Neuroimmune disease

Neuroimmune disease (disorder, syndrome, or condition) is an umbrella term for a group of certain diseases involving dysfunction of both the immune system and the nervous system. It is not one of the World Health Organization's (WHO) ICD-10 classifications of disease, but is used to refer to neurological diseases which are also recognized as immune or autoimmune diseases.

Neuroimmune disorders
Disorders Commonly Found In Adults:
 * Systemic lupus erythematosus
 * Multiple Sclerosis
 * Amyotrophic lateral sclerosis (ALS or Motor Neuron Disease)
 * Guillain-Barré syndrome
 * Myasthenia gravis
 * Neuromyelitis optica (NMO)

Potential neuroimmune disorders
These disorders have considerable evidence of a neuroimmune disease process, but are not widely accepted as neuroimmune conditions.

Two neuroimmune research units, one in Queensland, Australia and one in Florida, US, focus prominently on research into ME/CFS and multiple sclerosis.
 * Myalgic encephalomyelitis and Chronic fatigue syndrome
 * Gulf War Illness

Diseases which may have neuroimmune symptoms
A wide range of diseases have been proposed as neuroimmune diseases, but evidence is limited and most of those conditions are not recognized as having prominent immune symptoms or are not currently classed as neurological diseases.

Immune symptoms in ME/CFS
ME/CFS is classified as a neurological disorder by the World Health Organization, and the Canadian Consensus Criteria recognizes a range of immune symptoms, which are used in diagnosis. The more commonly used Fukuda criteria for chronic fatigue syndrome does not require any immune symptoms for diagnosis, but both swollen lymph nodes and frequent sore throat are diagnostic symptoms.

Learn more

 * Institute for Neuro-Immune Medicine
 * National Centre for Neuroimmunology and Emerging Diseases
 * Neuroimmune Syndromes (NeuroSensory Centers of America)
 * Immune system diseases - National Institute of Health