Active Hexose Correlated Compound

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Active hexose correlated compound (AHCC) is a supplement derived from shiitake mushrooms. It is rich in the polysaccharides alpha-glucan and beta-glucan and is a popular adjuvant cancer treatment in Japan.

In animal studies, AHCC had antioxidant[1] and anti-inflammatory[2] effects. It may enhance host resistance to bacterial[3][4] and viral infections.[5]

Immune modulation[edit | edit source]

Natural killer cell function[edit | edit source]

In animal models, AHCC has been shown to increase NK activity.[5] Other studies have found no significant increase in NK function.[6]

Cancer[edit | edit source]

In vitro and animal studies show AHCC may have anticancer effects.[7][8][9][10]

In humans, there is some evidence that AHCC may prolong survival in liver cancer patients.[11]

References[edit | edit source]

  1. ↑ Ye, She-Fang; Ichimura, Kaoru; Wakame, Koji; Ohe, Masato (December 19, 2003), "Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress", Life Sciences, 74 (5): 593–602, ISSN 0024-3205, PMID 14623030
  2. ↑ Mascaraque, Cristina; Suárez, María Dolores; Zarzuelo, Antonio; Sánchez de Medina, Fermín; Martínez-Augustin, Olga (December 2014), "Active hexose correlated compound exerts therapeutic effects in lymphocyte driven colitis", Molecular Nutrition & Food Research, 58 (12): 2379–2382, doi:10.1002/mnfr.201400364, ISSN 1613-4133, PMID 25186628
  3. ↑ Ikeda, Tatsuo; Ishibashi, Hiroko; Fujisaki, Ryuichi; Yamazaki, Masatoshi; Wakame, Kohji; Kosuna, Kenichi; Yamaguchi, Hideyo; Ono, Yasuo; Abe, Shigeru (2003), "[Prophylactic efficacy of a basidiomycetes preparation AHCC against lethal Candida albicans infection in experimental granulocytopenic mice]", Nihon Ishinkin Gakkai Zasshi = Japanese Journal of Medical Mycology, 44 (2): 127–131, ISSN 0916-4804, PMID 12748595
  4. ↑ Aviles, Hernan; Belay, Tesfaye; Fountain, Kimberly; Vance, Monique; Sun, Buxiang; Sonnenfeld, Gerald (August 2003), "Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditions", Journal of Applied Physiology (Bethesda, Md.: 1985), 95 (2): 491–496, doi:10.1152/japplphysiol.00259.2003, ISSN 8750-7587, PMID 12692142
  5. ↑ 5.0 5.1 Ritz, Barry W.; Nogusa, Shoko; Ackerman, Elizabeth A.; Gardner, Elizabeth M. (November 1, 2006), "Supplementation with Active Hexose Correlated Compound Increases the Innate Immune Response of Young Mice to Primary Influenza Infection", The Journal of Nutrition, 136 (11): 2868–2873, ISSN 0022-3166, PMID 17056815, retrieved November 9, 2016
  6. ↑ Terakawa, Naoyoshi; Matsui, Yoichi; Satoi, Sohei; Yanagimoto, Hiroaki; Takahashi, Kanji; Yamamoto, Tomohisa; Yamao, Jun; Takai, Soichiro; Kwon, A.-Hon; Kamiyama, Yasuo (September 5, 2008), "Immunological Effect of Active Hexose Correlated Compound (AHCC) in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial", Nutrition and Cancer, 60 (5): 643–651, doi:10.1080/01635580801993280, ISSN 0163-5581, PMID 18791928, retrieved November 9, 2016
  7. ↑ Yagita, Akikuni; Maruyama, Syoji; Wakasugi, Shinji; Sukegawa, Yasushi (February 2002), "H-2 haplotype-dependent serum IL-12 production in tumor-bearing mice treated with various mycelial extracts", In Vivo (Athens, Greece), 16 (1): 49–54, ISSN 0258-851X, PMID 11980361
  8. ↑ Hirose, Aya; Sato, Eri; Fujii, Hajime; Sun, Buxiang; Nishioka, Hiroshi; Aruoma, Okezie I. (July 15, 2007), "The influence of active hexose correlated compound (AHCC) on cisplatin-evoked chemotherapeutic and side effects in tumor-bearing mice", Toxicology and Applied Pharmacology, 222 (2): 152–158, doi:10.1016/j.taap.2007.03.031, ISSN 0041-008X, PMID 17555784
  9. ↑ Kidd, P.M. (February 2000), "The use of mushroom glucans and proteoglycans in cancer treatment", Alternative Medicine Review: A Journal of Clinical Therapeutic, 5 (1): 4–27, ISSN 1089-5159, PMID 10696116
  10. ↑ Cao, Zhiyun; Chen, Xuzheng; Lan, Lan; Zhang, Zhideng; Du, Jian; Liao, Lianming (April 2015), "Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-bearing mice", Nutrition Research and Practice, 9 (2): 129–136, doi:10.4162/nrp.2015.9.2.129, ISSN 1976-1457, PMC 4388943, PMID 25861418, retrieved November 9, 2016
  11. ↑ Cowawintaweewat, Suwanna; Manoromana, Suphon; Sriplung, Hutcha; Khuhaprema, Thiravud; Tongtawe, Pongsri; Tapchaisri, Pramuan; Chaicumpa, Wanpen (March 2006), "Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment", Asian Pacific Journal of Allergy and Immunology, 24 (1): 33–45, ISSN 0125-877X, PMID 16913187

hepatic involving or associated with the liver

renal involving, related to or in the area of the kidneys

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

adverse reaction Any unintended or unwanted response to a treatment, whether in a clinical trial or licensed treatment. May be minor or serious.

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