Neuroimmune model

The neuroimmune model or neuro immune hypothesis of ME/CFS proposes that an initial infection and immune activation, which can be caused by a number of different pathogens results in "a state of chronic peripheral immune activation driven by activated O&NS pathways that lead to progressive damage of self epitopes even when the initial infection has been cleared".

The ATP deficiency, inflammation and oxidative and nitrosative stress are proposed to result from this, and to be the cause of the symptoms characteristic of ME/CFS.

Notable studies and publications

 * 2011, Chronic fatigue syndrome – A neuroimmunological model (Full text)


 * 2013, A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome (Full text)


 * 2017, The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (Full text)

Learn more

 * A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome