Ampligen Exercise Tolerance - graph 1



Graph from study, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME): Characteristics of Responders to Rintatolimod.

Key to graph

 * "Rintatolimod" - chemical name for Ampligen
 * "ET" - exercise tolerance measured by seconds on a treadmill using a modified Bruce exercise test (i.e., a cardiac diagnostic test which starts at a lower workload than the standard test and is typically used for elderly or sedentary patients)
 * "ITT" - intent-to-treat population which is a statistical concept term used in studies to denote that the analysis includes every subject who was randomly placed in a treatment assignment group, and ignores noncompliance, protocol deviations, withdrawal, and anything that happens after randomization. It is considered a more accurate way to analyze data since noncompliance and protocol deviations would occur during clinical use.

Interpretation of graph

 * Panel A - total study population retested at 40 weeks
 * Panel B - subset of study population retested at 40 weeks who could complete >9 minutes using a modified Bruce exercise test prior to receiving rintatolimod