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=== Low blood volume === A high proportion of ME/CFS patients have been shown via a [[Dual Tag Test]] to have significantly lower blood volume than healthy controls.<ref>{{Cite journal | last = Hurwitz | first = BE | last2 = Coryell | first2 = VT | last3 = Parker | first3 = M | last4 = Martin | first4 = P | last5 = LaPerriere .... | first5 = A | last6 = Bilsker | first6 = MS | date = | title = Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function | url =http://www.clinsci.org/content/118/2/125 | journal = Clinical Science | volume = 118 | issue = 2 | pages = 125-135|via=}}</ref><ref>{{Cite journal | last = Streeten | first = DHP | last2 = Bell | first2 = D | date = 1998 | title = Circulating Blood Volume in Chronic Fatigue Syndrome | url =https://www.tandfonline.com/doi/abs/10.1300/J092v04n01_02 | journal = Journal of Chronic Fatigue Syndrome | volume = 4 | pages = 3-11|via=}}</ref> A 2018 study using a standard dual isotope [[Red blood cell|erythrocyte]] labelling technique to determine blood volume, [[Red blood cell|erythrocyte]] and plasma volume found significantly lower measured blood volume and red blood cell volume per body weight in female ME/CFS with clinical symptoms of orthostatic intolerance (OI) as compared to female ME/CFS patients without a clinical symptoms of orthostatic intolerance (OI).<ref name=":0" />
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