Folate

Folate (Vitamin B9) is involved in the metabolism of nucleic acids (the building blocks of RNA and DNA and is important for the synthesis of red blood cells. It is also critical in methylation.

Its active form, tetrahydrofolate (THF) is involved in pyrimidine nucleotide synthesis and is important in pregnancy and infancy.

Deficiency
Deficiency of either folate or Vitamin B12 can lead to megaloblastic anema.

Deficiency is associated with increased blood homocysteine and an increased risk of cardiovascular disease.

Folate is essential for brain development and function.

However high doses of folic acid may cause long term issues as it is not bio identical to folate found in vegetables, methylfolate is more advisable or long term use

MTHFR mutation
The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene influences the metabolism of folic acid, the synthetic form found in many supplements and fortified foods.

Chronic fatigue syndrome
High Homocysteine is found in the cerebral spinal fluid of ME/CFS patients and lowering it with B12/Folic acid may help cognitive symptoms.

Learn more

 * Folate, the Linus Pauling Institute