Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Carnitine
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== ME/CFS == [[Chronic fatigue syndrome]] (CFS) patients have been found to have statistically significantly lower serum total carnitine, free carnitine, and acylcarnitine levels.<ref name=":0">{{Citation| issn = 1058-4838| volume = 18| pages = 62-67| last1 = Kuratsune | first1 = H. | last2 = Yamaguti | first2 = K. | last3 = Takahashi | first3 = M. | last4 = Misaki | first4 = H. | last5 = Tagawa | first5 = S. | last6 = Kitani | first6 = T.| title = Acylcarnitine deficiency in chronic fatigue syndrome| journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America | date = January 1994 | pmid = 8148455|url= | author-link = | issue = Supp 1|chapter=|edition=|isbn=}}</ref><ref name=":1">{{Citation| doi = 10.1111/j.1468-1331.1995.tb00151.x| issn = 1351-5101| volume = 2 | issue = 5| pages = 425β428| last1 = Majeed | first1 = T. | last2 = de Simone | first2 = C. | last3 = Famularo | first3 = G. | last4 = Marcellini | first4 = S. | last5 = Behan | first5 = P.O. | title = Abnormalities of carnitine metabolism in chronic fatigue syndrome| journal = European Journal of Neurology | date = November 1995 | pmid = 24283722}}</ref><ref name="plioplys1995">{{Citation| issn = 0302-282X| volume = 32 | issue = 3| pages = 132β138| last1 = Plioplys | first1 = A.V. | last2 = Plioplys | first2 = S.| title = Serum levels of carnitine in chronic fatigue syndrome: clinical correlates| journal = Neuropsychobiology | date = 1995 | pmid = 8544970}}</ref> These serum levels were also found to correlate with clinical symptoms, where higher serum carnitine levels correlated with better functional capacity. Serum carnitine levels appeared to return to normal during remission. As carnitine is needed by the mitochondria, these findings may imply mitochondrial dysfunction. In a study in 1997, both L-carnitine and Amantadine were tested on 30 [[chronic fatigue syndrome|CFS]] patients. Amantadine was not well tolerated, but the L-carnitine was found to be very safe and to improve the clinical status of CFS patients.<ref name="plioplys1997">{{Citation| issn = 0302-282X| volume = 35 | issue = 1| pages = 16β23| last1 = Plioplys | first1 = A.V. | last2 = Plioplys | first2 = S.| title = Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome| journal = Neuropsychobiology | date = 1997 | pmid = 9018019}}</ref> [[Sarah Myhill]] checks acetyl-L-carnitine levels as part of her Mitochondrial Function tests.<ref>{{Cite web | url = https://drmyhill.co.uk/wiki/L_-_Carnitine | title = L - Carnitine | last = Myhill | first = Sarah | author-link = Sarah Myhill | date = | website = DoctorMyhill| archive-url = | archive-date = |url-status = | access-date=2021-03-21}}</ref> In a study of the levels of serum acylcarnitine in Japanese patients with various kinds of diseases, a significant decrease was only found in patients with CFS and chronic hepatitis type C, indicating that this might be a characteristic abnormality in only certain types of diseases.<ref name="kuratsune1998">{{Citation| issn = 1107-3756| volume = 2 | issue = 1| pages = 51β56| last1 = Kuratsune | first1 = H. | last2 = Yamaguti | first2 = K. | last3 = Lindh | first3 = G. | last4 = Evengard | first4 = B. | last5 = Takahashi | first5 = M. | last6 = Machii | first6 = T. | last7 = Matsumura | first7 = K. | last8 = Takaishi | first8 = J. | last9 = Kawata | first9 = S. | last10 = LΓ₯ngstrΓΆm | first10 = B. | last11 = Kanakura | first11 = Y. | last12 = Kitani | first12 = T. | last13 = Watanabe | first13 = Y.| title = Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases| journal = International Journal of Molecular Medicine | date = July 1998 | pmid = 9854142 | url = https://pubmed.ncbi.nlm.nih.gov/9854142 | author-link = |chapter=|edition=|isbn=}}</ref> A study of 25 patients and 25 controls in 2000 could not reproduce the finding of CFS patients having lower carnitine levels than control subjects. The authors concluded that "the present study demonstrates that serum carnitine deficiency does not contribute to or cause the symptoms in many CFS patients".<ref name="patricia2000">{{Citation| doi = 10.1016/S0300-2977(00)00030-9| issn = 0300-2977| volume = 57 | issue = 1| pages = 20β24| last1 = Soetekouw | first1 = Patricia M.M. B| last2 = Wevers | first2 = Ron A| last3 = Vreken | first3 = Peter | last4 = Elving | first4 = Lammy D| last5 = Janssen | first5 = Antoon J. M| last6 = van der Veen | first6 = Yvette | last7 = Bleijenberg | first7 = Gijs | last8 = van der Meer | first8 = Jos W. M| title = Normal carnitine levels in patients with chronic fatigue syndrome| journal = The Netherlands Journal of Medicine| access-date = 2016-11-09| date = July 2000| url = http://www.sciencedirect.com/science/article/pii/S0300297700000309}}</ref> While this conclusion refers to 'many' patients, the small study size may temper this conclusion. In 2004 acetyl-L-carnitine, propionyl-L-carnitine, and their combination were compared in 3 groups of 30 CFS patients during 24 weeks. Acetyl-L-carnitine significantly improved mental fatigue and propionyl-L-carnitine improved general fatigue.<ref name="vermeulen2004">{{Citation| issn = 1534-7796| volume = 66 | issue = 2| pages = 276β282| last1 = Vermeulen | first1 = Ruud C.W. | last2 = Scholte | first2 = Hans R.| title = Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome| journal = Psychosomatic Medicine | date = April 2004 | pmid = 15039515 | url = https://pubmed.ncbi.nlm.nih.gov/15039515 | author-link = |chapter=|edition=|isbn=}}</ref> In 2011 another study on 44 CFS patients and 49 healthy controls found that patients with chronic fatigue syndrome exhibited significantly altered concentrations of acylcarnitines. Significant correlations between acylcarnitine concentrations and clinical symptomatology were also demonstrated. The authors proposed that this disturbance in carnitine homeostasis could possibly be a result of the accumulation of [[omega 6 fatty acid]]s previously observed in this patient population. They hypothesized that the administration of [[omega 3 fatty acid]]s, in combination with carnitine, would increase CPT-1 activity and improve [[chronic fatigue syndrome]] symptoms.<ref name="reuter2011">{{Citation| doi = 10.1111/j.1365-2796.2010.02341.x| issn = 1365-2796| volume = 270 | issue = 1| pages = 76β84| last1 = Reuter | first1 = S.E. | last2 = Evans | first2 = A.M.| title = Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity| journal = Journal of Internal Medicine| access-date = 2016-11-09| date = 2011-07-01| url = http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2010.02341.x/abstract}}</ref>
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
This page is a member of 2 hidden categories:
Category:All articles with unsourced statements
Category:Articles with unsourced statements from unknown year
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs