Michael Zeineh

Michael Zeineh, MD, PhD, is an Assistant Professor of Radiology at the Stanford University Medical Center. He is board certified in Neuroradiology and Diagnostic Radiology. His medical interests are Neuroradiology, Clinical Functional MRI, and Clinical Diffusion Tensor Imaging. He has performed research in advanced MR imaging of Alzheimer's Disease, Epilepsy, Multiple Sclerosis, and Parkinson's Disease. He worked with Dr. Jose Montoya to investigate brain abnormalities in Chronic Fatigue Syndrome.

Education

 * 1995, B.S. in Biology from Caltech
 * 2003, MD/PhD from UCLA
 * 2004, Intership at UCLA School of Medicine
 * 2008, Residency in Radiology at Stanford University
 * 2009, Fellowship in Neuroradiology at Stanford University

Awards

 * 2015 Doris Duke Foundation Clinical Scientist Development Award - received a three-year grant of $486,000 to support his transition to an independent clinical research career.

Notable Studies for ME/CFS

 * 2015, Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome"'Abstract - Methods: Fifteen patients with CFS were identified by means of retrospective review with an institutional review board–approved waiver of consent and waiver of authorization. Fourteen age- and sex-matched control subjects provided informed consent in accordance with the institutional review board and HIPAA...Results: In the CFS population, FA was increased in the right arcuate fasciculus (P = .0015), and in right-handers, FA was also increased in the right inferior longitudinal fasciculus (ILF) (P = .0008). In patients with CFS, right anterior arcuate FA increased with disease severity (r = 0.649, P = .026). Bilateral white matter volumes were reduced in CFS (mean ± standard deviation, 467 581 mm3 ± 47 610 for patients vs 504 864 mm3 ± 68 126 for control subjects, P = .0026), and cortical thickness increased in both right arcuate end points, the middle temporal (T = 4.25) and precentral (T = 6.47) gyri, and one right ILF end point, the occipital lobe (T = 5.36). ASL showed no significant differences...Conclusions: Bilateral white matter atrophy is present in CFS. No differences in perfusion were noted. Right hemispheric increased FA may reflect degeneration of crossing fibers or strengthening of short-range fibers. Right anterior arcuate FA may serve as a biomarker for CFS.'"

Media coverage

 * 2014, Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder - The New York Times - Well section on November 24, 2014.
 * 2014, Findings of brain anomalies may shed light on chronic fatigue, SFGate, online version, by Erin Allday, Wednesday, October 29, 2014
 * 2014, Not just lazy: Chronic fatigue is real, new brain scans show, 29 October 2014, Today Health and Wellness

Online presence

 * Zeine Lab - Stanford Medicine Website
 * PubMed
 * LinkedIn

Learn more

 * 2014, Chronic fatigue? The syndrome may lead to brain abnormalities