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Cold shock protein
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Cold shock proteins (CSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions, in particular cold. Cold shock proteins include RNA binding motif 3 (RBM3) ==RNA binding motif 3 (RBM3)== RBM3 may improve neurological health. In rodents, it has been linked linked to the regeneration of synapses<ref>{{Cite journal | last = Al-Astal|first = HI | date = 2016 | title=Cellular Functions of RNA-Binding Motif Protein 3 (RBM3): Clues in Hypothermia, Cancer Biology and Apoptosis |url =https://www.ncbi.nlm.nih.gov/pubmed/27364162 | journal = Protein Pept Lett.|volume=| pages=|via=}}</ref><ref>{{Cite journal | last = | first = | date = 2015 | title=RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338605/ | journal = Nature|volume=| pages=|via=}}</ref> In a mouse model of [[Alzheimer's disease]] and [[prion disease]], cooling induced upregulation of RBM3 and resulted in delayed on-set of diseases and prolonged survial. In human subjects, upregulation of RBM3 was correlated with better prognosis in gastric<ref>{{Cite journal | last = Fangpeng|first = Ye | date = 2017 | title=High RNA-Binding Motif Protein 3 (RBM3) Expression is Independently Associated with Prolonged Overall Survival in Intestinal-Type Gastric Cancer |url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747149/ | journal = Med Sci Monit.|volume=| pages=|via=}}</ref> and colon<ref>{{Cite journal | last = Jang|first = HH | date = 2017 | title=Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer |url =https://www.ncbi.nlm.nih.gov/pubmed/28373441 | journal = Anticancer Research|volume=| pages=|via=}}</ref> cancer. ==See also== *[[Cryotherapy]] *[[Thermotherapy]] *[[Heat shock protein]] ==References== {{Reflist}} [[Category:Proteins]] [[Category:Stress response]]
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