Acid sensing ion channel 3

Acid Sensing Ion Channel 3 or Acid Sensing Ion Channel Subunit 3 or ASIC3 receptors sense muscle metabolites.

Exercise

White et al. (2012) found a trend towards both increasing ASIC3 and increasing transient receptor potential vanilloid type 1 (TRPV1) in chronic fatigue syndrome patients 24hrs after moderate exercise, but both multiple sclerosis patients and healthy controls had decreases in ASIC3, purinergic P2X 4 receptor (P2X4), and TRPV1 at 30 min post-exercise, and decreases in purinergic P2X 5 receptor (P2X5) 8hrs after exercise. Healthy controls also had significant decreases in P2X5 at 30 min post-exercise.

Notable studies

• 2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample - (Full text)
• 2012, Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome (Full text)
• 2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls (Full text)
• 2012, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome (Full Text)

See also

• Transient receptor potential vanilloid receptor 1
• Purinergic P2X 4 receptor
• Purinergic P2X 5 receptor
• Post-exertional malaise

Learn more

• ASIC3 Gene - Gene cards

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience.