Acid sensing ion channel 3

Acid sensing ion channel 3 or ASIC3 receptors sense muscle metabolites.

Exercise
White et al. (2012) found a trend towards both increasing ASIC3 and increasing transient receptor potential vanilloid type 1 (TRPV1) in chronic fatigue syndrome patients 24hrs after moderate exercise, but both multiple sclerosis patients and healthy controls had decreases in ASIC3, purinergic 2X 4 receptor (P2X4), and TRPV1 at 30 min post-exercise, and decreases in purinergic 2X 5 receptor (P2X5) 8hrs after exercise. Healthy controls also had significant decreases in P2X5 at 30 min post-exercise.