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Corticotropin-releasing factor receptor type 2
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{{stub}} {{NeedsImage}} '''Corticotropin-releasing factor receptor type 2''' or '''corticotropin-releasing hormone receptor 2''' or '''CRFR2''' or '''CRHR2''' or '''CRF2''' or '''CRF2''' or '''CRH2''' is a protein but CRFR2 may also refer to the gene that encodes the protein.<ref>{{Cite web | url = https://www.ncbi.nlm.nih.gov/gene/1395 | title = CRHR2 corticotropin releasing hormone receptor 2 [Homo sapiens (human)] - Gene - NCBI | website = ncbi.nlm.nih.gov|access-date=2021-11-20}}</ref> ==ME/CFS == CRFR2 may be upregulated in [[ME/CFS]] patients - although this has not yet been proven - and the degree of upregulation may be linked to the severity of [[ME/CFS]].<ref name="CT38-plans">{{Cite web | url = https://batemanhornecenter.org/cortene-plans-to-study-ct38-in-me-cfs-and-long-covid/ | title = Futue Plans for CT38 | last = Linford | first = Angela | authorlink = | date = 2021-09-03 | website = [[Bateman Horne Center]]| archive-url = | archive-date = |url-status = | access-date=2021-11-20}}</ref> The new drug [[CT38]] is currently in clinical trials at the [[Bateman Horne Center]] to determine if downregulating CRFR2 is an effective treatment or cure for [[ME/CFS]]. ==Notable studies == *2021, Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Pereira2021">{{Cite journal | last = Pereira | first = Gerard | last2 = Gillies | first2 = Hunter | last3 = Chanda | first3 = Sanjay | last4 = Corbett | first4 = Michael | last5 = Vernon | first5 = Suzanne D. | last6 = Milani | first6 = Tina | last7 = Bateman | first7 = Lucinda | date = 2021 | title=Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | url =https://www.frontiersin.org/article/10.3389/fnsys.2021.698240|journal=Frontiers in Systems Neuroscience|volume=15 | pages = 84|doi=10.3389/fnsys.2021.698240|issn=1662-5137|pmc=PMC8441022|pmid=34539356}}</ref> [https://doi.org/10.3389/fnsys.2021.698240 (Full text)] ==See also == *[[CRFR2 upregulation hypothesis]] *[[CT38]] *[[InTiME trial]] *[[Long COVID]] ==Learn more == *Sep 2021, [https://batemanhornecenter.org/cortene-plans-to-study-ct38-in-me-cfs-and-long-covid/ Cortene Weighs-In on Future Plans for CT38] - Bateman Horne Center *Sep 2021, [https://batemanhornecenter.org/september-message-cortene-study-published/ Cortene study published] *Sep 2021, [https://batemanhornecenter.org/dr-bateman-on-cortene-and-ct38/ Dr Bateman on Cortene and CT38] ==References == {{Reflist}} [[Category:Biochemistry and cell biology]] [[Category:Proteins]] [[Category:Genes]] [[Category:Peptides]]
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