Procollagen-proline dioxygenase

Procallagen-proline dioxygenase (also known as Protocollagen hydroxylase, Prolyl hydroxylase, Prolyl 4-hydroxylase and Protocollagen prolyl hydroxylase) is an enzyme involved in collagen synthesis. It catalyzes the formation of hydroxyproline via the following, Vitamin C-dependent reaction:

procollagen L-proline + 2-oxoglutarate + O2 → (2S, 4R)-4-hydroxyproline + succinate + CO2

Some prolyl hydroxylases also act on Hypoxia-inducible factors (HIFs) which are transcription factors that can modulate cellular metabolism under conditions of decreased oxygen.