Channelopathy hypothesis

Abhijit Chaudhuri and Peter Behan proposed that chronic fatigue syndrome was an acquired neurological channelopathy illness, meaning that the symptoms are the result of '''ion channel transportation problems affecting the body's nervous system. The channelopathy hypothosis was first published in 1999.

Evidence
Ion transportation symptoms are recognized in the diagnostic criteria of the International Consensus Criteria.

Abhijit Chaudhuri and Peter Behan. https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1099-1077(199901)14:1%3C7::AID-HUP64%3E3.0.CO;2-O
 * 1999, Chronic fatigue syndrome is an acquired neurological channelopathy. Hum. Psychopharmacol Clin Exp. 14, 7-17.


 * 2000, The symptoms of chronic fatigue syndrome are related to abnormal ion channel function.

10.1054/mehy.1998.0822 https://www.researchgate.net/profile/Christian_Demanet/publication/234841733_Monitoring_a_hypothetical_channelopathy_in_Chronic_Fatigue_Syndrome_preliminary_observations/links/0deec526e1c79ac883000000/Monitoring-a-hypothetical-channelopathy-in-Chronic-Fatigue-Syndrome-preliminary-observations.pdf 2003, Monitoring a hypothetical channelopathy in Chronic Fatigue Syndrome: preliminary observations