Martin Pall

Martin L. Pall, PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A. He states that he developed Chronic Fatigue Syndrome (CFS) from a varicella zoster virus infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.

Dr. Pall was one of the authors of the 2011 case definition, the International Consensus Criteria.

Education

 * 1962 - B.A., Johns Hopkins University, Baltimore, MD
 * 1968 - Ph.D., California Institute of Technology, Pasadena, CA

NO/ONOO-cycle
Dr. Pall developed the Nitric Oxide Cycle Theory, also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), Multiple Chemical Sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.

He believes that certain over-the-counter supplements, such as fish oil, CoQ10, vitamin E, NAC (N-acetylcysteine), magnesium, and other antioxidants, can help downregulate the oxidation caused by the nitric oxide cycle. He believes Vitamin B12 injections can also be a potent nitric oxide scavenger.

Book

 * 2007, Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome

Articles

 * 2007, Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD
 * 2009, Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS
 * 2010, How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others" by Martin Pall in Townsend Letter

Talks and interviews

 * 2007, "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol"
 * 2007, Speaker at the 2nd Invest in ME International ME Conference - Biochemical Underpinnings of ME/CFS - (Video)
 * 2014, Martin Pall explains "Unexplained Illnesses" (English with French subtitles)

Publications on ME/CFS

 * 2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome - (Abstract)
 * Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation - (Abstract)
 * 2000, Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger - (Abstract)
 * 2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite - (Full text)
 * 2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder - (Abstract)
 * 2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients - (Abstract)
 * 2002, Chronic fatigue syndrome/myalgic encephalitis - (Full access)
 * 2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients - (Abstract)
 * 2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due - (Abstract)
 * 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease - (Abstract)
 * 2011, Myalgic encephalomyelitis: International Consensus Criteria - (Full text)


 * 2011, Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue? - (Abstract)

Online presence

 * ResearchGate