Basal ganglia

Basal ganglia are a set of structures in the brain regulated by dopamine that play a role in action selection, voluntary movements and executive function, as well as perception of effort.

ME/CFS
A small study of chronic fatigue syndrome patients found increased choline in the basal ganglia. Increased choline can be a sign of immune activation or increased cell membrane turnover.

Notable studies

 * 2014, Decreased Basal Ganglia Activation in Subjects with Chronic Fatigue Syndrome: Association with Symptoms of Fatigue (Full text)
 * 2003, Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome (Full text)