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Angiotensin-converting enzyme
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{{stub}} <span class="noglossary">'''Angiotensin-converting enzyme'''</span> or '''ACE''' is a non-specific [[enzyme]] involved in metabolizing many different peptides, and converts angiotensin I to angiotensin II (ACE2).<ref name="consensus2004">https://academic.oup.com/eurheartj/article/25/16/1454/419006</ref > ==Function== ==ACE drugs== ===ACE inhibitors=== Angiotensin-converting enzyme inhibitors increase the level of [[Angiotensin I converting enzyme II|ACE2]]. ACE inhibitors are one of several classes of drugs recommended for the initial treatment of [[hypertension]], and are mainly used for high blood pressure and heart failure.<ref name="consensus2004" /><ref name="ACEI-drugsbank" /> ACE inhibitors include: * Captopril, a sulfur containing inhibitor * Benazepril (Lotensiin) * Cilazapril (Inhibace) * Enalapril (Vasotec, Epaned) * Fosinopril, a [[phosphorus]] containing inhibitor * Lisinopril (Prinivil, Zestril) * Moexipril (Univasc) * Perindopril (Aceon) * Quinapril (Accupril) * Ramipril (Altace) * Spirapril (Espirapril, Renormax) * Trandolapril (Mavik) * Zofenopril<ref name="ACEI-drugsbank">https://www.drugbank.ca/drugs/DB0069</ref><ref name="consensus2004" /><ref name="Cilazapril-drugsbank">https://www.drugbank.ca/drugs/DB00691</ref ><ref name="spirapril-drugsbank">https://www.drugbank.ca/drugs/DB01348</ref > Recently, concerns have been expressed about the effect of ACE inhibitors in patients exposed to the SARS-CoV-2 virus which causes [[COVID-19]] or the SARS-CoV virus that causes [[Severe acute respiratory syndrome|SARS]].<ref name="Fang2020">https://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(20)30116-8.pdf</ref> ==ME/CFS== ==See also== *[[Angiotensin I converting enzyme II]] (ACE2) ==Learn more== *[https://www.drugbank.ca/drugs/DB00691 Angiotensin-converting enzyme inhibitors] - drugbank.ca ==References== {{Reflist}} [[Category:Enzymes]] [[Category:Genes]]
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