Leukotriene

Leukotrienes are a family of eicosanoids produced by the oxidation of arachidonic acid by the enzyme arachidonate 5-lipoxygenase (ALOX5).

Leukotriene production is usually accompanied by the production of histamine and prostaglandins. Leukotrienes are important in asthma.

Leukotriene inhibitors
Leukotriene inhibitors are a potential treatment for mast cell diseases including mast cell activation syndrome.

Leukotriene inhibitors include Montelukast (Singulair), Zafirlukast (Accolate) and Zileuton (Zyflo/Zyflo CR).

Learn more

 * Medications to Treat Mast Cell Diseases - The Mast Cell Disease Society