Contents (condensed)

We are crowd-sourcing a knowledge base on the history, science and medicine of ME and CFS around the world. MEpedia is a patient community project being built by patients, founded by #MEAction. Read more about MEpedia and its principles.

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Five minute tasks
Only have a five minute spoon to give? Here is a list of small tasks you can help us with in roughly one to ten minutes of time.

Priority pages for expansion
Science: Citric acid cycle, Mitochondria, Exercise, Ampligen, Natural killer cell, Central nervous system, Nitric oxide hypothesis, Brain, Brain imaging

History and politics:

A note on ME v. CFS
We have separate pages for Myalgic Encephalomyelitis, ME/CFS and Chronic Fatigue Syndrome as well as SEID. The convention is that the terminology used in an ME-pedia article should match the terminology used in the underlying source. Where there is a tension between the term used in the source and the definition (e.g., ME defined by the Oxford criteria or CFS defined by the Canadian Consensus Criteria), it may be useful for clarity to mention the definition used.

The Disease
Infectious agents: Borrelia, Babesia, Bartonella, Borna Disease Virus, Chlamydia pneumoniae, Coxsackie A, Coxsackie B, cytomegalovirus, Ebola virus, echovirus, enterovirus, Epstein-Barr virus, H1N1, Herpesvirus, HHV-6, HHV-7, HSV-1, HSV-2, influenza, parvovirus B19,  Q Fever, Ross River Virus, Chlamydia Pneumonia, Mycoplasma Pneumonia, streptococcus, fungal infection

Triggers and risk factors: Blood donation, Candidiasis, Causes of death, Epidemiology, Genetics, Menstrual cycle*, Mold*, Pediatric*, Pregnancy, Stress*, Toxic exposure*, Trauma, Vaccine, Viral onset, bacterial disease onset, fungal disease onset

Signs and symptoms: Ataxia, attention deficits, auditory sequencing problems, balance problems, Cognitive dysfunction, Chronic pain, Chronic fatigue, concentration problems, difficulty comprehending social cues, dyslexia, executive function problems, Fatigue, Food intolerance, Irritable bowel syndrome, low motivation, Migraine Syndrome, multi-tasking problems, Muscle fatigability, Neurally mediated hypotension, Nonepileptic seizure, Optical dysfunction, Orientation in Space problems, Orthostatic intolerance, Planning problems, Post-exertional malaise, Postural orthostatic tachycardia, Receptive language problems, Seizure, Sleep disturbance, Slowed thought, Telomere shortening, Unrefreshing sleep, Word-finding problems

Medical hypotheses: Amygdala hypothesis*,  Autoimmune hypothesis, encephalitis, autoimmune encephalitis, Fatty acid hypothesis, Hygiene hypothesis*, Immune exhaustion hypothesis*, Infectious disease hypothesis, Ken Lassesen's model, Methylation cycle hypothesis, Microbiome hypothesis, Mold hypothesis*, Patricia Kane protocol, Vagus nerve hypothesis, Viral onset hypothesis Hypercoagulation hypothesis Acquired immune and mitochondrial dysfunction hypothesis

Body systems: Antibody, Autoantibody, Blood, Brain, B cell, Central sensitization, Cytokine, Chemokine, Cardiovascular system, Gastrointestinal system, Glutamate excitotoxicity, HPA axis*, Immune system, IL-1, IL-2, IL-6, IL-8, IL-10, IL-16, IL-17, IL-18, interferon, Leaky brain, Leaky gut, Macrophage, Microglia,  Microbiome,  Mucosal immune system, Nervous system, Natural killer cell, Neuroinflammation, Ribonuclease L, Spinal cord, Tumor necrosis factors, VEGF, T cell

Tests: Brain imaging, Cardiopulmonary exercise test, CellTrend diagnostic test, C reactive protein*, qEEG/LORETA, Erythrocyte sedimentation rate, Exercise, NCNED Griffith University diagnostic test, MRI, Orosomucoid, qEEG, SF-36, SPECT, Tilt Table, Two day exercise test, Natural Killer Cell (NKC) Function, arginine vasopressin, MTHFR and other methylation mutations, infectious disesases

Citizen science: 23andMe, American Gut, Any Treatment, Mendus, Phoenix Rising, UBiome, Know Your Genetics: Dr. Amy Yasko, WellnessFX, CH3Nutrigenomics; Dr. Amy Yasko, MTHFR.net, Genetic Genie, LiveWello

Biochemistry and cell biology: ATP, Cellular respiration, Citric acid cycle, D lactate*, Endocannabinoid, Glucocorticoid, Glutathione*, Histamine, Methylation cycle, Mitochondria, Nitric oxide, Oxidative phosphorylation, Phenylalanine, Tyrosine

Nutrients: Copper, Deadlock quartet, Folate, L-carnitine, Magnesium, Sam-e, TMG, Vitamin B2, Vitamin B6, Vitamin B12*, Vitamin C*, Vitamin D, Zinc

Neurotransmitters and hormones: Acetylcholine, Alpha-Melanocyte-stimulating hormone, Calicitriol, Calcidiol, Cortisol, Dopamine, Estriadol, Epinephrine, Estrogen, Glucocorticoid, Glutamate, Histamine, Hormones, Leptin, Melatonin, Neurotransmitters, Norepinephrine, Oxytocin, Progesterone, Prolactin, Prostaglandins, Serotonin, Testosterone, Vasopressin, Thyroid, MSH, HGH

Blood donation

Potential treatments
Category page: Potential treatments

Supplements: Probiotics, AHCC, CoQ10, L-carnitine, MitoQ, NADH, PrescriptAssist, Mutaflor, GcMAF, Colostrum, Transfer factors, Fish oil, EPA, DHA, Taurine, L-Glutamine, Glutathione, Niacinamide, B Vitamin Complex, Adaptogens (Eleuthro, Ginseng, Ashwaganda, Rhodiola, Licorice), Mangosteen, Vegan/non-whey Protein Powders with Amino Acid Complex, Greens Powders, D-Ribose, Quercetin, Nexavir, 5-Hydroxytryptophan, Melatonin

Supplement Sources: Pure Formulas, Be Well By Dr Frank Lipman, Seeking Health, MITOQ, Aloha, ProHealth, Thrive Marketplace, HolisticHeal, Vitacost.com

Foods: Cocoa (Dark chocolate)

Herbs: Medical marijuana, Kampo, Equilibrium

Diets: GAPS diet, Ketogenic diet, Low FODMAP Diet, Low Histamine Diet, Paleo diet, RPAH Elimination Diet, Specific carbohydrate diet, Vegan diet, Vegetarian diet

Antivirals: Valgancyclovir, Famciclovir, Valaciclovir, Acyclovir

Immunomodulators and immunostimulants: Ampligen, Low dose naltrexone, Equilibrant, Intravenous immunoglobulin, Staphylococcal vaccine, Immunovir, Medicinal mushrooms, Interferon

Anti-inflammatory drugs: Sulfasalazine

Anti-fungal drugs: Fluconazole, Itraconazole

Other drug treatments: Chelation, Cyclophosphamide, Prednisone, Rituximab, Trazodone

Toxin avoidance/removal: Fasting, Mold avoidance, Coffee enema

Uncategorized interventions: Traditional Chinese medicine, Cold immersion, Fecal matter transplant/Faecal bacteriotherapy, Helminthic therapy, Pacing, Energy envelope, Hyperbaric oxygen, Ozone, Altitude, Exercise, Vagus nerve stimulation, Exercise based on 2-day CPET, Lipid replacement therapy

Management guides: Taming the Gorilla (Action for ME), Notes for Carers (Greg Crowhurst), The Purple Booklet (ME Association), Spoon theory

Clinical doctors worldwide
Clinical doctors worldwide are listed by country.

Research
Researchers and Intiatives
 * Researchers Australia
 * Research initiatives Australia


 * Researchers Canada
 * Research initiatives Canada


 * Researchers Germany


 * Researchers Norway


 * Researchers USA
 * Research initiatives USA

Studies, biobanks, registries, mailing lists
 * Researchers UK
 * Research initiatives Europe
 * Notable studies
 * Biobanks & patient registries*
 * Researcher mailing lists

Psychological Paradigm
Psychological paradigm, mind-body approaches and related interventions: FINE trial, PACE trial, Graded Exercise Therapy, Cognitive Behavioral Therapy, Biopsychosocial Model, Deconditioning, Mickel therapy, Lightning process, Gupta programme, Psychoneuroimmunology, Meditation, Bodily distress syndrome, Functional somatic syndrome, Psychosomatic illness, Neurasthenia, Medically unexplained symptoms

Psychological paradigm proponents: Simon Wessely, Michael Sharpe, Peter White, Trudie Chalder, Rona Moss-Morris, Jessica Bavinton, Esther Crawley, Anthony Cleare, Ben Goldacre, Peter Manu, Brian Walitt, Edward Shorter

Psychological paradigm critics: James Coyne, Keith Laws, David Tuller, Ronald Davis, Bruce Levin, Arthur Reingold, Jonathan Edwards, Leonard Jason, Ellen Goudsmit, Angela Kennedy, Mark Zinn, Marcie Zinn

Patient mental health

By country: Diagnosis, treatments, insurance, disability, etc.

 * Africa:
 * Asia:
 * Australia & New Zealand:
 * Europe:
 * North America:
 * South America:

History
Important events timeline

Historical records: Osler's Web, Thirty Years of Disdain

Outbreaks: Outbreaks: Incline village 1984, Lyndonville 1985, Akureyri, Los Angeles 1934, Royal Free Hospital 1955, Dalston 1955, Adelaide 1949, Ayrshire 1980, Sacramento 1975

Deceased patients: Sophia Mirza, Thomas Hennessy, Jr., Vanessa Li, Lynn Gilderdale, Emily Collingridge, Chardale Dotson Irvine, Oliver Coles, Brynmor John, Victoria Elsbury-Legg, Roger Cicero, Memorial Lists

Major developments/controversies: PACE trial, XMRV

ME and CFS in popular culture

Patient advocacy

 * Patient groups worldwide
 * Advocacy/Fundraising initiatives
 * Famous patients
 * Notable patients
 * Notable healthy advocates
 * Notable quotes

Journals, TV, Articles, Books, Film, Interviews, Blogs, Discussion Forums
Many categories have multiple languages. Books and Discussion Forums are an example. Example of multiple countries are Film.


 * Journals
 * TV
 * Articles
 * Books
 * Film
 * Interviews
 * Blogs
 * Discussion Forums