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Coxsackie B virus
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=== Supplements === [[Selenium]] deficiency increases the virulence of coxsackievirus B3 infections in a mouse model.<ref>http://jn.nutrition.org/content/130/2/485S.full</ref> Drugs and supplements which may have some mild in vivo antiviral effects (at least in murine studies) against coxsackievirus B include: sophoridine (Sophora root extract),<ref>{{Cite journal | last = Zhang|first = Yuanyuan | last2 = Zhu | first2 = Haiyan | last3 = Ye | first3 = Guan | last4 = Huang | first4 = Chenggang | last5 = Yang | first5 = Yingzhen | last6 = Chen | first6 = Ruizhen | last7 = Yu | first7 = Yong | last8 = Cui | first8 = Xiaolan | date = 2006-03-20 | title = Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats |url =https://www.ncbi.nlm.nih.gov/pubmed/16309710|journal=Life Sciences|volume=78|issue=17 | pages = 1998–2005|doi=10.1016/j.lfs.2005.09.034|issn=0024-3205|pmid=16309710}}</ref> Arbidol (umifenovir),<ref>{{Cite journal | last = Shi|first = L. | last2 = Xiong | first2 = H. | last3 = He | first3 = J. | last4 = Deng | first4 = H. | last5 = Li | first5 = Q. | last6 = Zhong | first6 = Q. | last7 = Hou | first7 = W. | last8 = Cheng | first8 = L. | last9 = Xiao | first9 = H. | date = 2007 | title=Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo | url = https://www.ncbi.nlm.nih.gov/pubmed/17497238|journal=Archives of Virology|volume=152|issue=8 | pages = 1447–1455|doi=10.1007/s00705-007-0974-5|issn=0304-8608|pmid=17497238}}</ref><ref>{{Cite journal | last = Zhong|first = Qiong | last2 = Yang | first2 = Zhanqiu | last3 = Liu | first3 = Yuanyuan | last4 = Deng | first4 = Haiying | last5 = Xiao | first5 = Hong | last6 = Shi | first6 = Liqiao | last7 = He | first7 = Jing | date = 2009 | title = Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo | url = https://www.ncbi.nlm.nih.gov/pubmed/19291363|journal=Archives of Virology|volume=154|issue=4 | pages = 601–607|doi=10.1007/s00705-009-0346-4|issn=1432-8798|pmid=19291363}}</ref> astragaloside IV (from Astragalus membranous),<ref>{{Cite journal | last = Zhang|first = Yuanyuan | last2 = Zhu | first2 = Haiyan | last3 = Huang | first3 = Chenggang | last4 = Cui | first4 = Xiaolan | last5 = Gao | first5 = Yingjie | last6 = Huang | first6 = Yang | last7 = Gong | first7 = Wenfeng | last8 = Zhao | first8 = Ye | last9 = Guo | first9 = Shanshan | date = Feb 2006 | title = Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma | url = https://www.ncbi.nlm.nih.gov/pubmed/16495755|journal=Journal of Cardiovascular Pharmacology|volume=47|issue=2 | pages = 190–195|doi=10.1097/01.fjc.0000199683.43448.64|issn=0160-2446|pmid=16495755}}</ref> cinnamic acid (a metabolite of cinnamon spice),<ref>{{Cite journal | last = Ding|first = YuanYuan | last2 = Qiu | first2 = Lin | last3 = Zhao | first3 = GangTao | last4 = Xu | first4 = Jingfeng | last5 = Wang | first5 = Siwang | date = Aug 2010 | title = Influence of cinnamaldehyde on viral myocarditis in mice | url =https://www.ncbi.nlm.nih.gov/pubmed/20460981|journal=The American Journal of the Medical Sciences|volume=340|issue=2 | pages = 114–120|doi=10.1097/MAJ.0b013e3181dd3b43|issn=1538-2990|pmid=20460981}}</ref> emodin (from Rheum palmatum),<ref>{{Cite journal | last = Liu|first = Zhao | last2 = Wei | first2 = Fei | last3 = Chen | first3 = Liang-Jun | last4 = Xiong | first4 = Hai-Rong | last5 = Liu | first5 = Yuan-Yuan | last6 = Luo | first6 = Fan | last7 = Hou | first7 = Wei | last8 = Xiao | first8 = Hong | last9 = Yang | first9 = Zhan-Qiu | date = 2013-09-25 | title = In vitro and in vivo studies of the inhibitory effects of emodin isolated from Polygonum cuspidatum on Coxsakievirus B₄ | url = https://www.ncbi.nlm.nih.gov/pubmed/24071990|journal=Molecules (Basel, Switzerland)|volume=18|issue=10 | pages = 11842–11858|doi=10.3390/molecules181011842|issn=1420-3049|pmc=|pmid=24071990}}</ref> dihydroquercetin (DHQ),<ref>{{Cite journal | last = Galochkina | first = Anastasia V. | last2 = Anikin | first2 = Vadim B. | last3 = Babkin | first3 = Vasily A. | last4 = Ostrouhova | first4 = Liudmila A. | last5 = Zarubaev | first5 = Vladimir V. | date = Apr 2016 | title = Virus-inhibiting activity of dihydroquercetin, a flavonoid from Larix sibirica, against coxsackievirus B4 in a model of viral pancreatitis |url =https://www.ncbi.nlm.nih.gov/pubmed/26780775|journal=Archives of Virology|volume=161|issue=4 | pages = 929–938|doi=10.1007/s00705-016-2749-3|issn=1432-8798|pmid=26780775}}</ref> arsenic trioxide,<ref>{{Cite journal | last = Molin | first = Ylva | last2 = Frisk | first2 = Peter | last3 = Hjelm | first3 = Eva | last4 = Blomberg | first4 = Jonas | last5 = Friman | first5 = Göran | last6 = Ilbäck | first6 = Nils-Gunnar | date = Nov 2010 | title = Arsenic trioxide influences viral replication in target organs of coxsackievirus B3-infected mice | url =https://www.ncbi.nlm.nih.gov/pubmed/20638482|journal=Microbes and Infection|volume=12|issue=12-13 | pages = 1027–1034|doi=10.1016/j.micinf.2010.07.003|issn=1769-714X|pmid=20638482}}</ref> Spatholobus suberectus (Ji Xue Teng),<ref>{{Cite journal | last = Pang|first = Ji | last2 = Guo | first2 = Jin-peng | last3 = Jin | first3 = Min | last4 = Chen | first4 = Zhi-qiang | last5 = Wang | first5 = Xin-wei | last6 = Li | first6 = Jun-Wen | date = Oct 2011 | title = Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice | url =https://www.ncbi.nlm.nih.gov/pubmed/21717161|journal=Chinese Journal of Integrative Medicine|volume=17|issue=10 | pages = 764–769|doi=10.1007/s11655-011-0642-1|issn=1672-0415|pmid=21717161}}</ref> salidroside (from Rhodiola rosea),<ref>{{Cite journal | last = Wang|first = Haibo | last2 = Ding | first2 = Yuanyuan | last3 = Zhou | first3 = Jun | last4 = Sun | first4 = Xiaoli | last5 = Wang | first5 = Siwang | date = Mar 2009 | title = The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3 | url = https://www.ncbi.nlm.nih.gov/pubmed/18818064|journal=Phytomedicine: International Journal of Phytotherapy and Phytopharmacology|volume=16|issue=2-3 | pages = 146–155|doi=10.1016/j.phymed.2008.07.013|issn=1618-095X|pmid=18818064}}</ref> and quercetin.<ref>{{Cite journal | last = Colunga Biancatelli|first = Ruben Manuel Luciano | last2 = Berrill | first2 = Max | last3 = Catravas | first3 = John D. | last4 = Marik | first4 = Paul E. | date = 2020 | title=Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) | url = https://www.frontiersin.org/articles/10.3389/fimmu.2020.01451/full|journal=Frontiers in Immunology|language=English|volume=11|doi=10.3389/fimmu.2020.01451|issn=1664-3224}}</ref> Drugs and supplements which have in vitro antiviral effects against coxsackievirus B are listed [https://forums.phoenixrising.me/threads/enteroviruses-revisted.14478/#post-238690 here] (but typically in vitro antiviral activity does not translate to in vivo efficacy when the compound is taken orally, so these compounds are likely to have no therapeutic effect, but may be of interest as lead compounds in the development of new antiviral drugs). [[N-acetylcysteine|N-acetyl cysteine (NAC)]] has been proven to effectively treat Coxsackivirus B3 in vivo.<ref>{{Cite journal | last = Wang|first = Yao | last2 = Zhao | first2 = Shuoxuan | last3 = Chen | first3 = Yang | last4 = Wang | first4 = Ying | last5 = Wang | first5 = Tianying | last6 = Wo | first6 = Xiaoman | last7 = Dong | first7 = Yanyan | last8 = Zhang | first8 = Jian | last9 = Xu | first9 = Weizhen | date = 2020-07-01 | title = N-Acetyl cysteine effectively alleviates Coxsackievirus B-Induced myocarditis through suppressing viral replication and inflammatory response | url =http://www.sciencedirect.com/science/article/pii/S0166354219304735|journal=Antiviral Research|language=en|volume=179 | pages = 104699|doi=10.1016/j.antiviral.2019.104699|issn=0166-3542}}</ref>
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