Definitions of myalgic encephalomyelitis and chronic fatigue syndrome

Over the course of almost three decades, many definitions or criteria have been developed to diagnose either ME, CFS or ME/CFS and SEID.

ME

 * 1986 Ramsay definition
 * 2007 Nightingale definition
 * 2011 International Consensus Criteria
 * 2014 London criteria

Only the International Consensus Criteria is currently used in some research and by few clinicians in some countries.

CFS

 * 1988 CDC case definition ("Holmes criteria")
 * 1991 Oxford criteria
 * 1994 CDC case definition ("Fukuda criteria")
 * 2005 CDC case definition ("Empirical definition")

Combined (ME/CFS)

 * 2003 Canadian Consensus Criteria
 * 2007 NICE guidelines

SEID

 * 2015 IOM diagnostic criteria (SEID)

Comparison

 * Frank Twisk, Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms
 * Case Definition Comparison - Graph 1

Learn more
See: Comparative Graphs - Case Definition Comparison - Graph 1
 * CFS vs SEID - Tandfonline Four Symptom Criteria Noted
 * CFS and ME: Toward An Empirical Case Definition - NCBI - NLM - NIH.gov See: Graph - 1
 * Excluding Factors: Jason Critiques the IOM Definition for ME/CFS - Health Rising - Cort Johnson Four Symptom Criteria Noted