File:Gram-negative-TRPV4response.jpg

Summary
Gram-negative bacteria leading to LPS response and TRPV4 channel activation.

Description: Acute responses in epithelial cells after activation of TRPV4 by LPS. LPS shed by gram-negative bacteria during colonization near the epithelial surface activates TRPV4 channels expressed in ciliated epithelial cells, leading to a Ca2+ influx that triggers acute cellular responses such as the production of bactericidal nitric oxide and increased ciliary beat frequency. NO, nitric oxide; CBF, ciliary beat frequency.

Author: Boonen et al (2018. Citation: Toxins 2018, 10(8), 326; https://doi.org/10.3390/toxins10080326 Source: TRP Channels as Sensors of Bacterial Endotoxins Fig 3 https://www.mdpi.com/2072-6651/10/8/326