Sharni Hardcastle

Sharni Lee Hardcastle, BBioMedSc (Hons1) PhD, is a researcher at National Centre for Neuroimmunology and Emerging Diseases, Griffith University, School of Medical Science, Brisbane, Queensland, Australia.

Awards

 * 2016, Junior Investigator Award to encourage young CFS/FM researchers in recognition of their work awarded by IACFSME.
 * 2013, Gold Coast Women in Business Award - Empowering Young Women’s Award In recognition of significant leadership potential and outstanding qualities and performance.

Notable studies

 * 2015, Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients
 * 2015, Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)"'Conclusions: This study was the first to show significant differences in a number of receptors in NK, CD4+T and CD8+T cells in CFS/ME suggesting dysregulation in NK cell cytotoxic activity, receptor regulation and potentially cell adherence. Consistent with previous literature, our research suggests that CFS/ME patients have immunological dysregulation in the innate and adaptive immune cells. We have also highlighted significant differences in NK, CD4+T and CD8+T cells between moderate and severe CFS/ME patients, suggesting severity subgroups may have distinct immune perturbations and consequently aetiology. Further studies examining severity subgroups of CFS/ME patients may therefore contribute to the understanding of the pathomechanism associated with the illness.'"
 * 2015, Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients "'Conclusions: Severe CFS/ME patients differed from controls and moderate CFS/ME patients over time and expressed significant alterations in iNKT cell phenotypes, CD8+T cell markers, NK cell receptors and γδT cells at 6 months. This highlights the importance of further assessing these potential immune biomarkers longitudinally in both moderate and severe CFS/ME patients.'"
 * 2014, Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis
 * 2012, Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis

Talks & interviews

 * 2014, International Student Research Forum, Denmark. Sharni Hardcastle represented National Centre for Neuroimmunology and Emerging Diseases and gave both an oral and poster presentation about her CFS/ME research.https://www.griffith.edu.au/health/national-centre-neuroimmunology-emerging-diseases/news-and-events
 * 2013, The 2nd International Symposium for Chronic Fatique Syndrome/Myalgic Encephalomyelitis Presented: "The immunological profile of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis"

Online presence

 * PubMed
 * Twitter
 * Facebook
 * Website
 * ResearchGate

Learn more

 * [[National Centre for Neuroimmunology and Emerging Diseases] Website]