SAM-e

S-adenosyl-methionine, also known as ADE-SD4, Ademetionine, S-adenosylmethionine, and abbreviated AdoMet or SAMe, is an amino acid derivative synthesized in the body that acts as the body's main methyl donor in many different metabolic reactions. It may become depleted with B-vitamin deficiency, chronic inflammation, and has been observed to decrease with age. When a person is deficient in

Theory
SAMe may help people with ME or CFS by restoring methyl donor levels, allowing methylation reactions to continue at a normal rate. If there is a deficiency of methyl donors in the central nervous system, SAMe supplementation might be expected to improve some brain function, or improve mood. Among many other synthetic reactions, SAMe aids in the synthesis of the neurotransmitters norepinephrine, dopamine, and serotonin.

Evidence
A small number of studies have been conducted in fibromyalgia patients which showed some positive effects when taking SAMe. The main positive effect has been described as a reduction in pain levels. However, Volkmann et al (2009) found no significant effect in a ten day trial of fibromyalgia patients.

Learn more

 * SAMe - drugs.com