Clonazepam

Clonazepam, sold under the brand name Klonopin among others, is a tranquiliser of the benzodiazepine class. It binds to GABAA receptors and increases the effect of the neurotransmitter GABA.

It is used to treat seizures, anxiety and panic disorders, movement problems such as akathisia, bruxism or restless legs syndrome, muscle problems and some sleep disorders. Several ME/CFS specialists employ clonazepam in their treatment protocols for a variety of uses.

It is usually taken orally and begins having an effect within an hour, lasting between six and twelve hours. It can cause dependence and tolerance in long-term use, and withdrawal symptoms are common. Dependence occurs in one-third of people who take clonazepam for longer than four weeks.

Clinical use

 * Paul Cheney
 * Charles Lapp
 * David Bell

Costs and availability
Clonazepam is available in most countries with a prescription. It is available as a generic medication and is generally very inexpensive.