Brain

Chronic fatigue syndrome
One six year longitudinal MRI study found that Chronic Fatigue Syndrome (per Fukuda & Canadian Consensus Criteria) is associated with decreases in white matter, gray matter and blood volume deficits in the brain as compared to healthy controls.

A 2017 study by Natelson, et al, showed that:
 * patients with chronic fatigue syndrome (CFS) have higher brain ventricular lactate, more abnormal spinal fluids, lower brain glutathione, and reduced cerebral blood flow than controls,
 * psychiatric comorbidity does not influence any of these potential biological markers of CFS,
 * 50% of the patients had more than one of these abnormalities, and
 * a subgroup of CFS patients with brain abnormalities may have an underlying encephalopathy producing their illness.

Microglia
Microglia


 * "Microglia in Fibromyalgia & Chronic Fatigue Syndrome", About Health, 22 Feb 2016.

Notable studies

 * 2018, Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
 * 2017, Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study
 * 2017, CNS findings in chronic fatigue syndrome and a neuropathological case report
 * 2016, Relative increase in choline in the occipital cortex in chronic fatigue syndrome