Coxsackievirus B3

In mouse models, Ampligen was found to be protective of Coxsackie B3-induced myocarditis.

Selenium deficiency increases the virulence of Coxsackie B3 infections in a mouse model.

Coxsackievirus B3 cleaves Mitochondrial Antiviral Signaling (MAVS) protein to inhibit type I interferon induction. Conversely, upregulation of MAVS inhibits coxsackie B3 by increasing type-1 interferon production.