Muscle

In ME and CFS
Several of the key symptoms observed by Melvin Ramsay and a part of his Ramsay definition involved muscle including muscle fatigability along with muscle pain and clumsiness (ataxia). Patients also complain of muscle fasciculations.

Numerous abnormalities have been found in the skeletal muscle of Myalgic Encephalomyelitis patients including:


 * mitochondrial abnormalities found via muscle biopsy including: mitochondrial degeneration, deletions of mitochondrial DNA , the reduction of mitochondrial activity
 * Increased urinary creatine excretion during relapses
 * Increased creatine kinase (postviral fatigue syndrome)
 * Persistence of enteroviruses in muscle tissue