Caffeine: Difference between revisions

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===ME/CFS ===
===ME/CFS ===
Many people with ME/CFS use caffeine to improve mental alertness or [[concentration]] or to reduce [[fatigue]] in the short term, but the 2014 [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]] primer cautions against excessive usage due to the risk of [[tachycardia]] and [[agitation]].<ref name="Primer2014">{{Citation|date=2014|url=https://www.massmecfs.org/images/pdf/Primer_2014.pdf|title=Chronic Fatigue Syndrome Myalgic Encephalomyelitis Primer for Clinical Practitioners| last1  = ((International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis))|author-link=International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis| last2  = Friedberg       | first2 = Fred  | authorlink2 = Fred Friedberg | last3  = Bateman          | first3 = Lucinda| authorlink3 = Lucinda Bateman | last4  = Bested          | first4 = Alison C          | authorlink4 = Alison Bested | last5 =Davenport        | first5 = Todd  | authorlink5 = Todd Davenport | last6  = Friedman        | first6 = Kenneth J          | authorlink6 = Kenneth Friedman | last7  = Gurwitt          | first7 = Alan R | authorlink7 = Alan Gurwitt | last8  = Jason | first8 = Leonard A          | authorlink8 = Leonard Jason | last9  = Lapp  | first9 = Charles W          | authorlink9 = Charles Lapp | last10  = Stevens  | first10= Staci R| authorlink10= Staci Stevens | last11  = Underhill | first11= Rosemary A        | authorlink11= Rosemary Underhill | last12  = Vallings  | first12= Rosamund          | authorlink12= Rosamund Vallings|location=Chicago, USA|publisher= International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis}}
Many people with ME/CFS use caffeine to improve mental alertness or [[concentration]] or to reduce [[fatigue]] in the short term, but the 2014 [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]] primer cautions against excessive usage due to the risk of [[tachycardia]] and [[agitation]].<ref name="Primer2014">{{Citation|date=2014|url=https://www.massmecfs.org/images/pdf/Primer_2014.pdf|title=Chronic Fatigue Syndrome Myalgic Encephalomyelitis Primer for Clinical Practitioners| last1  = ((International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis))|author-link=International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis| last2  = Friedberg | first2 = Fred  | authorlink2 = Fred Friedberg | last3  = Bateman          | first3 = Lucinda| authorlink3 = Lucinda Bateman | last4  = Bested          | first4 = Alison C          | authorlink4 = Alison Bested | last5 =Davenport        | first5 = Todd  | authorlink5 = Todd Davenport | last6  = Friedman        | first6 = Kenneth J          | authorlink6 = Kenneth Friedman | last7  = Gurwitt          | first7 = Alan R | authorlink7 = Alan Gurwitt | last8  = Jason | first8 = Leonard A          | authorlink8 = Leonard Jason | last9  = Lapp  | first9 = Charles W          | authorlink9 = Charles Lapp | last10  = Stevens  | first10= Staci R| authorlink10= Staci Stevens | last11  = Underhill | first11= Rosemary A        | authorlink11= Rosemary Underhill | last12  = Vallings  | first12= Rosamund          | authorlink12= Rosamund Vallings|location=Chicago, USA|publisher= International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis}}
</ref> Consuming caffeine in the afternoon or evening is also advised against for ME/CFS patients due to the likelihood of it causing or contributing to [[insomnia]].<ref name="Primer2014"/> Adolescents and children with ME/CFS are advised to limit the use of caffeine for concentration/attention to times when it is particularly important, such as for exams, and to be aware of the caffeine found in energy drinks.<ref name="Rowe, et al, 2017">{{Cite journal | last1  = Rowe| first1 = Peter C.        | authorlink1 = Peter Rowe| last2  = Underhill | first2 = Rosemary A.|authorlink2 = Rosemary Underhill| last3  = Friedman | first3 = Kenneth J. | authorlink3 = Kenneth Friedman| last4 = Gurwitt | first4 = Alan | authorlink4 = Alan Gurwitt| last5 = Medow | first5 = Marvin S.| authorlink5 = Marvin Medow| last6 = Schwartz | first6 = Malcolm S. | authorlink6 = Malcolm Schwartz| last7  = Speight | first7 = Nigel | authorlink7 = Nigel Speight| last8  = Stewart | first8 = Julian M.| authorlink8 = Julian Stewart| last9 = Vallings  | first9 = Rosamund | authorlink9 = Rosamund Vallings| last10  = Rowe | first10 = Katherine S. | authorlink10 = Katherine Rowe| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer| journal = Frontiers in Pediatrics    | volume = 5 | issue =  | pages =121 | date = 2017| doi =10.3389/fped.2017.00121}}</ref>  
</ref> Consuming caffeine in the afternoon or evening is also advised against for ME/CFS patients due to the likelihood of it causing or contributing to [[insomnia]].<ref name="Primer2014"/> Adolescents and children with ME/CFS are advised to limit the use of caffeine for concentration/attention to times when it is particularly important, such as for exams, and to be aware of the caffeine found in energy drinks.<ref name="Rowe, et al, 2017">{{Cite journal | last1  = Rowe| first1 = Peter C.        | authorlink1 = Peter Rowe| last2  = Underhill | first2 = Rosemary A.|authorlink2 = Rosemary Underhill| last3  = Friedman | first3 = Kenneth J. | authorlink3 = Kenneth Friedman| last4 = Gurwitt | first4 = Alan | authorlink4 = Alan Gurwitt| last5 = Medow | first5 = Marvin S.| authorlink5 = Marvin Medow| last6 = Schwartz | first6 = Malcolm S. | authorlink6 = Malcolm Schwartz| last7  = Speight | first7 = Nigel | authorlink7 = Nigel Speight| last8  = Stewart | first8 = Julian M.| authorlink8 = Julian Stewart| last9 = Vallings  | first9 = Rosamund | authorlink9 = Rosamund Vallings| last10  = Rowe | first10 = Katherine S. | authorlink10 = Katherine Rowe| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer| journal = Frontiers in Pediatrics    | volume = 5 | issue =  | pages =121 | date = 2017| doi =10.3389/fped.2017.00121}}</ref>  



Revision as of 17:17, October 6, 2022

Caffeine is a central nervous system stimulant and the active ingredient in coffee.[1][2][3] For most healthy people, it is not harmful to consume up to 400mg of caffeine a day.[3][4]

Uses[edit | edit source]

Caffeine occurs naturally in coffee, tea, cocoa, chocolate, guarana, and many other plants, foods and drinks.[2][3] Caffeine can also be taken as a supplement and may be added to other food or drinks, especially energy drinks.[4]

Caffeine is typically used for:

Energy drinks[edit | edit source]

Drinks marketed as energy drinks or sometimes sports drinks typically contain a number of different stimulants, including:

Energy drink brands include such as Spike Shooter, Pimp Juice, Red Bull, and Cocaine. [5]

Caffeine powder[edit | edit source]

The FDA has issued a warning against the use of caffeine powder, which can provide 1200mg of caffine per 0.15 tablespoons of pure caffeine, this is three times the suggested safe daily limit and a level high enough to cause toxic effects, including seizures.[4]

Theory[edit | edit source]

Evidence[edit | edit source]

Perscription drugs[edit | edit source]

Caffeine is FDA-approved for:

  • migraine and tension-type headaches, when combined pain relief drugs
  • Preventing headaches after surgery (for people who regularly consume caffeine)
  • Caffeine citrate is approved for pauses in breathing that may be followed by low heart rate and low oxygen levels in newborns.

ME/CFS[edit | edit source]

Many people with ME/CFS use caffeine to improve mental alertness or concentration or to reduce fatigue in the short term, but the 2014 International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis primer cautions against excessive usage due to the risk of tachycardia and agitation.[6] Consuming caffeine in the afternoon or evening is also advised against for ME/CFS patients due to the likelihood of it causing or contributing to insomnia.[6] Adolescents and children with ME/CFS are advised to limit the use of caffeine for concentration/attention to times when it is particularly important, such as for exams, and to be aware of the caffeine found in energy drinks.[7]

Risks and side effects[edit | edit source]

For most adults, a limit of 400mg of caffeine daily is likely to be safe, although this may not necessarily be safe long term.[3][4] Just four cups of brewed coffee, ten cans of cola or two typical energy shot drinks provide the maximum recommended amount of 400mg of caffeine.[3] Caffeine sensitivity varies greatly between people so some people will experience harmful effects at much lower doses.[4]

High doses[edit | edit source]

Large doses of caffeine can cause serious adverse reactions, including even fatalities resulting from excessive consumption, especially in the form of "energy" drinks or caffeine powder.[4][5][8][2][3]

Caffeine is mildly addictive, but other substances found in energy drinks are more addictive.[8] Caffeine withdrawal is not considered dangerous.

Excessive caffeine intake causes:

Interactions[edit | edit source]

Caffeine may interact with certain perscription drugs or other supplements, particularly:

  • Ephedrine, which is used in decongestants
  • Theophylline, a medication used to open up bronchial airways.
  • Echinacea, a herbal supplement sometimes used to prevent colds or other infections[3]

Costs and availability[edit | edit source]

Very widely available and inexpensive.

Notable studies[edit | edit source]

  • 2015, Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome[9] - (Abstract)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 "Caffeine". MedlinePlus. Retrieved May 23, 2022.
  2. 2.0 2.1 2.2 2.3 2.4 "CAFFEINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews". WebMD. Retrieved May 23, 2022.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 "Caffeine: How much is too much?". Mayo Clinic. Retrieved May 23, 2022.
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Office of the Commissioner (December 2, 2021). "Spilling the Beans: How Much Caffeine is Too Much?". Food and Drug Administration. Retrieved May 23, 2022.
  5. 5.0 5.1 5.2 Clauson, Kevin A.; Shields, Kelly M.; McQueen, Cydney E.; Persad, Nikki (May 1, 2008). "Safety issues associated with commercially available energy drinks". Journal of the American Pharmacists Association. 48 (3): e55–e67. doi:10.1331/JAPhA.2008.07055. ISSN 1544-3191.
  6. 6.0 6.1 International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis; Friedberg, Fred; Bateman, Lucinda; Bested, Alison C; Davenport, Todd; Friedman, Kenneth J; Gurwitt, Alan R; Jason, Leonard A; Lapp, Charles W; Stevens, Staci R; Underhill, Rosemary A; Vallings, Rosamund (2014), Chronic Fatigue Syndrome Myalgic Encephalomyelitis Primer for Clinical Practitioners (PDF), Chicago, USA: International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
  7. Rowe, Peter C.; Underhill, Rosemary A.; Friedman, Kenneth J.; Gurwitt, Alan; Medow, Marvin S.; Schwartz, Malcolm S.; Speight, Nigel; Stewart, Julian M.; Vallings, Rosamund; Rowe, Katherine S. (2017). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer". Frontiers in Pediatrics. 5: 121. doi:10.3389/fped.2017.00121.
  8. 8.0 8.1 Calabrò, Rocco S.; Naro, Antonino; Bramanti, Placido (2016). "Chapter 72 - Caffeine and Taurine and Energy Drink Abuse". In Preedy, Victor R. (ed.). Neuropathology of Drug Addictions and Substance Misuse. 3. San Diego: Academic Press. pp. 723–732. ISBN 978-0-12-800634-4.
  9. Patrick, David M.; Miller, Ruth R.; Steiner, Theodore; Gardy, Jennifer L.; Parker, Shoshana M.; Tang, Patrick (April 3, 2015). "Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 3 (2): 122–125. doi:10.1080/21641846.2015.1024004. ISSN 2164-1846.