Mast cell activation syndrome

Mast cell activation disorder (MCAD) is a disorder where mast cells are normal in number but over-responsive to dietary and environmental triggers. Cells release excess histamine and other signaling molecules, causing symptoms.

Comorbidities
It is often found in patients with Ehlers-Danlos syndrome (EDS) and postural orthostatic tachycardia syndrome (POTS), a form of orthostatic intolerance.

It has been implicated in many other immunological diseases including autism, fibromyalgia, and chronic lyme disease.

Treatment
Over the counter antihistamines are a common treatment for MCAD. Some patients also use herbal antihistamines and supplements such as quercetin and diamine oxidase (DAO), an enzyme normally produced by the body that breaks down histamine. Vitamin C, which reduces blood histamine levels, may also be helpful along with magnesium, a cofactor for producing DAO.

Sauna may also be helpful. There is some evidence it may be useful in uritica, an autoimmune disease that involves the production of excess histamine.

Triggers
Stress, many foods and environmental allergens can trigger mast cell degranulation.

Food triggers
There are many food lists detailing common triggers but individual reactions will vary. Some individuals will react to all foods while others only some.

Some common good triggers include red wine, strawberries, raspberries, cherries, spinach, and leftovers (especially fish and meat).

Environmental triggers
Mold, air pollution, and car exhaust are common environmental triggers.

Learn more

 * Low Histamine Chef (Blog)
 * Mast cell activation syndrome, Wikipedia