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[[File:Dr. Charles Lapp.png|right|Source: Hunter-Hopkins Center]] '''Charles W. Lapp''', MD, is a retired Internal Medicine physician and the Medical Director Emeritus at [[Hunter-Hopkins Center]] in Charlotte, North Carolina, [[United States|US]], which has a practice specializing in [[ME/CFS]], [[FM|fibromyalgia]], and related conditions.<ref>{{Cite web | url = https://drlapp.com/staff/curriculum-vitae-charles-w-lapp-md/ | title = Curriculum Vitae β Charles W. Lapp, MD | last = | first = | authorlink = | date = | website = Hunter-Hopkins Center|language=en-US| archive-url = | archive-date = |url-status = | access-date=2020-10-26}}</ref> Earlier in his career, he practiced family medicine and pediatrics in Raleigh, NC.<ref name="retirement"/> He became interested in [[ME/CFS]] following an outbreak of three small epidemics of a chronic fatiguing illness in the Raleigh area. [[1984 Chapel Hill outbreak|One of these outbreaks]] was among all the members of the N.C. Symphony Orchestra.<ref>{{Cite web | url = http://newsok.com/article/3366622 | title = Cause of illness remains unknown | last = Garloch | first = Karen | date = 2009 | website = NewsOK| archive-url = | archive-date = |url-status = | access-date= | authorlink = }}</ref> From 1992 to 1995 Dr. Lapp acted as Medical Director of the Cheney Clinic in Charlotte, in collaboration with Dr. [[Paul Cheney]]. In August 1995, Dr. Lapp opened the [[Hunter-Hopkins Center]] in Charlotte, North Carolina where he practiced until his retirement in 2018.<ref name="retirement" /> His center does testing for disability insurance such as the [[two-day cardiopulmonary exercise test]] (2-day CPET) and a computer-assisted cognitive function test. Following Dr. Lapp's retirement in 2018, the Hunter-Hopkins Center director became Dr. [[Vincent Hillman|Vincent F. Hillman]] with Dr. [[Laura Black]] continuing on staff.<ref name="retirement">{{Cite web | url = https://drlapp.com/news/me-letter-february-2018/#retires | title = Dr. Lapp Retires and Dr. Vincent Hillman Takes the Helm | date = 2018-02-12|language=en-US|access-date=2018-12-23 | website = Hunter-Hopkins Center | last = Lapp | first = Charles | authorlink = Charles Lapp|archive-url=|archive-date=|url-status=}}</ref> Dr. Lapp serves on the editorial board of the journal, [[Fatigue: Biomedicine, Health & Behavior]], published on behalf of the [[IACFS/ME]].<ref>{{Cite web | url = https://www.tandfonline.com/action/journalInformation?show=editorialBoard&journalCode=rftg20& | title = Fatigue: Biomedicine, Health & Behavior | website = tandfonline.com|access-date=2019-11-01}}</ref> ==Awards== *2009, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]].<ref>{{Cite web | url = https://www.iacfsme.org/iacfs-me-awardees | title = IACFS/ME Awardees | website = IACFS/ME|access-date=2020-04-23}}</ref> ==IOM Committee on Diagnostic Criteria for ME/CFS== Dr Lapp was a reviewer for the [[Institute of Medicine report|2015 report]] produced by the [[Institute of Medicine]]'s Committee on Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.<ref>{{Cite web | url = https://www.nap.edu/resource/19012/MECFS_Powerpoint.pdf | title=ME/CFS Presentation | last = Institute of Medicine | first = | authorlink = Institute of Medicine | date = | website = National Academies Press| archive-url = | archive-date = |url-status = | access-date=2018-12-23}}</ref> ==Pediatric Case Definition== *2006, A [[Pediatric]] Case Definition for [[Myalgic Encephalomyelitis]] and [[Chronic Fatigue Syndrome]]<ref name="JasonL2006paed" /> [https://solvecfs.org/wp-content/uploads/2013/06/pediatriccasedefinitionshort.pdf (Full Text)] ==Clinical Trials== The [[Hunter-Hopkins Center]] was one of two clinical sites participating in the [[Hemispherx Biopharma]] 511/open label [[Ampligen]] trials to gain [[FDA]] approval, which was ultimately unsuccessful. The [[Ampligen]] phase III trial results were published in 2012.<ref name="Strayer, 2012" /><ref name=":0">{{Cite web | url = https://drlapp.com/research/#tabs_6431815605c1f658582e55-tab_2 | title = Ampligen {{!}} Research {{!}} Hunter-Hopkins Center, P.A. | last = Hunter-Hopkins Center | first = | authorlink = Hunter-Hopkins Center | date = | website = |language=en-US| archive-url = | archive-date = |url-status = | access-date=2018-12-23}}</ref> Ampligen, a brand name for '''Rintatolimod''', is an IV medication, and was given twice weekly at the Hunter-Hopkins infusion room during the trial. The Hunter-Hopkins Center is currently one of four clinics that can administer Ampligen in the US.<ref name=":0" /> ==Clinic location== Dr Lapp retired in 2018, other physicians with expertise in ME/CFS can be contacted at the clinic he founded. :Hunter-Hopkins Center :7421 Carmel Executive Park Dr. :Charlotte, North Carolina 28226 :Telephone: (704) 543-9692 :Email: drlapp@drlapp.net ==Notable studies== *1997, Management of Chronic Fatigue Syndrome in Children: A Practicing Clinician's Approach<ref>Charles W. Lapp. (1997). Management of Chronic Fatigue Syndrome in Children: A Practicing Clinician's Approach. ''Journal of Chronic Fatigue Syndrome,'' Vol. 3, Iss. 2, pp 59-76. http://dx.doi.org/10.1300/J092v03n02_07</ref> *1998, Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome.<ref name="Vojdani, 1998" /> *1999, The Relationship Between Chronic Fatigue Syndrome and Chemical Exposure<ref>Aristo Vojdani & Charles W. Lapp. (1999). The Relationship Between Chronic Fatigue Syndrome and Chemical Exposure. ''Journal of Chronic Fatigue Syndrome'', Vol. 5, Iss. 3-4, pp. 207-221. http://dx.doi.org/10.1300/J092v05n03_18</ref> *2006, Recognizing Pediatric CFS in the Primary Care Practice: A Practicing Clinician's Approach<ref>Charles W. Lapp. (2006). Recognizing Pediatric CFS in the Primary Care Practice: A Practicing Clinician's Approach. ''Journal of Chronic Fatigue Syndrome'', Vol. 13, Iss. 2-3, pp. 89-96. http://dx.doi.org/10.1300/J092v13n02_06</ref> *2007, Defining the Occurrence and Influence of Alpha-Delta Sleep in [[Chronic Fatigue Syndrome]]<ref name="Van Hoof, 2007" /> [https://www.ncbi.nlm.nih.gov/pubmed/17301585 (Abstract)] *2009, Severe versus Moderate criteria for the new [[pediatric]] case definition for [[ME/CFS]]<ref name="Jason, Dec2009" /> [https://www.ncbi.nlm.nih.gov/pubmed/19513826 (Abstract)] *2012, A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist [[rintatolimod]] in severe cases of chronic fatigue syndrome<ref name="Strayer, 2012" /> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031334 (Full Text)] *2014, No association found between the detection of either [[xenotropic murine leukemia virus-related virus]] or polytropic murine leukemia virus and [[chronic fatigue syndrome]] in a blinded, multi-site, prospective study by the establishment and use of the [[SolveCFS BioBank & Patient Registry|SolveCFS BioBank]]<ref>{{Cite journal | last = Irlbeck | first = David M. | last2 = Vernon | first2 = Suzanne D. | author-link2 = Suzanne Vernon | last3 = McCleary | first3 = K. Kimberly | author-link3 = Kim McCleary | last4 = Bateman | first4 = Lucinda | author-link4 = Lucinda Bateman | last5 = Klimas | first5 = Nancy G. | author-link5 = Nancy Klimas | last6 = Lapp | first6 = Charles W. | author-link6 = Charles Lapp | last7 = Peterson | first7 = Daniel L. | author-link7 = Daniel Peterson | last8 = Brown | first8 = James R. | last9 = Remlinger | first9 = Katja S.| date = 2014 | title = No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236736/ | journal = BMC Research Notes | volume = 7 | pages = 461|doi=10.1186/1756-0500-7-461|via= | last10 = Wilfret | last11 = Gerondelis | first11 = Peter | first10 = David A.}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236736/ (Full Text)] *2016, [[CDC]] Grand Rounds: [[Chronic Fatigue Syndrome]] β Advancing Research and Clinical Education. Morbidity and [[Mortality]] Weekly Report<ref>{{Cite journal | last1 = Unger | first1 = ER | authorlink = Elizabeth Unger | last2 = Lin | first2 = JS | author-link2 = Jin-Mann Sally Lin | last3 = Brimmer | first3 = DJ | author-link3 = | last4 = Lapp | first4 = CW | author-link4 = Charles Lapp | last5 = Komaroff | first5 = AL | author-link5 = Anthony Komaroff | last6 = Nath | first6 = A | author-link6 = Avindra Nath | last7 = Laird | first7 = S | author-link7 = | last8 = Iskander | first8 = J | author-link8 = John Iskander | title = CDC Grand Rounds: Chronic Fatigue Syndrome β Advancing Research and Clinical Education | journal = Morbidity and Mortality Weekly Report | volume = 65 | issue = 5051| page=1434β1438 | date = 2016 | doi=10.15585/mmwr.mm655051a4}} - </ref> - [https://www.cdc.gov/mmwr/volumes/65/wr/mm655051a4.htm (Full Text)] *2017, Multi-Site Clinical Assessment of [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study<ref name="Unger, 2017" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565838/ (Full Text)] *2019, Initiating care of a patient with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref>{{Cite journal | last = Lapp | first = Charles W. | authorlink = Charles Lapp | date = Jan 2019 | title = Initiating Care Of A Patient With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) | url = https://www.frontiersin.org/articles/10.3389/fped.2018.00415/abstract | journal = Frontiers in Pediatrics | volume = | issue = | pages = |doi=10.3389/fped.2018.00415|quote=|via=}}</ref> [https://www.frontiersin.org/articles/10.3389/fped.2018.00415/full (Full text)] *2019, Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning<ref>{{Cite journal | last = Proskauer | first = Charmian | authorlink = Charmian Proskauer | last2 = Rowe | first2 = Peter C. | author-link2 = Peter Rowe | last3 = Lapp | first3 = Charles W. | author-link3 = Charles Lapp | last4 = DeMaria | first4 = Alfred Jr | author-link4 = | last5 = Bateman | first5 = Lucinda | author-link5 = Lucinda Bateman | last6 = Attewell | first6 = John R. | last7 = Proskauer | first7 = Daniel | last8 = Kiernicki | first8 = David J. | last9 = Adebayo | first9 = Seyi | date = 2019 | title=Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning | url =https://www.frontiersin.org/articles/10.3389/fped.2018.00412/full | journal = Frontiers in Pediatrics|language=English | volume = 6 | issue = | pages = |doi=10.3389/fped.2018.00412|issn=2296-2360|pmc=|pmid=30671425|quote=|via=}}</ref> [https://www.frontiersin.org/articles/10.3389/fped.2018.00412/full (Full text)] ==Talks and interviews== *[http://www.cfidsselfhelp.org/library/dr-lapp's-recommedations-supplements Dr. Lappβs recommendations on supplements]<ref>{{Cite web | url = http://www.cfidsselfhelp.org/library/dr-lapp%27s-recommedations-supplements | title = Dr Lapp's Recommendations on Supplements {{!}} ME/CFS & Fibromyalgia Self-Help | last = Campbell | first = Bruce | authorlink = Bruce Campbell | date = | website = cfidsselfhelp.org| archive-url = | archive-date = |url-status = | access-date=2018-12-23}}</ref> *16 Feb 2016, CDC Grand Rounds - Chronic Fatigue Syndrome: Advancing Research and Clinical Education with Charles Lapp, MD, [[Elizabeth Unger]], PhD, MD, [[Anthony Komaroff]], MD and [[Avindra Nath]], MD ::[https://www.cdc.gov/grand-rounds/pp/2016/20160216-chronic-fatigue.html Grand Rounds Video] ::[https://www.cdc.gov/grand-rounds/pp/2016/20160216-presentation-chronic-fatigue-H.pdf Grand Rounds Presentation Slide Deck] *17 Apr 2017, [https://www.youtube.com/watch?v=RTzfWs6Fhl4 Dr Charles Lapp - An overview of ME/CFS Diagnosis and Management] ==HHS/CFSAC Testimony== *[http://www.hhs.gov/advcomcfs/meetings/presentations/cortjohnson.pdf Oct 29, 2009 Testimony (read by] [[Cort Johnson]]) ==Open Letter to ''The Lancet''== Three open letters to the editor of ''The Lancet'' urged the editor to commission a fully independent review of the [[PACE trial]], which the journal had published in 2011. In 2016, Dr. Lapp, along with 42 colleagues in the [[ME/CFS]] field, signed the second letter.<ref>{{Cite web | url = http://www.virology.ws/2016/02/10/open-letter-lancet-again/ | title = Open Letter Lancet Again | last = | first = | date = | website = | archive-url = | archive-date = |url-status = | access-date=}}</ref> In 2018, Dr. Lapp, with more than 100 colleagues in the [[ME/CFS]] field, signed the third letter.<ref>{{Cite web | url = http://www.virology.ws/2018/06/19/trial-by-error-an-open-letter-to-the-lancet-two-years-on/ | title = An Open Letter to The Lancet, Two Years On | last = | first = | date = | website = | archive-url = | archive-date = |url-status = | access-date=}}</ref> *10 February 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog] *18 June 2018, [http://www.virology.ws/2018/06/19/trial-by-error-an-open-letter-to-the-lancet-two-years-on/ Trial By Error: An Open Letter to The Lancet, Two Years On] ==Online presence== *[https://www.ncbi.nlm.nih.gov/pubmed/?term=Lapp%20CW%5BAuthor%5D&cauthor=true&cauthor_uid=25092471 PubMed - Charles Lapp] *[https://www.facebook.com/HunterHopkinsCenterFans/?filter=2 Hunter-Hopkins Center Facebook page] *[http://drlapp.com/ Hunter-Hopkins Center website] ==Learn more== *2012, [http://drlapp.com/ask-the-doctor/what-are-the-most-important-things-to-remember-about-cfs-fm/ What Are The Most Important Things To Remember About CFS/FM?] *[http://drlapp.com/staff/curriculum-vitae-charles-w-lapp-md/ Curriculum Vitae - Charles W. Lapp, MD] *2018, [https://www.healthrising.org/blog/2018/03/28/lapp-chronic-fatigue-syndrome-fibromyalgia-pioneer-retires/ An ME/CFS and FM Pioneer Says Good-bye: The Charles Lapp Interview]<ref>{{Cite web | url = https://www.healthrising.org/blog/2018/03/28/lapp-chronic-fatigue-syndrome-fibromyalgia-pioneer-retires/ | title = An ME/CFS and FM Pioneer Says Good-bye: The Charles Lapp Interview | last = Johnson | first = Cort | authorlink = Cort Johnson | date = 2018-03-28 | website = [[Health Rising]]|language=en-GB| archive-url = | archive-date = |url-status = | access-date=2018-12-23}}</ref> ==See also== *[[Hunter-Hopkins Center]] *[[NIH Post-Infectious ME/CFS Study]] *[[Ampligen]] *[[1984 Chapel Hill outbreak]] *Dr [[Vincent Hillman|Vincent F. Hillman]] *Dr [[Laura Black]] ==References== <references> <ref name="Jason, Dec2009">{{Citation | last = Jason | first1 = Leonard | author-link1 = Leonard Jason | last2 = Porter | first2 = Nicole | author-link2 = Nicole Porter | last3 = Shelleby | first3 = E | author-link3 = | last4 = Till | first4 = L | author-link4 = | last5 = Bell | first5 = David S | author-link5 = David Bell | last6 = Lapp | first6 = Charles W | author-link6 = Charles Lapp | last7 =Rowe | first7 = Kathy | author-link8 = Kathy Rowe | last8 = De Meirleir | first8 = Kenny | author-link8 = Kenny De Meirleir | title = Severe versus Moderate criteria for the new pediatric case definition for ME/CFS | journal = Child Psychiatry and Human Development | volume = 40 | issue = 4 | page = 609-20 | date = 2009 | pmid = | doi = 10.1007/s10578-009-0147-8 }}</ref> <ref name="JasonL2006paed">{{citation | last = Jason | first1 = Leonard A | author-link1 = Leonard Jason | last2 = Jordan | first2 = Karen | author-link2 = Karen Jordan | last3 = Miike | first3 = Teruhisa | author-link3 = Teruhisa Miike | last4 = Bell | first4 = David S | author-link4 = David Bell | last5 = Lapp | first5 = Charles| author-link5 = Charles Lapp | last6 = Torres-Harding | first6 = Susan | author-link6 = Susan Torres-Harding | last7 =Rowe | first7 = Kathy | author-link8 = Kathy Rowe | last8 = Gurwitt | first8 = Alan | author-link8 = Alan Gurwitt | last9 = De Meirleir | first9 = Kenny | author-link9 = Kenny de Meirleir | last10 = Van Hoof | first10 = Elke LS | author-link10 = Elke Van Hoof | title = A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome | journal = Journal of Chronic Fatigue Syndrome | volume = 13 | issue = 2-3 | pages = 1-44 | date = 2006 | doi = 10.1300/J092v13n02_01 | url = https://solvecfs.org/wp-content/uploads/2013/06/pediatriccasedefinitionshort.pdf }}</ref> <ref name="Strayer, 2012">{{Citation | last =Strayer | first1 = DR | author-link1 = David Strayer | last2 = Carter | first2 = WA | author-link2 = William Carter | last3 = Stouch | first3 = BC | author-link3 = | last4 = Stevens | first4 = SR | author-link4 = Staci Stevens | last5 = Bateman | first5 = L | author-link5 = Lucinda Bateman | last6 = Cimoch | first6 = PJ | author-link6 = | last7 =Lapp | first7 = CW | author-link8 = Charles Lapp | last8 = Peterson | first8 = DL | author-link8 = Daniel Peterson | last9 = Chronic Fatigue Syndrome AMP-516 Study Group | author-link9 = | last10 = Mitchell | first10 = WM | author-link10 = William Mitchell | title = A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. | journal = PLoS One | volume = 7 | issue = 3 | page = e31334 | date = 2012 | pmid = 22431963 | doi = 10.1371/journal.pone.0031334 }}</ref> <ref name="Unger, 2017">{{Citation | last =Unger | first1 = Elizabeth R. | author-link1 = Elizabeth Unger | last2 = Lin | first2 = Jin-Mann S. | author-link2 = Jin-Mann Sally Lin | last3 = Tian | first3 = Hao | author-link3 = | last4 = Natelson | first4 = Benjamin H. | author-link4 = Benjamin Natelson | last5 = Lange | first5 = Gudrun | author-link5 = Gudrun Lange | last6 = Vu | first6 = Diana | author-link6 = | last7 =Blate | first7 = Michelle | author-link7 = | last8 = Klimas | first8 = Nancy G. | author-link8 = Nancy Klimas | last9 = Balbin | first9 = Elizabeth G. | author-link9 = | last10 = Bateman | first10 = Lucinda | author-link10 = Lucinda Bateman | last11 = Allen | first11 = Ali | author-link11 = | last12 = Lapp | first12 = Charles W. | author-link12 = Charles Lapp | last13 = Springs | first13 = Wendy | author-link13 = | last14 = Kogelnik | first14 = Andreas M. | author-link14 = Andreas Kogelnik | last15 = Phan | first15 = Catrina C. | author-link15 = | last16 = Danver | first16 = Joan | author-link16 = | last17 = Podell | first17 = Richard N. | author-link17 = Richard Podell | last18 = Fitzpatrick | first18 = Trisha | author-link18 = | last19 = Peterson | first19 = Daniel L. | author-link19 = Daniel Peterson | last20 = Gottschalk | first20 = C. Gunnar| author-link20 = Gunnar Gottschalk | last21 = Rajeevan | first21 = Mangalathu S. | author-link21 = Mangalathu Rajeevan | last22 = MCAM Study Group | title = Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study. | journal = American Journal of Epidemiology | volume = 1-10 | issue = | page = | date = 2017 | pmid = | doi = 10.1093/aje/kwx029 }}</ref> <ref name="Van Hoof, 2007">{{Citation | last =Van Hoof | first1 = E | author-link1 = Elke Van Hoof | last2 = De Becker | first2 = P | author-link2 = Pascale De Becker | last3 = Lapp | first3 = C | author-link3 = Charles Lapp | last4 = Cluydts | first4 = R | author-link4 = | last5 = De Meirleir | first5 = K | author-link5 = Kenny de Meirleir | title = Defining the Occurrence and Influence of Alpha-Delta Sleep in Chronic Fatigue Syndrome | journal = The American Journal of the Medical Sciences | volume = 333 | issue = 2 | page = 78-84 | date = 2007 | pmid = 17301585 | doi = }}</ref> <ref name="Vojdani, 1998">{{Citation | last =Vojdani | first1 = A | author-link1 = | last2 = Choppa | first2 = PC | author-link2 = | last3 = Lapp | first3 = CW | author-link3 = Charles Lapp | title = Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome | journal = J Clin Lab Immunol | volume = 50 | issue = 1 | page = 1-16 | date = 1998 | pmid = 10189612 | doi = }}</ref> </references> [[Category:Researchers]] [[Category:US researchers]] [[Category:Clinicians]] [[Category:American clinicians]] [[Category:North Carolina clinicians]] [[Category:Psychological paradigm critics]] [[Category:PACE trial critics]] [[Category:CFSAC members]]
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