Autophagy related gene 13

Autophagy Related 13 or ATG13 is a gene that is involved in controlling autophagy.

ME/CFS
In May 2022, Simmaron Research announced that they were inserting several human genes including ATG13 into mice in order to research post-exertional malaise and fatigue. ATG13 activates the myokines interleukin 6 (IL-6) and Regulated upon activation, normally T-expressed, and presumably secreted (RANTES).

Notable studies

 * 2021, Molecular evidence of autophagy impairment as serum level of ATG13 is elevated in patients with myalgic encephalomyelitis and chronic fatigue syndrome: two independent case-control studies - (Pre-print, Full text)
 * 2022, Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE) - (Abstract)

Learn more

 * ATG13 Gene - Gene cards
 * May 2022, Seeing ME/CFS: Creating the First Mouse Models for the Disease - Simmaron Research
 * Sep 2022, Cleaning Crisis? Is Defective Mitochondrial Cleanup Impairing Energy Production in ME/CFS? - Simmaron Research