Autoimmune hypothesis

Theory
The Open Medicine Foundation, with immunologist Mark Davis, and geneticist Lars Steinmetz, is currently investigating the replication of T cells in ME, which may indicate an autoimmune disease is present in some ME/CFS patients.

Published Studies

 * 2018, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease


 * 2014, The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
 * 2013, In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation
 * 2012, Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
 * 2004, Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry? - Donald Staines

Talks & Interviews

 * 2015, Partnerships to Accelerate Biomarker and Mechanisms Discovery in ME/CFS and Fibromyalgia - Professor Alan Light discusses recent studies hypothesising autoimmune causation)

Learn more

 * T-cells, molecular Immunology and autoimmune hypothesis - Open Medicine Foundation