Post-exertional symptom exacerbation

Post-exertional symptom exacerbation or PESE is a significant increase in ME/CFS symptoms.

Definitions
Post-exertional symptom exacerbation is defined in a number of different ways:
 * The International Consensus Criteria (2011) refer to PESE as one of several required symptoms of post-exertional neuroimmune exhaustion (PENE)
 * The UK's NICE ME/CFS diagnostic criteria 2021 (NG206) refer to it as an alternative name for post-exertional malaise (PEM).