Wirth-Scheibenbogen hypothesis

Prof Dr Klaus Wirth and Prof Dr Carmen Scheibenbogen

Hypothesis
Endothelial dysfunction is proposed to be key to ME/CFS, which is regarded as a neurovascular disease.

Treatment
Self-administered Immunoglobulin G (IgG) is a proposed treatment, with a proof of concept trial completed in 2021.

Notable studies

 * 2021, An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - (Full text)


 * 2021, Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - (Full text)


 * 2021, Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study - (Full text)


 * 2020, A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors - (Full text)

Evidence and related studies

 * 2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls - (Full text)
 * 2011, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome - (Abstract)
 * 2009, Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects - (Abstract)