Coxsackievirus B4

Coxsackievirus B4 is an enterovirus that belong to the Picornaviridae family.

Coxsackievirus B4 has a cell tropism for natural killer cells and pancreatic islet cells, and is one of six variants of Coxsackie B.

Type 1 Diabetes
Several studies have suggested a relationship between Coxsackie B4 and the onset of Type 1 diabetes.

A study of patients with Type 1 Diabetes found that Coxsackie B4 was found to infect β cells and cause inflammation mediated by natural killer cells.