Cinnarizine

Cinnarizine is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group.

Potential uses
Cinnarizine is typically used for vertigo/Ménière's disease, vestibular conditions, tinnitus, nystagmus, motion sickness, nausea and vomiting. Cinnarizine relaxes the blood vessels; when used together with a nootropic, such as piracetam, it improves blood flow to the brain.

Pharmacodynamics
Cinnarizine has also known to have antiserotoninergic and antidopaminergic effects. Cinnarizine blocks muscarinic acetylcholine receptors, meaning it acts against vomiting.

The half-maximal inhibitory concentration of cinnarizine for smooth muscle contraction inhibition is 60mM.

Costs and availability
It is not available in the United States or Canada.

Learn more

 * Cinnarizine - DrugBank Online