Fatigue: Biomedicine, Health & Behavior - Volume 8, Issue 1, 2020


 * Effect of coenzyme Q10 supplementation on work-related fatigue in nurses: a double-blind, randomized placebo-controlled study
 * Predicting electronic cigarette dependence and perceived barriers for electronic cigarette cessation: examining the roles of fatigue severity and emotion dysregulation"Abstract - Background: Emotion dysregulation is an important individual difference variable for substance use. Limited empirical data has evaluated the influence of emotion dysregulation on e-cigarette use and outcomes related to use. Similarly, the role of fatigue has received little attention in this regard despite emerging links with e-cigarette use. Methods: Therefore, the present study examined a theoretically informed model focused on whether the experience of more severe fatigue explains, in part, the relation between emotion dysregulation and e-cigarette dependence and perceived barriers to e-cigarette cessation among 525 adult e-cigarette users (50.9% female, Mage = 35.25 years, SD = 10.10). Results: Results suggest that fatigue severity significantly explains part of the relation between emotion dysregulation and dependence (b = 0.04, 95% CI [0.02, 0.06]) as well as perceived barriers for e-cigarette cessation (b = 0.21, 95%CI [0.14, 0.29]). In addition, reverse models were tested that suggest emotion dysregulation may also explain, in part, the relation between fatigue severity and dependence (95% CI [0.07, 0.34]) as well as perceived barriers for e-cigarette cessation (95% CI [0.96, 1.92]). Conclusions: The current study provides initial empirical support for the role of fatigue severity in the relation between emotion dysregulation and e-cigarette use processes, but also highlights the potential for bi-directional effects."
 * Legitimizing myalgic encephalomyelitis/chronic fatigue syndrome: indications of change over a decade - (Abstract)
 * Temporal associations between physical activity, mental activity and fatigue dimensions in knee osteoarthritis: an exploratory intensive longitudinal study - (Abstract)
 * Fatigue and its associated risk factors: a survey of electronics manufacturing shift workers in Malaysia - (Abstract)


 * Effect of coenzyme Q10 supplementation on work-related fatigue in nurses: a double-blind, randomized placebo-controlled study"Abstract - Background: Work-related fatigue is common among nurses and may negatively affect patient safety and nurses’ well-being. Pharmacological interventions with stimulants have had mixed results. The aim of this study was to determine whether coenzyme Q10 (CoQ10) supplementation improved work-related fatigue in nurses. Methods: In phase one, all nurses working at our institution filled out questionnaires to assess fatigue and sleep quality. In phase two, a randomized, double-blind, placebo-controlled trial, nurses with significant work-related fatigue were randomly assigned to either 200 mg daily CoQ10 (n = 54) or placebo (n = 51). The primary endpoint was changed in fatigue from baseline to week 4 using a validated questionnaire, the nurses’ fatigue scale. The secondary outcome, sleep quality, was measured with the Pittsburgh Sleep Quality Index. Results: At baseline, 53.6% of 539 nurses had significant fatigue on the nurses’ fatigue scale. A total of 68.8% of all nurses worked over 25 shifts a month and 40.7% of them had significant fatigue. A significant correlation was found between fatigue and number of work shifts in those nurses (p = .004). A significant improvement in fatigue and sleep quality was found in the CoQ10 group as compared to the baseline and the placebo group (p = .06 and p = .001, respectively). Conclusion: Preferred multifactorial approaches, e.g. reduced work hours, to fatigue reduction are not currently feasible at our center. Given this practical limitation, CoQ10 supplementation was effective in improving fatigue in nurses and maybe a safe approach, ideally in conjunction with other work condition changes."