Acid sensing ion channel 3

Acid Sensing Ion Channel 3 or Acid Sensing Ion Channel Subunit 3  or ASIC3 receptors sense muscle metabolites.

Exercise
White et al. (2012) found a trend towards both increasing ASIC3 and increasing transient receptor potential vanilloid type 1 (TRPV1) in chronic fatigue syndrome patients 24hrs after moderate exercise, but both multiple sclerosis patients and healthy controls had decreases in ASIC3, purinergic P2X 4 receptor (P2X4), and TRPV1 at 30 min post-exercise, and decreases in purinergic P2X 5 receptor (P2X5) 8hrs after exercise. Healthy controls also had significant decreases in P2X5 at 30 min post-exercise.

Notable studies

 * 2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample - (Full text)
 * 2012, Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome (Full text)
 * 2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls (Full text)
 * 2012, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome (Full Text)

Learn more

 * ASIC3 Gene - Gene cards