Bupropion

Bupropion is an antidepressant medication sold under the brand names Wellbutrin, Aplenzin, and Zyban, and formerly Budeprion. In addition to treating depression, it is also used to treat seasonal affective disorder (SAD). As a norepinephrine-dopamine reuptake inhibitor (NDRI), it has a modest energizing effect and therefore may be useful for symptom management in ME patients. However, like all antidepressants, it does not address the underlying mechanisms of ME, so it must be used with caution. It should be used only to improve quality of life of an ME patient, rather than to increase functionality.

ME patients may tolerate brand name bupropion better than generic versions due to sensitivities.