Coenzyme Q10

Coenzyme Q10 (CoQ10) or ubiquinone is found in the mitochondria and as a component of the electron transport chain plays an important role in aerobic respiration.

Evidence

A trial of 50 mg CoQ10 taken with 5mg NADH twice daily for eight weeks found improvements in exercise performance/less exercise intolerance and a less fatigue and improved cognitive function, but those in the placebo group had better sensory and affective pain scores.

Plasma CoQ10 was found to be significantly lower in ME/CFS patients than in normal controls and correlated with symptom severity. A literature review found that CoQ10 was marginally deficient in people with chronic fatigue syndrome.

Ubiquinol-10 supplementation can improve autonomic nervous function and cognitive function in chronic fatigue syndrome.

Notable studies

• 2000, Nutritional Strategies for Treating Chronic Fatigue Syndrome (Full text)

• 2009, Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder (Abstract)
• 2016, Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome (Abstract)
• 2016,Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial - (Full text)

Learn more

• 2016, CoQ10, B-Vitamins and CFS
• Coenzyme Q10 Uses, Side effects and Dosage - WebMD

See also

• Dr Lapp's supplement recommendations
• Supplements

coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.

coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.

coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.

cognition Thought processes, including attention, reasoning, and memory.

plasma The liquid part of blood, lymph, or milk after removing any suspended material. Most of the time, "plasma" simply refers to blood, after all the blood cells have been removed. If you also remove the clotting factors, then the plasma is referred to as "serum".

coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.

heart rate (HR) - the number of times the heart beats within a certain time period, usually a minute

double blinded trial A clinical trial is double blinded if neither the participants nor the researchers know which treatment group they are allocated to until after the results are interpreted. This reduces bias. (Learn more: www.nottingham.ac.uk)