Björn Sigurdsson: Difference between revisions

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'''Björn Sigurdsson''', Dr. med., (1913 -1959) was the founder and first director of the Institute for Experimental Pathology at Keldur, University of Iceland,  Reykjavík, Iceland. He introduced the concept of slow viral infections ([[lentivirus]]es), that is, viruses that have a slow progression to disease after primary infection. While working with the contagious sheep diseases, maedi and visna, he and his collaborators were the first to grow a lentivirus ''in vitro''.<ref>{{Cite news|url=https://www.researchgate.net/publication/258568000_In_memoriam_Bjorn_Sigurdsson_born_100_years_ago_editorial|title=In memoriam Björn Sigurdsson born 100 years ago (editorial).|last=Ingvarsson|first=Sigurdur|date=Jan 2013|work=Icelandic Agricultural Sciences|access-date=2019-06-20|archive-url=|archive-date=|url-status=|quote=|author-link=}}</ref>
'''Björn Sigurdsson''', Dr. med., (1913 -1959) was the founder and first director of the Institute for Experimental Pathology at Keldur, University of Iceland,  Reykjavík, Iceland. He introduced the concept of slow viral infections ([[lentivirus]]es), that is, viruses that have a slow progression to disease after primary infection. While working with the contagious sheep diseases, maedi and visna, he and his collaborators were the first to grow a lentivirus ''in vitro''.<ref>{{Cite news |url =https://www.researchgate.net/publication/258568000_In_memoriam_Bjorn_Sigurdsson_born_100_years_ago_editorial | title = In memoriam Björn Sigurdsson born 100 years ago (editorial). | last = Ingvarsson | first = Sigurdur | date = Jan 2013|work=Icelandic Agricultural Sciences | access-date = 2019-06-20| archive-url = | archive-date = |url-status = | quote=}}</ref>


Sigurdsson studied and wrote about the [[1948-49 Akureyri outbreak|outbreak of Akureyri disease]], the name given to a disease epidemic simulating [[poliomyelitis]]. In a study of Icelandic children vaccinated against polio in 1956, Sigurdsson, et. al found significant differences in antibody response to [[Vaccine|vaccination]] depending on where the children lived. Children in Egilsstadir had only a slight antibody rise to type 2 and type 3 [[poliovirus]], while children in Thorshofn, which had recently had an outbreak of [[epidemic myalgic encephalomyelitis]], had a much stronger antibody response response to the polio vaccine. Sigurdsson postulated that this might be explained by "the existence of basic immunity acquired through a related infection."<ref name=":0">{{Cite journal|last=Sigurdsson|first=B|date=February 15, 1958|title=Response to poliomyelitis vaccination|url=https://www.ncbi.nlm.nih.gov/pubmed/13515219|journal=The Lancet|volume=1|pages=370-1|via=}}</ref>  
Sigurdsson studied and wrote about the [[1948-49 Akureyri outbreak|outbreak of Akureyri disease]], the name given to a disease epidemic simulating [[poliomyelitis]]. In a study of Icelandic children vaccinated against polio in 1956, Sigurdsson, et. al found significant differences in antibody response to [[Vaccine|vaccination]] depending on where the children lived. Children in Egilsstadir had only a slight antibody rise to type 2 and type 3 [[poliovirus]], while children in Thorshofn, which had recently had an outbreak of [[epidemic myalgic encephalomyelitis]], had a much stronger antibody response response to the polio vaccine. Sigurdsson postulated that this might be explained by "the existence of basic immunity acquired through a related infection."<ref name=":0">{{Cite journal | last = Sigurdsson | first = B | date = February 15, 1958 | title = Response to poliomyelitis vaccination | url =https://www.ncbi.nlm.nih.gov/pubmed/13515219 | journal = The Lancet | volume = 1 | pages = 370-1|via=}}</ref>  




==Notable studies==
==Notable studies==


* 1950, A disease epidemic in Iceland simulating poliomyelitis<ref name="ig1950">{{Cite journal|url=https://www.ncbi.nlm.nih.gov/pubmed/14771044|title=A disease epidemic in Iceland simulating poliomyelitis|last=Sigurdsson|first=B|author-link =Björn Sigurdsson|date=Sep 1950|journal=American Journal of Hygiene|volume=52|pages=222-38|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/14771044 (Abstract)]
* 1950, A disease epidemic in Iceland simulating poliomyelitis<ref name="ig1950">{{Cite journal | url = https://www.ncbi.nlm.nih.gov/pubmed/14771044 | title = A disease epidemic in Iceland simulating poliomyelitis | last = Sigurdsson | first = B | author-link = Björn Sigurdsson | date = Sep 1950 | journal = American Journal of Hygiene | volume = 52 | pages = 222-38|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/14771044 (Abstract)]


* 1956, Clinical findings six years after outbreak of Akureyri disease<ref name="sig1956">{{Cite journal|last=Sigurdsson|first=B.|author-link =Björn Sigurdsson|date=1956-05-26|title=Clinical findings six years after outbreak of Akureyri disease|url=https://www.ncbi.nlm.nih.gov/pubmed/13320872|journal=Lancet (London, England)|volume=270|issue=6926|pages=766–767|issn=0140-6736|pmid=13320872}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/13320872 (Abstract)]
* 1956, Clinical findings six years after outbreak of Akureyri disease<ref name="sig1956">{{Cite journal | last = Sigurdsson | first = B. | author-link = Björn Sigurdsson | date = 1956-05-26 | title = Clinical findings six years after outbreak of Akureyri disease | url =https://www.ncbi.nlm.nih.gov/pubmed/13320872 | journal = Lancet (London, England) | volume = 270 | issue = 6926 | pages = 766–767|issn=0140-6736|pmid=13320872}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/13320872 (Abstract)]


* 1958, Response to poliomyelitis vaccination<ref name=":0" />
* 1958, Response to poliomyelitis vaccination<ref name=":0" />
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*[[1948-49 Akureyri outbreak]] (Iceland)
*[[1948-49 Akureyri outbreak]] (Iceland)


*[[Outbreak]]
*[[Epidemic myalgic encephalomyelitis|Outbreak]]


==Learn more==
==Learn more==

Latest revision as of 14:49, April 3, 2023

Björn Sigurdsson, Dr. med., (1913 -1959) was the founder and first director of the Institute for Experimental Pathology at Keldur, University of Iceland, Reykjavík, Iceland. He introduced the concept of slow viral infections (lentiviruses), that is, viruses that have a slow progression to disease after primary infection. While working with the contagious sheep diseases, maedi and visna, he and his collaborators were the first to grow a lentivirus in vitro.[1]

Sigurdsson studied and wrote about the outbreak of Akureyri disease, the name given to a disease epidemic simulating poliomyelitis. In a study of Icelandic children vaccinated against polio in 1956, Sigurdsson, et. al found significant differences in antibody response to vaccination depending on where the children lived. Children in Egilsstadir had only a slight antibody rise to type 2 and type 3 poliovirus, while children in Thorshofn, which had recently had an outbreak of epidemic myalgic encephalomyelitis, had a much stronger antibody response response to the polio vaccine. Sigurdsson postulated that this might be explained by "the existence of basic immunity acquired through a related infection."[2]


Notable studies[edit | edit source]

  • 1950, A disease epidemic in Iceland simulating poliomyelitis[3] - (Abstract)
  • 1956, Clinical findings six years after outbreak of Akureyri disease[4] - (Abstract)
  • 1958, Response to poliomyelitis vaccination[2]


See also[edit | edit source]

Learn more[edit | edit source]

  • Wikipedia
  • Institution

References[edit | edit source]

  1. Ingvarsson, Sigurdur (January 2013). "In memoriam Björn Sigurdsson born 100 years ago (editorial)". Icelandic Agricultural Sciences. Retrieved June 20, 2019.
  2. 2.0 2.1 Sigurdsson, B (February 15, 1958). "Response to poliomyelitis vaccination". The Lancet. 1: 370–1.
  3. Sigurdsson, B (September 1950). "A disease epidemic in Iceland simulating poliomyelitis". American Journal of Hygiene. 52: 222–38.
  4. Sigurdsson, B. (May 26, 1956). "Clinical findings six years after outbreak of Akureyri disease". Lancet (London, England). 270 (6926): 766–767. ISSN 0140-6736. PMID 13320872.