Complement C4a

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Complement C4a is a glycoprotein and peptide that is expressed, primarily in the liver and in macrophages, in response to acute inflammation or tissue injury.[1][2] Complement C3 also has a role in allergy response.[3]

ME/CFS[edit | edit source]

Increased C4a levels have been found one to six hours after exercise challenge tests in ME/CFS patients but not in healthy controls.[4]

A significant correlation was found [in Chronic Fatigue Syndrome patients] between the increase in C4a and total symptom score (P < .05) and the fol- lowing individual symptoms: headaches (P < .02), joint problems (P < .05), and thinking difficulty (P < .03), through the use of 1-sided tests.[4] — Sorensen et al, 2003

Nijs et al. (2010) found a strong relation between the change in complement C4a level and an increase in post-exertional pain and fatigue in ME/CFS patients.[5] Previously, complement C4a, in combination with other proteins, was being considered as a potential marker of post-exertional malaise in ME/CFS.[6]

Notable studies[edit | edit source]

  • 2009, Transcriptional Control of Complement Activation in an Exercise Model of Chronic Fatigue Syndrome[6] (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ https://meshb.nlm.nih.gov/record/ui?name=Complement%20C4
  2. ↑ Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C
  3. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725201
  4. ↑ 4.0 4.1 Sorensen B, Streib JE, Strand M, Make B, Giclas PC, Fleshner M, Jones JF. Complement activation in a model of chronic fatigue syndrome.J Allergy Clin Immunol. 2003 Aug;112(2):397-403. pmid 12897748
  5. ↑ Nijs, J.; Van Oosterwijck, J.; Meeus, M.; Lambrecht, L.; Metzger, K.; Frémont, M.; Paul, L. (2010). "Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1β". Journal of Internal Medicine. 267 (4): 418–435. doi:10.1111/j.1365-2796.2009.02178.x. ISSN 1365-2796.
  6. ↑ 6.0 6.1 Sorensen, Bristol; Jones, James F; Vernon, Suzanne D; Rajeevan, Mangalathu S (January 2009). "Transcriptional Control of Complement Activation in an Exercise Model of Chronic Fatigue Syndrome". Molecular Medicine. 15 (1–2): 34–42. doi:10.2119/molmed.2008.00098. PMC 2583111. PMID 19015737.

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