Genetics of chronic fatigue syndrome

Chronic fatigue syndrome
There have been few studies of genetic factors in chronic fatigue syndrome.

A 2011 study by F. Albright, K. Light, A. Light, L. Bateman, and L. Cannon-Albright showed evidence of a heritable contribution to CFS. Using the extensive records of the Utah Population Database (UPDB), the study "shows clear evidence of significant excess familial clustering and significantly elevated risks for CFS among first, second, and third degree relatives of CFS cases. The results strongly support a genetic contribution to predisposition to CFS as it is currently defined and diagnosed by clinicians in Utah." Increased outbreak rates in first degree relatives are not automatically assumed to be genetic because the first degree relatives often share the same lifestyle and environment. However, a significantly increased incidence (95% confidence interval) in second and third degree relatives strongly indicated a genetic contribution to CFS, given the much lower likelihood of these relatives sharing common risks and environments. A 2001 study in the UK showed "there were significantly higher rates of CFS in the relatives of CFS cases compared with the relatives of control subjects." Three twin studies (one in Australia, one in Washington, US, both in 2001, and one in the UK in 2007) showed that the correlations for prolonged and chronic fatigue were significantly higher in monozygotic than dizygotic twins for each definition of chronic fatigue syndrome.

One study showed that patients with mitochondrial DNA from certain haplogroups correlated with variations in gastrointestinal, neurological, and inflammatory symptoms.

Notable Studies

 * 2016, Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome (Schlauch KA, Khaiboullina SF, Kenny de Meirleir, Rawat S, Petereit J, Rizvanov AA, Blatt N, Mijatovic T, Kulick D, Palotás A, Vincent Lombardi). The study was criticised by George Davey Smith who said "surprised it was published with no replication sample or adequate details of controls".
 * 2016, Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (Maureen Hanson, January 20). See also Mitochondrial DNA and ME/CFS - A Guide to the Hanson Lab's 2016 JTM Publication.

Media Coverage

 * 2016, Genome-wide associations
 * 2016, New study found SNPs for some symptoms (CFS Remission, January 23)