Kindling hypothesis

The Kindling hypothesis attempts to explain the hypersensitivities to pain, sensory input, and the immune system responses found in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Kindling "occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus resulting in hypersensitivity and spontaneous seizure-like activity."

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 * An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Full text)