Fucosyltransferase 2 enzyme

Fucosyltransferase 2 enzyme (FUT2) is an enzyme that adds fucose to N-glycans. Fucose N-glycans protect against intestinal dysbiosis and sepsis. 20-30% of humans carry nonsense mutations of FUT2 and are "non-secretors."

Microbiome
Genetic non-secretors of FUT2 and those who have reduced fucose N-glycans have reduced diversity, richness, and abundance of bifidobacteria, a commensal bacterium.

Disease risk
Non-secretors may have an increased risk of Crohn's disease and type 1 diabetes, but a decreased risk of norovirus and helicobacter pylori infection.

Learn more

 * FUT2, Wiki genes
 * 23andme - FUT2 gene- Norovirus Resistance