Notable studies

This page lists published ME/CFS studies that are notable, for particularly interesting findings, for controversial findings, or for their quality or their size.

Epidemiological

 * 2015, Institute of Medicine report (Ellen Wright Clayton, Lucinda Bateman)
 * 2015, National Institutes of Health Pathways to Prevention Workshop: Advancing the Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (C Green, P Cowan, R Elk)
 * 2014, Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008–2012 (IJ Bakken, K Tveito, N Gunnes)
 * 2013, The prevalence of chronic fatigue syndrome/myalgic encephalomyelitis: a meta-analysis (Samantha Johnston, Ekua Weba Brenu, Donald Staines, Sonya Marshall-Gradisnik)
 * 2011, Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care (Luis Nacul, Eliana Lacerda, Derek Pheby)
 * 2007, The burden of disease and injury in Australia 2003 (Stephen Begg, Theo Vos)
 * 2006, Prolonged Illness after infectious mononucleosis is associated with altered immunity but not with increased viral load (Cameron, B., Bharadwaj, M., Burrows, J., Fazou, C., Wakefield, D., Hickie, I., Ffrench, R., Khanna, R. and A. Lloyd) See also Model of Post Infective Fatigue Forming: the Dubbo Studies.
 * 2006, Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus (Vernon, S., Whistler, T., Cameron, B., Hickie, I., Reeves, W. and A. Lloyd) See also Model of Post Infective Fatigue Forming: the Dubbo Studies.
 * 2006, Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study (I Hickie, T Davenport, D Wakefield)
 * 2005, A systematic review describing the prognosis of chronic fatigue syndrome (Ruth Cairns, Matthew Hotopf)
 * 1996, Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups (Anthony Komaroff, Fagioli LR, Doolittle TH)

Immunological

 * 2011, Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study (Øystein Fluge, Ove Bruland, Kristin Risa, Anette Storstein, Einar K. Kristoffersen, Dipak Sapkota, Halvor Næss, Olav Dahl, Harald Nyland, Olav Mella)
 * 2008, Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis (Fuite J, Susan Vernon, Gordon Broderick)
 * 2008, Cytokine Polymorphisms Have a Synergistic Effect on Severity of the Acute Sickness Response to Infection (Vollmer‐Conna U, Piraino B, Cameron B)
 * 2007, [http://www.ncbi.nlm.nih.gov/pubmed/17712757 Postinfective fatigue syndrome is not associated with altered cytokine production. (Vollmer-Conna U, Cameron B, Pavlovic D)
 * 2006, A first study of cytokine genomic polymorphisms in CFS: positive association of TNF‐857 and IFNgamma 874 rare alleles (Carlo‐Stella N, Badulli C, De S)
 * 2005, [Association of chronic fatigue syndrome with human leucocyte antigen class II alleles] (Smith J, Fritz EL, Jonathan Kerr)
 * 2010, Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26 (Fletcher MA, Zeng XR, Maher K)
 * 2012, Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis (Ekua W Brenu, Mieke L van Driel, Donald Staines, Kevin J Ashton, Sharni L Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra B Ramos, Sonya Marshall-Gradisnik)
 * 2014, Deficient EBV-specific B-and T-cell response in patients with chronic fatigue syndrome (Madlen Loebel, Kristin Strohschein, Carolin Giannini, Uwe Koelsch, Sandra Bauer, Cornelia Doebis, Sybill Thomas, Nadine Unterwalder, Volker von Baehr, Petra Reinke, Michael Knops, Leif G. Hanitsch, Christian Meisel, Hans-Dieter Volk, Carmen Scheibenbogen)

Metabolic

 * 2014, Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment (Betsy Keller, John Pryor, Ludovic Giloteaux)
 * 2012, "Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls", AT White, Alan Light, RW Hughen, TA Vanhaitsma, Kathleen Light.
 * 2009, "Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects", Alan Light, AT White, RW Hughen, Kathleen Light.

Neurological

 * 2007, Symptoms of autonomic dysfunction in chronic fatigue syndrome (Julia Newton, O Okonkwo, K Sutcliffe)

Psychological

 * 2011, The PACE trial (Peter White, KA Goldsmith, AL Johnson, L Potts, R Walwyn, JC DeCesare, HL Baber, M Burgess, LV Clark, DL Cox, Jessica Bavinton, BJ Angus, Gabrielle Murphy, M Murphy, H O'Dowd, D Wilks, P McCrone, Trudie Chalder, Michael Sharpe)