Methylation cycle hypothesis

The methylation cycle hypothesis posits that a core component of the pathophysiology of chronic fatigue syndrome involves a partial block in the methylation cycle. An idea with origins in the autism community, its application to CFS was developed chiefly by biochemist Rich Van Konyenburg and discussed heavily on the discussion forum Phoenix Rising.

Evidence
There is little direct evidence to support the popular methylation protocols. However, numerous patients have reported benefit while others have reported no benefit.

Indirect evidence supporting a possible benefit of methylation cycle supplements include findings of increased homocysteine in the cerebrospinal fluid of CFS and fibromyalgia patients.