Angus Mackay

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Angus Mackay, is a PhD student who does research at Department of Biochemistry, University of Otago, Dunedin, New Zealand. He studies myalgic encephalomyelitis/chronic fatigue syndrome with his PHD supervisor, Dr. Warren Tate. Together they received a Lottery Health Research grant totaling $126,200 to develop a diagnostic blood test for ME/CFS.[1]

Research studies and publications[edit | edit source]

  • 2018, A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS[2]
  • 2019, Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome[3]
  • 2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[4] - (Full text)

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ Gibb, John (April 20, 2013). "Grant boosts hopes of finding biomarkers for CFS". Ortega Daily Times. Retrieved January 24, 2019.
  2. ↑ Mackay, Angus; Tate, Warren P. (December 2018). "A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS". International Journal of Immunopathology and Pharmacology. doi:10.1177/2058738418812342.
  3. ↑ Sweetman, Eiren; Ryan, Margaret; Edgar, Christina; Mackay, Angus; Vallings, Rosamund; Tate, Warren (January 2019). "Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome". International Journal of Immunopathology and Pharmacology. 33. doi:10.1177/2058738418820402.
  4. ↑ Sweetman, Eiren; Noble, Alex; Edgar, Christina; Mackay, Angus; Helliwell, Amber; Vallings, Rosamund; Ryan, Margaret; Tate, Warren (July 10, 2019). "Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Diagnostics. 9 (3): 73. doi:10.3390/diagnostics9030073. ISSN 2075-4418.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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