Chronic Lyme disease

Chronic lyme disease is caused by the bacterium Borrelia burgdorferi and transmitted through black legged ticks.

Symptoms
The signs and symptoms of Lyme disease vary and usually appear in stages.

Early Signs and Symptoms
 * Bull's eye rash (Not always present.)
 * Flu-like symptoms

Later Signs and Symptoms
 * Erythema migrans
 * Neurological problems

Less Common Signs and Symptoms
 * Heart problems, such as irregular heartbeat.
 * Eye inflammation
 * Liver inflammation (hepatitis).
 * Severe fatigue

United States

 * CDC two-step process: EIA/IFA and Western Blot.
 * Other Tests - ELISA, PCR, LTT-MELISA.
 * Blood, Urine and Other Tests Not Recommended by CDC

Treatment & Management

 * Approach Considerations
 * Treatment of Early Lyme Disease
 * Post-Treatment Lyme Disease Syndrome (Chronic lyme disease)

Research
Ticks that transmit Lyme disease reported in nearly half of all US counties - Science Daily By: Entomological Society of America

Quirky Lyme disease bacteria: Unlike most organisms, they don't need iron, but crave manganese - Science Daily - Source: Woods Hole Oceanographic Institution

Researchers identify new Borrelia species that causes Lyme disease - Science Daily - Source: Mayo Clinic

Gene Signature Could Lead To A New Way Of Diagnosing Lyme - UCSF News Center - By: Laura Kurtzman

Pathobiome Paradigm
Some future research will focus on a spectrum of pathogens instead of a "one pathogen-one disease" vision.

Lyme Disease vs Chronic Fatigue Syndrome
Lyme Disease and Chronic Fatigue Syndrome are different diseases. Research is published on Cerebrospinal Fluid and distinct differences were found.

Osler's Web outlines historical outbreaks that do not correlate with a tick borne pathogen.