Myocarditis

Myocarditis or inflammatory cardiomyopathy is inflammation of heart muscle. It can be caused by numerous toxic or infectious agents.

Coxsackie B3 is found in 20-25% of patients with cardiomyopathy and myocarditis. In mouse models, Ampligen was found to be protective of Coxsackie B3-induced myocarditis.

Several studies of a mouse model of Coxsackie B3 myocarditis have found that exercise increases the virulence of the infection and results in poorer outcomes.