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AXA1125
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{{NeedsImage}} '''AXA1125''' or '''LIVRQNac''' is a new drug developed by Axcella Therapeutics which is currently in clinical trials for post-exertional [[fatigue]] caused by [[Long COVID]].<ref name="OxOct2021">{{Cite web | url = https://www.ox.ac.uk/news/2021-10-29-oxford-test-potential-treatment-fatigue-long-covid-patients | title = Oxford to test potential treatment for fatigue in long COVID patients | last = | first = | author-link = | date = | website = University of Oxford|language=en| archive-url = | archive-date = |url-status = | access-date=2021-10-31}}</ref><ref name="cta-axcellatrial">{{Cite web | url = https://www.clinicaltrialsarena.com/news/axcella-trial-long-covid-treatment/ | title = Axcella commences trial of AXA1125 for Long COVID treatment | website = clinicaltrialsarena.com|language=en-GB | access-date = 2021-10-31}}</ref> AXA1125 has been described as a "novel composition of [[amino acid]]s" and a "metabolic modulator" and consists of five amino acids (arginine, glutamine, isoleucine, leucine, and valine) and [[N-acetylcysteine]] (NAC).<ref name="AXA1125-poster-2021">{{Cite web | url = https://axcellatx.com/wp-content/uploads/2021/03/AH002-20-NASH-TAG-2021-AXA1126-MoA-23rd-Poster_MT162.pdf | date = Mar 2021 | title =Mechanistic Insights Into AXA1125, a Novel Endogenous Metabolic Modulator Composition, Targeting Multiple NASH Drivers | first = Michael J. | last = Hamill | last2 = Nadine Daou | last3 = Arianna Nitzel | last4 = Lorena Pantano | last5 = Margaret Koziel | last6 = Manu V. Chakravarthy | publisher = Axcella Health Inc.}}</ref> ==Theory== AXA1125 is a endogenous metabolic modulator, which means it consists of naturally occurring substances that act in a way that modulates [[energy metabolism]].<ref name="AXA1125-poster-2021" /> AXA1125 was designed to treat non-alcoholic liver conditions.<ref name="AXA1125-poster-2021" /> ===Amino acids and precusors=== AXA1125 consists of a combination of: *[[Arginine]] *[[Glutamine]] *[[Isoleucine]] *[[Leucine]] *[[Valine]] *[[N-acetylcysteine]] (NAC), a precursor to several [[amino acid]]s<ref name="AXA1125-poster-2021" /> ==Evidence== ==Clinicians== ==Risks and safety== ==Costs and availability== ==See also == *[[Post-exertional malaise]] *[[Long COVID]] *[[Fatigue]] ==Learn more == *[https://www.ox.ac.uk/news/2021-10-29-oxford-test-potential-treatment-fatigue-long-covid-patients Oxford test potential treatment for fatigue in long COVID patients] - Oxford University *[https://axcellatx.com/wp-content/uploads/2021/03/AH002-20-NASH-TAG-2021-AXA1126-MoA-23rd-Poster_MT162.pdf Poster: Mechanistic Insights Into AXA1125, a Novel Endogenous Metabolic Modulator Composition, Targeting Multiple NASH Drivers] - Axcella Health Inc. ==References == {{Reflist}} [[Category:Potential treatments]] [[Category:Supplements]] [[Category:Amino acids]] [[Category:Endogenous metabolic modulators]] [[Category:Metabolic modulators]]
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