Talk:PACE trial

We should include links to the SMC "expert opinions" for each of the papers.Olliec (talk) 04:38, 29 November 2015 (PST)

We should include a link to a full copy (hosted where?) of the PACE "Manual for Therapists" (are there separate manuals for CBT/GET?). PACE web site copies deleted. Olliec (talk) 04:38, 29 November 2015 (PST)

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These are the main PACE trial papers, published to date:

2007 Published protocol: White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; PACE trial group. Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy. BMC Neurol. 2007; 7:6. http://www.biomedcentral.com/1471-2377/7/6

2011 Main PACE trial paper: White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare JC, Baber HL, Burgess M, Clark LV, Cox DL, Bavinton J, Angus BJ, Murphy G, Murphy M, O'Dowd H, Wilks D, McCrone P, Chalder T, Sharpe M; PACE trial management group. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet. 2011; 377:823-36. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/abstract

2012 Cost-effectiveness analysis (Includes employment and welfare benefits data): McCrone P, Sharpe M, Chalder T, Knapp M, Johnson AL, Goldsmith KA, White PD. Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: A cost-effectiveness analysis. PLoS ONE 2012; 7:e40808. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0040808

2013 [Alleged] "Recovery" paper: White PD, Johnson AL, Goldsmith K, Chalder T, Sharpe MC. Recovery from chronic fatigue syndrome after treatments given in the PACE trial. Psychological Medicine 2013; 43:2227-35. http://journals.cambridge.org/abstract_S0033291713000020

2013 Statistical Analysis Plan: Walwyn R, Potts L, McCrone P, Johnson AL, DeCesare JC, Baber H, Goldsmith K, Sharpe M, Chalder T, White PD. A randomised trial of adaptive pacing therapy, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome (PACE): statistical analysis plan. Trials 2013; 14:386. http://www.trialsjournal.com/content/14/1/386

2014 Adverse events and deterioration: Dougall D, Johnson A, Goldsmith K, Sharpe M, Angus B, Chalder T, White P. Adverse events and deterioration reported by participants in the PACE trial of therapies for chronic fatigue syndrome. J Psychosom Res. 2014; 77:20-6. http://www.sciencedirect.com/science/article/pii/S0022399914001883

2015 Mediation Analysis (contains the fitness step test results): Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial. Chalder T, Goldsmith KA, White PD, Sharpe M, Pickles AR. (2015) Lancet Psychiatry 2015; 2:141–52 http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366%2814%2900069-8/abstract

2015 Two Year Follow Up. Sharpe M, Goldsmith KA, Johnson AL, Chalder T, Walker J, White PD. Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial. Published Online: 27 October 2015. DOI: http://dx.doi.org/10.1016/S2215-0366(15)00317-X | http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00317-X/fulltext

There are also some minor PACE-related papers:

Lawn T, Kumar P, Knight B, Sharpe M, White PD. (2010) Psychiatric misdiagnoses in patients with chronic fatigue syndrome. JRSM Short Rep. 1:28.

Cella M, Sharpe M, Chalder T. (2011) Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale. J Psychosom Res. 71:124-8.

Cella M, White PD, Sharpe M, Chalder T. (2013) Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome. Psychological Medicine 43:375-380. doi:10.1017/S0033291712000979

Bourke JH, Johnson AL, Sharpe M, Chalder T, White PD. (2014) Pain in chronic fatigue syndrome; response to rehabilitative treatments in the PACE trial. Psychological Medicine 44:1545-52 doi:10.1017/S0033291713002201

Cox D, Burgess M, Chalder T, Sharpe M, White P, Clark L. (2013) Training, supervision and therapists' adherence to manual-based therapy. International Journal of Therapy and Rehabilitation 20:180-186.