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Citric acid cycle
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[[File:Citric acid cycle with aconitate 2.svg|400px|thumb|right|Overview of the citric acid cycle]] The '''citric acid cycle''' (CAC) also known as the '''''TCA cycle''''' '''''(tricarboxcylic acid cycle)''''' or the '''''Krebs cycle''''' is a series of [[enzyme-catalyzed]] chemical reactions that allow for [[aerobic respiration]] to occur within the [[Mitochondrion|mitochondria]] of the cell. When this cycle or its associated parts<ref>{{Cite web | url = http://me-pedia.org/wiki/Pyruvate_dehydrogenase | title = Pyruvate Dehydrogenase Complex | last = | first = | date = | website = | archive-url = | archive-date = |url-status = | access-date=}}</ref> are not functioning properly subsequent [[fatigue]] may take place. == Citric acid cycle in ME/CFS == A 2016 paper started to define how and why people with [[ME/CFS]] might experience poorly functioning [[cellular respiration]]<ref>{{Cite journal | last = Fluge | first = Øystein | last2 = Mella | first2 = Olav | last3 = Bruland | first3 = Ove | last4 = Risa | first4 = Kristin | last5 = Dyrstad | first5 = Sissel E. | last6 = Alme | first6 = Kine | last7 = Rekeland | first7 = Ingrid G. | last8 = Sapkota | first8 = Dipak | last9 = Røsland | first9 = Gro V. | date = 2016-12-22 | title = Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome | url =https://insight.jci.org/articles/view/89376 | journal = JCI Insight|language=en | volume = 1 | issue = 21|doi=10.1172/jci.insight.89376|issn=2379-3708}}</ref>while a review of published papers <ref>{{Cite journal | last = Filler | first = Kristin | last2 = Lyon | first2 = Debra | last3 = Bennett | first3 = James | last4 = McCain | first4 = Nancy | last5 = Elswick | first5 = Ronald | last6 = Lukkahatai | first6 = Nada | last7 = Saligan | first7 = Leorey N. | date = 2014-04-13 | title = Association of mitochondrial dysfunction and fatigue: A review of the literature | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136529/ | journal = BBA Clinical | volume = 1 | pages = 12–23|doi=10.1016/j.bbacli.2014.04.001|issn=2214-6474|pmc=4136529|pmid=25147756}}</ref> added empirical evidence of a relationship between mitochondrial dysfunction and fatigue. According to [[Ron Davis]], speaking at the 2016 [[IACFS/ME]] conference, "ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."<ref>{{Cite web | url = https://www.facebook.com/OpenMedicineFoundation/photos/a.332007933570301.63974.309364692501292/947648405339581/ | title = Open Medicine Foundation | website = facebook.com|language=en|access-date=2018-10-09}}</ref> ==Learn more== *[https://en.wikipedia.org/wiki/Citric_acid_cycle Wikipedia - Citric acid cycle] *[https://www.youtube.com/watch?v=juM2ROSLWfw Krebs / citric acid cycle | Cellular respiration | tricarboxylic acid cycle| Biology | Khan Academy]<ref>{{Cite web | url = https://www.youtube.com/watch?v=juM2ROSLWfw | title = Krebs / citric acid cycle {{!}} Cellular respiration {{!}} Biology {{!}} Khan Academy | last = | first = | date = Dec 11, 2009 | website = YouTube| publisher = Khan Academy| archive-url = | archive-date = |url-status = | access-date=}}</ref> ==See also== *[[Cellular respiration]] *[[Cell danger response hypothesis|Cell danger response]] ==References== {{Reflist}} [[Category:Biochemistry and cell biology]] [[Category:Energy system]] [[Category:Cellular respiration]] [[Category:Metabolic pathways]]
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