David Bell

David S. Bell, MD, is a retired American doctor who had a practice in General Medicine and Pediatrics. He was at the center of the 1985 Lyndonville outbreak of the disease in upper New York state in the United States. Dr. Bell serves on the Scientific Advisory Board of the Open Medicine Foundation.

He is one of the authors of the 2011 case definition, International Consensus Criteria.

Notable studies

 * 2012, Understanding long-term outcomes of chronic fatigue syndrome. Abstract: In a follow-up study "of the 25 participants diagnosed with CFS 25 years ago, 5 self-reported that they maintained a diagnosis of CFS, while 20 reported no longer having a CFS diagnosis...Those who remitted from CFS showed significantly more impairment on 21 out of 23 outcomes compared with controls,...suggest[ing] that over time many individuals will not maintain a CFS diagnosis but will not return to their premorbid level of functioning."
 * 2009, Severe versus Moderate criteria for the new pediatric case definition for ME/CFS. The study analyzed the Canadian Consensus Criteria when applied to pediatric patients and concluded: "Findings indicate that the Pediatric Case Definition for ME/CFS can distinguish between those with this illness and controls, and between those with Severe versus Moderate manifestations of the illness."
 * 2006, "A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome""'Summary: For a diagnosis of chronic fatigue syndrome (CFS), most researchers use criteria that were developed by Fukuda et al. (1994), with modifications suggested by Reeves et al. (2003). However, this case definition was established for adults rather than children. A Canadian Case Definition (ME/CFS; Myalgic Encephalomyelitis/CFS) has recently been developed, with more specific inclusion criteria (Carruthers et al., 2003). Again, the primary aim of this case definition is to diagnose adult CFS. A significant problem in the literature is the lack of both a pediatric definition of ME/CFS and a reliable instrument to assess it. These deficiencies can lead to criterion variance problems resulting in studies labeling children with a wide variety of symptoms as having ME/CFS. Subsequently, comparisons between articles become more difficult, decreasing the possibility of conducting a meta-analysis. This article presents recommendations developed by the International Association of Chronic Fatigue Syndrome Pediatric Case Definition Working group for a ME/CFS pediatric case definition. It is hoped that this pediatric case definition will lead to more appropriate identification of children and adolescents with ME/CFS.'"
 * 2003, Predictive immunophenotypes: Disease-related profile in chronic fatigue syndrome
 * 2000, The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome. Method: "Fifteen patients were randomly selected from a large population of patients with chronic fatigue syndrome, studied, and observed for several years (by DSB). Blood pressure (BP) and heart rate (HR) measured with Dinamap every minute for 30 minutes supine and 60 minutes standing were compared with these findings in 15 healthy age- and gender-matched control subjects and later during lower body compression with military antishock trousers (MAST). Plasma catecholamines and circulating erythrocyte and plasma volumes were also measured by isotopic dilution methods." Results: "Abnormal findings in the patients included excessive orthostatic reductions in systolic (P < 0.001) and diastolic BP (P < 0.001) and excessive orthostatic tachycardia (P < 0.01), together with presyncopal symptoms in 11 of the 15 patients and in none of the control subjects after standing for 60 min. Lower body compression with the MAST restored all orthostatic measurements to normal and overcame presyncopal symptoms within 10 min. Circulating erythrocyte but not plasma volumes were subnormal in the 12 women (P < 0.01) and plasma norepinephrine concentration rose excessively after standing for 10 min."

Talks & interviews

 * December 2015, Dr. David Bell, Tunstin, California
 * June 2015, Dr. David S. Bell, ME/CFS Presentation, Swedish Medical Center, Seattle Washington
 * October, 2011, Dr. Bell on Norwegian ME chemotherapy drug trial. [English with Norwegian subtitles]
 * January 2010, Q & A After XMRV Lecture By Dr David Bell part 2
 * January 2010, Q & A After XMRV Lecture By Dr David Bell part 1
 * 2000 Documentary, I Remember Me, directed by Kim A. Snyder
 * 1996, Primetime Live TV Show - Sick and Tired

Journal of Chronic Fatigue Syndrome

 * 1995, Chronic Fatigue Syndrome in Children"Abstract - 'Chronic fatigue syndrome (CFS), formerly called chronic Epstein-Barr virus syndrome, chronic mononucleosis, and numerous other names, is a symptom complex characterized by marked functional limitation which affects children as well as adults. The symptom complex, physical examination, laboratory evaluation, clinical course, and differential diagnosis are reviewed with particular emphasis upon CFS in children. Management consists of a comprehensive treatment plan including medical, educational, and psychosocial support wiih the aim of reducing both symptom and activity limitation. While etiology is unknown, the use of the term 'chronic fatigue syndrome' is appropriate for children with marked functional limitation due to unexplained fatigue who have the associated symptom complex and physical examination findings characteristic of this condition.'"

Open Medicine Foundation

 * Aug 1, 2016, Prognosis of ME/CFS

Health Rising

 * Oct 4, 2015, Dr. Bell on Understanding Orthostatic Intolerance in Chronic Fatigue Syndrome and Fibromyalgia
 * Oct 2, 2015, When Panic Isn't: Dr. Bell on Maggie's ME/CFS and Fibromyalgia Story
 * Sept 30, 2015, Dr. David Bell on Low Blood Volume in Chronic Fatigue Syndrome
 * Aug 18, 2015, Dr. Bell's Home Orthostatic Intolerance (OI) Test

Books

 * Neuro-immune fatigue ME/CFS/FM and cellular hypoxia, David Bell - WingSpan Press - 2007
 * Faces of CFS: case studies of chronic fatigue syndrome, David Bell - The Author - 2000
 * A parents' guide to CFIDS: how to be an advocate for your child with chronic fatigue immune dysfunction, David Bell - Haworth Medical Press - 1999
 * The doctor's guide to chronic fatigue syndrome: understanding, treating, and living with CFIDS, David Bell - Addison-Wesley Pub. Co. - 1994
 * Curing fatigue: a step-by-step plan to uncover and eliminate the causes of chronic fatigue, David Bell - Stef Donev - Rodale Press - 1993
 * The disease of a thousand names: CFIDS--chronic fatigue/immune dysfunction syndrome, David Bell - Unknown Binding – 1991

Open Letter to The Lancet
Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Bell, along with 41 colleagues in the ME/CFS field, signed the second letter.
 * 10 February 2016, An open letter to The Lancet, again - Virology blog

Online presence

 * PubMed - DS Bell

Learn more

 * Wikipedia - David Sheffield Bell
 * 2016, Dr. David Bell Joins OMF Scientific Advisory Board (see Open Medicine Foundation)
 * 1990, Chronic Fatigue Syndrome