Cyclophosphamide

Cyclophosphamide is a chemotherapy and immunosuppressant drug. It is often used as an adjuvant drug with other chemotherapy medications especially for leukemia and lymphomas. (These cancers include Hodgkin’s and non-Hodgkin's lymphoma, Burkitt’s lymphoma, chronic lymphocytic leukemia (CLL), chronic myelocytic leukemia (CML), acute myelocytic leukemia (AML), acute lymphocytic leukemia (ALL), t-cell lymphoma (mycosis fungoides), multiple myeloma, neuroblastoma, retinoblastoma, rhabdomyosarcoma, Ewing's sarcoma; breast, testicular, endometrial, ovarian, and lung cancers, and in conditioning regimens for bone marrow transplantation.)

Norwegian Study - Cyclo/ME
There is no evidence for the use of the drug to treat ME/CFS.

A Norwegian group, led by the researchers, Dr. Øystein Fluge and Professor Olav Mella, who have been studying Rituximab use in ME/CFS, also ran a clinical trial, called CycloME. The trial tested the effects of cyclophosphamide on ME/CFS patients that have been non-responders to Rituximab.

Costs & availability
At present, only one clinical trial site, CycloME, is testing cyclophosphamide for use in ME/CFS.

Notable studies

 * Apr 2020, Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study - (Full text)

Learn more

 * Wikipedia - Cyclophosphamide
 * CycloME - Cyclophosphamide in ME/CFS