561539|journal=Infection|volume=27|issue=3 | pages = 231–231 | last = Goossens | first = H.A.T. | last2 = van den Bogaard | first2 = A. E. J.M. | last3 = Nohlmans | first3 = M. K.E. | last4 = van den Bogaard | first4 = A. E. J.M. | language=en|doi=10.1007/BF02561539|issn=1439-0973}}</ref><ref name="Goossens1999b">{{Cite journal | title = Evaluation of Fifteen Commercially Available Serological Tests for Diagnosis of Lyme Borreliosis | date = 1999-09-01 | url = https://doi.org/10.1007/s100960050347|journal=European Journal of Clinical Microbiology and Infectious Diseases|volume=18|issue=8 | pages = 551–560 | last = Goossens | first = H.A.T. | last2 = van den Bogaard | first2 = A.E. | last3 = Nohlmans | first3 = M. K. E.|language=en|doi=10.1007/s100960050347|issn=1435-4373}}</ref><ref name="Dessau2018">{{Cite journal | title = To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borreliosis | date = 2018-02-01 | url = https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(17)30488-3/abstract|journal=Clinical Microbiology and Infection|volume=24|issue=2 | pages = 118–124 | last = Dessau|first = R.B. | last2 = Dam | first2 = A. P. van | last3 = Fingerle | first3 = V. | last4 = Gray | first4 = J. | last5 = Hovius | first5 = J.W. | last6 = Hunfeld | first6 = K.P. | last7 = Jaulhac | first7 = B. | last8 = Kahl | first8 = O. | last9 = Kristoferitsch | first9 = W. | last10 = Lindgren | first10 = P.-E. | last11 = Markowicz | first11 = M.|language=English|doi=10.1016/j.cmi.2017.08.025|pmid=28887186|issn=1198-743X}}</ref> | ||
==Treatments == | ==Treatments == | ||
| Line 15: | Line 15: | ||
==Notable studies== | ==Notable studies== | ||
*2020, Cytomegalovirus, Epstein-Barr Virus, and Human herpesvirus-6 Infections in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Shikova2020">{{Cite journal|last=Shikova|first=Evelina| | *2020, Cytomegalovirus, Epstein-Barr Virus, and Human herpesvirus-6 Infections in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Shikova2020">{{Cite journal | last = Shikova | first = Evelina | authorlink = | last2 = Reshkova | first2 = Valentina | authorlink2 = | last3 = Kumanova | first3 = Аntoniya | author-link3 = | last4 = Raleva | first4 = Sevdalina | author-link4 = | last5 = Alexandrova | first5 = Dora | author-link5 = | last6 = Capo | first6 = Natasa | author-link6 = | last7 = Murovska | first7 = Modra | date = 2020 | title=Cytomegalovirus, Epstein-Barr virus, and human herpesvirus-6 infections in patients with myalgic еncephalomyelitis/chronic fatigue syndrome | url =https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25744|journal=Journal of Medical Virology|language=en|volume=|issue=| pages=|doi=10.1002/jmv.25744|issn=1096-9071|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://doi.org/10.1002/jmv.25744 (Abstract)] | ||
== See also == | == See also == | ||
* [[List of herpesvirus infection studies]] | * [[List of herpesvirus infection studies]] | ||
* [[Abortive infection theory of ME/CFS]] (Dr Lerner's theory that abortive herpesviruses cause ME/CFS) | |||
== Learn more == | == Learn more == | ||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
| Line 29: | Line 31: | ||
[[Category:Viruses]] | [[Category:Viruses]] | ||
[[Category:Herpesviruses]] | [[Category:Herpesviruses]] | ||
Latest revision as of 22:32, August 30, 2023
 | This article needs cleanup to meet MEpedia's guidelines. The reason given is: This page needs additional references or sources for verification - multiple references need to be added. (2022) |
Cytomegalovirus (CMV) is a common herpesvirus found in humans. Like other herpesviruses, it is a life-long infection that remains in a latent state inside the human body, until it is 'reactivated' by appropriate conditions.
Prevalence[edit | edit source]
CMV infects between 60% to 70% of adults in industrialized countries and close to 100% in emerging countries.[citation needed]
Much is unknown about CMV, although it has been found in salivary glands and myeloid blood cells such as monocytes. It has also been linked to the development of certain cancers. Congenital CMV is a leading infectious cause of deafness, learning disabilities, and intellectual disability. A common treatment for CMV is valganciclovir, commonly known as Valcyte.[1]
Several herpesviruses including cytomegalovirus may cause false positives on Lyme disease tests.[2][3][4]
Treatments[edit | edit source]
- Artesunate
- Gancyclovir (brand names include Cytovene)
- Valganciclovir (brand names include Valcyte)
Notable studies[edit | edit source]
- 2020, Cytomegalovirus, Epstein-Barr Virus, and Human herpesvirus-6 Infections in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[5] - (Abstract)
See also[edit | edit source]
- List of herpesvirus infection studies
- Abortive infection theory of ME/CFS (Dr Lerner's theory that abortive herpesviruses cause ME/CFS)
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Gupta, Mohit; Shorman, Mahmoud (2019). Cytomegalovirus. Treasure Island (FL): StatPearls Publishing. PMID 29083720.
- ↑ Goossens, H.A.T.; van den Bogaard, A. E. J.M.; Nohlmans, M. K.E.; van den Bogaard, A. E. J.M. (May 1, 1999). "Epstein-barr virus and cytomegalovirus infections cause false-positive results in IgM two-test protocol for early lyme borreliosis". Infection. 27 (3): 231–231. doi:10.1007/BF02561539. ISSN 1439-0973.
- ↑ Goossens, H.A.T.; van den Bogaard, A.E.; Nohlmans, M. K. E. (September 1, 1999). "Evaluation of Fifteen Commercially Available Serological Tests for Diagnosis of Lyme Borreliosis". European Journal of Clinical Microbiology and Infectious Diseases. 18 (8): 551–560. doi:10.1007/s100960050347. ISSN 1435-4373.
- ↑ Dessau, R.B.; Dam, A. P. van; Fingerle, V.; Gray, J.; Hovius, J.W.; Hunfeld, K.P.; Jaulhac, B.; Kahl, O.; Kristoferitsch, W.; Lindgren, P.-E.; Markowicz, M. (February 1, 2018). "To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borreliosis". Clinical Microbiology and Infection. 24 (2): 118–124. doi:10.1016/j.cmi.2017.08.025. ISSN 1198-743X. PMID 28887186.
- ↑ Shikova, Evelina; Reshkova, Valentina; Kumanova, Аntoniya; Raleva, Sevdalina; Alexandrova, Dora; Capo, Natasa; Murovska, Modra (2020). "Cytomegalovirus, Epstein-Barr virus, and human herpesvirus-6 infections in patients with myalgic еncephalomyelitis/chronic fatigue syndrome". Journal of Medical Virology. doi:10.1002/jmv.25744. ISSN 1096-9071.
