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Cyclophosphamide
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==Evidence== ===Norwegian Study - Cyclo/ME=== There is only limited evidence for the use of the drug cyclophosphamide to treat [[ME/CFS]], and only for patients who meet the [[Canadian Consensus Criteria]].<ref name="Rekeland2020" /> In the study, Rekeland et al. (2020) found that intravenous cyclophosphamide improved symptoms in over 50% of patients, and this improvement was maintained in the long term. In the trial 55% of patients responded positively to the drug, with an improvement in fatigue and overall physical functioning, with 68% of the responders having sustained remission of ME/CFS after 4 years (15 of the 40 patients).<ref name="Rekeland2020" /> The authors urged caution due to the lack of a control group. The presence of [[Human leukocyte antigen genes|HLA genes]] [[HLA-DQB1]]*03:03 and/or [[HLA-C]]*07:04 was associated with patients who responded positively to the cyclophosphamide. A Norwegian group, led by the researchers, Dr. [[Øystein Fluge]] and Professor [[Olav Mella]], who have been studying [[Rituximab]] use in [[ME/CFS]], also ran a clinical trial, called [[CycloME]]. The trial tested the effects of cyclophosphamide on [[ME/CFS]] patients that have been non-responders to [[Rituximab]].<ref>{{Cite web | url = https://clinicaltrials.gov/ct2/show/NCT02444091 | title = Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS) | last = | first = | authorlink = | date = | website = clinicaltrials.gov|language=en|archive-url=|archive-date=|access-date=2020-05-06}}</ref><ref name=":0">{{Cite web | url = https://helse-bergen.no/avdelinger/kreftbehandling-og-medisinsk-fysikk/forsking-pa-me | title = Forsking på ME | last = | first = | authorlink = | date = 2020-04-30 | website = Helse Bergen|language=no-nn|archive-url=|archive-date=|access-date=2020-05-06}}</ref> {{See also|CycloME}}
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