Trazodone

Trazodone is an antidepressant drug that has also been marketed under the brand names Desyrel, Oleptro, and Trialodine. It belongs to the serotonin modulator class of antidepressants.

There is virtually no evidence for the use of Trazodone to treat ME/CFS. In 2012 Solve ME/CFS Initiative contracted Biovista to use drug models to identify existing drugs that may be worth investigating for treatment. The results suggested Trazodone was worth considering.

Notable studies

 * 2008, Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome
 * 2010, Trazodone for the treatment of fibromyalgia: an open-label, 12-week study
 * 2011, Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study

Media coverage

 * Low Dose Naltrexone Drug Combination Proposed for Chronic Fatigue Syndrome (ME/CFS)

Learn more

 * Wikipedia - Trazodone