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Cellular respiration
(section)
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==Myalgic Encephalomyelitis and cellular respiration== Patients with myalgic encephalomyelitis (ME) have been observed to have an overall lower maximal cellular respiration capacity than control groups.<ref>{{Cite journal | last = Tomas | first = Cara | authorlink = Cara Tomas | last2 = Brown | first2 = Audrey | author-link2 = Audrey Brown | last3 = Strassheim | first3 = Victoria | author-link3 = Victoria Strassheim | last4 = Elson | first4 = Joanna | author-link4 = Joanna Elson | last5 = Newton | first5 = Julia | author-link5 = Julia Newton | last6 = Manning | first6 = Philip | date = Oct 24, 2017 | title = Cellular bioenergetics is impaired in patients with chronic fatigue syndrome | url =http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186802 | journal = PLOS ONE|language=en | volume = 12 | issue = 10| pages = e0186802|doi=10.1371/journal.pone.0186802|issn=1932-6203|pmc=|pmid=29065167|via=}}</ref> This would mean that a cell would be unable to keep up with its energy needs. Some studies have observed decreased production of ATP and other metabolic intermediates in patients with ME.<ref>{{Cite journal | last = Nguyen | first = Thao | authorlink = Thao Nguyen | date = 2017 | title=Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation | url =http://apjai-journal.org/wp-content/uploads/2018/07/AP-011117-0188.pdf | journal=APJAI | volume = | pages = |via=}}</ref><ref>{{Cite journal | last = Naviaux | first = Robert K. | last2 = Naviaux | authorlink = Robert Naviaux | first2 = Jane C. | last3 = Li | author-link2 = Jane Li | first3 = Kefeng | last4 = Bright | first4 = A. Taylor | last5 = Alaynick | first5 = William A. | last6 = Wang | first6 = Lin | last7 = Baxter | first7 = Asha | last8 = Nathan | first8 = Neil | last9 = Anderson | first9 = Wayne | date = Sep 13, 2016 | title = Metabolic features of chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/27573827 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 113 | issue = 37| pages = E5472β5480|doi=10.1073/pnas.1607571113|issn=1091-6490|pmc=5027464|pmid=27573827}}</ref>
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