Discoidin Domain Receptor Tyrosine Kinase 1

Discoidin Domain Receptor Tyrosine Kinase 1 or DDR1 is a tyrosine kinase receptor.

Alternative names

 * RTK6
 * CD167
 * CD167 Antigen-Like Family Member A 3 4
 * Protein-Tyrosine Kinase RTK-6

Function
DDR1 is a tyrosine kinase receptor for collagen.

Diseases
Altered DDR function may be associated with:
 * Cancer, particularly familial breast cancer and cervix small cell carcinoma
 * Lymphangioleiomyomatosis (LAM)
 * Idiopathic pulmonary fibrosis
 * Meninges sarcoma
 * Tissue fibrosis

Drugs
Established DDR1 inhibitors, including:
 * imatinib, a kinase inhibitor
 * dasatinib
 * nilotinib

Drugs targetting DDR1 include:
 * fostamatinib, a kinase inhibitor (investigational)
 * pralsetinib (investigational)
 * ATP (investigational)
 * DDR1-IN-1