Chronotropic incompetence

Chronotropic incompetence is a smaller or reduced increase in heart rate during exercise and "reflects an inability to appropriately increase cardiac output because of smaller than expected increases in heart rate", and has been found in people with ME/CFS. Chronotropic incompetence may determine both symptoms and activity limitations in myalgic encephalomyelitis/chronic fatigue syndrome.

Notable studies

 * 2019, Chronotropic incompetence: an overlooked determinant of symptoms and activity limitation in myalgic encephalomyelitis/chronic fatigue syndrome? (Abstract)