MEpedia:Contents

Welcome to MEpedia.org

We aim to co-create a knowledge base on the history, science and medicine of ME and CFS.

MEpedia.org is a project of #MEAction. Join our group of authors and editors.

Create a new article
To create a new article, simply search for the title of the article you wish to create. If a page does not already exist, you will see an option to create the page.

Start or expand a topic idea
You can also add a topic idea to list below below, being an article on one of the below topics, or expanding a stub article.

Correct our typos
You can also copyedit existing articles for typos and edit for clarity.

Check our references
You can make sure facts are properly cited and references are in correct format.

We aim to serve a general audience, a research audience, and a patient audience. All entries should be cited and make clear to distinguish what has and has not been established by peer-reviewed research findings. Articles should aim to provide both a general overview of a specific topic as well as discuss its implications or applications in ME and CFS.

Formatting with MediaWiki
Writing articles on MEpedia requires familiarizing yourself with some of the basic formatting code used by MediaWiki, the software that powers both Wikipedia and MEpedia. Here are some articles that may be helpful:


 * Formatting (e.g, bold, italics, bullets)
 * Creating internal and external links

Editorial guidelines
There is no formal editorial policy per se – that will likely evolve with time. When writing or editing each page it is helpful to consider:


 * Accessibility: What is the general information you would need to know to understand this topic? (What you are likely to find on a typical Wikipedia page)


 * Specificity: What are the relevant research findings, context, detail or applications of this topic to ME and CFS? (What you are unlikely to find on Wikipedia)


 * Connection: How does the topic relate and link to other topics (and MEpedia pages)?


 * Source quality: What is the quality of the source of the information? If it is a research study, was it a randomized double-blind trial? Was there a large sample size? What research definition(s) were used? Are there other studies that conflict with the results of that study? If a piece of information is without clear scientific support, it can still be included but must be clearly contextualized within the article as theory, anecdote or observation.


 * Medical hypotheses: If you want to go in-depth on a well-known hypothesis that may have only limited support in the scientific literature, consider starting a separate medical hypothesis page. For example: Methylation cycle hypothesis or Amygdala hypothesis or Mold hypothesis


 * Naming conventions: We have created separate pages for Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and ME/CFS. On all other pages the name used when citing scientific research is the name(s) the authors used in their study. The diagnostic criteria used can always be determined by looking at the original article. In general, it is not necessary to explain that the Fukuda criteria were used as the most common criteria, however it may be useful to describe when a study used either the Canadian Consensus Criteria, the Oxford Criteria, or another less used criteria, particularly if it is helpful for contextualizing the results of the study, or when studies that used different criteria have conflicting results.

Topic ideas
Here are some ideas of articles that need to be written (not remotely exhaustive!). Pages in red need to be started. Pages in blue are stub pages that need expanding.

Infectious agents: Herpesvirus Epstein barr virus cytomegalovirus HSV-1 HSV-2 influenza HHV-6 HHV-7 Coxsackie A Coxsackie B Babesia Bartonella enterovirus Parvovirus B-19 Ross River Virus Borna Disease Virus Q Fever

Triggers and risk factors: Viral onset Trauma Pregnancy Menstrual cycle Stress Vaccine Toxic exposure Candidiasis Mold Epidemiology

Signs and symptoms: Orthostatic intolerance Ataxia Cognitive dysfunction Postural orthostatic tachycardia Neurally mediated hypotension Sleep disturbance Fatigue Post-exertional malaise Nonepileptic seizure Seizure Migraine Muscle fatigability Food intolerance

Body systems: Nervous system HPA axis Brain Spinal cord Neuroinflammation Microglia Leaky brain Glutamate excitotoxicity Central sensitization Gastrointestinal system Microbiome Leaky gut Immune system Mucosal immune system B cell Natural killer cell Macrophage Cytokines IL-2 interferon IL-10 IL-1 IL-18 IL-17 Tumor necrosis factors Ribonuclease L Antibody Autoantibody Cardiovascular system Blood

Tests: Cardiopulmonary exercise test Two day exercise test Erythrocyte sedimentation rate C reactive protein Brain imaging MRI SPECT Exercise

Names and related conditions: Myalgic Encephalomyelitis Chronic Fatigue Syndrome ME/CFS Systemic Exertion Intolerance Disease Chronic epstein barr Chronic lyme disease Mold illness Biotoxin illness Environmental illness Multiple Chemical Sensitivity Gulf War Illness Mast cell activation disorder Mastocytosis Ehlers Danlos Syndrome Fibromyalgia Small intestine bacterial overgrowth Lactic acidosis Autoimmune disease Cancer Thyroid disease Non-Hodgkin's lymphoma

Definitions: Definitions of ME and CFS Canadian Consensus Criteria International Consensus Criteria Oxford criteria Fukuda criteria Holmes criteria

US Government Institute of Medicine report Pathways to prevention report Trans-NIH Working Group

Biochemistry and cell biology: Methylation cycle Citric acid cycle Mitochondria D lactate Lactic acid Nitric oxide Glutathione glucocorticoid endocannabinoid Histamine

Nutrients: Vitamin D Vitamin C Copper Folate B12 B6 B2 Deadlock quartet TMG Sam-e L-carnitine Zinc Magnesium

Supplements: Probiotics AHCC CoQ10 MitoQ PrescriptAssist Mutaflor GcMAF Colostrum Transfer factors

Antivirals: Valgancyclovir Famciclovir Valaciclovir Acyclovir Immunovir

Immuomodulators and immunostimulants: Ampligen Low dose naltrexone Equilibrant Intravenous immunoglobulin Staphylococcal vaccine

Anti-inflammatory drugs:

Other drug treatments: Rituximab Prednisone

Diets: Vegan diet Vegetarian diet Paleo diet Ketogenic diet GAPS diet Specific carbohydrate diet

Uncategorized interventions: Mold avoidance Fasting Chelation Fecal matter transplant Helminth therapy Pacing Energy envelope Dark chocolate Medical marijuana Hyperbaric oxygen Ozone Altitude Coffee enema

Hypotheses: Methylation cycle hypothesis Amygdala hypothesis Hygiene hypothesis

Outbreaks: Incline village Lydonville Akuyeri Los Angeles Royal Free Hospital

Notable patients: Karina Hansen Joanne Sophia Mirza Lynn Gilderdale Emily Collingridge Whitney Dafoe Tom Kindlon Graham McPhee Jennie Spotila Laura Hillenbrand Martin McCutcheon Naomi Whittingham Jane Colby Countess of Mar Brian Vastag Jennifer Brea Ryan Prior Hillary Johnson Julie Rehmeyer Leonard Jason Charles Shepherd Nasim Marie Jafry Ken Lassesen

Deceased patients Sophia Mirza Vanessa Li Lynn Gilderdale Emily Collingridge Chardale Dotson Irvine

Psychological paradigm, mind-body approaches and related interventions: PACE trial graded exercise therapy cognitive behavioral therapy biopsychosocial deconditioning Mickel therapy Lightning process Gupta programme Psychoneuroimmunology meditation Bodily distress syndrome Functional somatic syndrome Psychosomatic illness Neurasthenia

Psychological paradigm proponents Simon Wessely Michael Sharpe Peter White Trudie Chalder Rona Moss-Morris Jessica Bavinton Esther Crawley

Psychological paradigm critics James Coyne Keith Laws David Tuller Ronald Davis Bruce Levin Arthur Reingold Jonathan Edwards Leonard Jason

Exercise

Citizen science: 23andMe UBiome American Gut Mendus Any Treatment Phoenix Rising

Books: Plague The State of Me Love and Fatigue in America Osler's Web America's Biggest Cover-Up

Films: What About ME I Remember Me Forgotten Plague Canary in a Coal Mine The Last Great Medical Cover Up

Notable TV segments Sick and Tired

Clinical Doctors: Sarah Myhill Lucinda Bateman Derek Enlander Kenny de Meirleir William Weir Nancy Klimas Courtney Craig Daniel Peterson Nigel Speight Peter Behan Charles Shepherd Anna Dorothea Hoeck Cecile Jadin Phillipe Bottello

Research initiatives: Invest in ME Open Medicine Foundation Chronic Fatigue Initiative Solve ME/CFS Microbe Discovery Project UK CFS/ME Collaborative Invest in ME Conference

 Researchers: Ronald Davis Jared Younger Alan Light Melvin Ramsay Judy Mikovits Amolak Bansal Julia Newton Andreas Kogelnik Jose Montoya David Bell Mady Hornig Eric Schadt Ian Lipkin Elizabeth Dowsett Byron Hyde Elaine Defreitas David Berg John Chia Sonya Marshall-Gradisnik Donald Staines Carmen Scheibenbogen Simon Carding

Patient Groups ME Association Tymes Trust Irish ME/CFS Association

Media Wiki articles

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