File:Genetics ME-CFS-Perez-Klimas-2019.jpg

Title: (or description)
Functional analysis of SNPs identified three main clusters of pathways as sharing at least 30% SNP related genes.
 * Immune-related SNPs: Cytokine Signaling in Immune System pathway; includes other immune-related pathways such as interferon signaling, autoimmune responses, and T-cell receptor signaling.
 * Hormone-related SNPs: Nuclear-Receptors Meta-Pathway and includes hormone related pathways such as steroid hormone, estrogen, and androgen biosynthesis, glucuronidation, and the pregnane x receptor pathway.
 * Metabolism-related SNPs: Pathways in Cancer, however, closer inspection shows many metabolic processes such as enzyme reactions (protein kinase A, calcium and calmodulin signaling), and G proteins signaling which regulate metabolic enzymes, which are all involved in the regulation of glycogen, sugar and lipid metabolism.

Author: (or citation)
Perez M, Juandoo R, Hilton K, Del Alamo A, Gemayel K, Klimas NG, Craddock TJA, Nathanson L (2019). Front. Pediatr. 7(206). doi: 10.3389/fped.2019.00206

Source: (e.g. internet address)
Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study Figure 1.

Other information:
Pathway overlap networks in ME/CFS. Pathways identified via over-representation analysis (nodes) connected by shared genes with SNPs (edges). Upper panel gives total number of SNPs per pathway and likelihood of annotation (p-value). Lower panel shows pathways most affected by deleterious SNPs.