SAM-e

S-adenosylmethionine or SAME-e is an amino acid creates of methionine that is synthesized in the body that acts as the body's main methyl donor in many different metabolic reactions.

S-adenosylmethionine is available as a nutritional supplement and is also known as: and abbreviated as:
 * ADE-SD4
 * Ademetionine, *Adenosylmethionine
 * S-Adenosyl Methionine, S-Adenosyl-L-Methionine or S-Adenosylmethionine,
 * S-Adenosylmethionine Butanedisulfonate
 * S-Adenosylmethionine Tosylate, S-Adenosylmethionine Tosylate Disulfate,
 * SAMe or SAM-e,
 * Sammy or Samyr,
 * AdoMet, SAM-e or SAMe,

S-adenosylmethionine may become depleted with B-vitamin deficiency, chronic inflammation, and has been observed to decrease with age.

Theory
Low levels of SAMe have been found in people with liver disease and depression. It may also have a role in reducing pain or help reduce symptoms of osteoarthritis or other illnesses.

SAMe may help people with ME/CFS by restoring methyl donor levels, allowing methylation reactions to continue at a normal rate. If there is a deficiency of methyl donors in the central nervous system, SAMe supplementation might be expected to improve some brain function, or improve mood. Among many other synthetic reactions, SAMe aids in the synthesis of the neurotransmitters norepinephrine, dopamine, and serotonin.

Evidence
A small number of studies have been conducted in fibromyalgia patients which showed some positive effects when taking SAMe. The main positive effect has been described as a reduction in pain levels. However, Volkmann et al (2009) found no significant effect in a ten day trial of fibromyalgia patients.

Learn more

 * SAMe - drugs.com
 * S-Adenosyl-L-Methionine (SAMe): In Depth
 * SAM-e (S-adenosylmethionine, SAMe - WebMD