Indoleamine-2,3-dioxygenase 2

Indoleamine-2,3-dioxygenase 2 is more commonly known as IDO2 is an enzyme in the kynurenine pathway involved in the metabolism of the essential amino acid tryptophan. The gene encoding IDO2, also known as IDOL1, is also sometimes referred to as IDO2.

ME/CFS
The ME/CFS Severely Ill Big Data Project analyzed genes of 20 patients who were severely ill with ME and CFS, and identified several different genetic defects in the genes encoding the IDO2 enzyme.

Notable studies and publications

 * 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS (Full text)

Learn more

 * IDO2 - National Center for Biotechnology Information