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Carl-Gerhard Gottfries
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[[File:Carl-Gerhard Gottfries.png|200px|thumb|right|Source:Erik Nilsson]] '''Carl-Gerhard Gottfries''', MD, PhD, is a Swedish professor, [[ME/CFS]] doctor, and founder of the [[Gottfries Clinic]], Mölndal, [[Sweden]]. After developing [[chronic fatigue syndrome]] following a case of the flu, he discovered that monthly injections of a staphylococcus aureus vaccine boosted his immune system, successfully allowing him to return to work. He has continued using a staphylococcus vaccine injection every month for over fifty years.<ref>{{Cite web | url = https://www.healthrising.org/blog/2015/11/21/gottfries-chronic-fatigue-syndrome-story/ | title = Carl-Gerhard Gottfries: A Swedish Chronic Fatigue Syndrome Story | last = | first = | date = | website = | archive-url = | archive-date = |url-status = | access-date=}}</ref> ==Clinic== [[Gottfries Clinic]] AB (Gottfriesmottagningen), was previously financed through the health-care system, but now is privately operated. It is a specialty clinic for the 1) evaluation, diagnosis and treatment of patients with [[fibromyalgia]] and [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] (ME/CFS), chronic fatigue and widespread muscular pain, and 2) research for developing and treatment for such patients. Located at Krokslätts Torg 5, Mölndal, Sweden.<ref>http://www.gottfriesclinic.se/in-english/gottfries-clinic/</ref> ==2017 Ramsay Award== A team comprised of Dr. [[Jonas Bergquist]] and Dr. [[Jonas Blomberg]] of Uppsala University and Dr. Carl-Gerhard Gottfries and Dr. [[Olof Zachrisson]] of the [[Gottfries Clinic]] were awarded a 2017 [[Ramsay Award]] grant from the [[Solve ME/CFS Initiative]] for research into [[biomarker]]s for initiation (infection) and metabolic derangement in [[ME/CFS]].<ref>http://solvecfs.org/2017-ramsay-award-program-results/</ref> ==Talks and interviews== *Sept 2014, [https://www.youtube.com/watch?v=TCF_RYCnHW4 Interview with Professor Carl-Gerhard Gottfries, Part 1: Background and Vaccine] *Sept 2014, [https://www.youtube.com/watch?v=cUlXZ8qmNrI Interview with Professor Carl-Gerhard Gottfries, Part 2: Experience and The Clinic] *Sept 2014, [https://www.youtube.com/watch?v=q0wUSkK4Z20 Interview with Professor Carl-Gerhard Gottfries, Part 3: The Clinic and Urgent Needs] *Sept 2014, [https://www.youtube.com/watch?v=Kyyc6U1M7pY Interview with Professor Carl-Gerhard Gottfries, Part 4: Continued Research] ==Notable studies== *1997, Increased concentrations of homocysteine in the cerebrospinal fluid in patients with [[fibromyalgia]] and [[chronic fatigue syndrome]]<ref>{{Cite journal | last = Regland | first = B | last2 = Andersson | first2 = M | last3 = Abrahamsson | first3 = L | last4 = Bagby | first4 = J | last5 = Dyrehag | first5 = LE | last6 = Gottfries | first6 = CG | author-link6 = Carl-Gerhard Gottfries | date = 1997 | title = Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/9310111 | journal = Scandinavian Journal of Rheumatology | volume = 26 | issue = 4 | pages = 301-7|pmid=9310111|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/9310111 (Abstract)] *1998, Effects of [[Staphylococcus vaccine|staphylococcus toxoid vaccine]] on pain and fatigue in patients with [[fibromyalgia]]/[[chronic fatigue syndrome]]<ref>{{Cite journal | last = Andersson | first = M | last2 = Bagby | first2 = JR | last3 = Dyrehag | first3 = L | last4 = Gottfries | first4 = C | author-link4 = Carl-Gerhard Gottfries | date = 1998 | title = Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/10700309 | journal = European Journal of Pain | volume = 2 | issue = 2 | pages = 133-142|pmid=10700309|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/10700309 (Abstract)] *2000, Nickel [[Allergy]] is Found in a Majority of Women with [[Chronic Fatigue Syndrome]] and Muscle Pain - and may be Triggered by Cigarette Smoke and Dietary Nickel Intake <ref>{{Cite journal | last = Regland | first = Bjorn | last2 = Zachrisson | first2 = Olof | author-link2 = Olof Zachrisson | last3 = Stejskal | first3 = Vera | last4 = Gottfries | first4 = Carl Gerhard | author-link4 = Carl-Gerhard Gottfries | date = 2000 | title = Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance | url =https://www.tandfonline.com/doi/abs/10.1300/J092v08n01_04 | journal = Journal of Chronic Fatigue Syndrome | volume = 8 | issue = 1 | pages = 57-65|doi=10.1300/J092v08n01_04|via=}}</ref>[https://www.tandfonline.com/doi/abs/10.1300/J092v08n01_04 (Abstract)] *2002, A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale)<ref>{{Cite journal | last = Zachrisson | first = O | author-link = Olof Zachrisson | last2 = Regland | first2 = B | last3 = Jahreskog | first3 = M | last4 = Kron | first4 = M | last5 = Gottfries | first5 = CG | author-link5 = Carl-Gerhard Gottfries | date = Jun 2002 | title = A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale) | url = https://www.ncbi.nlm.nih.gov/pubmed/12069875 | journal = J Psychosomatic Research | volume = 52 | issue = 6 | pages = 501-9|pmid=12069875|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/12069875 (Abstract)] *2004, Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement<ref>{{Cite journal | last = Zachrisson | first = O | author-link = Olof Zachrisson | last2 = Colque-Navarro | first2 = P | last3 = Gottfries | first3 = CG | author-link3 = Carl-Gerhard Gottfries | last4 = Regland | first4 = B | last5 = Möllby | first5 = R | date = Feb 2004 | title = Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement | url = https://www.ncbi.nlm.nih.gov/pubmed/14735403 | journal = European Journal of Clinical Microbiology & Infectious Disease | volume = 23 | issue = 2 | pages = 98-105|doi=10.1007/s10096-003-1062-8|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/14735403 (Abstract)] *2006, Long-Term Treatment with a [[Staphylococcal vaccine|''Staphylococcus'' Toxoid Vaccine]] in Patients with [[Fibromyalgia]] and [[Chronic Fatigue Syndrome]]<ref>Carl-Gerhard Gottfries, Ove Häger, Björn Regland & [[Olof Zachrisson]]. (2006). Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome. ''Journal of Chronic Fatigue Syndrome'', Vol. 13, Iss. 4, pp. 29-40. DOI:10.1300/J092v13n04_04</ref> [https://www.tandfonline.com/doi/abs/10.1300/J092v13n04_04 (Abstract)] *2011, Murine gammaretrovirus group G3 was not found in Swedish patients with [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] and [[fibromyalgia]]<ref name="Elfaitouri, 2011" /> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024602 (Full Text)] *2012, No evidence for [[Xenotropic murine leukemia virus-related virus|xenotropic murine leukemia-related virus]] infection in [[Sweden]] using internally controlled multiepitope suspension array serology<ref name="Blomberg, 2012" /> [http://cvi.asm.org/content/19/9/1399.long (Full Text)] *2013, Epitopes of Microbial and Human [[Heat shock protein|Heat Shock Protein]] 60 and Their Recognition in [[Myalgic Encephalomyelitis]]<ref name="Elfaitouri, 2013" /> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081155 (Full Text)] *2015, Response to [[Vitamin B12]] and [[Folic acid|Folic Acid]] in [[Myalgic Encephalomyelitis]] and [[Fibromyalgia]]<ref name="Regland, 2015" />[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406448/ (Full Text)] *2018, Infection Elicited [[Autoimmune disease|Autoimmunity]] and [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]]: An Explanatory Model<ref name="Blomberg, 2018" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818468/ (Full Text)] *2018, A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal | last = Nilsson | first = MKL | last2 = Zachrisson | first2 = O | author-link2 = Olof Zachrisson | last3 = Gottfries | first3 = C | author-link3 = Carl-Gerhard Gottfries | last4 = Matousek | first4 = M | last5 = Peilot | first5 = B | last6 = Forsmark | first6 = S | last7 = Schuit | first7 = RC | last8 = Carlsson | first8 = ML | last9 = Kloberg | first9 = A | last10 = Carlsson | first10 = A | date = Jun 2018 | title = A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/29212562 | journal = Acta Neuropsychiatrica | volume = 30 | issue = 3 | pages = 148-157|doi=10.1017/neu.2017.35|pmid=29212562}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/29212562 (Abstract)] *2019, Antibodies to Human [[Herpesviruses]] in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients<ref>{{Cite journal | last = Blomberg | first = Jonas | author-link = Jonas Blomberg | last2 = Rizwan | first2 = Muhammad | author-link2 = | last3 = Böhlin-Wiener | first3 = Agnes | author-link3 = | last4 = Elfaitouri | first4 = Amal | author-link4 = | last5 = Julin | first5 = Per | author-link5 = | last6 = Zachrisson | first6 = Olof | author-link6 = Olof Zachrisson | last7 = Rosén | first7 = Anders | last8 = Gottfries | first8 = Carl-Gerhard | author-link8 = Carl-Gerhard Gottfries | date = | title = Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients |url =https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/abstract | journal = Frontiers in Immunology | volume = | issue = | pages=|doi=10.3389/fimmu.2019.01946|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/full (Abstract)] *2020, Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts<ref name="Bynke2020">{{Cite journal | last = Bynke | first = Annie | author-link = | last2 = Julin | first2 = Per | author-link2 = | last3 = Gottfries | first3 = Carl-Gerhard | author-link3 = Carl-Gerhard Gottfries | last4 = Heidecke | first4 = Harald | author-link4 = | last5 = Scheibenbogen | first5 = Carmen | author-link5 = Carmen Scheibenbogen | last6 = Bergquist | first6 = Jonas | author-link6 = Jonas Bergquist | date = 2020-08-01 | title = Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts |url =http://www.sciencedirect.com/science/article/pii/S2666354620300727 | journal = Brain, Behavior, & Immunity - Health|language=en | volume = 7 | issue = | pages = 100107|doi=10.1016/j.bbih.2020.100107|issn=2666-3546|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://www.sciencedirect.com/science/article/pii/S2666354620300727 (Full text)] ==See also== *[[Staphylococcus aureus]] *[[Staphylococcus vaccine]] *[[Sweden]] *[[Dr Markov's chronic bacterial intoxication syndrome (CBIS) theory of ME/CFS]] (Dr Markov has evidence that ME/CFS is caused by a dysbiosis in the kidneys) ==Learn more== *[https://www.healthrising.org/blog/2015/11/21/gottfries-chronic-fatigue-syndrome-story/ 2015 - Carl-Gerhard Gottfries: A Swedish Chronic Fatigue Syndrome Story] by [[Cort Johnson]] ==References== <references> <ref name="Blomberg, 2012">{{Citation | last1 = Blomberg | first1 = Jonas | author-link1 = Jonas Blomberg | last2 =Blomberg | first2 = Fredrik | author-link2 = | last3 = Sjösten | first3 = Anna | author-link3 = | last4 = Sheikholvaezin | first4 = Ali | author-link4 = | last5 =Bölin-Wiener | first5 = Agnes | author-link5 = | last6 =Elfaitouri | first6 = Amal | author-link6 = | last7 = Hessel | first7 = Sanna | author-link7 = | last8 = Gottfries | first8 = Carl-Gerhard | author-link8 = Carl-Gerhard Gottfries | last9 =Zachrisson | first9 = Olof | author-link9 = Olof Zachrisson | last10 = Öhrmalma | first10 = Christina | author-link10 = | last11 = Jobs | first11 = Magnus | author-link11 = | last12 = Pipkorn | first12 = Rüdiger | author-link12 = | title = No Evidence for Xenotropic Murine Leukemia-Related Virus Infection in Sweden Using Internally Controlled Multiepitope Suspension Array Serology | journal = Clinical and Vaccine Immunology | volume = 19 | issue = 9 | page = 1399-1410 | date = 2012 | pmid = | doi = 10.1128/CVI.00391-12 }}</ref> <ref name="Blomberg, 2018">{{Citation | last1 = Blomberg | first1 = Jonas | author-link1 = Jonas Blomberg | last2 = Gottfries | first2 = Carl-Gerhard | author-link2 = Carl-Gerhard Gottfries | last3 = Elfaitouri | first3 = Amal | author-link3 = | last4 = Rizwan | first4 = Muhammad | author-link4 = | last5 =Rosén | first5 = Anders| author-link5 = | title = Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model | journal = Frontiers in Immunology | volume = 2018 | issue = 9 | page = 229 | date = 2018 | pmid = | doi = 10.3389/fimmu.2018.00229 }}</ref> <ref name="Elfaitouri, 2011">{{Citation | last1 = Elfaitouri | first1 = A | author-link1 = | last2 =Shao | first2 = X | author-link2 = | last3 = Mattsson Ulfstedt | first3 = J | author-link3 = | last4 = Muradrasoli | first4 = S | author-link4 = | last5 =Bölin Wiener | first5 = A | author-link5 = | last6 = Golbob | first6 = S | author-link6 = | last7 = Ohrmalm | first7 = C | author-link7 = | last8 = Matousek | first8 = M | author-link8 = | last9 =Zachrisson | first9 = O | author-link9 = Olof Zachrisson | last10 = Gottfries | first10 = C-G | author-link10 = Carl-Gerhard Gottfries | last11 = Blomberg | first11 = J | author-link11 = Jonas Blomberg | title = Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. | journal = PLoS One | volume =6 | issue = 10 | page = | date = 2011 | pmid = | doi = 10.1371/journal.pone.0024602 }}</ref> <ref name="Elfaitouri, 2013">{{Citation | last1 = Elfaitouri | first1 = A | author-link1 = | last2 =Herrmann | first2 = B | author-link2 = | last3 = Bölin-Wiener | first3 = A | author-link3 = | last4 = Wang | first4 = Y | author-link4 = | last5 = Gottfries | first5 = C-G | author-link5 = Carl-Gerhard Gottfries | last6 =Zachrisson | first6 = O | author-link6 = Olof Zachrisson | last7 = Pipkorn | first7 = R | author-link7 = | last8 = Rönnblom | first8 = L | author-link8 = | last9 =Blomberg | first9 = J | author-link9 = Jonas Blomberg | title = Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis | journal = PLoS One | volume = 8 | issue = 11 | page = | date = 2013 | pmid = | doi = 10.1371/journal.pone.0081155 }}</ref> <ref name="Regland, 2015">{{Citation | last1 = Regland | first1 = Björn | author-link1 = | last2 =Forsmark | first2 = Sara | author-link2 = | last3 = Halaouate | first3 = Lena | author-link3 = | last4 = Matousek | first4 = Michael | author-link4 = | last5 = Peilot | first5 = Birgitta | author-link5 = | last6 =Zachrisson | first6 = Olof | author-link6 = Olof Zachrisson | last7 = Gottfries | first7 = Carl-Gerhard | author-link8 = Carl-Gerhard Gottfries | title = Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia. | journal = PLoS ONE | volume = 10 | issue = 4 | page = | date = 2015 | pmid = | doi = 10.1371/journal.pone.0124648 }}</ref> </references> [[Category:Clinicians]] [[Category:Swedish clinicians]] [[Category:Researchers]] [[Category:Sweden researchers]]
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