BRRF1

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BRRF1 encodes the transcription factor for Na, which is may have a role in Epstein-Barr virus (EBV)replication.[1][2][3]

Function[edit | edit source]

ME/CFS[edit | edit source]

Ariza (2021) published a hypothesis | last4 showing a role for BRRF1 and BLLF3 in the immune dysfunction found in ME/CFS.

Notable[edit | edit source]

  • 2021, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back![1] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

  • Outside articles: e.g. WebMD, Merck Manual

References[edit | edit source]

  1. ↑ 1.0 1.1 Ariza, Maria Eugenia (January 29, 2021). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!". Biomolecules. 11 (2): 185. doi:10.3390/biom11020185. ISSN 2218-273X. PMC 7912523. PMID 33572802.
  2. ↑ Hong, Gregory K.; Delecluse, Henri-Jacques; Gruffat, Henri; Morrison, Thomas E.; Feng, Wen-Hai; Sergeant, Alain; Kenney, Shannon C. (May 2004). "The BRRF1 Early Gene of Epstein-Barr Virus Encodes a Transcription Factor That Enhances Induction of Lytic Infection by BRLF1". Journal of Virology. 78 (10): 4983–4992. doi:10.1128/JVI.78.10.4983-4992.2004. ISSN 0022-538X. PMID 15113878.
  3. ↑ Yoshida, Masahiro; Watanabe, Takahiro; Narita, Yohei; Sato, Yoshitaka; Goshima, Fumi; Kimura, Hiroshi; Murata, Takayuki (July 20, 2017). "The Epstein-Barr Virus BRRF1 Gene Is Dispensable for Viral Replication in HEK293 cells and Transformation". Scientific Reports. 7 (1): 6044. doi:10.1038/s41598-017-06413-7. ISSN 2045-2322.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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