Cognitive dysfunction

Cognitive dysfunction is a constant struggle for most ME/CFS patients and they often describe it as "brain fog". It is also a symptom of fibromyalgia and patients refer to it as "fibro fog".

Cognitive dysfunction in ME/CFS can take many different forms. Cognitive issues commonly observed in ME/CFS include attention deficit, auditory sequencing problems, brain fog, concentration problems, difficulty comprehending social cues, dyscalculia, dyslexia, executive function problems, linguistics reversals, memory loss, multi-tasking problems, planning problems, receptive language problems, slowed thought, spatial disorientation, word-finding problems, cognitive overload, slow processing of information and poor working memory.

Exercise and Cognitive Dysfunction
A healthy person becomes more alert after exercise, but people with ME/CFS find their cognitive difficulties increase, they become much slower at mental activities, and cognitive tasks seem to take extra effort.

Symptom recognition
Mandatory

Cognitive dysfunction is a mandatory symptom to diagnose ME/CFS with the Canadian Consensus Criteria (CCC). .

Optional

Cognitive dysfunction is an optional symptom in Systemic Exertion Intolerance Disease (SEID) criteria and the International Consensus Criteria (ICC) which diagnoses myalgic encephalomyelitis (ME).

Diagnosis

 * Mild cognitive impairment (MCI)
 * Food For The Brain - Cognitive Function Test
 * Cognitive Dysfunction and “Brain Fog” in POTS

Notable studies

 * 2001, Neuropsychological functioning in chronic fatigue syndrome: a review. (Abstract)
 * 2006, Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome (Full text)
 * 2015, Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome (Full Text)
 * 2016, Cognitive Dysfunction in Chronic Fatigue Syndrome: a Review of Recent Evidence (Abstract)
 * 2016, qEEG / LORETA in Assessment of Neurocognitive Impairment in a Patient with Chronic Fatigue Syndrome: A Case Report (Full Text)

"Our case study confirmed the pattern of dysregulation in the cortex reviewed in the introduction. Furthermore, since both periods of phase shift/lock durations were found to be significantly shorter, that might contribute to an increased rate of phase reset, also seen in our data. Phase reset deregulation--phase locking periods being too brief and phase reset happening too often—appear to be consistent with the associated lower rate of information processing and reaction times found in the ME and CFS literature. These deregulated states represent the brain during nonoptimal functioning, rendering it inefficient for most types of information processing functioning, whether it is executive functioning, memory, perceptual reasoning or information processing speed. When phase lock is significantly less than normal, as in this data set, the ability of the brain to sustain commitment of resources to mediate different functions is severely compromised. Phase shift duration in this data is also hypoactive, meaning that significantly less neurons are being recruited to perform a function than normal. The results here indicate slowed verbal comprehension, executive functions, perceptual reasoning, processing speed and memory, the sum total of which is known as cognitive impairment."



Possible causes
Mady Hornig has found evidence in the cerebral spinal fluid of ME/CFS patients that may explain their cognitive dysfunction.

Learn more
"According to the Marshall Pathogenesis, cognitive dysfunction is caused by microbe s. More severe forms of cognitive dysfunction are seen in diseases such as Alzheimer's, diseases for which there is strong evidence of a bacteria l etiology. Often associated with chronic fatigue syndrome,1) cognitive dysfunction is also seen in patients with multiple sclerosis,2) depression,3) fibromyalgia,4) and dozens of others diseases."
 * 2015, Dr. Gudrun Lange Reviews Neuropsychological Testing for CFS and FM
 * 2016, Case Study: "Brain Fog" in CFS can be seen in qEEG/Loreta
 * 2018, Study Identifies the Types of Cognitive Dysfunction That Are Most Prevalent in Fibromyalgia
 * Cognitive dysfunction (brain fog)