Virology blog

Virology blog is a science blog centered on viruses and viral disease by Vincent Racaniello, PhD. Professor Racaniello also hosts the TWiV podcast.

PACE trial
The PACE trial has been covered extensively by David Tuller and one article with Julie Rehmeyer.

A list of articles on the PACE trial can be found here. They can also be found on David Tuller's page.

David Tuller spoke at length and in detail on the PACE trial on the TWiV podcast: TWiV 397: Trial by Error. He called the PACE trial preposterous and a pack of nonsense, and a piece of crap. He discussed the FINE trial, The Lancet, British Medical Journal (BMJ) and PLOS ONE, patients being ill yet deconstructing the PACE Trial, how ME/CFS is a disease being treated inappropriately with Exercise, GET and CBT, touches on the Institute of Medicine report and SEID, Valerie Eliot Smith and Karina Hansen, and more.

Data release
This article has a link to the RAW DATA.

Trial By Error, Continued: The Real Data

By: David Tuller

"‘The PACE trial is a fraud.’ Ever since Virology Blog posted my 14,000-word investigation of the PACE trial last October, I’ve wanted to write that sentence. (I should point out that Dr. Racaniello has already called the PACE trial a “sham,” and I’ve already referred to it as “doggie-poo.” I’m not sure that “fraud” is any worse. Whatever word you use, the trial stinks.)

Let me be clear: I don’t mean “fraud” in the legal sense—I’m not a lawyer–but in the sense that it’s a deceptive and morally bankrupt piece of research. The investigators made dramatic changes from the methodology they outlined in their protocol, which allowed them to report purported “results” that were much, much better than those they would have been able to claim under their originally planned methods. Then they reported only the better-looking “results,” with no sensitivity analyses to analyze the impact of the changes—the standard statistical approach in such circumstances."

XMRV
XMRV was also covered here.