White matter

White matter refers to areas of the central nervous system (CNS) that are mainly made up of myelinated axons, through which messages pass.

Ehlers-Danlos Syndrome
In 2016, a study done in France with 59 EDS patients found 36 (61%) had lesions in the white matter of their brain, potentially indicative of physical trauma. If the physical trauma happened before age 18, patient had more lesions of the reticular formation. The study authors used their findings to theorize that physical trauma could bring an onset of EDS.