Tricyclic antidepressant

Tricyclic antidepressants are a class of antidepressants named for their three-ringed chemical structure. They are effective for treatment of depression but are less commonly used now that alternatives with fewer side effects exist. However they remain a good option if those treatments are not effective in a given case.

Approved tricyclics
As of June 2016, the FDA has approved the following tricyclic antidepressants to treat depression:
 * Amitriptyline
 * Amoxapine
 * Desipramine (Norpramin)
 * Doxepin
 * Imipramine (Tofranil)
 * Nortriptyline (Pamelor)
 * Protriptyline (Vivactil)
 * Trimipramine (Surmontil)

Use in ME
Tricyclic antidepressants such as amitriptyline or clomipramine are commonly used in ME/CFS to treat chronic pain and to aid regular sleep.