Arnaud Germain

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Arnaud Germain is researcher of ME/CFS at the Hanson lab, Cornell University, Ithaca, United States.[1][2]

Notable studies[edit | edit source]

  • 2022, Plasma metabolomics reveals disrupted response and recovery following maximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[3] - (Full text)
  • 2021, In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling[4] - (Full text)
  • 2020, Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids[5] - (Full text)
2020, Letter to the Editor of Metabolites[6] - (Full letter)
  • 2018, Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology[7] - (Full Text)
  • 2017, Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism[8] - (Full text)
  • 2016, Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms[9] - (Full Text)

Clinic location[edit | edit source]

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

  • Institution

References[edit | edit source]

  1. ↑ "Members". Hanson Lab. Retrieved April 2, 2022.
  2. ↑ "Research Associates, Post-Docs, and Research Staff | Department of Molecular Biology and Genetics". Cornell University. Retrieved April 2, 2022.
  3. ↑ Germain, Arnaud; Giloteaux, Ludovic; Moore, Geoffrey E.; Levine, Susan M.; Chia, John K.; Keller, Betsy A.; Stevens, Jared; Franconi, Carl J.; Mao, Xiangling; Shungu, Dikoma C.; Grimson, Andrew (March 31, 2022). "Plasma metabolomics reveals disrupted response and recovery following maximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". JCI Insight. doi:10.1172/jci.insight.157621. ISSN 0021-9738.
  4. ↑ Germain, Arnaud; Levine, Susan M.; Hanson, Maureen R. (March 2021). "In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling". Proteomes. 9 (1): 6. doi:10.3390/proteomes9010006. ISSN 2227-7382. PMC 7931008.
  5. ↑ Germain, Arnaud; Barupal, Dinesh K.; Levine, Susan M.; Hanson, Maureen R. (January 14, 2020). "Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids". Metabolites. 10 (1): 34. doi:10.3390/metabo10010034. ISSN 2218-1989.
  6. ↑ Hanson, Maureen R.; Germain, Arnaud (May 25, 2020). "Letter to the Editor of Metabolites". Metabolites. 10 (5): 216. doi:10.3390/metabo10050216. ISSN 2218-1989.
  7. ↑ Germain, Arnaud; Ruppert, David; Levine, Susan M.; Hanson, Maureen R. (December 2018). "Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology". Metabolites. 8 (4): 90. doi:10.3390/metabo8040090.
  8. ↑ Germain, Arnaud; Ruppert, David; Levine, Susan M.; Hanson, Maureen R. (2017). "Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism". Molecular BioSystems. 13: 371-379. doi:10.1039/C6MB00600K. PMC 5365380. PMID 28059425.
  9. ↑ Hanson, Maureen R.; Gu, Zhenglong; Keinan, Alon; Ye, Kaixiong; Germain, Arnaud; Billing-Ross, Paul (December 20, 2016). "Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms". Journal of Translational Medicine. 14 (1): 342. doi:10.1186/s12967-016-1104-5. ISSN 1479-5876. PMC 5175376. PMID 27998272.

plasma The liquid part of blood, lymph, or milk after removing any suspended material. Most of the time, "plasma" simply refers to blood, after all the blood cells have been removed. If you also remove the clotting factors, then the plasma is referred to as "serum".

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

metabolomics The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

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