Luis Nacul

Dr Luis Carlos Nacul is a Clinical Associate Professor and researcher at the London School of Hygiene and Tropical Medicine in London, United Kingdom. He leads the CureME team and the UK ME/CFS biobank. He serves as a Member Substitute for EUROMENE, an international not-for-profit organization for ME/CFS research.

He is a doctor and general practitioner, with training across medicine, epidemiology and public health. In 2018, Dr Nacul was appointed to the review committee for the NICE guidelines for ME/CFS used by the British NHS.

ME/CFS Common Data Element (CDE) Project
Dr Nacul serves on the Fatigue Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control & Prevention.

Notable studies and publications

 * 2007, The Development of an Epidemiological Definition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - (Abstract)
 * 2011, Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care - (Full Text)
 * 2011, Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis - (Full Text)
 * 2011, The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers - (Full Text)
 * 2014, Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: A proposed protocol - (Full Text)
 * 2017, How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies? - (Full text)
 * 2017, Public Review - Draft of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials - (Full Text)
 * 2017, Editorial - Using a participatory approach to develop and implement the UK ME/CFS Biobank
 * 2017, Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome
 * 2017, The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis - (Full text)
 * 2018, Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls - (Full Text)
 * 2018, Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review - (Full text)
 * 2018, Hand grip strength as a clinical biomarker for ME/CFS and Disease Severity - (Abstract)
 * 2018, The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - (Full text)
 * 2019, Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study - (Full text)
 * 2019, Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study - (Abstract)
 * 2019, Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - (Full text)
 * 2019, HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome - (Full text)
 * 2019, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a hyper-regulated immune system driven by an interplay between regulatory T cells and chronic human herpesvirus infections - (Abstract)
 * 2019, A logistic regression analysis of risk factors in ME/CFS pathogenesis - (Full text)
 * 2019, Rethinking the Standard of Care for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - (Full text)
 * 2019, How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS - (Full text)
 * 2020, Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology - (Full text)
 * 2021, The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies - (Full text)
 * 2021, European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe - (Full text)
 * 2022, Systematic review and meta‐analysis of cognitive impairment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) - (Full text)

Talks and interviews

 * 2015, Speaker at the 10th Invest in ME International ME Conference - DVD available Speech title - Incidence and Prevalence of ME
 * 2018, UK CFS/ME Research Collaborative Conference - The UK ME/CFS Biobank: Accelerating global research in ME/CFS


 * 13 Mar 2019, Infrastructure & Translational Research in ME/CFS: the Experience of CureME & the UK ME/CFS Biobank given at the International Research Symposium, Geelong, Australia, sponsored by Emerge Australia
 * 21 Sep 2019, ME/FM Society of BC: Presentation by Dr. Luis Nacul - Has ME/CFS research helped clinicians and patients?  Can we do better?

Learn more

 * LSHTM bio