Citric acid cycle

Citric acid cycle

Simply put, the Citric acid cycle/Krebs cycle/TCA cycle is a series of enzyme-catalyzed chemical reactions that form a key part of aerobic respiration in cells. This work takes place inside the mitochondria.

A recent paper started to define how and why people with ME (pwME) have poorly functioning cellular respiration while a review of published papers added empirical evidence of a relationship between mitochondrial dysfunction and fatigue.

According to Ron Davis, speaking at the 2016 IACFS/ME conference, ""ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."

Learn more

 * Wikipedia - Citric acid cycle
 * Krebs / citric acid cycle | Cellular respiration | tricarboxylic acid cycle| Biology | Khan Academy