Neil McGregor

Neil R. McGregor, BDS, MDSc, PhD is a periodontist with an interest in ME/CFS research stemming from treating ME/CFS patients with temporomandibular dysfunction syndrome. He is a senior researcher at the Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Australia and an Adjunct Professor at Victoria University, Melbourne, Australia. Dr. McGregor was a former co-editor of the Journal of Chronic Fatigue Syndrome.

Books

 * 2006, Pediatric Chronic Fatigue Syndrome by [[Kenny de Meirleir], Neil McGregor, and Elke L.S. Van Hoof]
 * Chapter Five - "Metabolism in Chronic Fatigue Syndrome" in the book, Advances in Clinical Chemistry.

Notable studies

 * 2017, The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome "Abstract - Introduction: The human gut microbiota has the ability to modulate host metabolism. Metabolic profiling of the microbiota and the host biofluids may determine associations significant of a host–microbe relationship. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term disorder of fatigue that is poorly understood, but has been linked to gut problems and altered microbiota. Objectives: Find changes in fecal microbiota and metabolites in ME/CFS and determine their association with blood serum and urine metabolites. Methods: A workflow was developed that correlates microbial counts with fecal, blood serum and urine metabolites quantitated by high-throughput ¹H NMR spectroscopy. The study consists of thirty-four females with ME/CFS (34.9 ± 1.8 SE years old) and twenty-five non-ME/CFS female (33.0 ± 1.6 SE years old). Results: The workflow was validated using the non-ME/CFS cohort where fecal short chain fatty acids (SCFA) were associated with serum and urine metabolites indicative of host metabolism changes enacted by SCFA. In the ME/CFS cohort a decrease in fecal lactate and an increase in fecal butyrate, isovalerate and valerate were observed along with an increase in Clostridium spp. and a decrease in Bacteroides spp. These differences were consistent with an increase in microbial fermentation of fiber and amino acids to produce SCFA in the gut of ME/CFS patients. Decreased fecal amino acids positively correlated with substrates of gluconeogenesis and purine synthesis in the serum of ME/CFS patients. Conclusion: Increased production of SCFA by microbial fermentation in the gut of ME/CFS patients may be associated with deleterious effects on the host energy metabolism
 * 2016, Widespread pain and altered renal function in ME/CFS patients
 * 2015, Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients
 * 2011, The Biochemistry of Chronic Pain and Fatigue
 * 2009, Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome
 * 2000, Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome

Online presence

 * LinkedIn
 * ResearchGate
 * PubMed
 * Twitter
 * Facebook
 * Website
 * YouTube

Learn more

 * Wikipedia
 * Institution
 * Meet the Scientists: Dr Neil McGregor