Bocidelpar

Bocidelpar or ASP0367 or MA-0211 is an experimental drug that may improve mitochondria and endothelial function. Bocidelpar is undergoing clinical trials under the name ASP0367 for Duchenne Muscular Dystrophy, ME/CFS, hypoxia, kidney failure and mitochondrial myopathies (which result in mitochondria dysfunction). Bocidelpar was developed by Astrella Pharma's subsidiary Mitobridge and is being fast tracked by the FDA.

Theory
Bocidelpar is investigated to determine whether it can turn on the Peroxisome Proliferator-Activated Receptor delta (PPAR-δ) pathway, which is the pathway that turns on different genes in order to regulate mitochondria. The theory is that turning on this pathway will improve muscle function at a cellular level.

Evidence
The first clinical trial for ME/CFS is trial NCT04855201, which has not yet published any results. The trial involves 40 adults aged between 18 and 60, and is randomized clinical trial with quadruple blinding.

Clinicial trial results will look at oxygen uptake changes, exercise test values for aerobic exercise including measuring change in aerobic capacity and anaerobic threshold changes, with cardiopulmonary exercise testing being one of the tests carried out.

Clinicians
David Systrom is helping conduct the current clinical trial of bocidelpar at Brigham and Women's Hospital, Boston, United States.

Risks and safety
Unknown.

Learn more

 * ASP0367 (MA-0211) development pipeline
 * A Study to Evaluate ASP0367 in Participants With Reduced Maximum Oxygen Uptake Due to Poor Systemic Oxygen Extraction - Clinical trial
 * April 2022, $8 Million Clinical Trial of a Mitochondrial Booster Underway in ME/CFS - Cort Johnson, Health Rising
 * Science - Mitobridge