Leptin

Leptin is a hormone involved in energy expenditure. Blood leptin levels vary exponentially with body fat mass (not linearly). Higher leptin levels are correlated with higher levels of inflammation.

Purpose
Leptin is primarily produced in the adipocytes of white adipose (fat) tissue. It helps to regulate energy balance by inhibiting feelings of hunger.

In M.E.
Two studies found correlation between leptin levels and symptom severity. Another study found raised leptin levels in patients. Several other studies have been published on leptin in ME and CFS.

Australian researcher Michael Musker is undertaking a study entitled "Chronic fatigue syndrome: Leptin, interleukin 6 and clinical symptoms".

Learn more

 * 2014, Phoenix Rising - Leptin
 * 2015, Getting “Younger”: Leptin, Chronic Fatigue Syndrome and Fibromyalgia
 * 2015, Pandora Research Report: Jarred Younger - Leptin in the Role of Neuroinflammation, Pain and Fatigue (Jarred Younger)
 * 2015, Leveraging Leptin - Dr Courtney Craig
 * 2016 Self Hacked Interview
 * 2016, The Fatigue and Pain Hormone? Leptin Shows Up Again – in Fibromyalgia
 * 2016, All About Leptin: Its Role in Chronic Inflammation, CFS and Weight
 * 2017, Researchers identify biomarkers associated with chronic fatigue syndrome severity