SAM-e

SAMe or S-Adenosyl-Methionine. SAMe is an amino acid derivative normally synthesized in the body that may become depleted with sickness or age. SAMe helps maintain stable mood and joint function. In addition, SAMe has also shown benefits for the liver and brain.

Theory
SAMe may help people with ME or CFS by improving some brain function symptoms, as well as providing a mood lifter. SAMe aids in the synthesis of the neurotransmitters norepinephrine, dopamine, and serotonin. SAMe may also facilite healthy methylation.