Trazodone

Trazodone is an antidepressant drug.

There is virtually no evidence for the use of Trazodone to treat ME/CFS. In 2012 Solve ME/CFS Initiative contracted Biovista to use drug models to identify existing drugs that may be worth investigating for treatment. The results suggested Trazodone was worth considering.

Notable studies

 * 2008, Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome
 * 2010, Trazodone for the treatment of fibromyalgia: an open-label, 12-week study
 * 2011, Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study

Media coverage

 * Low Dose Naltrexone Drug Combination Proposed for Chronic Fatigue Syndrome (ME/CFS)

Learn more

 * Wikipedia - Trazodone