Cymbalta

Duloxetine, more commonly known under the brand name Cymbalta is an antidepressant drug that is also licensed for anxiety and for several different types of chronic pain. Duloxetine is also sold under the name Yentreve in some countries. Duloxetine is a selective-norepinephrine reuptake inhibitor antidepressant (SNRI), and was only approved in the US in 2004.

Theory
Cymbalta may be useful for some symptoms of ME/CFS, particularly pain, as well as for any co-existing depression or anxiety.

Chronic pain
Duloxetine is licensed for fibromyalgia, musculoskeletal pain, and pain caused by diabetic peripheral neuropathy (a form of nerve pain).

Risks and safety
Cymbalta has been associated with very long term and problematic discontinuation symptoms, which led to a number of law suits in the United States.

Costs and availability
Cymbalta/duloxetine is a prescription only drug.

Generic Cymbalta (duloxetine) is widely available in many countries, which has reduced costs.

Learn more

 * Cymbalta overview - FDA
 * Duloxetine - drugs.com