Osteoporosis

Osteoporosis, a condition where bones thin and weaken, usually in older adults, resulting in increase risk of bone fractures, especially stress fractures. The risk of developing osteoporosis is considered higher in people with ME/CFS.

A study in 2014, showed that patients without osteoporosis in the CFS cohort exhibited a 1.16-fold higher risk of fracture than did those in the non-CFS cohort. The researches concluded that although the cause remains unclear, CFS-related fracture might not be associated with osteoporosis.

Potential treatments
This study is the first to show that vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of wingless-type MMTV integration site family/β-catenin/activating transcription factor 4 signaling, which is achieved through the serine/threonine kinase and mitogen-activated protein kinase signaling pathways. Therefore, our results suggest that vitamin C improves bone regeneration.

Notable studies

 * 2014, Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study - (Full text)

Learn more

 * Chronic Fatigue Syndrome and Osteoporosis
 * Osteoporosis - a long term complication of CFS