Notable studies

This page lists published ME/CFS studies that are notable, for particularly interesting findings, for their quality or their size.


 * Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England

[1] Nacul LC, Lacerda EM, Pheby D, et al. Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care. BMC Med. 2011;28:9:91.

[2] Komaroff AL, Fagioli LR, Doolittle TH, et al. Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups. Am J Med. 1996;101(3):281-90.

[3] Johnston S, Brenu EW, Staines D, et al. The prevalence of chronic fatigue syndrome/myalgic encephalomyelitis: a meta-analysis. Clin Epidemiol. 2013;5:105.

[4] AIHW, Begg S, Vos T, et al. 2007. The burden of disease and injury in Australia 2003. Cat. no. PHE 82. Canberra: AIHW. Viewed 19 September 2015. Available from: http://www.aihw.gov.au/publication-detail/?id=6442467990

[5] Cairns R, Hotopf M. A systematic review describing the prognosis of chronic fatigue syndrome. Occup Med. 2005;55(1):20-31.

[6] Green C, Cowan P, Elk R, et al. National Institutes of Health Pathways to Prevention Workshop: Advancing the Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Ann Int Med. 2015;162(12);860.

[7] Clayton ER, Alegría M, Bateman L, et al. for the Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. 2015. https://www.iom.edu/Reports/2015/ME-CFS.aspx

[8] Fluge Ø, Bruland O, Risa K, et al. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS One. 2011;6(10):e26358.

[9] Bakken IJ, Tveito K, Gunnes N, et al. Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008–2012. BMC Med. 2014;12:167.

[10] Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. 2006;333:575.

[11] Fuite J, Vernon, SD, Broderick G. Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis. Genomics. 2008;92(6):393-399.

[12] Vollmer-Conna U, Cameron B, Pavlovic D, et al. Postinfective fatigue syndrome is not associated with altered cytokine production. Clin Infect Dis. 2007;45(6); 732-735. [12] Vollmer‐Conna U, Piraino B, Cameron B, et al. Cytokine Polymorphisms Have a Synergistic Effect on Severity of the Acute Sickness Response to Infection. Clinical Infectious Diseases. 2008;47(11):1418-1425.

[12b] Carlo‐Stella N, Badulli C, De S, et al. A first study of cytokine genomic polymorphisms in CFS: positive association of TNF‐857 and IFNgamma 874 rare alleles. Clin Exp Rheumatol 2006;24(2):179–182.

[13] Smith J, Fritz EL, Kerr JR, et al. Association of chronic fatigue syndrome with human leucocyte antigen class II alleles. Clin Pathol. 2005;58:(8):860-3.

[14] Fletcher MA, Zeng XR, Maher K, et al. Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26. PLoS One. 2010;5(5):e10817

[15] Brenu EW, van Driel ML, Staines DR, et al. Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med. 2012;10(1):88-90.

[16] Loebel M, Strohschein K, Giannini C, et al. Deficient EBV-specific B-and T-cell response in patients with chronic fatigue syndrome. PloS One. 2014;9(1):e85387.

[17] Keller BA, Pryor JL, Giloteaux L. Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment. J Transl Med. 2014;12:104.

[18] White A, Light A, Hughen R, et al. Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls. Psychosom Med. 2011;74(1):46-54.

[19] Newton JL, Okonkwo O, Sutcliffe K, et al. Symptoms of autonomic dysfunction in chronic fatigue syndrome. QJM. 2007;100(8):519-26.