Osteoporosis

Osteoporosis, a condition where bones thin and weaken, usually in older adults, resulting in increase risk of bone fractures, especially stress fractures. The risk of developing osteoporosis is considered higher in people with ME/CFS.

A study in 2014, showed that patients without osteoporosis in the CFS cohort exhibited a 1.16-fold higher risk of fracture than did those in the non-CFS cohort. The researches concluded that although the cause remains unclear, CFS-related fracture might not be associated with osteoporosis.

Presentation
Fractures and their causative and repair mechanisms have been topics subject to various forms of investigation for several decades.

Potential treatments
Vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of signaling pathways. Therefore, it is suggested that vitamin C improves bone regeneration.

Notable studies

 * 2014, Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study - (Full text)


 * 2019, Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways


 * 2019, Will the Elderly Benefit from a Fruit and Vegetable Nutritional Program? The Case of Vitamin C and Bone Health

Learn more

 * Chronic Fatigue Syndrome and Osteoporosis
 * Osteoporosis - a long term complication of CFS
 * Bone remodeling