Talk:Cytokine storm

references -- ~Njt (talk) 18:09, April 20, 2020 (PDT)
"Exuberant immune responses induced following infection have been described as a “cytokine storm,” associated with excessive levels of proinflammatory cytokines and widespread tissue damage." - Guo and Thomas (2017) PMC5580809

"The term "cytokine storm” to describe an immune response to influenza infection was first used in late 2003 in reference to influenza-associated encephalopathy [3] [4]. Thus far, the influenza-induced cytokine storm has been linked to uncontrolled proinflammatory responses, which induce significant immunopathology and severe disease outcomes [5] [6] [7] [8]." - Guo and Thomas (2017) PMC5580809

Term first used in 2003 - Yokota (2003) in Japanese

"The term 'cytokine storm' is now used in popular culture as an explanation for the distinctly unpleasant feeling we all sense at the onset of flu. The expression certainly has common currency, with 21 000 Google hits 12 months ago and 55 000 at the time of writing this article. The two-part Special Feature in the January and February issues of Immunology and Cell Biology acknowledges that the sense of this term, with the added complexity of knowing that the mediators involved are also necessary, at lower concentrations, for innate immunity to function, has finally come of age. While the articles on HIV, hepatitis, flaviviruses, tuberculosis, toxoplasmosis, shigellosis, schistosomiasis and visceral leishmaniasis essentially concern local pathological events from these cytokines, those on poxviruses, dengue, influenza and malaria describe variants of the consequences of a systemic response. Salmonella, because of its range of serovars, has a foot in each camp. The interesting omission is sepsis. Research into this condition has never managed to gain a foothold in some countries, despite it being the major cause of death in intensive care units in all first world countries and a part of the cytokine storm literature since 1981." - Clark (2007) doi: 10.1038/sj.icb.7100062


 * See also: link

~Njt (talk) 18:09, April 20, 2020 (PDT)