Hypothalamic-pituitary-adrenal axis

Hypothalamic-pituitary-adrenal axis (HPA axis)

Notable studies
La disociación de los ritmos circadianos podría deberse a la privación del sueño y a la desorganización social, y / o la reducción en la actividad física que típicamente acompaña al CFS. Por analogía con el desfase horario y el trabajo por turnos, la arritmia circadiana podría ser un factor importante para iniciar y perpetuar los síntomas cardinales del síndrome de fatiga crónica, especialmente cansancio, deterioro de la concentración y deterioro intelectual.
 * 2000, Chronic Fatigue Syndrome: A Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis "'Abstract - Chronic fatigue syndrome is a severe, often disabling disorder with prevalence as high as 422 cases per 100,000 in the United States. Aside from the adverse effects to patients' quality of life, sequela of the disorder include a negative impact on the economy as well as a burden on public health care costs. Some avenues of current research into the possible genesis of the syndrome are neurally mediated hypotension, viral pathogen, immunological disorders, lymphocyte enzyme system abnormalities, or a purely psychological root. This paper is a review of the literatures as to a neuroendocrinologic cause, namely dysfunction of the hypothalamic-pituitary-adrenal axis.'"
 * 1996, Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome