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===Examples === Example of biomedical research for ME/CFS include: * finding [[evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy (2019) Mueller, et al|widespread metabolite abnormalities]]<ref name="Mueller2019">{{Cite journal | url = https://link.springer.com/epdf/10.1007/s11682-018-0029-4 | title = Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy | last = Mueller | first = Christina | author-link = Christina Mueller | last2 = Lin | first2 = Joanne C | author-link2 = Joanne Lin | date = 2019|doi=10.1007/s11682-018-0029-4|archive-url=|archive-date=|url-status= | access-date = 2019-01-17 | author-link3 = Sulaiman Sheriff | author-link4 = Andrew Maudsley | author-link5 = Jarred Younger | last3 = Sheriff | last4 = Maudsley | last5 = Younger | first3 = Sulaiman | first4 = Andrew A| first5 = Jarred W | volume = | issue = | pages = | page = | journal = Brain Imaging and Behavior}}</ref><ref name="RamsayAward20190117">{{Cite web | url = http://go.solvecfs.org/webmail/192652/97033877/74d435097e87231f24cffe4d9de93da8e3f71c0e077a67417eba10cbd269ccb1 | title = Brain Imaging and Behavior publication from Dr. Jarred Younger’s SMCI Ramsay pilot study supports involvement of neuroinflammation in ME/CFS | website = go.solvecfs.org | access-date = 2019-01-17 | date = | last = | first = | author-link = |archive-url=|archive-date=|url-status=}}</ref> * [[Brain]] studies finding [[neuroinflammation]] in ME/CFS<ref name="Mueller2019" /><ref name="Nakatomi2014">{{Cite journal | last = Nakatomi | first = Yasuhito | last2 = Mizuno | first2 = Kei | last3 = Ishii | first3 = Akira | last4 = Wada | first4 = Yasuhiro | last5 = Tanaka | first5 = Masaaki | last6 = Tazawa | first6 = Shusaku | last7 = Onoe | first7 = Kayo | last8 = Fukuda | first8 = Sanae | last9 = Kawabe | first9 = Joji | date = 2014-06-01 | title = Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study | url = http://jnm.snmjournals.org/content/55/6/945 | journal = Journal of Nuclear Medicine|language=en | volume = 55 | issue = 6 | pages = 945–950|doi=10.2967/jnumed.113.131045|issn=0161-5505|pmid=24665088}}</ref><ref name="Zeineh2014">{{citation | last = Zeineh | first1 = Michael M | author-link1 = Michael Zeineh | last2 = Kang | first2 = James | author-link2 = James Kang | last3 = Atlas | first3 = Scott W | author-link3 = Scott Atlas | last4 = Raman | first4 = Mira M | author-link4 = Mira Raman | last5 = Reiss | first5 = Allan L | author-link5 = Allan Reiss | last6 =Norris | first6 = Jane L | author-link6 = Jane Norris | last7 = Valencia | first7 = Ian | author-link8 = Ian Valencia | last8 = Montoya | first8 = Jose G | author-link8 = Jose Montoya | title = Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome| journal = Radiology | volume = 274 | issue = 2| pages = 517–526 | date = 2014-10-29| doi = 10.1148/radiol.14141079| url= http://pubs.rsna.org/doi/abs/10.1148/radiol.14141079}}</ref><ref name="RamsayAward20190117">{{Cite web | url = http://go.solvecfs.org/webmail/192652/97033877/74d435097e87231f24cffe4d9de93da8e3f71c0e077a67417eba10cbd269ccb1 | title = Brain Imaging and Behavior publication from Dr. Jarred Younger’s SMCI Ramsay pilot study supports involvement of neuroinflammation in ME/CFS | website = go.solvecfs.org | access-date = 2019-01-17 | date = | last = | first = | author-link = |archive-url=|archive-date=|url-status=}}</ref> * the creation of a test to simulate post-exertional malaise by using salt to test mitochondria responses to biochemical stress in a patient blood sample<ref name="Davis2019">{{Cite journal | last = Davis | first = R.W. | author-link = Ronald Davis | last2 = Wilhelmy | first2 = J. | author-link2 = Julie Wilhelmy | last3 = Nemat-Gorgani | first3 = M. | author-link3 = Mohsen Nemat-Gorgani | last4 = Kashi | first4 = A. | author-link4 = Alex Kashi | last5 = Esfandyarpour | first5 = R. | author-link5 = Rahim Esfandyarpour | date = Apr 25, 2019 | title = A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) | url = https://www.pnas.org/content/early/2019/04/24/1901274116 | journal = Proceedings of the National Academy of Sciences|language=en | volume = 116 | issue = 21 | pages = 10250-10257|doi=10.1073/pnas.1901274116|issn=0027-8424|pmid=31036648|quote=|via=}}</ref> * multiple studies finding immune dysregulation including reduced [[natural killer cell]] function,<ref>{{Cite journal | title = Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis |url =http://www.ncbi.nlm.nih.gov/pubmed/24343819 | journal = International Immunology | date = Apr 2014|issn=1460-2377|pmid=24343819 | pages = 233–242 | volume = 26 | issue = 4|doi=10.1093/intimm/dxt068| first = Ekua Weba | last = Brenu | first2 = Teilah K. | last2 = Huth | first3 = Sharni L. | last3 = Hardcastle | first4 = Kirsty | last4 = Fuller | first5 = Manprit | last5 = Kaur | first6 = Samantha | last6 = Johnston | first7 = Sandra B. | last7 = Ramos | first8 = Don R. | last8 = Staines | first9 = Sonya M. | last9 = Marshall-Gradisnik}}</ref><ref>{{Cite journal | last = Victoria Scott | first = David Strayer | date = 2015 | title = Low NK Cell Activity in Chronic Fatigue Syndrome (CFS) and Relationship to Symptom Severity | url = https://www.omicsonline.org/open-access/low-nk-cell-activity-in-chronic-fatigue-syndrome-cfs-and-relationship-to-symptom-severity-2155-9899-1000348.php?aid=59415 | journal = Journal of Clinical & Cellular Immunology|language=en | volume = 6 | issue = 4|doi=10.4172/2155-9899.1000348|issn=2155-9899}}</ref> and [[cytokine]] dysregulation<ref name="Montoya, 2017">{{citation | last1 = Montoya | first1 = Jose G. | author-link1 = Jose Montoya | last2 = Holmes | first2 = Tyson H. | author-link2 = | last3 = Anderson | first3 = Jill N. | author-link3 = | last4 = Maecker | first4 = Holden T. | author-link4 = | last5 = Rosenberg-Hasson | first5 = Yael | author-link5 = | last6 = Valencia | first6 = Ian J. | author-link6 = | last7 = Chu | first7 = Lily| author-link8 = Lily Chu | last8 = Younger | first8 = Jarred W. | author-link8 = Jarred Younger | last9 = Tato | first9 = Cristina M. | author-link9 = | last10= Davis | first10 = Mark M. | author-link10 = Mark Davis| title = Cytokine signature associated with disease severity in chronic fatigue syndrome patients| journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 114 | issue = 34 | page = E7150-E7158| date = 2017 | pmid = | doi = 10.1073/pnas.1710519114 }}</ref> elevated numbers of [[regulatory T cell]]s<ref>{{Cite journal | last = Brenu | first = Ekua Weba | last2 = Huth | first2 = Teilah K. | last3 = Hardcastle | first3 = Sharni L. | last4 = Fuller | first4 = Kirsty | last5 = Kaur | first5 = Manprit | last6 = Johnston | first6 = Samantha | last7 = Ramos | first7 = Sandra B. | last8 = Staines | first8 = Don R. | last9 = Marshall-Gradisnik | first9 = Sonya M. | date = Apr 2014 | title = Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis |url =http://www.ncbi.nlm.nih.gov/pubmed/24343819 | journal = International Immunology | volume = 26 | issue = 4 | pages = 233–242|doi=10.1093/intimm/dxt068|issn=1460-2377|pmid=24343819}}</ref> and increased [[mast cell]] populations<ref>{{Cite journal | last = Rönnberg | first = E | last2 = Calounova | first2 = G | last3 = Pejler | first3 = G | date = June 2017 | title = Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients |url =https://www.ncbi.nlm.nih.gov/pubmed/27362406 | journal = Asian Pac J Allergy Immunol | volume = 35 | issue = 2 | pages = 75-81|via=}}</ref> * [[ME/CFS Severely Ill, Big Data Study]] * [[NIH Post-Infectious ME/CFS Study]]
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