Byron Hyde



Dr. Bryon Hyde is a family practice physician in Ottawa, Canada, who has dedicated his practice solely to ME/CFS since 1984. In 1988, he founded the Nightingale Research Foundation, which is committed to exploring and understanding Myalgic Encephalomyelitis and Chronic Fatigue Syndrome (M.E. and CFS) and fibromyalgia-type illnesses.

Notable studies

 * 2003, Clinical Improvement in Chronic Fatigue Syndrome Is Associated with Enhanced Natural Killer Cell-Mediated Cytotoxicity: The Results of a Pilot Study with Isoprinosine®"'Abstract - Chronic fatigue syndrome is associated with systemic and cognitive symptoms and with several immune abnormalities. The clinical impact of Isoprinosine® was evaluated in sixteen CFS patients, followed for 28 weeks in a single-blind, placebo controlled trial. Patients were also monitored for various immune parameters. Improvement based on clinical staging was observed in six of ten treated patients (60%). Clinically improved patients showed significantly enhanced natural killer (NK) cell activity, which correlated with the duration of Isoprinosine treatment (p >0.03). Treatment with Isoprinosine resulted in significantly increased numbers of CD4+ T helper cells (p >0.03). Treatment with Isoprinosine for 12 weeks did not appreciably influence the in vitro production of IFN-y, IL-1oc, IL-10 or IL-12. However, IL-12 was significantly increased at week 28 (p >0.02) in patients who improved after treatment with Isoprinosine. These results suggest that taking Isoprinosine may benefit a subgroup of patients with CFS, and this clinical improvement is associated with enhanced NK cell function and IL-12 levels. Further trials to evaluate the use of Isoprinosine in the treatment of CFS patients are warranted.'"

Clinic location

 * Nightingale Research Foundation
 * 121 Iona Street, Ottawa Ontario K1Y 3M1, Canada
 * info@nightingale.ca

Talks & interviews

 * 2016 ME/cvs Vereniging Wetenschap voor Patienten / Science for Patients on YouTube (English with Dutch subtitles)
 * 82. ‪Introduction / Introductie - Dr. Byron Hyde‬, MD
 * 83. Symptoms of ME / ME-symptomen -Dr. Byron Hyde, MD
 * 84. ‪CFS / CVS - Dr. Byron Hyde, MD
 * 85. ME, viruses and bacteria / ME, virussen en bacteriën - Dr. Byron Hyde, MD
 * 86. ‪ME and the role of enteroviruses / ME en de rol van enterovirussen - Dr. Byron Hyde‬, MD
 * 2007, Speaker at the 2nd Invest in ME International ME Conference on ME and Insurance companies DVD available
 * 2006, A new and simple definition of Myalgic Encephalomyelitis and a new simple definition of Chronic Fatigue Syndrome & A Brief History of Myalgic Encephalomyelitis and an Irreverent History of Chronic Fatigue Syndrome (London Conference of May 12)
 * 2006, Speaker at the 1st Invest in ME International ME Conference on The epidemiology, definitions and techniques of investigation of the ME and CFS patient and the resulting pathological findings DVD available


 * How I Help CFS/ME Patients in Canada - Byron Hyde, MD (Vimeo)


 * Prof. Kenny de Meirleir and Dr. Byron Hyde on ME/CFS (Daily Motion)

Books

 * 2011, Missed Diagnoses: Myalgic Encephalomyelitis & Chronic Fatigue Syndrome
 * 1992, The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Free PDF download)

Online presence

 * The Nightingale Research Foundation