Aloe vera: Difference between revisions

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=== Tissue healing ===
=== Tissue healing ===
Aloe’s tissue-healing properties are thought to come from its rich polysaccharide content. [[Mannose]]-rich aloe polysaccharides, like [[Glucomannan]] and [[acemmanan]], along with [[gibberellin]], a growth hormone, interact with growth factor receptors on [[Fibroblast|fibroblasts]], a type of cell that synthesizes [[collagen]] and [[extracellular matrix]]. This has been found to significantly increase collagen synthesis in ''in vitro'' and ''in vivo'' animal studies,<ref>{{Cite journal|last=Chithra|first=P.|last2=Sajithlal|first2=G. B.|last3=Chandrakasan|first3=G.|date=1998-4|title=Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats|url=https://www.ncbi.nlm.nih.gov/pubmed/9562243|journal=Molecular and Cellular Biochemistry|volume=181|issue=1-2|pages=71–76|doi=10.1023/a:1006813510959|issn=0300-8177|pmid=9562243}}</ref><ref>{{Cite journal|last=Heggers|first=J. P.|last2=Kucukcelebi|first2=A.|last3=Listengarten|first3=D.|last4=Stabenau|first4=J.|last5=Ko|first5=F.|last6=Broemeling|first6=L. D.|last7=Robson|first7=M. C.|last8=Winters|first8=W. D.|date=1996|title=Beneficial effect of Aloe on wound healing in an excisional wound model|url=https://www.ncbi.nlm.nih.gov/pubmed/9395659|journal=Journal of Alternative and Complementary Medicine (New York, N.Y.)|volume=2|issue=2|pages=271–277|doi=10.1089/acm.1996.2.271|issn=1075-5535|pmid=9395659}}</ref> and in ''in vitro'' human studies.<ref>{{Cite journal|last=Jiang|first=Q.|last2=Wu|first2=B. Y.|last3=Chen|first3=X. D.|last4=Liu|first4=L. Y.|date=2010/03|title=[Influence of Aloe polysaccharide on proliferation and hyaluronic acid and hydroxyproline secretion of human fibroblasts in vitro].|url=http://europepmc.org/abstract/med/20226148|journal=Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine|volume=8|issue=3|pages=256–262|doi=10.3736/jcim20100310|issn=1672-1977|pmid=20226148}}</ref> Aloe polysaccharides may also promote fibroblast proliferation.<ref>{{Cite journal|last=Yao|first=Hong|last2=Chen|first2=Yan|last3=Li|first3=Shaoguang|last4=Huang|first4=Liying|last5=Chen|first5=Wei|last6=Lin|first6=Xinhua|date=2009-08-01|title=Promotion proliferation effect of a polysaccharide from Aloe barbadensis Miller on human fibroblasts in vitro|url=http://www.sciencedirect.com/science/article/pii/S0141813009000828|journal=International Journal of Biological Macromolecules|volume=45|issue=2|pages=152–156|doi=10.1016/j.ijbiomac.2009.04.013|issn=0141-8130}}</ref> [[Acemannan]] has been found in animal studies to accelerate bone formation.<ref>{{Cite journal|last=Boonyagul|first=Sani|last2=Banlunara|first2=Wijit|last3=Sangvanich|first3=Polkit|last4=Thunyakitpisal|first4=Pasutha|date=2014-7|title=Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model|url=https://www.ncbi.nlm.nih.gov/pubmed/23315202|journal=Odontology|volume=102|issue=2|pages=310–317|doi=10.1007/s10266-012-0101-2|issn=1618-1255|pmid=23315202}}</ref>
Aloe’s tissue-healing properties are thought to come from its rich polysaccharide content. [[Mannose]]-rich aloe polysaccharides, like [[Glucomannan]] and [[acemmanan]], along with [[gibberellin]], a growth hormone, interact with growth factor receptors on [[Fibroblast|fibroblasts]], a type of cell that synthesizes [[collagen]] and [[extracellular matrix]]. This has been found to significantly increase collagen synthesis in ''in vitro'' and ''in vivo'' animal studies,<ref>{{Cite journal|last=Chithra|first=P.|last2=Sajithlal|first2=G. B.|last3=Chandrakasan|first3=G.|date=1998-4|title=Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats|url=https://www.ncbi.nlm.nih.gov/pubmed/9562243|journal=Molecular and Cellular Biochemistry|volume=181|issue=1-2|pages=71–76|doi=10.1023/a:1006813510959|issn=0300-8177|pmid=9562243}}</ref><ref>{{Cite journal|last=Heggers|first=J. P.|last2=Kucukcelebi|first2=A.|last3=Listengarten|first3=D.|last4=Stabenau|first4=J.|last5=Ko|first5=F.|last6=Broemeling|first6=L. D.|last7=Robson|first7=M. C.|last8=Winters|first8=W. D.|date=1996|title=Beneficial effect of Aloe on wound healing in an excisional wound model|url=https://www.ncbi.nlm.nih.gov/pubmed/9395659|journal=Journal of Alternative and Complementary Medicine (New York, N.Y.)|volume=2|issue=2|pages=271–277|doi=10.1089/acm.1996.2.271|issn=1075-5535|pmid=9395659}}</ref><ref name=":1">{{Cite journal|last=Atiba|first=Ayman|last2=Nishimura|first2=Mayumi|last3=Kakinuma|first3=Shizuko|last4=Hiraoka|first4=Takeshi|last5=Goryo|first5=Masanobu|last6=Shimada|first6=Yoshiya|last7=Ueno|first7=Hiroshi|last8=Uzuka|first8=Yuji|date=2011-06-01|title=Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production|url=http://www.sciencedirect.com/science/article/pii/S0002961010006124|journal=The American Journal of Surgery|volume=201|issue=6|pages=809–818|doi=10.1016/j.amjsurg.2010.06.017|issn=0002-9610}}</ref><ref name=":2">{{Cite journal|last=Thunyakitpisal|first=Pasutha|last2=Banlunara|first2=Wijit|last3=Sangvanich|first3=Polkit|last4=Sasithanasate|first4=Siriruk|last5=Jettanacheawchankit|first5=Suwimon|date=2009|title=Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing|url=https://www.jstage.jst.go.jp/article/jphs/109/4/109_08204FP/_article/-char/ja/|journal=Journal of Pharmacological Sciences|language=en|volume=109|issue=4|pages=525–531|doi=10.1254/jphs.08204FP|issn=1347-8613}}</ref> and in ''in vitro'' human studies.<ref>{{Cite journal|last=Jiang|first=Q.|last2=Wu|first2=B. Y.|last3=Chen|first3=X. D.|last4=Liu|first4=L. Y.|date=2010/03|title=[Influence of Aloe polysaccharide on proliferation and hyaluronic acid and hydroxyproline secretion of human fibroblasts in vitro].|url=http://europepmc.org/abstract/med/20226148|journal=Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine|volume=8|issue=3|pages=256–262|doi=10.3736/jcim20100310|issn=1672-1977|pmid=20226148}}</ref> Aloe polysaccharides may also promote fibroblast proliferation.<ref name=":1" /><ref name=":2" /><ref>{{Cite journal|last=Yao|first=Hong|last2=Chen|first2=Yan|last3=Li|first3=Shaoguang|last4=Huang|first4=Liying|last5=Chen|first5=Wei|last6=Lin|first6=Xinhua|date=2009-08-01|title=Promotion proliferation effect of a polysaccharide from Aloe barbadensis Miller on human fibroblasts in vitro|url=http://www.sciencedirect.com/science/article/pii/S0141813009000828|journal=International Journal of Biological Macromolecules|volume=45|issue=2|pages=152–156|doi=10.1016/j.ijbiomac.2009.04.013|issn=0141-8130}}</ref> [[Acemannan]] has been found in animal studies to increase expression of [[bone matrix protein]]-2<ref>{{Cite journal|last=Thunyakitpisal|first=Pasutha Din|last2=Sangvanich|first2=Polkit|last3=Lardungdee|first3=Peechanika|last4=Jettanacheawchankit|first4=Suwimon|last5=Jittapiromsak|first5=Nawaporn|date=2007|title=Effect of Acemannan on BMP-2 Expression in Primary Pulpal Fibroblasts And Periodontal Fibroblasts, in vitro Study|url=https://www.jstage.jst.go.jp/article/jarde/4/3/4_3_149/_article/-char/ja/|journal=Journal of Oral Tissue Engineering|language=en|volume=4|issue=3|pages=149–154|doi=10.11223/jarde.4.149|issn=1348-9623}}</ref> and accelerate bone formation.<ref>{{Cite journal|last=Boonyagul|first=Sani|last2=Banlunara|first2=Wijit|last3=Sangvanich|first3=Polkit|last4=Thunyakitpisal|first4=Pasutha|date=2014-7|title=Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model|url=https://www.ncbi.nlm.nih.gov/pubmed/23315202|journal=Odontology|volume=102|issue=2|pages=310–317|doi=10.1007/s10266-012-0101-2|issn=1618-1255|pmid=23315202}}</ref>
 
https://journals.sagepub.com/doi/abs/10.1177/1934578X1400900836


'''Other applications'''
'''Other applications'''

Revision as of 01:46, September 9, 2019

Aloe vera is a desert succulent plant, which produces a soothing gel used to calm skin pain and nerve flares. The gel is extracted from the leaves of the plant and is often included in cosmetics and topical creams. Aloe vera is used in traditional medicine as a skin treatment.

It is a component of The Cusack Protocol, a proposed alternative treatment for Ehlers-Danlos Syndrome.

Components[edit | edit source]

Aloe contains more than 75 potential active components including vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids and amino acids.[1]

Applications[edit | edit source]

Tissue healing[edit | edit source]

Aloe’s tissue-healing properties are thought to come from its rich polysaccharide content. Mannose-rich aloe polysaccharides, like Glucomannan and acemmanan, along with gibberellin, a growth hormone, interact with growth factor receptors on fibroblasts, a type of cell that synthesizes collagen and extracellular matrix. This has been found to significantly increase collagen synthesis in in vitro and in vivo animal studies,[2][3][4][5] and in in vitro human studies.[6] Aloe polysaccharides may also promote fibroblast proliferation.[4][5][7] Acemannan has been found in animal studies to increase expression of bone matrix protein-2[8] and accelerate bone formation.[9]

Other applications

Applied topically, aloe vera has been used to prevent UV damage. It also has anti-inflammatory, immune modulating, and antiviral effects.[1]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 Surjushe, Amar; Vasani, Resham; Saple, D G (2008). "ALOE VERA: A SHORT REVIEW". Indian Journal of Dermatology. 53 (4): 163–166. doi:10.4103/0019-5154.44785. ISSN 0019-5154. PMC 2763764. PMID 19882025.
  2. Chithra, P.; Sajithlal, G. B.; Chandrakasan, G. (1998-4). "Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats". Molecular and Cellular Biochemistry. 181 (1–2): 71–76. doi:10.1023/a:1006813510959. ISSN 0300-8177. PMID 9562243. Check date values in: |date= (help)
  3. Heggers, J. P.; Kucukcelebi, A.; Listengarten, D.; Stabenau, J.; Ko, F.; Broemeling, L. D.; Robson, M. C.; Winters, W. D. (1996). "Beneficial effect of Aloe on wound healing in an excisional wound model". Journal of Alternative and Complementary Medicine (New York, N.Y.). 2 (2): 271–277. doi:10.1089/acm.1996.2.271. ISSN 1075-5535. PMID 9395659.
  4. 4.0 4.1 Atiba, Ayman; Nishimura, Mayumi; Kakinuma, Shizuko; Hiraoka, Takeshi; Goryo, Masanobu; Shimada, Yoshiya; Ueno, Hiroshi; Uzuka, Yuji (June 1, 2011). "Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production". The American Journal of Surgery. 201 (6): 809–818. doi:10.1016/j.amjsurg.2010.06.017. ISSN 0002-9610.
  5. 5.0 5.1 Thunyakitpisal, Pasutha; Banlunara, Wijit; Sangvanich, Polkit; Sasithanasate, Siriruk; Jettanacheawchankit, Suwimon (2009). "Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing". Journal of Pharmacological Sciences. 109 (4): 525–531. doi:10.1254/jphs.08204FP. ISSN 1347-8613.
  6. Jiang, Q.; Wu, B. Y.; Chen, X. D.; Liu, L. Y. (2010/03). "[Influence of Aloe polysaccharide on proliferation and hyaluronic acid and hydroxyproline secretion of human fibroblasts in vitro]". Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 8 (3): 256–262. doi:10.3736/jcim20100310. ISSN 1672-1977. PMID 20226148. Check date values in: |date= (help)
  7. Yao, Hong; Chen, Yan; Li, Shaoguang; Huang, Liying; Chen, Wei; Lin, Xinhua (August 1, 2009). "Promotion proliferation effect of a polysaccharide from Aloe barbadensis Miller on human fibroblasts in vitro". International Journal of Biological Macromolecules. 45 (2): 152–156. doi:10.1016/j.ijbiomac.2009.04.013. ISSN 0141-8130.
  8. Thunyakitpisal, Pasutha Din; Sangvanich, Polkit; Lardungdee, Peechanika; Jettanacheawchankit, Suwimon; Jittapiromsak, Nawaporn (2007). "Effect of Acemannan on BMP-2 Expression in Primary Pulpal Fibroblasts And Periodontal Fibroblasts, in vitro Study". Journal of Oral Tissue Engineering. 4 (3): 149–154. doi:10.11223/jarde.4.149. ISSN 1348-9623.
  9. Boonyagul, Sani; Banlunara, Wijit; Sangvanich, Polkit; Thunyakitpisal, Pasutha (2014-7). "Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model". Odontology. 102 (2): 310–317. doi:10.1007/s10266-012-0101-2. ISSN 1618-1255. PMID 23315202. Check date values in: |date= (help)