Intranasal mechanical stimulation

Intranasal mechanical stimulation or INMEST is a method of stimulating the vagus nerve from inside the nose.

Evidence in ME/CFS
A small placebo-controlled randomized clinical trial by Rodriguez et al. (2020) of moderate and severe patients with ME/CFS found that a 30% reduction in symptoms was achieved after 8 weeks of INMEST treatment; however the fatigue level of patients did not change. The trial used patients who fulfilled the Canadian Consensus Criteria. Dr Jan-Erik Juto, one of the authors of Rodriguez et al. (2020), is a co-founder and stakeholder of Albilion Medical Systems AB, who developed INMEST.

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 * Intranasal Mechanical Stimulation - Albilion Medical Systems AB