Calcitonin gene-related peptide monoclonal antibody: Difference between revisions
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'''Calcitonin gene-related peptide monoclonal antibodies''' (mAbs) or '''CGRP mAbs''' are a new type of preventative [[migraine]] treatment.<ref name="migrainetrust">{{Cite web|url=https://migrainetrust.org/live-with-migraine/healthcare/treatments/calcitonin-gene-related-peptide-monoclonal-antibodies/|title=Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies|website=The Migraine Trust|language=en-US|access-date=2021-10-12}}</ref><ref name="drugscom" /> CGRP mAbs block the release of calcitonin gene-related peptide, a neurotransmitter known to cause migraines. | '''Calcitonin gene-related peptide monoclonal antibodies''' (mAbs) or '''CGRP mAbs''' are a new type of preventative [[migraine]] treatment.<ref name="migrainetrust">{{Cite web | url = https://migrainetrust.org/live-with-migraine/healthcare/treatments/calcitonin-gene-related-peptide-monoclonal-antibodies/ | title = Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies | website = The Migraine Trust|language=en-US | access-date = 2021-10-12}}</ref><ref name="drugscom" /> CGRP mAbs block the release of calcitonin gene-related peptide, a neurotransmitter known to cause migraines. | ||
Unlike known the small molecule CGRP antagonists known as [[:Category:Gepants|gepants]], CGRP mAbs are used for preventation rather than treatment of an existing migraine.<ref name="drugscom">{{Cite web|url=https://www.drugs.com/medical-answers/new-drugs-treatment-prevention-migraine-3515053/|title=What are the new drugs for the treatment of migraines?|website=Drugs.com|language=en|access-date=2021-10-12}}</ref><ref name="gepants">{{Cite journal|last=Negro|first=Andrea|author-link=|last2=Martelletti|first2=Paolo|author-link2 | Unlike known the small molecule CGRP antagonists known as [[:Category:Gepants|gepants]], CGRP mAbs are used for preventation rather than treatment of an existing migraine.<ref name="drugscom">{{Cite web | url = https://www.drugs.com/medical-answers/new-drugs-treatment-prevention-migraine-3515053/ | title = What are the new drugs for the treatment of migraines? | website = Drugs.com|language=en | access-date = 2021-10-12}}</ref><ref name="gepants">{{Cite journal | last = Negro | first = Andrea | author-link = | last2 = Martelletti | first2 = Paolo | author-link2 = | date = Jun 2019 | title = Gepants for the treatment of migraine | url =https://pubmed.ncbi.nlm.nih.gov/31081399/ | journal = Expert Opinion on Investigational Drugs | volume = 28 | issue = 6 | pages = 555–567|doi=10.1080/13543784.2019.1618830|issn=1744-7658|pmc=|pmid=31081399|access-date=|quote=|via=}}</ref> | ||
==Drugs== | ==Drugs== | ||
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== Uses == | == Uses == | ||
A small retrospective chart review by Kang and Govindarajan (2020) found that CGRP mAbs also significantly decreased peripheral nerve [[pain]] in patients who also had migraines.<ref>{{Cite journal|last=Kang|first=Seung Ah|last2=Govindarajan|first2=Raghav|date=2021|title=Anti-calcitonin gene–related peptide monoclonal antibodies for neuropathic pain in patients with migraine headache|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/mus.27153|journal=Muscle & Nerve|language=en|volume=63|issue=4|pages=563–567|doi=10.1002/mus.27153|issn=1097-4598}}</ref> | A small retrospective chart review by Kang and Govindarajan (2020) found that CGRP mAbs also significantly decreased peripheral nerve [[pain]] in patients who also had migraines.<ref>{{Cite journal | last = Kang | first = Seung Ah | last2 = Govindarajan | first2 = Raghav | date = 2021 | title=Anti-calcitonin gene–related peptide monoclonal antibodies for neuropathic pain in patients with migraine headache | url =https://onlinelibrary.wiley.com/doi/abs/10.1002/mus.27153 | journal = Muscle & Nerve|language=en | volume = 63 | issue = 4 | pages = 563–567|doi=10.1002/mus.27153|issn=1097-4598}}</ref> | ||
==News and articles == | ==News and articles == | ||
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[[Category:Antibodies]] | [[Category:Antibodies]] | ||
[[Category:Potential treatments]] | [[Category:Potential treatments]] | ||
[[Category:Antimigraine agents]] |
Latest revision as of 16:57, April 3, 2023
This article is a stub. |
Calcitonin gene-related peptide monoclonal antibodies (mAbs) or CGRP mAbs are a new type of preventative migraine treatment.[1][2] CGRP mAbs block the release of calcitonin gene-related peptide, a neurotransmitter known to cause migraines.
Unlike known the small molecule CGRP antagonists known as gepants, CGRP mAbs are used for preventation rather than treatment of an existing migraine.[2][3]
Drugs[edit | edit source]
Currently FDA-licensed CGRP mAbs are:
- Eptinezumab (Vyepti), approved in 2020
- Erenumab (Aimovig), approved in 2018
- Fremanezumab (Ajovy), approved in 2018
- Galcanezumab (Emgality), approved in 2018[2]
Uses[edit | edit source]
A small retrospective chart review by Kang and Govindarajan (2020) found that CGRP mAbs also significantly decreased peripheral nerve pain in patients who also had migraines.[4]
News and articles[edit | edit source]
- 2020, Can migraines be untangled by new medical thinking? - The Observer
Learn more[edit | edit source]
- Calcitonin gene-related peptide monoclonal antibodies - The Migraine Trust
- CGRP Medications - Migraine Australia
See also[edit | edit source]
References[edit | edit source]
- ↑ "Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies". The Migraine Trust. Retrieved October 12, 2021.
- ↑ 2.0 2.1 2.2 "What are the new drugs for the treatment of migraines?". Drugs.com. Retrieved October 12, 2021.
- ↑ Negro, Andrea; Martelletti, Paolo (June 2019). "Gepants for the treatment of migraine". Expert Opinion on Investigational Drugs. 28 (6): 555–567. doi:10.1080/13543784.2019.1618830. ISSN 1744-7658. PMID 31081399.
- ↑ Kang, Seung Ah; Govindarajan, Raghav (2021). "Anti-calcitonin gene–related peptide monoclonal antibodies for neuropathic pain in patients with migraine headache". Muscle & Nerve. 63 (4): 563–567. doi:10.1002/mus.27153. ISSN 1097-4598.