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Calcitonin gene-related peptide
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'''Calcitonin gene-related peptide''' or '''CGRP''' is a neurosensory peptide that has a key role in [[pain]] and is a key sensory [[neurotransmitter]] involved in immune function, and is mainly expressed in the central and peripheral sensory nerves.<ref name="Assas2014">https://www.frontiersin.org/articles/10.3389/fnins.2014.00023/full</ref><ref name="Abudool2017">{{Cite book | date = 2017 | last = Abudool | first = A.A. | last2 = Kodji | first2 = X. | last3 = Brain | first3 = S.D. | title = Encyclopedia of Endocrine Diseases |url =https://www.researchgate.net/publication/315915334_Calcitonin_Gene-Related_Peptide_CGRP|chapter=Calcitonin Gene-Related Peptide (CGRP)|language=en|location=New York| publisher = Elsevier | volume = 4 | pages = 425-435|doi=10.1016/b978-0-12-801238-3.95757-x|isbn=978-0-12-812200-6|pmc=|pmid=|access-date=|quote=|via=}}</ref> CGRP is part of the [[calcitonin]] gene family.<ref name="PMC4308419">{{Cite journal | last = Granstein | first = Richard D. | author-link = | last2 = Wagner | first2 = John A. | author-link2 = | last3 = Stohl | first3 = Lori L. | author-link3 = | last4 = Ding | first4 = Wanhong | author-link4 = | date = Mar 2015 | title = Calcitonin Gene-Related Peptide: Key Regulator of Cutaneous Immunity | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308419/ | journal = Acta physiologica (Oxford, England) | volume = 213 | issue = 3 | pages = 586–594|doi=10.1111/apha.12442|issn=1748-1708|pmc=4308419|pmid=25534428|access-date=|quote=|via=}}</ref><ref name="PMC4187032">{{Cite journal | last = Russell | first = F.A. | author-link = | last2 = King | first2 = R. | author-link2 = | last3 = Smillie | first3 = S.-J. | author-link3 = | last4 = Kodji | first4 = X. | author-link4 = | last5 = Brain | first5 = S.D. | author-link5 = | date = Oct 2014 | title = Calcitonin Gene-Related Peptide: Physiology and Pathophysiology | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187032/ | journal = Physiological Reviews | volume = 94 | issue = 4 | pages = 1099–1142|doi=10.1152/physrev.00034.2013|issn=0031-9333|pmc=4187032|pmid=25287861|access-date=|quote=|via=}}</ref> CGRP triggers [[migraine]]s in people who experience migraines but not in others.<ref name="Goadsby2010">https://europepmc.org/article/MED/20820195</ref> Known isoforms of CGRP are '''αCGRP''' (alpha CGRP) and '''βCGRP''' (beta CGRP).<ref name="Assas2014" /> ==Purpose == The [[nervous system]] and [[immune system]] release CGRP when [[transient receptor potential vanilloid receptor 1]] (TRPV1) is activated.<ref name="Assas2014" /> CGRP regulates inflammation in the skin, has a key role in neurogenic inflammation and has protective effects on the heart.<ref name="Kim2021" /> ===αCGRP=== αCGRP or CGRP-I is a vasodilator, appears to act as an immunomodulator, and may affect the inflammatory cascade to a pathological threat .<ref name="Assas2014" /><ref name="Kim2021">https://www.sciencedirect.com/science/article/pii/S2666354621001642</ref> ===βCGRP=== βCGRP or CGRP-II.<ref name="Assas2014" /><ref name="Kim2021" /> ==ME/CFS == αCGRP is the main isotype in sensory neurons in the [[dorsal root ganglion]].<ref name="Assas2014" /> ==Evidence == CGRP antagonists have been found to be effective in the treatment and prevention of [[migraine]]s. ==News and interviews == *[https://migraine.com/clinical/interview-dr-goadsby-expect-cgrp Interview with Dr. Goadsby, what to expect of CGRP] - Migraine.com ==Learn more == ==See also == *[[Calcitonin gene-related peptide monoclonal antibody]] *[[Migraine]] *[[:Category:Gepants|Gepants]] (category) ==References == {{Reflist}} [[Category:Biochemistry and cell biology]] [[Category:Peptides]] [[Category:Vasodilators]] [[Category:Neurotransmitters]] [[Category:Neurotransmitters and hormones]]
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