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Body temperature
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==ME/CFS== ===<span id="dysregulation">Temperature dysregulation</span>=== Temperature dysregulation, '''heat intolerance''' and '''cold intolerance''' are common symptoms of [[ME/CFS]], and are is recognised in the [[Canadian Consensus Criteria]] as a neuroendocrine symptom. *53.9% - 58.7% of the 2073 patients in a Belgian study of 2001 reported symptom exacerbation in extremes of temperature.<ref name="symptoms2001">{{citation | last1 = De Becker | first1 = P | author-link1 = Pascale De Becker | last2 = McGregor | first2 = N | author-link2 = Neil McGregor | last3 = De Meirleir | first3 = K | author-link3 = Kenny de Meirleir | title = A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome. | journal = Journal of Internal Medicine | volume = 250 | issue = 3 | page = 234-240 | date = Sep 2001 | pmid = 11555128 | url = http://www.ncbi.nlm.nih.gov/pubmed/11555128 }}</ref> *Katrina Berne reports a prevalence of 75-80% for heat/cold intolerance.<ref>{{Cite book | last = Berne | first = Katrina | author-link = Katrina Berne | date = Dec 1, 1995 | title = Running on Empty: The Complete Guide to Chronic Fatigue Syndrome (CFIDS)|edition= 2nd |url= https://www.amazon.co.uk/Running-Empty-Complete-Chronic-Syndrome/dp/0897931912/ | publisher = Hunter House | page = 58 |isbn= 978-0897931915}}</ref> In the [[London criteria]] for ME, sensitivity to both heat and cold is mentioned under the criteria of ''periods of impaired circulation compatible with autonomic dysfunction''.<ref name="Londoncriteria">{{Citation | url =http://www.axfordsabode.org.uk/me/mecrit2014.htm|archive-url=http://web.archive.org/web/20150923181011/http://www.axfordsabode.org.uk/me/mecrit2014.htm|archive-date=2015-09-23|url-status=dead | title = Myalgic Encephalomyelitis (ME). Criteria and clinical guidelines. 2014 | date = Oct 15, 2014 | last = Howes | first = Sandra | author-link = Sandra Howes | last2 = Goudsmit | first2 = Ellen M. | author2link = Ellen Goudsmit | last3 = Shepherd | first3 = Charles |author3link = Charles Shepherd}}</ref> ===<span id="instability">Temperature instability</span>=== Temperature instability and heat or cold intolerance are ME symptoms recognized in the [[International Consensus Criteria]].<ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | author-link1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | author-link2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | author-link3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | author-link4 = Nancy Klimas | last5 = Broderick | first5 = G | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = T | author-link6 = Terry Mitchell | last7 = Staines | first7 = D | author-link8 = Donald Staines | last8 = Powles | first8 = ACP | author-link8 = A C Peter Powles | last9 = Speight | first9 = N | author-link9 = Nigel Speight | last10 = Vallings | first10 = R | author-link10 = Rosamund Vallings | last11 = Bateman | first11 = L | author-link11 = Lucinda Bateman | last12 = Bell | first12 = DS | author-link12 = David Bell | last13 = Carlo-Stella | first13 = N | author-link13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | author-link14 = John Chia | last15 = Darragh | first15 = A | author-link15 = Austin Darragh | last16 = Gerken | first16 = A | author-link16 = Anne Gerken | last17 = Jo | first17 = D | author-link17 = Daehyun Jo | last18 = Lewis | first18 = DP | author-link18 = Donald Lewis | last19 = Light | first19 = AR | author-link19 = Alan Light | last20 = Light | first20 = KC | author-link20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | author-link21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | author-link22 = John McLaren-Howard | last23 = Mena | first23 = I | author-link23 = Ismael Mena | last24 = Miwa | first24 = K | author-link24 = Kunihisa Miwa | last25 = Murovska | first25 = M | author-link25= Modra Murovska | last26 = Stevens | first26 = SR | author-link26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}</ref> '''Loss of thermostatic stability''' and '''intolerance of extremes of temperatures''' are separate diagnostic criteria in the [[International Consensus Criteria]] for ME. Indicators of temperature instability are listed as subnormal body temperature, marked fluctuations of temperature throughout the day; sweating episodes, recurrent feelings of [[low-grade fever|feverishness]] with or without low grade fever, and cold extremities, e.g. fingers and toes.<ref name="ICC2011primer" />
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