Tryptase alpha/beta 1

Tryptase alpha/beta 1 or TPSAB1 is a protein-encoding gene for tryptase.

Hereditary alpha tryptasemia syndrome
Extra copies of the TPSAB1 gene is known as familial hypertryptasemia (FHT) or hereditary alpha tryptasemia (HAT) and is one of several possible causes for increased tryptase production. It is common and often does not cause illness,

Hereditary alpha tryptasemia syndrome (HATS) is a multi-systemic illness involving an increased number of TPSAB1 genes with a cluster of symptoms similar tobthose found in MCAS.

Other symptoms and diseases
The TPSAB1 has also been implicated in pruritus, unexplained, gastrointestinal symptoms, and in other diseases including the recently discovered Hereditary Alpha Tryptasemia.

Learn more

 * TPSAB1 Gene - Gene cards