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Acceptance and commitment therapy
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===ME/CFS === A Swedish feasibility study of ACT in 40 patients with ME/CFS indicated that the treatment was accepted by participants, with a drop-out rate of 20% and no reported harmful effects during or after treatment.<ref name="Jonsjo2019" /> The primary outcome measured was psychological flexibility, which is a concept within ACT. The authors plan to do a larger randomized controlled trial with objective outcomes measures to test the efficacy of ACT in patients with ME/CFS.<ref name="Olsson2019">{{Cite web | url = https://www.s4me.info/threads/the-prevalence-and-impact-of-psychoneuroimmunological-factors-in-me-cfs-effects-and-mechanisms-of-act-2019-olsson-et-al.8461/ | title = The prevalence and impact of psychoneuroimmunological factors in ME/CFS: Effects and mechanisms of ACT (2019) Olsson et al. | website = Science for ME|language=en-US | access-date = 2019-03-17}}</ref> A larger randomized trial by Pedersen et al. compared ACT (2018) to enhanced care in patients with multiple functional somatic syndromes included many patients with [[chronic fatigue syndrome]].<ref name="Pedersen">{{Cite journal | last = Pedersen | first = Heidi Frølund | last2 = Agger | first2 = Johanne L. | last3 = Frosthom | first3 = Lisbeth | last4 = Jensen | first4 = Jens S. | last5 = Ørnbøl | first5 = Eva | last6 = Fink | first6 = Per | last7 = Schröder | first7 = Andreas | date = 2018-06-26 | title = Acceptance and Commitment group Therapy for patients with multiple functional somatic syndromes: a three-armed trial comparing ACT in a brief and extended version with enhanced care | url =https://www.ncbi.nlm.nih.gov/pubmed/29941062 | journal = Psychological Medicine | pages = 1–10|doi=10.1017/S0033291718001666|issn=1469-8978|pmid=29941062}}</ref> Approximately 75% of the 180 patients in the trial met diagnostic criteria for chronic fatigue syndrome. Although the primary outcome, patient-rated overall health improvement, was significantly greater in the ACT-group, most of the 18 secondary outcomes showed no change over time compared to the control group. According to the authors, the results suggest "limited or no clinical effect of ACT as compared with enhanced care."<ref name="Pedersen" />
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