Stem cell therapy

Stem cell therapy, in particular the use of mesenchymal stromal cells (MSCs) is a potential treatment that has been suggested for ME/CFS.

Theory
[[File:Mesenchymal-stem-cell-effects.png|alt=Diagram showing stimulated, suppressed and inhibited effects on immune system.|thumb|right|Immunomodulatory effects of MSC stem cell therapy.

Notes:

Red arrow, stimulation

black arrow, suppression

blunt-ended arrow, direct inhibition

Source: Mereno-Manzano and Oltra García (2018). Cell Culture. {{collapse-this|Abbreviations: iDC, immature dendritic cell; IL, interleukin;

HGF, hepatocyte growth factor;

TGF-β, transforming growth factor-β;

PGE-2, prostaglandin E2; IDO, indoleamine-2,3-dioxygenase;

NO, nitric oxide; PD-L1, programmed death-ligand 1;

hMSC, human mesenchymal stem cell;

Treg, T regulatory; Th, T helper cell

CTL, cytotoxic T cell; mDC, mature dendritic cell

PD-1, programmed cell death protein ;1

PMN, polymorphonuclear leukocyte;

NK, Natural killer cell ]]

Evidence
Clinical trials of stem cell therapies have not yet been published.

Learn more

 * Culturing Adult Stem Cells for Cell-Based Therapeutics: Neuroimmune Applications