Indoleamine-2,3-dioxygenase

Indoleamine-2,3-dioxygenase or indolamine-2,3-dioxygenase or IDO is an enzyme involved in the human body's metabolism of the essential amino acid tryptophan.

The IDO enzyme degrades (converts) tryptophan into kynurenine, and this process is strongly linked to the IDO1 and IDO2 genes.

Notable studies and publications

 * 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS (Full text)

Learn more

 * 2020, IDO and Kynurenine Metabolites in Peripheral and CNS Disorders (Full text)
 * 2018, Indoleamine 2, 3-dioxygenase regulation of immune response (Review) (Full text)