Vagus nerve infection hypothesis

The vagus nerve hypothesis proposes that the symptoms of Chronic Fatigue Syndrome are caused by an infection of the vagus nerve.

In 2013, Michael Van ElZakker, a postdoctoral researcher at Harvard Medical School, published the hypothesis.

The vagus nerve is responsible for the sickness response.

Van Elzakker believes that any infectious agent with an affinity for nerve tissues can cause a vagus nerve infection, including HHV-6, Epstein-Barr virus, Varicella zoster virus, chicken pox, certain kinds of enteroviruses and even borrelia, the bacterium that causes Lyme disease. He thinks this could explain why no single infective agent has been isolated as the cause of CFS, even though all of these agents have been associated with disease.

Notable studies

 * 2016, Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome

Learn more

 * 2016, Vagus Nerve infection hypothesis and the Driscoll Theory