Microglia



Microglia are a type of glial cell located in the brain and spinal cord. They are the resident macrophages of the central nervous system scavenging dead or damaged cells or encircling them when the brain is injured or infected. They are more abundant in grey matter than white.

Chronic fatigue syndrome
Chronic inflammation of microglia has been found in ME/CFS patients.

Valcyte (valganciclovir), a drug commonly used as an off-label treatment for ME/CFS and Cytovene (ganciclovir) inhibit microglial activation. Low-dose naltrexone (LDN, another off-label treatment) inhibits microglial activation via the TLR4 receptor.

Notable studies

 * 2015, Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

Learn more

 * Cell Motility of Microglia Cultured in TIC by Cell Press via YouTube
 * Depletion of microglia and inhibition of exosome synthesis halt tau propagation by Research Square via YouTube
 * 2-Minute Neuroscience: Glial Cells by Neuroscientifically Challenged via YouTube
 * February 21, 2018 - Microglia in Fibromyalgia and Chronic Fatigue Syndrome by Adrienne Dellwo for Very Well Health