Autoantibody: Difference between revisions

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
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|Muscarinic acetylcholine receptor M1
|Muscarinic acetylcholine receptor M1
|Yes<ref name=":3">{{Cite journal|last=Tanaka|first=Susumu|last2=Kuratsune|first2=Hirohiko|last3=Hidaka|first3=Yoh|last4=Hakariya|first4=Yukiko|last5=Tatsumi|first5=Ke-Ita|last6=Takano|first6=Toru|last7=Kanakura|first7=Yuzuru|last8=Amino|first8=Nobuyuki|date=Aug 2003|title=Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/12851722|journal=International Journal of Molecular Medicine|volume=12|issue=2|pages=225–230|issn=1107-3756|pmid=12851722}}</ref>
|53% (32 of 60)<ref name=":3">{{Cite journal|last=Tanaka|first=Susumu|last2=Kuratsune|first2=Hirohiko|last3=Hidaka|first3=Yoh|last4=Hakariya|first4=Yukiko|last5=Tatsumi|first5=Ke-Ita|last6=Takano|first6=Toru|last7=Kanakura|first7=Yuzuru|last8=Amino|first8=Nobuyuki|date=Aug 2003|title=Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/12851722|journal=International Journal of Molecular Medicine|volume=12|issue=2|pages=225–230|issn=1107-3756|pmid=12851722}}</ref>
|Yes<ref name=":5">{{Cite web|url=http://www.dysautonomiainternational.org/pdf/Vernino_Muscarinic_Abstract.pdf|title=M1and M2 Muscarinic receptor antibodies among patients with Postural Orthostatic Tachycardia Syndrome: potential disease biomarker|last=Dubey|first=Divyanshu|last2=Hopkins|first2=Steve|date=|website=|archive-url=|archive-date=|dead-url=|access-date=|last3=Vernino|first3=Steven}}</ref>
|Yes<ref name=":5">{{Cite web|url=http://www.dysautonomiainternational.org/pdf/Vernino_Muscarinic_Abstract.pdf|title=M1and M2 Muscarinic receptor antibodies among patients with Postural Orthostatic Tachycardia Syndrome: potential disease biomarker|last=Dubey|first=Divyanshu|last2=Hopkins|first2=Steve|date=|website=|archive-url=|archive-date=|dead-url=|access-date=|last3=Vernino|first3=Steven}}</ref>
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|Yes<ref>{{Cite journal|last=Yu|first=Xichun|last2=Li|first2=Hongliang|last3=Murphy|first3=Taylor A.|last4=Nuss|first4=Zachary|last5=Liles|first5=Jonathan|last6=Liles|first6=Campbell|last7=Aston|first7=Christopher E.|last8=Raj|first8=Satish R.|last9=Fedorowski|first9=Artur|date=2018-04-04|title=Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/29618472|journal=Journal of the American Heart Association|volume=7|issue=8|doi=10.1161/JAHA.117.008351|issn=2047-9980|pmc=|pmid=29618472}}</ref>
|Yes<ref>{{Cite journal|last=Yu|first=Xichun|last2=Li|first2=Hongliang|last3=Murphy|first3=Taylor A.|last4=Nuss|first4=Zachary|last5=Liles|first5=Jonathan|last6=Liles|first6=Campbell|last7=Aston|first7=Christopher E.|last8=Raj|first8=Satish R.|last9=Fedorowski|first9=Artur|date=2018-04-04|title=Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/29618472|journal=Journal of the American Heart Association|volume=7|issue=8|doi=10.1161/JAHA.117.008351|issn=2047-9980|pmc=|pmid=29618472}}</ref>
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|Dopamine D2 receptor
|Yes<ref name=":3" />
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|Mu-opioid receptor
|Mu-opioid receptor
|Yes<ref name=":3" />
|15% (9 of 60)<ref name=":3" />
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|Serotonin 5-HT1A receptor   
|Yes<ref name=":3" />
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|Serotonin (neurotransmitter)
|Serotonin or 5-hydroxytryptamine (5-HT)
|Yes<ref name=":4">{{Cite journal|last=Klein|first=R.|last2=Berg|first2=P. A.|date=1995-10-16|title=High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders|url=https://www.ncbi.nlm.nih.gov/pubmed/9392689|journal=European Journal of Medical Research|volume=1|issue=1|pages=21–26|issn=0949-2321|pmid=9392689}}</ref>
|62% (26 of 42)<ref name=":4">{{Cite journal|last=Klein|first=R.|last2=Berg|first2=P. A.|date=1995-10-16|title=High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders|url=https://www.ncbi.nlm.nih.gov/pubmed/9392689|journal=European Journal of Medical Research|volume=1|issue=1|pages=21–26|issn=0949-2321|pmid=9392689}}</ref>
 
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|Gangliosides
|Gangliosides
|Yes<ref name=":4" />
|43% (18 of 42)<ref name=":4" />
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|Phospholipids
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|38% (16 of 42)<ref name=":4" />
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|Antinuclear antibodies (ANA)
|Antinuclear antibodies (ANA)
|Yes<ref>{{Cite journal|last=Nishikai|first=Masahiko|date=Jun 2007|title=[Antinuclear antibodies in patients with chronic fatigue syndrome]|url=https://www.ncbi.nlm.nih.gov/pubmed/17561698|journal=Nihon Rinsho. Japanese Journal of Clinical Medicine|volume=65|issue=6|pages=1067–1070|issn=0047-1852|pmid=17561698}}</ref><ref>{{Cite journal|last=Konstantinov|first=K|last2=von Mikecz|first2=A|last3=Buchwald|first3=D|last4=Jones|first4=J|last5=Gerace|first5=L|last6=Tan|first6=E M|date=1996-10-15|title=Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507629/|journal=Journal of Clinical Investigation|volume=98|issue=8|pages=1888–1896|issn=0021-9738|pmid=8878441}}</ref>
|56.7% (34 of 60)<ref name=":3" />
 
Yes<ref>{{Cite journal|last=Nishikai|first=Masahiko|date=Jun 2007|title=[Antinuclear antibodies in patients with chronic fatigue syndrome]|url=https://www.ncbi.nlm.nih.gov/pubmed/17561698|journal=Nihon Rinsho. Japanese Journal of Clinical Medicine|volume=65|issue=6|pages=1067–1070|issn=0047-1852|pmid=17561698}}</ref><ref>{{Cite journal|last=Konstantinov|first=K|last2=von Mikecz|first2=A|last3=Buchwald|first3=D|last4=Jones|first4=J|last5=Gerace|first5=L|last6=Tan|first6=E M|date=1996-10-15|title=Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507629/|journal=Journal of Clinical Investigation|volume=98|issue=8|pages=1888–1896|issn=0021-9738|pmid=8878441}}</ref>
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Revision as of 03:51, November 22, 2020

An autoantibody is a type of antibody created by the immune system which targets the organism's own tissues, cells, or cell components. Many autoimmune diseases are caused by autoantibodies.

Autoantibodies found in ME/CFS and its comorbid conditions of POTS and OH[edit | edit source]

Various studies have detected autoantibodies in myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) as well as in its common comorbid conditions of postural orthostatic tachycardia syndrome (POTS) and orthostatic hypotension (OH). The table below lists the autoantibodies found in ME/CFS, POTS and OH.

Autoantibodies Found in ME/CFS, POTS and OH
Autoantibody target ME/CFS POTS OH
Adrenergic receptor alpha 1  Yes[1]
Adrenergic receptor alpha 2
Adrenergic receptor beta 1   Yes[1] Yes[2]
Adrenergic receptor beta 2 Yes[3] Yes[1] Yes[2]
   
Muscarinic acetylcholine receptor M1 53% (32 of 60)[4] Yes[5]
Muscarinic acetylcholine receptor M2 Yes[5] Yes[2]
Muscarinic acetylcholine receptor M3 Yes[3] Yes[2]
Muscarinic acetylcholine receptor M4 Yes[3]
   
Nicotinic ganglionic acetylcholine receptor alpha 3 Yes[6]
Nicotinic ganglionic acetylcholine receptor beta 4 Yes[6]
   
Angiotensin II type 1 receptor Yes[7]
Mu-opioid receptor 15% (9 of 60)[4]
Serotonin or 5-hydroxytryptamine (5-HT) 62% (26 of 42)[8]
Gangliosides 43% (18 of 42)[8]
Phospholipids 38% (16 of 42)[8]
Microtubule-associated protein 2 (MAP2) Yes[9]
Phosphatidylinositol Yes[10]
Antinuclear antibodies (ANA) 56.7% (34 of 60)[4]

Yes[11][12]

Insoluble cellular antigens Yes[13]
Cardiolipin Yes[14]
Heat shock protein HSP60 Yes[15]
Anti-citrullinated protein Yes[16]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 Li, Hongliang; Yu, Xichun; Liles, Campbell; Khan, Muneer; Vanderlinde-Wood, Megan; Galloway, Allison; Zillner, Caitlin; Benbrook, Alexandria; Reim, Sean (February 26, 2014). "Autoimmune basis for postural tachycardia syndrome". Journal of the American Heart Association. 3 (1): e000755. doi:10.1161/JAHA.113.000755. ISSN 2047-9980. PMC 3959717. PMID 24572257.
  2. 2.0 2.1 2.2 2.3 Yu, Xichun; Stavrakis, Stavros; Hill, Michael A.; Huang, Shijun; Reim, Sean; Li, Hongliang; Khan, Muneer; Hamlett, Sean; Cunningham, Madeleine W. (January 2012). "Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension". Journal of the American Society of Hypertension: JASH. 6 (1): 40–47. doi:10.1016/j.jash.2011.10.003. ISSN 1878-7436. PMC 3259269. PMID 22130180.
  3. 3.0 3.1 3.2 Loebel, Madlen; Grabowski, Patricia; Heidecke, Harald; Bauer, Sandra; Hanitsch, Leif G.; Wittke, Kirsten; Meisel, Christian; Reinke, Petra; Volk, Hans-Dieter (February 2016). "Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome". Brain, Behavior, and Immunity. 52: 32–39. doi:10.1016/j.bbi.2015.09.013. ISSN 1090-2139. PMID 26399744.
  4. 4.0 4.1 4.2 Tanaka, Susumu; Kuratsune, Hirohiko; Hidaka, Yoh; Hakariya, Yukiko; Tatsumi, Ke-Ita; Takano, Toru; Kanakura, Yuzuru; Amino, Nobuyuki (August 2003). "Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome". International Journal of Molecular Medicine. 12 (2): 225–230. ISSN 1107-3756. PMID 12851722.
  5. 5.0 5.1 Dubey, Divyanshu; Hopkins, Steve; Vernino, Steven. "M1and M2 Muscarinic receptor antibodies among patients with Postural Orthostatic Tachycardia Syndrome: potential disease biomarker" (PDF). Cite has empty unknown parameter: |dead-url= (help)
  6. 6.0 6.1 Watari, Mari; Nakane, Shunya; Mukaino, Akihiro; Nakajima, Makoto; Mori, Yukiko; Maeda, Yasuhiro; Masuda, Teruaki; Takamatsu, Koutaro; Kouzaki, Yanosuke (February 28, 2018). "Autoimmune postural orthostatic tachycardia syndrome". Annals of Clinical and Translational Neurology. 5 (4): 486–492. doi:10.1002/acn3.524. ISSN 2328-9503. PMC 5899914. PMID 29687025.
  7. Yu, Xichun; Li, Hongliang; Murphy, Taylor A.; Nuss, Zachary; Liles, Jonathan; Liles, Campbell; Aston, Christopher E.; Raj, Satish R.; Fedorowski, Artur (April 4, 2018). "Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome". Journal of the American Heart Association. 7 (8). doi:10.1161/JAHA.117.008351. ISSN 2047-9980. PMID 29618472.
  8. 8.0 8.1 8.2 Klein, R.; Berg, P. A. (October 16, 1995). "High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders". European Journal of Medical Research. 1 (1): 21–26. ISSN 0949-2321. PMID 9392689.
  9. Vernon, Suzanne D.; Reeves, William C. (May 25, 2005). "Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome". Journal of Autoimmune Diseases. 2: 5. doi:10.1186/1740-2557-2-5. ISSN 1740-2557. PMC 1177983. PMID 15916704.
  10. Maes, Michael; Mihaylova, Ivanka; Leunis, Jean-Claude (December 2007). "Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression". Neuro Endocrinology Letters. 28 (6): 861–867. ISSN 0172-780X. PMID 18063934.
  11. Nishikai, Masahiko (June 2007). "[Antinuclear antibodies in patients with chronic fatigue syndrome]". Nihon Rinsho. Japanese Journal of Clinical Medicine. 65 (6): 1067–1070. ISSN 0047-1852. PMID 17561698.
  12. Konstantinov, K; von Mikecz, A; Buchwald, D; Jones, J; Gerace, L; Tan, E M (October 15, 1996). "Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome". Journal of Clinical Investigation. 98 (8): 1888–1896. ISSN 0021-9738. PMID 8878441.
  13. von Mikecz, A.; Konstantinov, K.; Buchwald, D. S.; Gerace, L.; Tan, E. M. (February 1997). "High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome". Arthritis and Rheumatism. 40 (2): 295–305. ISSN 0004-3591. PMID 9041942.
  14. Hokama, Yoshitsugi; Campora, Cara Empey; Hara, Cynthia; Kuribayashi, Tina; Le Huynh, Diana; Yabusaki, Kenichi (2009). "Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome". Journal of Clinical Laboratory Analysis. 23 (4): 210–212. doi:10.1002/jcla.20325. ISSN 1098-2825. PMID 19623655.
  15. Elfaitouri, Amal; Herrmann, Björn; Bölin-Wiener, Agnes; Wang, Yilin; Gottfries, Carl-Gerhard; Zachrisson, Olof; Pipkorn, Rϋdiger; Rönnblom, Lars; Blomberg, Jonas (2013). "Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis". PloS One. 8 (11): e81155. doi:10.1371/journal.pone.0081155. ISSN 1932-6203. PMC 3842916. PMID 24312270.
  16. "Anti-citrullinated protein antibodies in CFS". Cite has empty unknown parameter: |dead-url= (help)