Martin Pall

Martine Pall, PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.

Dr. Pall developed the Nitric Oxide Cycle Theory, also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), Multiple Chemical Sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.

He believes that certain over-the-counter supplements, such as fish oil, CoQ10, vitamin E, NAC (N-acetylcysteine), and other anti-oxidants, can help downregulate the oxidation caused by the nitric oxide cycle. He believes Vitamin B12 injections can also be a potent nitric oxide scavenger.

Dr. Pall was one of the authors of the International Consensus Criteria.

Articles

 * 2009 Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS
 * 2007 Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD''

Talks and Interviews

 * 2007 Speaker at the 2nd Invest in ME International ME Conference - Biochemical Underpinnings of ME/CFS - DVD available

Publications on ME/CFS

 * 2011, Myalgic encephalomyelitis: International Consensus Criteria.
 * 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease.
 * 2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due.
 * 2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.
 * 2002, Chronic fatigue syndrome/myalgic encephalitis.
 * 2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.
 * 2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.
 * 2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome.