Quetiapine

Quetiapine, also known under the brand name Seroquel, is an atypical antipsychotic drug which is sometimes used off-label at lower doses to treat insomnia. Quetiapine is also a dopamine serotonin antagonist.

Quetiapine may be used for Schizophrenia, Bipolar disorder (manic depression), or, when combined with an antidepressant, to treat depression.

ME/CFS and Fibromyalgia
It is a sedating drug sometimes used for off-label for insomnia, including in patients with Fibromyalgia.

Evidence
There are no clinical trials for the use of quetiapine in patients with chronic fatigue syndrome or fibromyalgia. There have been several small clinical trials of 25mg of quetiapine in patients with insomnia, with mixed results.

The International Consensus Criteria primer advises against the use of quetiapine in overweight patients with myalgic encephalomyelitis.

Notable studies

 * 2012, The role of Antipsychotics in the Management of Fibromyalgia - (Abstract)

Learn more

 * British Association for Psychopharmacology consensus statement on evldence-based treatment of insomnia, parasomnias and cicadian rhythm disorders: An update