Esther Crawley

Professor Esther Crawley is a reader in Child Health at the University of Bristol in the United Kingdom. She is a proponent of Cognitive Behavioural Therapy (CBT) and graded exercise therapy (GET) as treatments for paediatric chronic fatigue syndrome.

She is vice-chair of the UK CFS/ME Research Collaborative (CMRC) and leads the paediatric centre for children and young people with ME/CFS at the Royal United Hospital in Bath. (Previously at the Royal National Hospital for Rheumatic Diseases In Bath). Her work has been funded by the National Institute for Health Research (NIHR) and Action for ME.

She has published studies in the Journal of Psychosomatic Research and collaborates with Peter White of QMUL. Doctor Crawley is the Lead Medical Advisor at the British charity Association of Young People with ME (AYME) having replaced Dr Nigel Speight in 2009.

Notable studies
S.M.I.L.E. Lightning Process trial

SMILE was a pilot trial on children with ME/CFS and involved comparing the effects of standard medical treatment (SMC) against that of the Lightning Process & SMC. Children aged 12 to 18 were drawn from the Bristol & Bath areas with those too well to attend hospital appointments excluded. The charity Association of Young People with ME (AYME) was a participant in the trial and gave evidence in support during the trial ethics procedure.

MAGENTA trial

Doctor Crawley is studying CBT and GET in children. . The protocol and peer review history have been published.

The trial started in September 2015 and studies 100 paediatric patients aged 8-17 in centres in Bath, Newcastle and Cambridge who randomly receive graded exercise therapy or activity management. It aimed to be completed in August 2016.

FITNET online CBT study

This a major study led by Dr Crawley funded by the NIHR which began in May 2016 and is due to be completed by May 2022. . The projected cost is £994,430 and participants include UMC Utrecht and Radboud University Medical Centre in the Netherlands. The charity AYME and the Science Media Centre are also involved to "help is inform patients".

The study aim is to test FITNET-NHS (specialist CBT for paediatric CFS/ME delivered on-line) compared with Activity Management in terms of cost-effectiveness and clinical success.

Media coverage & interviews

 * 2016, BBC News:Chronic fatigue syndrome on rise among 16-year-olds
 * 2016, BBC Radio 4 Women's Hour (27 Jan 2016):Talks about teenage girls and [[chronic fatigue syndrome].]

Controversies and Criticism
SMILE Trial

In a joint statement in August 2010, the ME Association and the Young ME Sufferers Trust called the SMILE study "unethical". They quoted the Medical Research Council guidelines on research in children, "Research involving children should only be carried out if it cannot feasibly be carried out on adults. The ME Association and The Young ME Sufferers Trust do not believe that it is ethically right to use children in trialling an unproven and controversial process such as the Lightning Process." Invest in ME in a letter to the National Research Ethics Committee (NRES) described the process as "rather like CBT but with bullying and risks of harm."

James Coyne has criticised Crawley's work with regard to public availability of data & the involvement of Phil Parker in the SMILE study.

Daniel Clark has noted that the primary outcome measure was changed from school attendance to scores on a self-report questionnaire. He stated, "Given that LP involves making claims to patients about their own ability to control symptoms in exactly the sort of way likely to lead to response bias."

The study only received final ethical approval after prolonged protests from patient groups in January 2011.

Complaints and Death Threats

Dr Crawley has been the subject of complaints to the General Medical Council (GMC) and claimed to have received death threats

Canadian Consensus Criteria

In an reply to an Editorial in the British Medical Journal by Fiona Goodle, Crawley (with Peter White and Alastair Miller) rejected using the Canadian Consensus Criteria to diagnose patients labelling it as "not practical", although conceding post-exertional malaise (which is part of the criteria) "may need incorporating in future definitions to help differentiate CFS from more general fatigue."

Freedom of information requests
A number of Freedom of Information requests have been made to Dr Crawley about her work. One request revealed records were not kept of patients subsequently re-diagnosed with another illness at Dr Crawley's paediatric clinic.

Online presence

 * Royal United Bath Hospitals: Fatigue Management, Children
 * Esther Crawley's PubMed history
 * University of Bristol - Esther Crawley
 * School of Social and Community Medicine at Bristol University
 * University of Bristol: Esther Crawley's research publications