Mirtazapine

Mirtazapine, sold under the brand names Remeron and Remeron SolTab, is an atypical tetracyclic antidepressant which is used primarily in the treatment of depression. In addition to its antidepressant properties, mirtazapine has anxiolytic, sedative, antiemetic, antiallergenic, and appetite stimulant effects and is sometimes used in the treatment of anxiety disorders, insomnia, nausea and vomiting, and to aid weight gain when desirable. It is taken by mouth.

A 2018 Cochrane Review reported that mirtazapine is unlikely to substantially reduce pain in people with fibromyalgia. A small number of people may experience some improvement (moderate pain relief, better sleep). Specifically, mirtazapine reduced pain by 30% or more in five out of 10 people but it was not better than placebo in reducing fatigue, depression, or improving health‐related quality of life. They found no benefit of mirtazapine over placebo for pain relief of 50% or greater.

Uses
In a recent Cochrane study fibromyalgia patients mirtazapine has been found to use a useful sleep aid for sleep problems, to reduce pain intensity, and to reduce pain by 30% ina significant number of patients. Mirtazapine was not found effective in reducing fibromyalgia pain by 50% and significant side effects occurred in some patients.

Side Effects
More commonly reported ones are: Less commonly reported ones are: It is not known whether mirtazepine is safe for use in children.
 * Sleepiness
 * Weight gain
 * Elevated alanine aminotransferase

Notable studies

 * 2017, Mirtazapine for fibromyalgia in adults (Abstract)

Learn more

 * Remeron - drugs.com