Toxicant-induced loss of tolerance (TILT)

Toxicant-induced loss of tolerance or TILT is a proposed term for a new class of diseases involving chemical intolerance, previously called Multiple Chemical Sensitivity (MCS) or Idiopathic Environmental Intolerance (IEI). The TILT hypothesis describes how chemical intolerances to synthetic or natural chemicals, foods, or drugs develops. People with TILT are said to be have been TILTed.

Theory
The TILT hypothesis is that there are two stages to developing chemical intolerances:

The Quick Environmental Exposure and Sensitivity Inventory (QEESI) is a self-report questionnaire to identify who may have MCS/IEI.

Treatment
The main approach is to manage symptoms of chemical intolerance by identifying the chemicals, food or drugs that the person is intolerant to, and then avoiding then.

Notable studies
Toxicant-induced loss of tolerance for chemicals, foods, and drugs: assessing patterns of exposure behind a global phenomenon (Full text)
 * 2021,

Learn more

 * TILT research - UT Health San Antonio
 * Common chemical triggers and alternatives - UT Health San Antonio
 * TILT Brochure