Brigitte Huber
Brigitte Huber, PhD, is a Professor of Integrative Physiology & Pathobiology, at the Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts.[1] She has studied the presence of retrovirus HERV K-18 as a potential biomarker for those who develop myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) after a case of infectious mononucleosis.[2] HERV-K18 is one of many endogenous human retroviruses in the normal human genome. It can be activated in a variety of ways and affect the outcome of Epstein-Barr virus infection and influence autoimmune disease.[3]Dr. Huber's research has shown that there are more HERV K-18 alleles in post-mononucleosis ME/CFS patients than in controls.[4]
In 2011, Dr. Huber and her lab associates were one of the groups who were unable to duplicate Dr. Judy Mikovits's finding of the presence of XMRV in ME/CFS patients.[5]In 2013, she and her lab associates were unable to show reactivation of human herpesvirus 6 (Human herpesvirus 6) or human herpesvirus 7 (HHV-7) in chronic fatigue syndrome.[6]
Education[edit | edit source]
- BA, Biology, University of Zurich
- MSc, Pharmacology, University of Basel
- PhD, Immunogenetics, University of London
- Postdoctoral Training, Harvard Medical School
Talks and interviews[edit | edit source]
- 2010, Speaker at the 5th Invest in ME International ME Conference on Presence of Retrovirus as a Biomarker for ME/CFS DVD available
Studies[edit | edit source]
- 2001, Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.[7] (Full Text)
- 2011, Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays.[8] (Full text)
- 2013, Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients[9] (Full Text)
Online presence[edit | edit source]
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ http://sackler.tufts.edu/Faculty-and-Research/Faculty-Profiles/Brigitte-Huber-Profile
- ↑ http://www.investinme.org/IIMEC5.shtml
- ↑ http://sackler.tufts.edu/Faculty-and-Research/Faculty-Research-Pages/Brigitte-Huber
- ↑ http://www.investinme.org/IIMEC5.shtml
- ↑ Oakes B1, Qiu X, Levine S, Hackett J Jr, Huber BT. (2011). Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays. Advances in Virology, 2011:854540. doi: 10.1155/2011/854540. Epub 2011 Jul 27. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22312356
- ↑ Oakes B, Hoagland-Henefield M, Komaroff AL, Erickson JL, Huber BT. (2013). Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients. Clinical Infectious Disease,56 (10):1394-400. doi: 10.1093/cid/cit086. Epub 2013 Feb 13. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23408682
- ↑ Sutkowski N1, Conrad B, Thorley-Lawson DA, Huber BT. (2001). Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. Immunity, 15 (4):579-89
- ↑ Oakes B, Qiu X, Levine S, Hackett J Jr, Huber BT. (2011). Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays. Advances in Virology,2011:854540. doi: 10.1155/2011/854540
- ↑ Oakes B, Hoagland-Henefield M, Komaroff AL, Erickson JL, Huber BT. (2013). Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients. Clinical Infectious Disease, 56 (10):1394-400. doi: 10.1093/cid/cit086
