Savella

Savella or milnacipran (generic drug name) is an antidepressant that is also licensed for use to treat fibromyalgia in adults. No studies have been carried out on the effectiveness of Savella in ME/CFS patients, although off-label use of psychiatric medications in ME/CFS has generally been ineffective.

Evidence
Savella is an FDA-approved drug for adults with fibromyalgia, with improvements in pain, sleep and more limited improvements in fatigue.

No clinical trials have been done for Savella/milnacipran in ME/CFS.

Costs and availability
Perscription only drug.

Notable studies

 * 2011, Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis - (Full text)


 * 2014, Milnacipran versus other antidepressive agents for depression - (Full text)


 * 2014, Effects of milnacipran on the multidimensional aspects of fatigue and the relationship of fatigue to pain and function: pooled analysis of 3 fibromyalgia trials - (Full text)


 * 2015, Milnacipran for pain in fibromyalgia in adults - (Full text)


 * 2015, Preliminary experience using milnacipran in patients with juvenile fibromyalgia: lessons from a clinical trial program - (Full text)


 * 2016, The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study - (Full text)


 * 2018, Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study - (Full text)


 * 2018, Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia - (Full text)

Learn more

 * Savella - drugs.com