Autoantibody: Difference between revisions

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
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|Antinuclear antibodies (ANA)
|68/48 kDa protein
|56.7% (34 of 60)<ref name=":3" />
|13% (15 of 114); 0% controls<ref>{{Cite journal|last=Nishikai|first=M.|last2=Tomomatsu|first2=S.|last3=Hankins|first3=R. W.|last4=Takagi|first4=S.|last5=Miyachi|first5=K.|last6=Kosaka|first6=S.|last7=Akiya|first7=K.|date=2001-07|title=Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders|url=https://pubmed.ncbi.nlm.nih.gov/11477286/|journal=Rheumatology (Oxford, England)|volume=40|issue=7|pages=806–810|doi=10.1093/rheumatology/40.7.806|issn=1462-0324|pmid=11477286}}</ref>
 
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68% (41 of 60); 15% controls<ref>{{Cite journal|last=Konstantinov|first=K|last2=von Mikecz|first2=A|last3=Buchwald|first3=D|last4=Jones|first4=J|last5=Gerace|first5=L|last6=Tan|first6=E M|date=1996-10-15|title=Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507629/|journal=Journal of Clinical Investigation|volume=98|issue=8|pages=1888–1896|issn=0021-9738|pmid=8878441}}</ref>
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|'''Antinuclear autoantibodies (ANA)'''
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|68/48 kDa protein
|ANA (All)
|13% (15 of 114); 0% controls<ref>{{Cite journal|last=Nishikai|first=M.|last2=Tomomatsu|first2=S.|last3=Hankins|first3=R. W.|last4=Takagi|first4=S.|last5=Miyachi|first5=K.|last6=Kosaka|first6=S.|last7=Akiya|first7=K.|date=2001-07|title=Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders|url=https://pubmed.ncbi.nlm.nih.gov/11477286/|journal=Rheumatology (Oxford, England)|volume=40|issue=7|pages=806–810|doi=10.1093/rheumatology/40.7.806|issn=1462-0324|pmid=11477286}}</ref>
|56.7% (34 of 60)<ref name=":3" />68% (41 of 60); 15% controls<ref>{{Cite journal|last=Konstantinov|first=K|last2=von Mikecz|first2=A|last3=Buchwald|first3=D|last4=Jones|first4=J|last5=Gerace|first5=L|last6=Tan|first6=E M|date=1996-10-15|title=Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507629/|journal=Journal of Clinical Investigation|volume=98|issue=8|pages=1888–1896|issn=0021-9738|pmid=8878441}}</ref>
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|ssDNA (single-stranded DNA)
|<ref name=":7">{{Cite journal|last=Vernon|first=Suzanne D|last2=Reeves|first2=William C|date=2005-05-25|title=Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177983/|journal=Journal of Autoimmune Diseases|volume=2|pages=5|doi=10.1186/1740-2557-2-5|issn=1740-2557|pmc=1177983|pmid=15916704}}</ref>
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|Cardiolipin
|dsDNA (double-stranded DNA)
|95% (38 of 40)<ref>{{Cite journal|last=Hokama|first=Yoshitsugi|last2=Campora|first2=Cara Empey|last3=Hara|first3=Cynthia|last4=Kuribayashi|first4=Tina|last5=Le Huynh|first5=Diana|last6=Yabusaki|first6=Kenichi|date=2009|title=Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/19623655|journal=Journal of Clinical Laboratory Analysis|volume=23|issue=4|pages=210–212|doi=10.1002/jcla.20325|issn=1098-2825|pmid=19623655}}</ref>
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|HSP60 (Chlamydia pneumoniae peptide)
|HSP60 (Chlamydia pneumoniae peptide)
|24% IgM 15 of 61)<ref>{{Cite journal|last=Elfaitouri|first=Amal|last2=Herrmann|first2=Björn|last3=Bölin-Wiener|first3=Agnes|last4=Wang|first4=Yilin|last5=Gottfries|first5=Carl-Gerhard|last6=Zachrisson|first6=Olof|last7=Pipkorn|first7=Rϋdiger|last8=Rönnblom|first8=Lars|last9=Blomberg|first9=Jonas|date=2013|title=Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis|url=https://www.ncbi.nlm.nih.gov/pubmed/24312270/|journal=PloS One|volume=8|issue=11|pages=e81155|doi=10.1371/journal.pone.0081155|issn=1932-6203|pmc=3842916|pmid=24312270}}</ref>
|24% IgM 15 of 61)<ref>{{Cite journal|last=Elfaitouri|first=Amal|last2=Herrmann|first2=Björn|last3=Bölin-Wiener|first3=Agnes|last4=Wang|first4=Yilin|last5=Gottfries|first5=Carl-Gerhard|last6=Zachrisson|first6=Olof|last7=Pipkorn|first7=Rϋdiger|last8=Rönnblom|first8=Lars|last9=Blomberg|first9=Jonas|date=2013|title=Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis|url=https://www.ncbi.nlm.nih.gov/pubmed/24312270/|journal=PloS One|volume=8|issue=11|pages=e81155|doi=10.1371/journal.pone.0081155|issn=1932-6203|pmc=3842916|pmid=24312270}}</ref>
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|Microtubule-associated protein 2 (MAP2)
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|Cardiolipin
|95% (38 of 40)<ref>{{Cite journal|last=Hokama|first=Yoshitsugi|last2=Campora|first2=Cara Empey|last3=Hara|first3=Cynthia|last4=Kuribayashi|first4=Tina|last5=Le Huynh|first5=Diana|last6=Yabusaki|first6=Kenichi|date=2009|title=Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/19623655|journal=Journal of Clinical Laboratory Analysis|volume=23|issue=4|pages=210–212|doi=10.1002/jcla.20325|issn=1098-2825|pmid=19623655}}</ref>
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Revision as of 02:55, November 24, 2020

An autoantibody is a type of antibody created by the immune system which targets the organism's own tissues, cells, or cell components. Many autoimmune diseases are caused by autoantibodies.

Autoantibodies found in ME/CFS and its comorbid conditions of POTS and OH[edit | edit source]

Various studies have detected autoantibodies in myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) as well as in its common comorbid conditions of postural orthostatic tachycardia syndrome (POTS) and orthostatic hypotension (OH). The table below lists the autoantibodies found in ME/CFS, POTS and OH.

Autoantibodies Found in ME/CFS, POTS and OH
Autoantibody target ME/CFS POTS OH
Adrenergic receptor alpha 1  Yes[1]
Adrenergic receptor alpha 2
Adrenergic receptor beta 1   Yes[1] Yes[2]
Adrenergic receptor beta 2 Elevated[3] Yes[1] Yes[2]
   
Muscarinic acetylcholine receptor M1 53% (32 of 60)[4] Yes[5]
Muscarinic acetylcholine receptor M2 Yes[5] Yes[2]
Muscarinic acetylcholine receptor M3 Elevated[3] Yes[2]
Muscarinic acetylcholine receptor M4 Elevated[3]
   
Nicotinic ganglionic acetylcholine receptor alpha 3 Yes[6]
Nicotinic ganglionic acetylcholine receptor beta 4 Yes[6]
   
Angiotensin II type 1 receptor Yes[7]
Mu-opioid receptor 15% (9 of 60)[4]
Serotonin or 5-hydroxytryptamine (5-HT) 62% (26 of 42)[8]
Gangliosides 43% (18 of 42)[8]
Phospholipids 38% (16 of 42)[8]
Antineutrophil cytoplasmic antibodies (ANCA) 47% (28 of 60)[9]
68/48 kDa protein 13% (15 of 114); 0% controls[10]
Antinuclear autoantibodies (ANA)
ANA (All) 56.7% (34 of 60)[4]68% (41 of 60); 15% controls[11]
ssDNA (single-stranded DNA) [12]
dsDNA (double-stranded DNA)
HSP60 (Chlamydia pneumoniae peptide) 24% IgM 15 of 61)[13]
Microtubule-associated protein 2 (MAP2) [12]
Cardiolipin 95% (38 of 40)[14]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 Li, Hongliang; Yu, Xichun; Liles, Campbell; Khan, Muneer; Vanderlinde-Wood, Megan; Galloway, Allison; Zillner, Caitlin; Benbrook, Alexandria; Reim, Sean (February 26, 2014). "Autoimmune basis for postural tachycardia syndrome". Journal of the American Heart Association. 3 (1): e000755. doi:10.1161/JAHA.113.000755. ISSN 2047-9980. PMC 3959717. PMID 24572257.
  2. 2.0 2.1 2.2 2.3 Yu, Xichun; Stavrakis, Stavros; Hill, Michael A.; Huang, Shijun; Reim, Sean; Li, Hongliang; Khan, Muneer; Hamlett, Sean; Cunningham, Madeleine W. (January 2012). "Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension". Journal of the American Society of Hypertension: JASH. 6 (1): 40–47. doi:10.1016/j.jash.2011.10.003. ISSN 1878-7436. PMC 3259269. PMID 22130180.
  3. 3.0 3.1 3.2 Loebel, Madlen; Grabowski, Patricia; Heidecke, Harald; Bauer, Sandra; Hanitsch, Leif G.; Wittke, Kirsten; Meisel, Christian; Reinke, Petra; Volk, Hans-Dieter (February 2016). "Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome". Brain, Behavior, and Immunity. 52: 32–39. doi:10.1016/j.bbi.2015.09.013. ISSN 1090-2139. PMID 26399744.
  4. 4.0 4.1 4.2 Tanaka, Susumu; Kuratsune, Hirohiko; Hidaka, Yoh; Hakariya, Yukiko; Tatsumi, Ke-Ita; Takano, Toru; Kanakura, Yuzuru; Amino, Nobuyuki (August 2003). "Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome". International Journal of Molecular Medicine. 12 (2): 225–230. ISSN 1107-3756. PMID 12851722.
  5. 5.0 5.1 Dubey, Divyanshu; Hopkins, Steve; Vernino, Steven. "M1and M2 Muscarinic receptor antibodies among patients with Postural Orthostatic Tachycardia Syndrome: potential disease biomarker" (PDF). Cite has empty unknown parameter: |dead-url= (help)
  6. 6.0 6.1 Watari, Mari; Nakane, Shunya; Mukaino, Akihiro; Nakajima, Makoto; Mori, Yukiko; Maeda, Yasuhiro; Masuda, Teruaki; Takamatsu, Koutaro; Kouzaki, Yanosuke (February 28, 2018). "Autoimmune postural orthostatic tachycardia syndrome". Annals of Clinical and Translational Neurology. 5 (4): 486–492. doi:10.1002/acn3.524. ISSN 2328-9503. PMC 5899914. PMID 29687025.
  7. Yu, Xichun; Li, Hongliang; Murphy, Taylor A.; Nuss, Zachary; Liles, Jonathan; Liles, Campbell; Aston, Christopher E.; Raj, Satish R.; Fedorowski, Artur (April 4, 2018). "Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome". Journal of the American Heart Association. 7 (8). doi:10.1161/JAHA.117.008351. ISSN 2047-9980. PMID 29618472.
  8. 8.0 8.1 8.2 Klein, R.; Berg, P. A. (October 16, 1995). "High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders". European Journal of Medical Research. 1 (1): 21–26. ISSN 0949-2321. PMID 9392689.
  9. von Mikecz, A.; Konstantinov, K.; Buchwald, D. S.; Gerace, L.; Tan, E. M. (February 1997). "High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome". Arthritis and Rheumatism. 40 (2): 295–305. ISSN 0004-3591. PMID 9041942.
  10. Nishikai, M.; Tomomatsu, S.; Hankins, R. W.; Takagi, S.; Miyachi, K.; Kosaka, S.; Akiya, K. (2001-07). "Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders". Rheumatology (Oxford, England). 40 (7): 806–810. doi:10.1093/rheumatology/40.7.806. ISSN 1462-0324. PMID 11477286. Check date values in: |date= (help)
  11. Konstantinov, K; von Mikecz, A; Buchwald, D; Jones, J; Gerace, L; Tan, E M (October 15, 1996). "Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome". Journal of Clinical Investigation. 98 (8): 1888–1896. ISSN 0021-9738. PMID 8878441.
  12. 12.0 12.1 Vernon, Suzanne D; Reeves, William C (May 25, 2005). "Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome". Journal of Autoimmune Diseases. 2: 5. doi:10.1186/1740-2557-2-5. ISSN 1740-2557. PMC 1177983. PMID 15916704.
  13. Elfaitouri, Amal; Herrmann, Björn; Bölin-Wiener, Agnes; Wang, Yilin; Gottfries, Carl-Gerhard; Zachrisson, Olof; Pipkorn, Rϋdiger; Rönnblom, Lars; Blomberg, Jonas (2013). "Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis". PloS One. 8 (11): e81155. doi:10.1371/journal.pone.0081155. ISSN 1932-6203. PMC 3842916. PMID 24312270.
  14. Hokama, Yoshitsugi; Campora, Cara Empey; Hara, Cynthia; Kuribayashi, Tina; Le Huynh, Diana; Yabusaki, Kenichi (2009). "Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome". Journal of Clinical Laboratory Analysis. 23 (4): 210–212. doi:10.1002/jcla.20325. ISSN 1098-2825. PMID 19623655.