Notable studies

This page lists published ME/CFS studies that are notable, for particularly interesting findings, for controversial findings, or for their quality or their size.

Epidemiological

 * Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care (2011, Luis Nacul, Eliana Lacerda, Derek Pheby)
 * Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups (1996, Anthony Komaroff, Fagioli LR, Doolittle TH)
 * The prevalence of chronic fatigue syndrome/myalgic encephalomyelitis: a meta-analysis (2013, Samantha Johnston, Ekua Weba Brenu, Donald Staines, Sonya Marshall-Gradisnik
 * The burden of disease and injury in Australia 2003 (2007, Stephen Begg, Theo Vos)


 * Cairns R, Hotopf M. A systematic review describing the prognosis of chronic fatigue syndrome. Occup Med. 2005;55(1):20-31.
 * [6] Green C, Cowan P, Elk R, et al. National Institutes of Health Pathways to Prevention Workshop: Advancing the Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Ann Int Med. 2015;162(12);860.
 * [7] Clayton ER, Alegría M, Bateman L, et al. for the Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. 2015. https://www.iom.edu/Reports/2015/ME-CFS.aspx
 * [9] Bakken IJ, Tveito K, Gunnes N, et al. Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008–2012. BMC Med. 2014;12:167.
 * [10] Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. 2006;333:575.

Immunological

 * [8] Fluge Ø, Bruland O, Risa K, et al. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS One. 2011;6(10):e26358.
 * [11] Fuite J, Vernon, SD, Broderick G. Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis. Genomics. 2008;92(6):393-399.
 * [12] Vollmer-Conna U, Cameron B, Pavlovic D, et al. Postinfective fatigue syndrome is not associated with altered cytokine production. Clin Infect Dis. 2007;45(6); 732-735.
 * [12] Vollmer‐Conna U, Piraino B, Cameron B, et al. Cytokine Polymorphisms Have a Synergistic Effect on Severity of the Acute Sickness Response to Infection. Clinical Infectious Diseases. 2008;47(11):1418-1425.
 * [12b] Carlo‐Stella N, Badulli C, De S, et al. A first study of cytokine genomic polymorphisms in CFS: positive association of TNF‐857 and IFNgamma 874 rare alleles. Clin Exp Rheumatol 2006;24(2):179–182.
 * [13] Smith J, Fritz EL, Kerr JR, et al. Association of chronic fatigue syndrome with human leucocyte antigen class II alleles. Clin Pathol. 2005;58:(8):860-3.
 * [14] Fletcher MA, Zeng XR, Maher K, et al. Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26. PLoS One. 2010;5(5):e10817
 * [15] Brenu EW, van Driel ML, Staines DR, et al. Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med. 2012;10(1):88-90.
 * [16] Loebel M, Strohschein K, Giannini C, et al. Deficient EBV-specific B-and T-cell response in patients with chronic fatigue syndrome. PloS One. 2014;9(1):e85387.

Metabolic

 * [17] Keller BA, Pryor JL, Giloteaux L. Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment. J Transl Med. 2014;12:104.
 * [18] White A, Light A, Hughen R, et al. Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls. Psychosom Med. 2011;74(1):46-54.

Neurological

 * [19] Newton JL, Okonkwo O, Sutcliffe K, et al. Symptoms of autonomic dysfunction in chronic fatigue syndrome. QJM. 2007;100(8):519-26.

Psychological

 * PACE trial