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Cytochrome P450 2C19
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===Variant combinations === {| class="wikitable" |- ! Likely effect !! Combination |- | Ultrarapid metabolizer: normal or increased activity (~5β30% of patients) || Two increased activity alleles (*17) or one functional allele (*1) plus one increased-activity allele (*17), eg and rs12248560. |- | Extensive metabolizer: homozygous wild-type or normal activity (~35β50% of patients) || Two functional (*1) alleles e.g. |- | Intermediate metabolizer: heterozygote or intermediate activity (~18β45% of patients) || <!-- Example --> |- | Poor metabolizer: homozygous variant, mutant, low, or deficient activity (~2β15% of patients) || <!-- Example--> <ref name="Scott2013">{{Cite journal | last = Scott | first = S.A. | last2 = Sangkuhl | first2 = K. | last3 = Stein | first3 = C.M. | last4 = Hulot | first4 = J.-S. | last5 = Mega | first5 = J.L. | last6 = Roden | first6 = D.M. | last7 = Klein | first7 = T.E. | last8 = Sabatine | first8 = M.S. | last9 = Johnson | first9 = J.A. | date = 2013 | title = Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update | url =https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1038/clpt.2013.105|journal=Clinical Pharmacology & Therapeutics|language=en|volume=94|issue=3 | pages = 317β323|doi=10.1038/clpt.2013.105|issn=1532-6535|pmc=3748366|pmid=23698643}}</ref> |}
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