Sirtuin 1

Sirtuin 1 or SIRT1 refers to an enzyme or the gene encoded by the enzyme from the silent information regulator (Sir2)-like family. Levels of SIRT1 expression may be associated with ME/CFS.

Other names
Sirtuin 1 is also known as
 * SIR2L1
 * NAD-Dependent Protein Deacetylase Sirtuin-1
 * NAD-Dependent Protein Deacylase Sirtuin-1
 * HSIRT1
 * HSIR2

Function
Sirtuins or silent information regulator (Sir2)-like family deacetylases are a group of enzymes found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed, and are closely related to histone deacetylases. Their purpose in human disease is not well understood.

Notable studies

 * 2018, PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle - Conference proceedings (Abstract)
 * This refers to mice exhausted by excessive activity, which is an exclusion for chronic fatigue syndrome.
 * Results Compared with C group, CFS group appeared serious damage caused by fighting, and the concentration of serum testosterone decreased significantly (p<0.01 or p<0.05) while cortisol concentration increased significantly (p<0.01 or p<0.05). Regarding antioxidant stress system indexes, the expression of MDA, T-SOD and GSH-PX significantly increased (p<0.05). The concentration of MEK and SIRT3 decreased significantly (p<0.01 or p<0.05). Compared with CFS group, VD intervention group (bVD, mVD and aVD) showed less damage caused by fighting and significantly lighter body weight (p<0.05), and the concentration of serum testosterone increased significantly (p<0.05) while that of cortisol decreased significantly (p<0.01 or p<0.05). The expression of MDA decreased significantly (p<0.05), on the countrary, T-AOC, T-SOD and GSH-PX increased significantly (p<0.05). The expressions of MEK, p-ERK/ERK, SIRT1 and SIRT3 were significantly upregulated (p<0.01 or p<0.05).


 * 2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample (Full text)
 * 2015, Novel Associations of F2-Isoprostanes, F3- Isoprostanes and Isofurans in Older Adults with Chronic Fatigue Syndrome: An Exploratory Study - (Full Text)
 * 2011, Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome (Full text)

Learn more

 * SIRT1 gene - Gene cards