Fibromyalgia drugs

Fibromyalgia drugs include prescription drugs currently approved or used off-label for Fibromyalgia (FM/FMS), and experimental drugs under investigation.

There are currently three FDA approved drugs for fibromyalgia:
 * Cymbalta (duloxetine)
 * Lyrica (pregabalin), and
 * Savella (milnapracin)

Sleep medications
''Brands and their generics can have different side effects and interactions. Review EACH brand name and EACH generic name medication's side effects and possible drug interactions with your doctor and pharmacist.''

Sleep dysfunction is a prominent symptom in FM. There are several types of sleep medications used for FM; antihistamines, benzodiazepines, nonbenzodiazepines, sedating antidepressants and sedating antipsychotics.

Drug trials

 * ASP8062
 * 2017, A Phase 2a, Randomized, Double-Blind Placebo-controlled, Parallel-group Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia


 * Cannabinoid-based therapy
 * 2017, Intec Pharma Launches Phase 1 Trial of Cannabinoid-based Therapy for Fibromyalgia, Lower Back Pain.


 * IMC-1


 * 2016, The Pridgen Revolution? Dr. Pridgen on Bringing His Antiviral Approach to Fibromyalgia To Market


 * "Almost three years ago, Dr. Pridgen threatened to turn the world of fibromyalgia treatment on its head. Few had connected fibromyalgia with viruses or even immune problems when Pridgen announced that a) FM is caused herpes simplex virus reactivation and b) that it could be treated with antivirals."


 * 2016, Novel Fibromyalgia Treatment Granted FDA Fast Track Designation


 * "In the successful Phase II trial in fibromyalgia, IMC-1 was studied to confirm the hypothesis that chronic tissue-resident herpes simplex virus type 1 (HSV-1) may be one of the underlying causes of fibromyalgia and causally related to fibromyalgia symptoms or recurrence. IMC-1 is a novel fixed-dose oral combination antiviral medication designed to suppress this suspected virus and thus alleviate fibromyalgia symptoms."


 * 2017, Through the “Valley of Death”: Dr. Pridgen, Fibromyalgia and the Looming Trials


 * "First there were the anecdotal reports – FM patients were not just getting better but some, and not just a few, were getting well using something entirely new – an antiviral protocol, of all things, created not by a pain specialist or rheumatologist but by a surgeon."


 * 2017, A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia


 * "IMC-1 was efficacious and safe in treating symptoms of fibromyalgia, supporting the hypothesis that herpes virus infections may contribute to this syndrome. Improved retention rates, decreased adverse event rates, and evidence of efficacy on a broad spectrum of outcome measures are suggestive that IMC-1 may represent an effective, novel treatment for fibromyalgia."

Drug trials failed and drugs abandoned

 * TNX-102


 * 2016, The drug failed in its primary goal in providing pain relief and Tonix Pharmaceuticals will not be moving forward in developing a Ffbromyalgia drug.


 * Phase III clinical trial of DS-5565 found ineffective


 * 2017, The Big Hurt: Second Major Fibromyalgia Drug in a Year Fails


 * "In the three 13-week, double-blind, global, phase 3 ALDAY clinical trials evaluating Mirogabalin for the treatment of pain associated with fibromyalgia, Mirogabalin did not meet the primary efficacy endpoint to demonstrate a statistically significant reduction in the weekly average of worst daily pain score from baseline to Week 13."


 * BCG vaccine, the planned clinical trial was withdrawn in 2022
 * 2017, Century-old vaccine gives new hope to fibromyalgia community
 * 2018, FDA gives approval for clinical trial.

Learn more

 * Having Seizures or Blackouts? The Tramadol Connection
 * How Lyrica Changes the Fibromyalgia Brain


 * Why Your Fibro Meds Aren't Working