Alpha-lipoic acid: Difference between revisions
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Alpha-lipoic acid (ALA) is a | Alpha-lipoic acid (ALA) is a highly potent antioxidant<ref>{{Cite journal|last=Kaiser|first=Jon D.|author-link=Jon Kaiser|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2015|title=A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/26379906|journal=International Journal of Clinical and Experimental Medicine|volume=8|issue=7|pages=11064–11074|doi=|issn=1940-5901|pmc=4565289|pmid=26379906|access-date=|quote=|via=}}</ref> synthesized by mitochondria, and is important for energy metabolism. It exists in two chemical forms, R-ALA and L-ALA, although only R-ALA is naturally found in the human body.{{citation needed|date=Oct 2019}} ALA in food sources is protein-bound and has no effect on increasing free-form ALA plasma levels.<ref name=":0">{{Cite journal|last=Park|first=Sungmi|last2=Karunakaran|first2=Udayakumar|last3=Jeoung|first3=Nam Ho|last4=Jeon|first4=Jae-Han|last5=Lee|first5=In-Kyu|date=2014|title=Physiological effect and therapeutic application of alpha lipoic acid|url=https://www.ncbi.nlm.nih.gov/pubmed/25005184|journal=Current Medicinal Chemistry|volume=21|issue=32|pages=3636–3645|doi=10.2174/0929867321666140706141806|issn=1875-533X|pmid=25005184}}</ref> | ||
Alpha lipoic acid is a cofactor for some of the key enzymes (alpha keto acid dehydrogenase, [[pyruvate dehydrogenase]], etc) involved in generating energy from food and oxygen in mitochondria and thus plays a critical role in energy production within the cell’s mitochondria.<ref name=":0" /> Since one theory of CFS/ME is mitochondria dysfunction, supplementation may aid in energy production and reduce fatigue. Co-administration of ALA with other mitochondrial nutrients, such as [[acetyl-L-carnitine]] and [[coenzyme Q10]], appears more effective in improving cognitive dysfunction and reducing oxidative mitochondrial dysfunction.<ref>{{Cite journal|last=Liu|first=Jiankang|date=Jan 2008|title=The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview|url=https://www.ncbi.nlm.nih.gov/pubmed/17605107|journal=Neurochemical Research|volume=33|issue=1|pages=194–203|doi=10.1007/s11064-007-9403-0|issn=0364-3190|pmid=17605107|last2=|first2=|pmc=|quote=|last3=|first3=|last4=|first4=|last5=|first5=|last6=|first6=|last7=|first7=|last8=|first8=|author-link=|author-link2=|access-date=|author-link3=|author-link4=|author-link5=|author-link6=|via=}}</ref> | Alpha lipoic acid is a cofactor for some of the key enzymes (alpha keto acid dehydrogenase, [[pyruvate dehydrogenase]], etc) involved in generating energy from food and oxygen in mitochondria and thus plays a critical role in energy production within the cell’s mitochondria.<ref name=":0" /> Since one theory of CFS/ME is mitochondria dysfunction, supplementation may aid in energy production and reduce fatigue. Co-administration of ALA with other mitochondrial nutrients, such as [[acetyl-L-carnitine]] and [[coenzyme Q10]], appears more effective in improving cognitive dysfunction and reducing oxidative mitochondrial dysfunction.<ref>{{Cite journal|last=Liu|first=Jiankang|date=Jan 2008|title=The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview|url=https://www.ncbi.nlm.nih.gov/pubmed/17605107|journal=Neurochemical Research|volume=33|issue=1|pages=194–203|doi=10.1007/s11064-007-9403-0|issn=0364-3190|pmid=17605107|last2=|first2=|pmc=|quote=|last3=|first3=|last4=|first4=|last5=|first5=|last6=|first6=|last7=|first7=|last8=|first8=|author-link=|author-link2=|access-date=|author-link3=|author-link4=|author-link5=|author-link6=|via=}}</ref> | ||
Revision as of 18:19, December 5, 2019
Alpha-lipoic acid (ALA) is a highly potent antioxidant[1] synthesized by mitochondria, and is important for energy metabolism. It exists in two chemical forms, R-ALA and L-ALA, although only R-ALA is naturally found in the human body.[citation needed] ALA in food sources is protein-bound and has no effect on increasing free-form ALA plasma levels.[2]
Alpha lipoic acid is a cofactor for some of the key enzymes (alpha keto acid dehydrogenase, pyruvate dehydrogenase, etc) involved in generating energy from food and oxygen in mitochondria and thus plays a critical role in energy production within the cell’s mitochondria.[2] Since one theory of CFS/ME is mitochondria dysfunction, supplementation may aid in energy production and reduce fatigue. Co-administration of ALA with other mitochondrial nutrients, such as acetyl-L-carnitine and coenzyme Q10, appears more effective in improving cognitive dysfunction and reducing oxidative mitochondrial dysfunction.[3]
Uses[edit | edit source]
In Germany lipoic acid has long been prescribed for diabetic neuropathy, cirrhosis, and mushroom and heavy metal poisonings.[4]
Lipoic acid can be administered intravenously. Supplemental oral ALA is 30-40% absorbed from the gastrointestinal tract. Supplemental forms often comprise a 50-50 mixture of R- and S-lipoic acid enantiomers. The R-form is better absorbed. Liquid formulas are also better absorbed.[5]
Side Effects[edit | edit source]
Supplementing ALA can result in nausea,malodorous urine, headache, weakness, pain, spams, and rash. Side effects are more commonly seen it higher doses.[4] It may interact with diabetic medications to cause hypoglycemia.
Clinical Trials[edit | edit source]
Diabetic Neuropathy[edit | edit source]
Meta-analyses of randomized controlled trials suggest that infusion of 300 to 600 mg/day of lipoic acid for 2 to 4 weeks significantly reduced symptoms of diabetic neuropathy.[6] A randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for 5 weeks significantly improved neuropathic symptoms. There was no difference between the low, moderate or high dose groups.[7] Improvements in neuropathy from these trials are not always corroborated with electrodiagnostic testing. It is thought, that the beneficial effects of ALA on neuropathy may be due to effects on the small nerve fibers, making it a candidate treatment for small fiber neuropathy.[8]
Multiple Sclerosis[edit | edit source]
A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for 2 weeks was safe. Those with the higher serum concentrations of lipoic acid had the lowest serum concentrations of MMP-9 — a marker of inflammation.[9] A 2-year trial of 1,200 mg/day LA in secondary progressive MS demonstrated a significant reduction of whole-brain atrophy and trend toward improvement in walking speed.[4]
References[edit | edit source]
- ↑ Kaiser, Jon D. (2015). "A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome". International Journal of Clinical and Experimental Medicine. 8 (7): 11064–11074. ISSN 1940-5901. PMC 4565289. PMID 26379906.
- ↑ 2.0 2.1 Park, Sungmi; Karunakaran, Udayakumar; Jeoung, Nam Ho; Jeon, Jae-Han; Lee, In-Kyu (2014). "Physiological effect and therapeutic application of alpha lipoic acid". Current Medicinal Chemistry. 21 (32): 3636–3645. doi:10.2174/0929867321666140706141806. ISSN 1875-533X. PMID 25005184.
- ↑ Liu, Jiankang (January 2008). "The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview". Neurochemical Research. 33 (1): 194–203. doi:10.1007/s11064-007-9403-0. ISSN 0364-3190. PMID 17605107.
- ↑ 4.0 4.1 4.2 Waslo, Carin; Bourdette, Dennis; Gray, Nora; Wright, Kirsten; Spain, Rebecca (May 6, 2019). "Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis". Current Treatment Options in Neurology. 21 (6): 26. doi:10.1007/s11940-019-0566-1. ISSN 1092-8480. PMID 31056714.
- ↑ Uchida, Ryota; Okamoto, Hinako; Ikuta, Naoko; Terao, Keiji; Hirota, Takashi (September 21, 2015). "Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats". International Journal of Molecular Sciences. 16 (9): 22781–22794. doi:10.3390/ijms160922781. ISSN 1422-0067. PMC 4613335. PMID 26402669.
- ↑ Han, Tingting; Bai, Jiefei; Liu, Wei; Hu, Yaomin (October 2012). "A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy". European Journal of Endocrinology. 167 (4): 465–471. doi:10.1530/EJE-12-0555. ISSN 1479-683X. PMID 22837391.
- ↑ Ziegler, Dan; Ametov, Alexander; Barinov, Alexey; Dyck, Peter J.; Gurieva, Irina; Low, Phillip A.; Munzel, Ullrich; Yakhno, Nikolai; Raz, Itamar (November 2006). "Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial". Diabetes Care. 29 (11): 2365–2370. doi:10.2337/dc06-1216. ISSN 0149-5992. PMID 17065669.
- ↑ Swiecka, Marta; Maslinska, Maria; Kwiatkowska, Brygida (2018). "Small fiber neuropathy as a part of fibromyalgia or a separate diagnosis?" (PDF). International Journal of Clinical Rheumatology. 13 (6): 353–359. Retrieved October 29, 2019.
- ↑ Yadav, V.; Marracci, G.; Lovera, J.; Woodward, W.; Bogardus, K.; Marquardt, W.; Shinto, L.; Morris, C.; Bourdette, D. (April 2005). "Lipoic acid in multiple sclerosis: a pilot study". Multiple Sclerosis (Houndmills, Basingstoke, England). 11 (2): 159–165. doi:10.1191/1352458505ms1143oa. ISSN 1352-4585. PMID 15794388.
