Endothelial dysfunction

Endothelial dysfunction is a dysfunction in the endothelium, which is a thin layer that covers the inner surface of all blood vessels, separating the circulating blood from the tissues.

Symptom recognition
Endothelial dysfunction has only very recently been recognized within ME/CFS patients.

Notable studies

 * 2021, An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - (Full text)
 * 2021, Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome–Results From Open-Label Cyclophosphamide Intervention Study - (Full text)
 * 2021, Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - (Full text)
 * 2021, Persistent endotheliopathy in the pathogenesis of long COVID syndrome - (Full text)
 * 2020, Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability - (Full text)
 * 2020, Endothelial senescence and chronic fatigue syndrome, a COVID-19 based hypothesis - (Full text)
 * 2020, Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome - (Full text)
 * 2017, Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways - (Abstract)

Learn more

 * Endothelial dysfunction - Stanford healthcare