Post-exertional malaise

Post-exertional malaise (PEM) is a worsening of many ME/CFS symptoms as a result of physical or mental exertion. It is often referred to as "the marker" by patients, ME/CFS organizatons, and clinicians and researchers that work in the ME/CFS field.

Notable studies

 * Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression, Meyer et al, 2013
 * Myalgic Encephalomyelitis: Symptoms and Biomarkers, Jason et al, 2015
 * Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Shukla et al, 2015

Notable articles

 * Suggestion to replace PEM (Post Exertional Malaise) with PAR (Post Activity Relapse), ME Blogg, 2015

Talks & interviews

 * Post-Exertion Malaise: The Intersection of Biology and Behavior, Dane Cook, Solve ME/CFS, 2015

Learn more

 * Post-Exertional Malaise in Chronic Fatigue Syndrome, Jennie Spotila, Solve ME/CFS, 2010
 * Post-Exertional Malaise: Cause and Effect, Jennie Spotila, Solve ME/CFS, 2012
 * Definition of Post-Exertional Malaise, About Health, 2015