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Björn Sigurdsson
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{{stub}} {{NeedsImage}} '''Björn Sigurdsson''', Dr. med., (1913 -1959) was the founder and first director of the Institute for Experimental Pathology at Keldur, University of Iceland, Reykjavík, Iceland. He introduced the concept of slow viral infections ([[lentivirus]]es), that is, viruses that have a slow progression to disease after primary infection. While working with the contagious sheep diseases, maedi and visna, he and his collaborators were the first to grow a lentivirus ''in vitro''.<ref>{{Cite news |url =https://www.researchgate.net/publication/258568000_In_memoriam_Bjorn_Sigurdsson_born_100_years_ago_editorial | title = In memoriam Björn Sigurdsson born 100 years ago (editorial). | last = Ingvarsson | first = Sigurdur | date = Jan 2013|work=Icelandic Agricultural Sciences | access-date = 2019-06-20| archive-url = | archive-date = |url-status = | quote=}}</ref> Sigurdsson studied and wrote about the [[1948-49 Akureyri outbreak|outbreak of Akureyri disease]], the name given to a disease epidemic simulating [[poliomyelitis]]. In a study of Icelandic children vaccinated against polio in 1956, Sigurdsson, et. al found significant differences in antibody response to [[Vaccine|vaccination]] depending on where the children lived. Children in Egilsstadir had only a slight antibody rise to type 2 and type 3 [[poliovirus]], while children in Thorshofn, which had recently had an outbreak of [[epidemic myalgic encephalomyelitis]], had a much stronger antibody response response to the polio vaccine. Sigurdsson postulated that this might be explained by "the existence of basic immunity acquired through a related infection."<ref name=":0">{{Cite journal | last = Sigurdsson | first = B | date = February 15, 1958 | title = Response to poliomyelitis vaccination | url =https://www.ncbi.nlm.nih.gov/pubmed/13515219 | journal = The Lancet | volume = 1 | pages = 370-1|via=}}</ref> ==Notable studies== * 1950, A disease epidemic in Iceland simulating poliomyelitis<ref name="ig1950">{{Cite journal | url = https://www.ncbi.nlm.nih.gov/pubmed/14771044 | title = A disease epidemic in Iceland simulating poliomyelitis | last = Sigurdsson | first = B | author-link = Björn Sigurdsson | date = Sep 1950 | journal = American Journal of Hygiene | volume = 52 | pages = 222-38|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/14771044 (Abstract)] * 1956, Clinical findings six years after outbreak of Akureyri disease<ref name="sig1956">{{Cite journal | last = Sigurdsson | first = B. | author-link = Björn Sigurdsson | date = 1956-05-26 | title = Clinical findings six years after outbreak of Akureyri disease | url =https://www.ncbi.nlm.nih.gov/pubmed/13320872 | journal = Lancet (London, England) | volume = 270 | issue = 6926 | pages = 766–767|issn=0140-6736|pmid=13320872}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/13320872 (Abstract)] * 1958, Response to poliomyelitis vaccination<ref name=":0" /> ==See also== *[[1948-49 Akureyri outbreak]] (Iceland) *[[Epidemic myalgic encephalomyelitis|Outbreak]] ==Learn more== *Wikipedia *Institution ==References== {{reflist}} [[Category:Researchers]] [[Category:Iceland researchers]] [[Category:Clinicians]] [[Category:Icelandic clinicians]]
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