Hydroxyproline

Hydroxyproline is an amino acid and a major component of collagen. The formation of hydroxyproline is catalyzed via the enzyme procollagen-proline dioxygenase via a reaction that requires vitamin C.

High plasma hydroxyproline
Elevated plasma hydroxyproline is associated with increased risk of connective tissue injuries and metabolic bone diseases, e.g. osteoporosis.

ME/CFS
Elevated levels of hydroxyproline, a marker of collagen breakdown, was found by Wenzhong Xiao in the ME/CFS Severely Ill, Big Data Study. Robert Naviaux’s work has suggested it as a possible biomarker for female ME/CFS patients.

Learn more

 * Metabolic bone disease - Encyclopedia Britannica