Metabolic features of chronic fatigue syndrome

Metabolic features of chronic fatigue syndrome is an important study of Chronic Fatigue Syndrome patients that shows the following significance:


 * "Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a characteristic chemical signature but also revealed an unexpected underlying biology. Metabolomics showed that chronic fatigue syndrome is a highly concerted hypometabolic response to environmental stress that traces to mitochondria and was similar to the classically studied developmental state of dauer. This discovery opens a fresh path for the rational development of new therapeutics and identifies metabolomics as a powerful tool to identify the chemical differences that contribute to health and disease."

Authors
Ronald Davis (Editor), Robert Naviaux, Jane C. Naviaux, Kefeng Li, A. Taylor Bright, William A. Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson, Eric Gordon

Analysis of Metabolic features of chronic fatigue syndrome

 * MEAction's Naviaux’s metabolism paper is about as big as you think states: "ME patients are in a sort of protective hibernation, limiting their consumption of resources and engaging in a hypometabolic state as a response to infection or other stressors. By examining patients’ metabolites in detail, it was found that this degree of protective hibernation correlates directly to clinical severity."

Six questions answered on Metabolic features of chronic fatigue syndrome
Dr. Robert Naviaux answers questions about his findings.


 * 1) Real illness with chemical signature and CFS is Metabolic, not all in the mind
 * 2) Cell Danger Response (CDR) does not switch off and results in a "siege metabolism"
 * 3) People do not hibernate, CFS has a metabolic signature of dauer
 * 4) Men and women are different in this disease, not related to testosterone or estrogen
 * 5) Epigenetics and Methylation pathways relevant to this disease
 * 6) This paper is not related to treatment although Metabolomics will be relevant to any clinical trial of CFS

Learn more

 * Lipid raft
 * Naviaux Lab