Acetylcholinesterase

Aceytlcholinesterase inhibitors inhibit the acetylcholinesterase enzyme from breaking down acetylcholine, resulting in higher circulating levels of the neurotransmitter.

They are used to treat myasthenia gravis and postural orthostatic tachycardia.

Examples of inhibitors
Compounds which function as reversible competitive or noncompetitive inhibitors of cholinesterase are those most likely to have therapeutic uses. These include:


 * Some organophosphates not listed under "Irreversible" below
 * Carbamates
 * Physostigmine
 * Neostigmine
 * Pyridostigmine
 * Ambenonium
 * Demecarium
 * Rivastigmine
 * Phenanthrene derivatives
 * Galantamine
 * Caffeine – noncompetitive (also an Adenosine receptor antagonist)
 * Rosmarinic acid - ester of Caffeic acid. Found in plants species of Lamiaceae family.
 * Alpha-Pinene - noncompetitive reversible
 * Piperidines
 * Donepezil
 * Tacrine, also known as tetrahydroaminoacridine (THA')
 * Edrophonium
 * Huperzine A
 * Ladostigil
 * Ungeremine
 * Lactucopicrin