Succinate dehydrogenase

Succinate dehydrogenase (SDH) is an enzyme involved in the Krebs cycle. It oxidizes succinate to fumarate. It is also known as succinate-coenzyme Q reductase or respiratory Complex II.

A small study of chronic fatigue syndrome patients found an inversion of the cytochrome oxidase/succinate dehydrogenase ratio in muscle biopses.

A study of poliovirus found that polio infection rapidly decreases cellular oxygen consumption (and thus energy production through cellular respiration) by inhibiting succinate dehydrogenase and blocking mitochondrial electron transport.