Cold shock protein

Cold shock proteins (CSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions, in particular cold. Cold shock proteins include RNA binding motif 3 (RBM3)

RNA binding motif 3 (RBM3)
RBM3 may improve neurological health. In rodents, it has been linked linked to the regeneration of synapses https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338605/ https://www.ncbi.nlm.nih.gov/pubmed/27364162. In a mouse model of Alzheimer's disease and prion disease, cooling induced upregulation of RBM3 and resulted in delayed on-set of diseases and prolonged survial.

In human subjects, upregulation of RBM3 was correlated with better prognosis in gastric https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747149/ and colon https://www.ncbi.nlm.nih.gov/pubmed/28373441 cancer.