Coenzyme Q10

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Coenzyme Q10 (CoQ10) or ubiquinone is found in the mitochondria and as a component of the electron transport chain plays an important role in aerobic respiration.

Evidence[edit | edit source]

Improvements in fatigue scores with CoQ10 and NADH. Souce: Castro-Marrero et al. (2016), Clinical Nutrition 35(4):826-834.

A trial of 50 mg CoQ10 taken with 5mg NADH twice daily for eight weeks found improvements in exercise performance/less exercise intolerance and a less fatigue and improved cognitive function, but those in the placebo group had better sensory and affective pain scores.[1]

Plasma CoQ10 was found to be significantly lower in ME/CFS patients than in normal controls and correlated with symptom severity.[2] A literature review found that CoQ10 was marginally deficient in people with chronic fatigue syndrome.[3]

Ubiquinol-10 supplementation can improve autonomic nervous function and cognitive function in chronic fatigue syndrome.[4]

Notable studies[edit | edit source]

  • 2000, Nutritional Strategies for Treating Chronic Fatigue Syndrome[3] (Full text)
  • 2009, Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder[2] (Abstract)
  • 2016, Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome[4] (Abstract)
  • 2016,Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial[1] - (Full text)

Learn more[edit | edit source]

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References[edit | edit source]