Tryptase alpha/beta 1

Tryptase alpha/beta 1 or TPSAB1 is a protein-encoding gene for tryptase.

Hereditary alpha tryptasemia syndrome
Extra copies of the TPSAB1 gene is known as familial hypertryptasemia (FHT) or hereditary alpha tryptasemia (H⍺T or HAT) and is one of several possible causes for increased tryptase production. HAT is common and often does not cause illness.

Hereditary alpha tryptasemia syndrome (HATS) is a recently discovered multi-systemic illness involving an increased number of TPSAB1 genes with a cluster of symptoms similar to those found in MCAS.

Other symptoms and diseases
The TPSAB1 has also been implicated in pruritus, medically unexplained (functional) gastrointestinal symptoms and in.

Learn more

 * TPSAB1 Gene - Gene cards
 * Hereditary Alpha Tryptasemia Syndrome FAQ - National Institute of Allergy and Infectious Diseases