Central nervous system fatigue

Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system, including the brain and spinal cord, which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function.

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 * Fatigue Explained? Japanese Assert Brain Damage Causes Fatigue in Chronic Fatigue Syndrome