Adenosine triphosphate

Adenosine triphosphate (ATP) is the molecule that supplies and stores energy needed for biochemical reactions in all cell processes. It is commonly referred to as the energy currency of cells. The cell manufactures most of the ATP needed in the mitochondria, however some ATP is manufactured in a less efficient and smaller amount in the cytoplasm.

Notable Studies related to ME and CFS

 * 2016, Elevated Energy Production in Chronic Fatigue Syndrome Patients "'Abstract: Chronic Fatigue Syndrome (CFS) is a debilitating disease characterized by physical and mental exhaustion. The underlying pathogenesis is unknown, but impairments in certain mitochondrial functions have been found in some CFS patients. To thoroughly reveal mitochondrial deficiencies in CFS patients, here we examine the key aspects of mitochondrial function in blood cells from a paired CFS patient-control series. Surprisingly, we discover that in patients the ATP levels are higher and mitochondrial cristae are more condensed compared to their paired controls, while the mitochondrial crista length, mitochondrial size, shape, density, membrane potential, and enzymatic activities of the complexes in the electron transport chain remain intact. We further show that the increased ATP largely comes from non-mitochondrial sources. Our results indicate that the fatigue symptom in this cohort of patients is unlikely caused by lack of ATP and severe mitochondrial malfunction. On the contrary, it might be linked to a pathological mechanism by which more ATP is produced by non-mitochondrial sources."

Video

 * Video explanation of Khan Academy video explanation of ATP
 * Bozeman Science video explanation of ATP

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 * Adenosine triphosphate