Post-exertional malaise

Post-exertional malaise (PEM) is a worsening of many ME/CFS symptoms as a result of physical or mental exertion. It is often referred to as "the marker" by patients, ME/CFS organizatons, clinicians and researchers that work in the ME/CFS field. PEM can last for days to weeks after the exertion.

Notable studies

 * 1999, Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome
 * 2013, Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression, Meyer et al, 2013
 * 2015, Myalgic Encephalomyelitis: Symptoms and Biomarkers, Jason et al, 2015
 * 2015, Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Shukla et al, 2015



Notable articles

 * Suggestion to replace PEM (Post Exertional Malaise) with PAR (Post Activity Relapse), ME Blogg, 2015

Talks & interviews

 * 2016, Inducing Post-Exertional Malaise in ME/CFS: A Look at the Research Evidence (Peter Rowe)
 * 2015, Post-Exertion Malaise: The Intersection of Biology and Behavior, Dane Cook, Solve ME/CFS

Learn more

 * Post-Exertional Malaise in Chronic Fatigue Syndrome, Jennie Spotila, Solve ME/CFS, 2010
 * Post-Exertional Malaise: Cause and Effect, Jennie Spotila, Solve ME/CFS, 2012
 * Definition of Post-Exertional Malaise, About Health, 2015
 * Post-Exertional Malaise Video, ME/CFS Ghost, 2016
 * 2016, The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?