Nitric oxide hypothesis

The NO/ONOO J cycle (pronounced no/oh no) is also known as the nitric oxide hypothesis, and was developed by Dr Martin Pall.

Theory
Dr Martin L. Pall states: "I propose here a novel hypothesis of CFS in which either viral or bacterial infection induces one or more cytokines, IL-1beta IL-6, TNF-alpha and IFN-gamma. These induce nitric oxide synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with superoxide radicals to generate the potent oxidant peroxynitrite. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."

Learn more

 * How Can We Cure NO/ONOO− Cycle Diseases?, Martin L. Pall, 2010
 * Nitric oxide and its possible implication in ME/CFS (Part 1 of 2), Phoenix Rising, August 25, 2014
 * Nitric oxide and its possible implication in ME/CFS (Part 2 of 2), Phoenix Rising, August 28, 2014
 * Nitric oxide - Encyclopaedia of Neuroscience
 * Fluge/Mella Take out Patent on Nitric Oxide Treatment for ME/CFS, Health Rising, 31 Jul 2015