File:MECFS-neuroeffects-brain.jpg

Title: (or description)
Key neurological pathomechanisms in ME/CFS are intracranial hypertension, impaired cerebral blood flow, Hyperventilation/hypocapnia, and adrenergic hyperactivity.

Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig. 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia.

Author: (or citation)

 * 2021, An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome