Tubulin polymerization promoting protein

Tubulin Polymerization Promoting Protein or TPPP is a protein-encoding gene that may be associated with ME/CFS. The TPPP protein is expressed in the brain. TPPP is expressed in the brain.

ME/CFS
The largest genetic study of ME/CFS patients was published by Hajdarevic et al. in 2022; and analysed data from over 2,500 patients from the UK Biobank, Norway and Denmark, reported they "did not find any ME/CFS risk loci displaying genome-wide significance". The study did find that the Tubulin Polymerization Promoting Protein (TPPP) region may be implicated in ME/CFS.

Notable studies

 * 2022, Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci - (Full text)