Kynurenine

Kynurenine is an amino acid that is produced in the body by the metabolism of the essential amino acid tryptophan.

ME/CFS
The Open Medicine Foundation's ME/CFS Severely Ill, Big Data Study found that patients in the study group with severe ME had one of several defects involving the IDO2 gene, which affected tryptophan - kynurenine metabolism. This lead to the Metabolic Trap theory.

In May 2020, the Open Medicine Foundation announced a pilot treatment trial of kynurenine for ME/CFS.

Learn more

 * Kynurenine - PubChem
 * L-Kynurenine - PubChem