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Cytochrome P450 2C19
(section)
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==Drug responses == CYP2C19 variants are known to affect the metabolism of the [[tricyclic antidepressant]]s [[amitriptyline]], [[clomipramine]], [[doxepin]] and [[imipramine]], the [[selective serotonin reuptake inhibitor]]s (SSRIs) [[citalopram]] and [[sertraline]], the antifungal drug voriconazole, and the antiplatelet agent clopidogrel which reduces blood clotting.<ref name="Petrovic2019">{{Cite journal | last = Petrović|first = Jelena | authorlink = | last2 = Pešić | first2 = Vesna | authorlink2 = | last3 = Lauschke | first3 = Volker M. | author-link3 = | date = Jan 2020 | title = Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906321/|journal=European Journal of Human Genetics|volume=28|issue=1 | pages = 88–94|doi=10.1038/s41431-019-0480-8|issn=1018-4813|pmc=6906321|pmid=31358955|access-date=|quote=|via=}}</ref> An FDA warning was been added to clopidogrel in 2009 which started that genetic testing was available to determine if a patient could be a poor metabolizer, and that this would make the drug less effective.<ref name="FDA2009">{{Cite journal | last = Center for Drug Evaluation and Research|first = | authorlink = | date = 2019-06-28 | title = FDA Drug Safety Communication: Reduced effectiveness of Plavix (clopidogrel) in patients who are poor metabolizers of the drug | url =https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fda-drug-safety-communication-reduced-effectiveness-plavix-clopidogrel-patients-who-are-poor|journal=FDA|language=en|volume=|issue=| pages=|doi=|pmc=|pmid=|access-date=|quote=|via=}}</ref>
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