Vitamin C

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin found particularly in citrus fruits and green vegetables. One of its roles is as an antioxidant, that is, it helps to protect cells from damage by oxidative stress and also improves mitochondrial function. Another role is as a cofactor for several enzymes. Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Vitamin C is buffered in the whole body, even skin tissue .Several studies indicates the recovery from Vitamin C depletion will require several months of treatment.

Homeostasis
Vitamin C is ingested, absorbed from the intestinal lumen and transported to various peripheral organs with the blood. Finally, vitamin C is excreted in the renal glomeruli and reabsorbed through the tubular systems. Tissue concentrations are dependent on all of these processes. Vitamin C is buffered in the whole body, even skin tissue. Vitamin C is also buffered in bone marrow, and bone marrow is probably also involved in the vitamin C homeostasis process.

Function
High levels of vitamin C are buffered in the eyes, pituitary, adrenal gland, pancreas, liver, spleen and brain. Vitamin C is also buffered in relative high levels in the muscles and skin. It is important in mast cell activation disorder for its role in the breakdown of histamine and as a mast cell stabilizer. Vitamin C is also a co-factor in collagen synthesis, making it a potentially important nutrient in Ehlers-Danlos syndrome and other connective tissue disorders. Vitamin C are buffered in various parts in the body. Vitamin C are also buffered in bone marrow, and deficiency of vitamin C may lead to osteoporosis.

Adrenal gland
The adrenal gland can inject vitamin C into the blood.

Depletion
Several studies indicates the recovery from Vitamin C depletion will require several months of treatment. Vitamin C concentrations in plasma and circulating cells were studied in young healthy men and women  each of whom were given six to seven different doses of the vitamin in two depletion-repletion studies. Seven healthy men (4A) and fifteen healthy women (4B), all nonsmokers, age 19-27 years were studied as inpatients. To decrease hospitalization time, outpatient subjects prior to admission were instructed to consume a diet containing < 60 mg of vitamin C. When inpatients, throughout hospitalization they consumed a defined diet containing less than 5 mg of vitamin C daily. Deficiencies of other nutrients were prevented by supplementation. When plasma vitamin C concentrations achieved nadir of <10 µM, vitamin C in solution was administered at 15 mg orally in the fasted state twice daily (30 mg total per day) until steady state for the dose was achieved.

ME/CFS
Dr. Rosamund Vallings, an ME/CFS expert, warns against very high dose mega vitamin C supplementation, stating that: "those with CFS...maybe worsened by high dose vitamin C, as the immune system is often already very overactive, and Vitamin C may aggravate this condition."

Osteoporosis
Longer periods of Vitamin C deficiency may lead to osteoporosis.

Mast cell activation disorder
Numerous studies have found Vitamin C to be inversely correlated with histamine and that the administration of Vitamin C reduces blood histamine levels. It does this potentially through several mechanisms: by inhibiting mast cell production; by increasing diamine oxidase (an enzyme that breaks down histamine); by inhibiting mast cell degranulation (and the release of histamine in the first place), and by inhibiting histidine decarboxylase (the enzyme that forms histamine).

Notable studies

 * 2014, Mitochondrial dysfunction and chronic disease: treatment with natural supplements (Full text)

Learn more

 * Linus Pauling Institute Micronutrient Information Center - Vitamin C