Palmitoylethanolamide

Palmitoylethanolamide or Palmitoylethanolamine (PEA) is a naturally occurring fatty acid that is available as a supplement and may have benefits for chronic pain, fibromyalgia, and for some mast cell activation or neurological diseases.

PEA is also known as palmitoylethanolamide powder, hydroxyethylpalmitamide, Impulsin, N-(2-Hydroxyethyl) hexadecanamide, N-(2-Hydroxyethyl)palmitamide, Palmitamide MEA, Palmitic Acid Monoethanolamide, um-PEA, Palmidrol, and under various brand names including Normast®︎.

Ultramicronized PEA
Ultramicronized PEA, also known as um-PEA or PEA-um is a form of palmitoylethanolamide available under the brand name Normast.

Costs and availability
Available without a prescription, in the form of a powder, sublingual treatment, capsules and cream.

Normast
Epitech's Normast is probably the best known brand of PEA, and has been used for multiple clinical trials including for fibromyalgia pain, in spinal cord injury patients where it was found to be not statistically more effective than a placebo for nerve pain, spasicity, and insomnia, and for other chronic health conditions. Normast ultramicronized PEA and is manufactured in Italy.

Other brands
Brands of PEA other than Normast include Levagen or Levagan+, Optipea, PeaCURE, PeaPlex, PeaPure, Mirica, and Soothamide.

Buy online

 * Vitalitus - United States
 * Normast - ViaFarmacia, Italy, worldwide shipping
 * RS Supplements - Netherlands, worldwide shipping

Notable studies

 * 2012, New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide
 * 2002, The Palmitoylethanolamide Family: A New Class of Anti-Inflammatory Agents?
 * 2009, The potential benefits of palmitoylethanolamide in palliation: a qualitative systematic review (Full text)
 * 2014, Palmitoylethanolamide in CNS health and disease (Abstract)

Learn more

 * Palmitoylethanolamide (PEA) - WebMD
 * PEA Frequently Asked Questions - Vitalitus